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公开(公告)号：CR20210608A
公开(公告)日：2022-02-11
申请号：CR20210608
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , GUIDO SAMANTHA , HOOD SARAH CAROL , THOMSON STEPHEN , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , KESAVAN SARATHY , MAXWELL JOHN PATRICK , OVERHOFF KIRK ALAN , STAVROPOULOS KATHY , XU JINWANG , CLARK MICHAEL PHILIP , GAGNON KEVIN JAMES , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , LOOKER ADAM , MEDEK ALES , FLEMING GABRIELLE SIMONE , HURLEY DENNIS JAMES , RONKIN STEVEN M , SHRESTHA MUNA , JONES PETER , BOUCHER DIANE , BRODNEY MICHAEL AARON , GARCIA BARRANTES PEDRO MANUEL , NUHANT PHILIPPE MARCEL , HALL AMY BETH , RODAY SETU , SAWANT RUPA , SPOSATO MARISA , BANDARAGE UPUL KEERTHI , JOHNSON JR MAC ARTHUR , LAI MEI-HSIU , MAXWELL BRAD , SWETT REBECCA JANE , ZAKY MARIAM , COTTRELL KEVIN MICHAEL , GREY JR RONALD LEE , LIU SIYING , ROEPER STEFANIE , TANG QING , TAPLEY TIMOTHY LEWIS , SHI YI
IPC: A61K31/429 , A61K31/4162 , A61P1/16 , A61P11/00 , C07D231/56 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: La descripción proporciona compuestos útiles para tratar la deficiencia de alfa-1 antitripsina (AATD), de acuerdo con la fórmula (I), tautómeros de estos, sales farmacéuticamente aceptables de los compuestos, sales farmacéuticamente aceptables de los tautómeros, derivados deuterados de los compuestos, derivados deuterados de los tautómeros y derivados deuterados de las sales, formas sólidas de esos compuestos y procesos para preparar esos compuestos
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公开(公告)号：CA3140039A1
公开(公告)日：2020-12-10
申请号：CA3140039
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , BRODNEY MICHAEL AARON , CLARK MICHAEL PHILIP , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GAGNON KEVIN JAMES , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , GREY JR RONALD LEE , GUIDO SAMANTHA , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , JOHNSON JR , JONES PETER , KESAVAN SARATHY , LAI MEI-HSIU , LIU SIYING , LOOKER ADAM , MAXWELL BRAD , MAXWELL JOHN PATRICK , MEDEK ALES , NUHANT PHILIPPE MARCEL , OVERHOFF KIRK ALAN , RODAY SETU , ROEPER STEFANIE , RONKIN STEVEN M , SAWANT RUPA , SHI YI , SHRESTHA MUNA , SPOSATO MARISA , STAVROPOULOS KATHY , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN , XU JINWANG , ZAKY MARIAM , COTTRELL KEVIN MICHAEL
IPC: A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D231/56 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
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公开(公告)号：AU2021246527A1
公开(公告)日：2022-10-27
申请号：AU2021246527
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： GIROUX SIMON , CLARK MICHAEL PHILIP , BRODNEY MICHAEL AARON , JONES PETER , DENINNO MICHAEL PAUL , GU WENXIN , TANG QING , STONE STEVEN DAVID , SENTER TIMOTHY J , GALE-DAY ZACHARY , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE , COTTRELL KEVIN MICHAEL
IPC: C07D215/20 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00 , C07D215/22 , C07D215/24 , C07D215/38 , C07D217/24 , C07D217/26 , C07D401/04 , C07D401/12 , C07D405/14 , C07D413/12 , C07D413/14
Abstract: 7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-l-antitrypsin modulators for treating alpha-l-antitrypsin deficiency (AATD).
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公开(公告)号：AU2020286424A1
公开(公告)日：2022-01-06
申请号：AU2020286424
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , BRODNEY MICHAEL AARON , CLARK MICHAEL PHILIP , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GAGNON KEVIN JAMES , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , GREY JR RONALD LEE , GUIDO SAMANTHA , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , LAI MEI-HSIU , LIU SIYING , LOOKER ADAM , MAXWELL BRAD , MAXWELL JOHN PATRICK , MEDEK ALES , NUHANT PHILIPPE MARCEL , OVERHOFF KIRK ALAN , RODAY SETU , ROEPER STEFANIE , RONKIN STEVEN M , SAWANT RUPA , SHI YI , SHRESTHA MUNA , SPOSATO MARISA , STAVROPOULOS KATHY , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN , XU JINWANG , ZAKY MARIAM , COTTRELL KEVIN MICHAEL
IPC: C07D231/56 , A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
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公开(公告)号：CO2021005884A2
公开(公告)日：2021-05-20
申请号：CO2021005884
申请日：2021-05-05
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , BRODNEY MICHAEL AARON , ECCLES MARY ELIZABETH , GAGNON KEVIN JAMES , HOOD SARAH CAROL , HUSSEY JOSHUA KENNEDY , LOOKER ADAM , MAXWELL JOHN PATRICK , MEDEK ALES , NAVAMAL METTACHIT , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , TANG QING , WALDO MICHAEL , BANDARAGE UPUL KEERTHI , BOUCHER DIANE M , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , DEWEY FANNING LEV TYLER , FIMOGNARI JR ROBERT FRANCIS , GARCIA BARRANTES PEDRO M , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , NUHANT PHILIPPE MARCEL , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , XU JINWANG , MAXWELL BRAD D , COTTRELL KEVIN MICHAEL
IPC: A61P1/16 , A61K31/4162 , A61K31/4178 , A61K31/4196 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61P11/00 , C07D471/14 , C07D487/04 , C07D487/14 , C07D519/00
Abstract: Nuevos compuestos, composiciones y métodos para usar y preparar los mismos, los cuales pueden ser útiles para tratar la deficiencia de alfa-1 antitripsina (AATD).
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Patent Agency Ranking
公开(公告)号：UY38403A
公开(公告)日：2020-04-30
申请号：UY38403
申请日：2019-10-07
Applicant: VERTEX PHARMA
Inventor： JONES PETER , NUHANT PHILIPPE MARCEL , BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE M , DEWEY FANNING LEV TYLER , ECCLES MARY ELIZABETH , FIMOGNARI JR ROBERT FRANCIS , GAGNON KEVIN JAMES , BOYD MICHAEL JOHN , GARCÍA BARRANTES PEDRO M , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , HUSSEY JOSHUA KENNEDY , JOHNSON JR , KESAVAN SARATHY , LOOKER ADAM , MAXWELL BRAD D , MAXWELL JOHN PATRICK , MEDEK ALES , NAVAMAL METTACHIT , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , WALDO MICHAEL , XU JINWANG , DAMAGNEZ VERONIQUE , BRODNEY MICHAEL AARON
IPC: A61P1/16 , A61K31/4162 , A61K31/437 , A61K31/497 , A61P11/00 , C07D471/14 , C07D487/04 , C07D487/14 , C07F5/04
Abstract: Nuevos compuestos, composiciones y métodos de uso y preparación de los mismos, que pueden ser útiles para el tratamiento de la deficiencia de alfa-1 antitripsina (AATD).
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公开(公告)号：BR112021022832A2
公开(公告)日：2022-01-18
申请号：BR112021022832
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM , MEDEK ALES , AMY BETH HALL , MAXWELL BRAD , CAVAN MCKEON BLIGH , DENNIS JAMES HURLEY , BOUCHER DIANE , GABRIELLE SIMONE FLEMING , XU JINWANG , JOHN PATRICK MAXWELL , STAVROPOULOS KATHY , KEVIN JAMES GAGNON , KEVIN MICHAEL COTTRELL , KIRK ALAN OVERHOFF , LEV TYLER DEWEY FANNING , MAC ARTHUR JOHNSON JR , ZAKY MARIAM , SPOSATO MARISA , LAI MEI-HSIU , MICHAEL AARON BRODNEY , MICHAEL JOHN BOYD , MICHAEL PHILIP CLARK , SHRESTHA MUNA , PEDRO MANUEL GARCIA BARRANTES , JONES PETER , PHILIPPE MARCEL NUHANT , TANG QING , REBECCA JANE SWETT , ROBERT DANIEL GIACOMETTI , ROBERT FRANCIS FIMOGNARI , RONALD LEE GREY JR , SAWANT RUPA , GUIDO SAMANTHA , SARAH CAROL HOOD , KESAVAN SARATHY , RODAY SETU , GIROUX SIMON , LIU SIYING , ROEPER STEFANIE , THOMSON STEPHEN , STEVEN M RONKIN , TIMOTHY LEWIS TAPLEY , UPUL KEERTHI BANDARAGE , DAMAGNEZ VERONIQUE , SHI YI
IPC: C07D231/56 , A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: pirrois tricíclicos condensados como moduladores da alfa-1 antitripsina. a divulgação fornece compostos úteis para tratar a deficiência de alfa-1 antitripsina (aatd), de acordo com a fórmula (i), seus tautômeros, sais farmaceuticamente aceitáveis dos compostos, sais farmaceuticamente aceitáveis dos tautômeros, derivados deuterados dos compostos, derivados deuterados dos tautômeros e derivados deuterados dos sais, formas sólidas desses compostos e processos para produzir esses compostos.
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公开(公告)号：CA3114672A1
公开(公告)日：2020-04-23
申请号：CA3114672
申请日：2019-10-04
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , BRODNEY MICHAEL AARON , ECCLES MARY ELIZABETH , GAGNON KEVIN JAMES , HOOD SARAH CAROL , HUSSEY JOSHUA KENNEDY , LOOKER ADAM , MAXWELL JOHN PATRICK , MEDEK ALES , NAVAMAL METTACHIT , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , TANG QING , WALDO MICHAEL , BANDARAGE UPUL KEERTHI , BOUCHER DIANE M , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , DEWEY FANNING LEV TYLER , FIMOGNARI JR , GARCIA BARRANTES PEDRO M , GIROUX SIMON , GREY JR , HALL AMY BETH , HURLEY DENNIS JAMES , JOHNSON JR , JONES PETER , KESAVAN SARATHY , NUHANT PHILIPPE MARCEL , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , XU JINWANG , MAXWELL BRAD D , COTTRELL KEVIN MICHAEL
IPC: C07D487/04 , A61K31/4162 , A61K31/4178 , A61K31/4196 , A61K31/437 , A61K31/4985 , A61K31/5377 , A61K31/7056 , C07D471/14 , C07D487/14 , C07D519/00 , C07H13/02
Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).
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公开(公告)号：JOP20210301A1
公开(公告)日：2023-01-30
申请号：JOP20210301
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： SHI YI , TAPLEY TIMOTHY LEWIS , SWETT REBECCA JANE , XU JINWANG , MAXWELL JOHN PATRICK , SHRESTHA MUNA , OVERHOFF KIRK ALAN , BANDARAGE UPUL KEERTHI , BRODNEY MICHAEL AARON , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , TANG QING , THOMSON STEPHEN , GAGNON KEVIN JAMES , GREY JR RONALD LEE , JONES PETER , JOHNSON JR MAC ARTHUR , GUIDO SAMANTHA , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , DAMAGNEZ VERONIQUE , RODAY SETU , RONKIN STEVEN M , ROEPER STEFANIE , ZAKY MARIAM , SAWANT RUPA , SPOSATO MARISA , STAVROPOULOS KATHY , GARCIA BARRANTES PEDRO MANUEL , FANNING LEV TYLER DEWEY , FLEMING GABRIELLE SIMONE , FIMOGNARI ROBERT FRANCIS , CLARK MICHAEL PHILIP , COTTRELL KEVIN MICHAEL , KESAVAN SARATHY , LAI MEI-HSIU , LOOKER ADAM , LIU SIYING , MAXWELL BRAD , MEDEK ALES , NUHANT PHILIPPE MARCEL , HOOD SARAH CAROL , HALL AMY BETH , HURLEY DENNIS JAMES
Abstract: يوفرالكشفالحاليمركباتمُفيدةلعلاجنقصمضادتريبسينألفا-1 (AATD)،وفقًاللصيغة (I): (I)،ومماثلاتكيميائيةمنها،وأملاحمقبولةصيدليًامنالمركبات،وأملاحمقبولةصيدليًامنالمماثلاتالكيميائية،ومشتقاتمُعالجةبالديوتريوممنالمركبات،ومشتقاتمعالجةبالديوتريوممنالمماثلاتالكيميائية،ومشتقاتمُعالجةبالديوتريوممنالأملاح،والصورالصلبةمنتلكالمركباتوعملياتتحضيرتلكالمركبات.
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公开(公告)号：AU2021246104A1
公开(公告)日：2022-10-20
申请号：AU2021246104
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： GIROUX SIMON , CLARK MICHAEL PHILIP , TANG QING , NUHANT PHILIPPE MARCEL , JONES PETER , MESSERSMITH DAVID , BANDARAGE UPUL KEERTHI , COTTRELL KEVIN MICHAEL , BRODNEY MICHAEL AARON , FLEMING GABRIELLE SIMONE , WANG JIAN , XU JINWANG , DANIEL KEVIN BRETT , BOYD MICHAEL JOHN , MORRIS MARK A , WAAL NATHAN D , COLLIER PHILIP NOEL , KESAVAN SARATHY , RONKIN STEVEN M , DENG HONGBO , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE
IPC: C07D209/10 , A61K31/404 , A61P11/00 , A61P29/00 , A61P43/00 , C07D209/12 , C07D209/14 , C07D209/22 , C07D209/24 , C07D209/42 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04
Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).
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