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    Τ-형 칼슘 채널에 활성을 지닌 신규 1,4-다이아제판 피라졸 화합물
    22.
    发明公开
    Τ-형 칼슘 채널에 활성을 지닌 신규 1,4-다이아제판 피라졸 화합물 有权
    作为T型钙通道拮抗剂的1,4-二氮杂双环衍生物

    公开(公告)号：KR1020120097288A

    公开(公告)日：2012-09-03

    申请号：KR1020110016788

    申请日：2011-02-24

    Applicant: 한국과학기술연구원

    Inventor： 조용서 ,  민선준 ,  배애님 ,  이재균 ,  임혜원 ,  최기현 ,  서선희 ,  송치만 ,  구수진

    IPC: C07D403/12 ,  C07D403/14 ,  A61K31/551 ,  A61P25/00

    Abstract: PURPOSE: A pharmaceutical composition containing 1,4-diazepane pyrazole compound and a pharmaceutically acceptable salt thereof is provided to be used as an agent for preventing or treating brain diseases, heart diseases, cancer, epilepsy, and pain. CONSTITUTION: A 1,4-diazepane pyrazole compound is denoted by chemical formula 1. A pharmaceutical composition for preventing and treating brain diseases such as epilepsy, depression, Parkinson's diseases, dementia, sleep disorders, or heart diseases such as hypertension, cardiac arrhythmia, or myocardial infarction, or pain contains the compound of chemical formula 1 as an active ingredient. A method for preparing the compound of chemical formula 1 comprises a step of reacting pyrazolemethyl amine of chemical formula 2 with chloroacetyl chloride.

    Abstract translation: 目的：提供含有1,4-二氮杂环庚烷吡唑化合物及其药学上可接受的盐的药物组合物，用作预防或治疗脑疾病，心脏病，癌症，癫痫和疼痛的药剂。 构成：1,4-二氮杂环庚烷吡唑化合物由化学式1表示。用于预防和治疗脑疾病如癫痫，抑郁症，帕金森病，痴呆，睡眠障碍或心脏病如高血压，心律失常， 或心肌梗塞，或疼痛含有化学式1的化合物作为活性成分。 制备化学式1的化合物的方法包括使化学式2的吡唑甲胺与氯乙酰氯反应的步骤。

    Ｔ-형 칼슘 채널에 활성을 지닌 피라조일 피페리딘 화합물
    23.
    发明公开
    Ｔ-형 칼슘 채널에 활성을 지닌 피라조일 피페리딘 화합물 有权
    吡唑啉酮化合物作为T型钙通道拮抗剂

    公开(公告)号：KR1020120097287A

    公开(公告)日：2012-09-03

    申请号：KR1020110016787

    申请日：2011-02-24

    Applicant: 한국과학기술연구원

    Inventor： 조용서 ,  민선준 ,  이재균 ,  배애님 ,  임혜원 ,  최기현 ,  서선희 ,  송치만 ,  최연희

    IPC: C07D401/12 ,  A61K31/454 ,  A61P25/00

    Abstract: PURPOSE: A pharmaceutical composition containing pyrazoyl piperidine compounds and pharmaceutically acceptable salt thereof is provided to prevent or treat brain diseases, heard diseases, cancer, and pain. CONSTITUTION: A pyrazoyl piperidine compound is denoted by chemical formula 1. A pharmaceutical composition for treating cerebral diseases, cardiac diseases, cancer, or pain contains the compound of chemical formula 1 as an active ingredient. A method for preparing the compound comprises: a step of reacting piperidine acetate of chemical formula 2 and pyrazole methyl amine of chemical formula 3 of a step of reacting piperidine compound of chemical formula 4 with an aldehyde compound of chemical formula 5 by reduction-amination. [Reference numerals] (AA) Reductive amination

    Abstract translation: 目的：提供含有吡唑基哌啶化合物及其药学上可接受的盐的药物组合物，以预防或治疗脑疾病，听到疾病，癌症和疼痛。 构成：化学式1表示吡唑基哌啶化合物。用于治疗脑疾病，心脏病，癌症或疼痛的药物组合物含有化学式1的化合物作为活性成分。 制备该化合物的方法包括：使化学式2的哌啶乙酸酯与化学式3的吡唑甲胺与化学式4的哌啶化合物与化学式5的醛化合物的还原胺化反应的步骤。 （参考号）（AA）还原胺化

    2-피롤리돈기를 포함하는 옥사졸리디논 유도체 또는 이의 약학적으로 허용 가능한 염 및 이들의 제조방법
    25.
    发明公开
    2-피롤리돈기를 포함하는 옥사졸리디논 유도체 또는 이의 약학적으로 허용 가능한 염 및 이들의 제조방법 有权
    含有2-吡咯烷酮基或其药学上可接受的盐的氧杂环丁酮衍生物及其制备方法

    公开(公告)号：KR1020120056078A

    公开(公告)日：2012-06-01

    申请号：KR1020100117602

    申请日：2010-11-24

    Applicant: 한국과학기술연구원

    Inventor： 금교창 ,  김은경 ,  배애님 ,  김유승 ,  강순방 ,  서선희 ,  바타라이디팍

    IPC: C07D413/10 ,  A61K31/422 ,  A61P31/04

    CPC classification number: Y02A50/473 ,  Y02A50/481

    Abstract: PURPOSE: An antibacterial composition containing novel oxazolidinone derivative is provided to ensure antibacterial activity against gram positive bacteria. CONSTITUTION: A novel oxazolidinone derivative with antibacterial activity is denoted by chemical formula 1. A method for preparing the compound of chemical formula 1 or the salt thereof comprises: a step of reacting an amine group of a compound of chemical formula 2 with a compound of chemical formula 3 or 4; and a step of substituting a hydroxyl group of an oxazolidinone derivative or a pharmaceutically acceptable salt thereof with a halogen group or methoxy group. An antibacterial composition contains the oxazolidinone derivative of chemical formula 1 or a salt thereof as an active ingredient.

