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    PROTEIN LAYERS AND THEIR USE IN ELECTRON MICROSCOPY
    41.
    发明申请
    PROTEIN LAYERS AND THEIR USE IN ELECTRON MICROSCOPY 审中-公开
    蛋白质层及其在电子显微镜中的应用

    公开(公告)号：WO2008145951A1

    公开(公告)日：2008-12-04

    申请号：PCT/GB2008/001437

    申请日：2008-04-23

    Applicant: ISIS INNOVATION LIMITED ,  SINCLAIR, John, Charles ,  NOBLE, Martin, Edward, Mäntylä

    Inventor： SINCLAIR, John, Charles ,  NOBLE, Martin, Edward, Mäntylä

    IPC: C07K14/00 ,  C07K14/47 ,  C07K19/00 ,  G01N1/28 ,  H01J37/20

    CPC classification number: C07K14/001 ,  C07K14/24 ,  C07K14/47 ,  C07K19/00 ,  C07K2319/00 ,  H01J37/20 ,  H01J37/295 ,  H01J2237/201

    Abstract: Protein layers (1) repeating regularly in two dimensions comprise protein protomers (2) which each comprise at least two monomers (5), (6) genetically fused together. The monomers (5), (6) are monomers of respective oligomer assemblies (3), (4) into which the monomers are assembled to assembly of the protein layer. The first oligomer assembly (3) belongs to a dihedral point group of order O, where O equals (3), (4) or (6) and has a set of O rotational symmetry axes of order (2). The second oligomer assembly (4) has a rotational symmetry axis of order (2). Due to the symmetry of the oligomer assemblies (3), (4), the rotational symmetry axes of each second oligomer assembly (4) is aligned with one of said set of O rotational symmetry axes of a first oligomer assembly (3) with (2) protomers being arranged symmetrically therearound. Thus, an 2-fold fusion between the oligomer assemblies (3), (4) is produced and the arrangements of the rotational symmetry axes of the oligomer assemblies (3), (4) cause the protein layer to repeat regularly. The protein layer has many uses, for example to support molecular entities for biosensing, x-ray crystallography or electron microscopy.

    Abstract translation: 在二维中规则重复的蛋白质层（1）包含蛋白质反转录剂（2），其每个包含至少两个基因融合在一起的单体（5），（6）。 单体（5），（6）是各自的低聚物组件（3），（4）的单体，其中单体组装成蛋白质层的组装。 第一低聚物组件（3）属于阶数为O的二面点组，其中O等于（3），（4）或（6），并具有一组O旋转对称轴（2）。 第二低聚物组件（4）具有顺序（2）的旋转对称轴。 由于低聚物组件（3），（4）的对称性，每个第二低聚物组件（4）的旋转对称轴线与第一低聚物组件（3）的所述一组O旋转对称轴线之一与（ 2）检测器在其周围对称布置。 因此，产生低聚物组件（3），（4）之间的2倍融合，并且低聚物组件（3），（4）的旋转对称轴的布置使得蛋白质层定期重复。 蛋白质层具有许多用途，例如支持用于生物传感，X射线晶体学或电子显微镜的分子实体。

    SAMPLE BLOCK HOLDER
    44.
    发明公开
    SAMPLE BLOCK HOLDER 有权
    PROBENBLOCKHALTER

    公开(公告)号：EP2771665A1

    公开(公告)日：2014-09-03

    申请号：EP12844105.2

    申请日：2012-10-25

    Applicant: FEI Company

    Inventor： BARRETT, Matthew ,  SMITH, Michael, D. ,  GERYK, Michal ,  SCAGNETTI, Paul ,  TOVEY, Richard

    IPC: G01N1/36 ,  G01N23/225

    CPC classification number: H01J37/20 ,  G01N2223/307 ,  G01N2223/418 ,  G01N2223/616 ,  H01J37/16 ,  H01J2237/2007 ,  H01J2237/201 ,  H01J2237/28 ,  H01J2237/2826

    Abstract: A sample holder assembly includes a sample tray, a base plate, a stage mount, and a calibration standard mounted onto the stage mount. Three mating structures on the bottom of the base plate mate with corresponding structures on a stage mount that is attached to the sample stage of the SEM. An optional contacting conductor provides electrical contact between the stage mount and the base plate so that charge generated on the sample by the electron beam can leave the sample through the sample conductive layer to the sample tray, to the base plate, to the stage mount, and through the grounded stage.

    Abstract translation: 样品架组件包括样品托盘，底板，载物台和安装在载物台上的校准标准品。 底板底部的三个配合结构与安装在扫描电镜样品台上的台架上的相应结构相配合。 可选的接触导体提供台架和基板之间的电接触，使得通过电子束在样品上产生的电荷可以使样品通过样品导电层到达样品托盘，到基板，到台架， 并通过接地阶段。

    Stage assembly, particle-optical apparatus comprising such a stage assembly, and method of treating a sample in such an apparatus
    45.
    发明公开
    Stage assembly, particle-optical apparatus comprising such a stage assembly, and method of treating a sample in such an apparatus 有权
    级装置，具有用于在这样的设备中处理的样品这样的装置和方法粒子光学设备

    公开(公告)号：EP1780765A2

    公开(公告)日：2007-05-02

    申请号：EP06123224.5

    申请日：2006-10-31

    Applicant: FEI COMPANY

    Inventor： Tappel, Hendrik ,  Hees. van, Ian ,  Lankers, Danny ,  Giannuzzi, Lucille ,  Veen, van, Gerard ,  Young, Richard

    IPC: H01J37/20 ,  H01L21/68 ,  H01J37/30

    CPC classification number: H01L21/68 ,  G01R31/2898 ,  H01J37/20 ,  H01J37/3005 ,  H01J37/3056 ,  H01J2237/201 ,  H01J2237/202 ,  H01J2237/20207 ,  H01J2237/20214 ,  H01J2237/20221 ,  H01J2237/20242 ,  H01L21/68764

    Abstract: A particle-optical apparatus comprising:
    - A first source, for generating a first irradiating beam along a first axis;
    - A second source, for generating a second irradiating beam along a second axis that intersects the first axis at a beam intersection point, the first and second axes defining a beam plane,
    - A stage assembly for positioning a sample in the vicinity of the beam intersection point, provided with:

    - A sample table to which the sample can be mounted;
    - A set of actuators, arranged so as to effect translation of the sample table along directions substantially parallel to an X-axis perpendicular to the beam plane, a Y-axis parallel to the beam plane, and a Z-axis parallel to the beam plane, said X-axis, Y-axis and Z-axis being mutually orthogonal and passing through the beam intersection point,

    wherein the set of actuators is further arranged to effect:
    - rotation of the sample table about a rotation axis substantially parallel to the Z-axis, and;
    - rotation of the sample table about a flip axis substantially perpendicular to the Z-axis,

    whereby the flip axis can itself be rotated about the rotation axis.

    Abstract translation: 甲粒子光学设备，包括： - 第一源，用于产生沿着第一轴的第一照射束; - 第二源，用于沿第二轴线产生第二照射束确实相交的第一轴线在束交叉点，所述第一和第二轴线限定一个光束平面上， - 为在附近定位样品A级组件（3） 光束交点，设置有： - 以可安装样品的样品台; - 一组致动器，布置成实现所述试样台的平移沿着方向基本上平行于在X轴垂直于光束平面，平行于束平面的Y轴，和平行Z轴的光束 规划所述X轴，Y轴和Z轴相互正交，并穿过分束交点，worin该组致动器进一步被布置成作用： - 样品台的旋转绕旋转轴线基本上平行于 Z轴，和; - 约倒装轴用的试样台大致垂直于所述Z轴，由此翻转轴线本身可以绕旋转轴线旋转。

    반도체장치의 제조방법 및 반도체 제조장치
    46.
    发明公开
    반도체장치의 제조방법 및 반도체 제조장치 有权
    半导体器件制造方法和半导体制造设备

    公开(公告)号：KR1020150041126A

    公开(公告)日：2015-04-15

    申请号：KR1020157006153

    申请日：2012-09-26

    Applicant: 미쓰비시덴키 가부시키가이샤

    Inventor： 테라시마토모히데 ,  요시우라야스히로 ,  오츠키에이코

    IPC: H01L21/67 ,  H01J37/30 ,  H01L21/677

    CPC classification number: H01L21/263 ,  H01J37/30 ,  H01J37/3002 ,  H01J2237/201 ,  H01J2237/202 ,  H01J2237/20221 ,  H01J2237/30455 ,  H01J2237/317 ,  H01L21/67115 ,  H01L21/67718 ,  H01L21/67745 ,  H01L21/6776 ,  H01L21/68 ,  H01L21/67748

    Abstract: 본원의발명에관한반도체장치의제조방법은, 복수의피처리물을, 제1트레이위와, 상기제1트레이와접하는제2트레이위에늘어놓은공정과, 상기제1트레이와상기제2트레이가접하는접촉위치의바로위에형성된조사장치로부터조사물을방출하면서, 상기조사장치를상기접촉위치를횡단하는방향인제1 방향을따라스윙시키고, 상기제1트레이와상기제2트레이를상기제1 방향과수직을이루는제2 방향으로이동시킴으로써상기복수의피처리물에상기조사물을조사하는것을복수회반복하는복수의조사공정과, 상기복수의조사공정의사이에적어도 1회실시되고, 상기제1트레이와상기제2트레이의상기제2 방향으로향하는방향을변경하지않고상기제1트레이와상기제2트레이의위치를교체하는교체공정을구비한다.

    Abstract translation: 根据本发明的半导体器件制造方法包括将多个处理对象布置在与第一托盘相邻的第一托盘和第二托盘上的步骤，多个施加步骤，其中将应用物质应用于多个 通过从第一托盘和第二托盘彼此接触的接触位置正上方形成的施加装置发射施加物质，通过沿着第一方向跨越接触位置摆动施加装置来重复加工物体一定次数 并且通过沿着与第一方向垂直的第二方向移动第一托盘和第二托盘，以及互换步骤，将第一托盘和第二托盘互换在适当位置，而不改变对应于第一托盘和第二托盘的方向 所述第二方向，所述交换步骤在所述多个之中至少执行一次 应用步骤。

    PROTEIN LAYERS AND THEIR USE IN ELECTRON MICROSCOPY
    49.
    发明授权
    PROTEIN LAYERS AND THEIR USE IN ELECTRON MICROSCOPY 有权
    蛋白层和它们在电子

    公开(公告)号：EP2167529B1

    公开(公告)日：2011-08-24

    申请号：EP08737092.0

    申请日：2008-04-23

    Applicant: ISIS Innovation Limited

    Inventor： SINCLAIR, John, Charles ,  NOBLE, Martin, