公开(公告)号：ZA9818B

公开(公告)日：1998-07-02

申请号：ZA9818

申请日：1998-01-02

Applicant: ABBOTT LAB

Inventor： DAVIDSEN STEVEN K ,  SHEPPARD GEORGE S ,  XU LIANHONG ,  CURTIN MICHAEL L ,  WADA CAROL K ,  FLORJANCIC ALAN SCOTT ,  GIESLER JAMIE R ,  GUO YAN ,  MICHAELIDES MICHAEL R ,  HOLMS JAMES H

IPC: A61K31/165 ,  A61K31/197 ,  A61K31/381 ,  A61K31/404 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4406 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C233/32 ,  C07C259/06 ,  C07D207/32 ,  C07D207/323 ,  C07D207/335 ,  C07D209/14 ,  C07D213/50 ,  C07D235/14 ,  C07D263/32 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D333/22 ,  C07F ,  A61K ,  C07C

公开(公告)号：CY1111599T1

公开(公告)日：2015-10-07

申请号：CY091100278

申请日：2009-03-12

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Ενώσειςπουέχουντονχημικότύπο: (I), είναιχρήσιμεςγιατηναναστολήκινασώντυροσίνηςπρωτεΐνης. Στηνπαρούσαεφεύρεσηαποκαλύπτονταικαιδημοσιοποιούνταιωςαναφοράεπίσηςμέθοδοιγιατηνπαρασκευήτωνενώσεων, τωνσυνθέσεωνπουπεριέχουντιςενώσεις, καιτωνμεθόδωναγωγήςχρησιμοποιώνταςτιςενώσεις.

公开(公告)号：CA2358951C

公开(公告)日：2009-10-20

申请号：CA2358951

申请日：2000-01-27

Applicant: ABBOTT LAB

Inventor： STEINMAN DOUGLAS H ,  DAVIDSEN STEVEN K ,  DAI YUJIA ,  MICHAELIDES MICHAEL R ,  CURTIN MICHAEL L ,  HEYMAN HOWARD R ,  HOLMS JAMES H

IPC: C07D317/28 ,  A61K31/335 ,  A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14

Abstract: Compounds having formula (I) are matric metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：NZ544712A

公开(公告)日：2009-09-25

申请号：NZ54471204

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Disclosed are compounds of formula (I) wherein: X is S; Z is C; R1 and R3 are as described in the specification; and R2 is hydrogen or alkyl. Compounds of the type disclosed are tyrosine kinase inhibitors useful in the treatment of cancer.

公开(公告)号：BRPI0412894A

公开(公告)日：2006-10-03

申请号：BRPI0412894

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: A61P35/00 ,  C07D491/04 ,  C07D495/04 ,  C07D498/04 ,  A61K31/4355 ,  A61K31/4365

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：AU2004259765A1

公开(公告)日：2005-02-03

申请号：AU2004259765

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： HRNCIAR PETER ,  DAVIS HEATHER M ,  BURCHAT ANDREW F ,  WADA CAROL K ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  FREY ROBIN R ,  RAFFERTY PAUL ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  MUCKEY MELANIE A ,  DAVIDSEN STEVEN K ,  MICHAELIDES MICHAEL R ,  BETSCHMANN PATRICK

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：DE69809924T2

公开(公告)日：2003-08-21

申请号：DE69809924

申请日：1998-07-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DELLARIA JOSEPH F ,  FLORJANCIC ALAN S ,  GIESLER JAMIE ,  GONG JIANCHUN ,  GUO YAN ,  HEYMAN H ROBIN ,  HOLMS JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H ,  WADA CAROL K ,  XU LIANHONG

IPC: C07D233/74 ,  A61K31/275 ,  A61K31/351 ,  A61K31/352 ,  A61K31/4035 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4465 ,  A61K31/45 ,  A61K31/454 ,  A61K31/50 ,  A61P1/02 ,  A61P1/04 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C259/06 ,  C07C311/05 ,  C07C311/18 ,  C07C317/28 ,  C07C317/40 ,  C07C323/47 ,  C07C323/62 ,  C07D207/40 ,  C07D207/404 ,  C07D207/416 ,  C07D209/48 ,  C07D211/88 ,  C07D213/68 ,  C07D233/76 ,  C07D233/78 ,  C07D237/14 ,  C07D263/44 ,  C07D275/04 ,  C07D275/06 ,  C07D309/14 ,  C07D311/18 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07C259/00

Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：ES2187443T3

公开(公告)日：2003-06-16

申请号：ES00905758

申请日：2000-01-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAI YUJIA ,  DAVIDSEN STEVEN K ,  HEYMAN HOWARD R ,  HOLMES JAMES H ,  MICHAELIDES MICHAEL R

IPC: A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28 ,  A61K31/335

Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：HU0105477A2

公开(公告)日：2002-05-29

申请号：HU0105477

申请日：2000-01-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAI YUJIA ,  DAVIDSEN STEVEN K ,  HEYMAN HOWARD R ,  HOLMES JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H

IPC: A61K31/341 ,  A61K31/357 ,  A61K31/40 ,  A61K31/421 ,  A61P1/02 ,  A61P1/04 ,  A61P17/02 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/09 ,  C07D207/14 ,  C07D207/48 ,  C07D263/04 ,  C07D307/14 ,  C07D317/28

Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：AT212992T

公开(公告)日：2002-02-15

申请号：AT95904287

申请日：1994-12-08

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B JR ,  DAVIDSEN STEVEN K ,  CURTIN MICHAEL L ,  HEYMAN H ROBIN ,  SHEPPARD GEORGE S ,  XU LIANHONG ,  CARRERA GEORGE M JR ,  GARLAND ROBERT B

IPC: C07D487/04 ,  A61K31/41 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/505 ,  A61P7/02 ,  A61P11/00 ,  A61P11/16 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention relates to compounds of formula and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.