    Abstract translation: 目的：提供含有新恶唑烷酮衍生物的抗菌组合物，以确保对革兰氏阳性菌的抗菌活性。 构成：具有抗菌活性的新型恶唑烷酮衍生物由化学式1表示。化学式1化合物或其盐的制备方法包括：使化学式2的化合物的胺基与 化学式3或4; 以及将恶唑烷酮衍生物或其药学上可接受的盐的羟基与卤素基或甲氧基取代的步骤。 抗菌组合物含有化学式1的恶唑烷酮衍生物或其盐作为活性成分。

    1,6-이치환-3-아미노-4,5,6,7-테트라하이드로-1Ｈ-피라졸로［3,4-ｃ］피리딘-7-온 화합물 및 이 화합물의 제조방법
    26.
    发明公开
    1,6-이치환-3-아미노-4,5,6,7-테트라하이드로-1Ｈ-피라졸로［3,4-ｃ］피리딘-7-온 화합물 및 이 화합물의 제조방법 有权
    新的1,6-二异丙基氨基-4,5,6,7-四氢-1H-吡唑并[3,4-C]吡啶-7-酮化合物及其制备方法

    公开(公告)号：KR1020110139988A

    公开(公告)日：2011-12-30

    申请号：KR1020100060138

    申请日：2010-06-24

    Applicant: 한국과학기술연구원

    Inventor： 남길수 ,  배애님 ,  최경일 ,  추현아 ,  와니 ,  서선희

    IPC: C07D471/04 ,  C07D403/02 ,  A61K31/437 ,  A61P35/00

    CPC classification number: C07D471/04

    Abstract: PURPOSE: A novel 1,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-one is provided to suppress cancer cells. CONSTITUTION: A 1,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-7-one compound is denoted by chemical formula 1. A pharmaceutical composition for anticancer contains the compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. A method for preparing the compound of chemical formula 1 comprises a step of alkylating 3-amino compounds of chemical formula 2 with haloalkylcarbonyl piperazine of chemical formula 3 by alkylating.

    Abstract translation: 目的：提供新颖的1,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮以抑制癌细胞。 构成：1,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮化合物由化学式1表示。用于抗癌的药物组合物含有化合物 的化学式1或其药学上可接受的盐作为活性成分。 制备化学式1的化合物的方法包括通过烷基化将化学式2的3-氨基化合物与化学式3的卤代烷基羰基哌嗪烷基化的步骤。

    3,6-이치환-4,5,6,7-테트라하이드로-1Ｈ-피라졸로［3,4-ｃ］피리딘-7-온 화합물과 이 화합물의 제조방법
    27.
    发明公开
    3,6-이치환-4,5,6,7-테트라하이드로-1Ｈ-피라졸로［3,4-ｃ］피리딘-7-온 화합물과 이 화합물의 제조방법 有权
    新的3,6-取代-4,5,6,7-四氢-1H-吡唑并[3,4-C]吡啶-7-酮化合物及其制备方法

    公开(公告)号：KR1020110121868A

    公开(公告)日：2011-11-09

    申请号：KR1020100041360

    申请日：2010-05-03

    Applicant: 한국과학기술연구원 ,  서울대학교산학협력단

    Inventor： 남길수 ,  배애님 ,  최경일 ,  와니 ,  서선희 ,  추현아

    IPC: C07D471/02 ,  C07D487/04 ,  A61P35/00 ,  A61K31/437

    Abstract: PURPOSE: A novel 3,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one compound is provided to suppress cancer cell and to be used as an anticancer agent. CONSTITUTION: A 3,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one is denoted by chemical formula 1. A pharmaceutical composition for anticancer contains the compound of chemical formula 1 as an active ingredient. A method for preparing the compound of chemical formula 1 comprises: a step of performing acrylation of 3-amino compound of chemical formula 2 with acyl halide compound of chemical formula 3 to prepare 3-haloacylcarbamoyl compound of chemical formula 4; and a step of substituting 3-haloacylcarbamoyl compound of chemical formula 4 with amine compounds of chemical formula 5.

    Abstract translation: 目的：提供新的3,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮化合物以抑制癌细胞并用作抗癌剂 。 构成：3,6-二取代-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-7-酮由化学式1表示。用于抗癌的药物组合物含有 化学式1为活性成分。 制备化学式1化合物的方法包括：用化学式3的酰卤化合物进行化学式2的3-氨基化合物的丙烯酸化以制备化学式4的3-卤代酰基氨基甲酰基化合物的步骤; 和用化学式5的胺化合物代替化学式4的3-卤代酰基氨基甲酰基化合物的步骤。

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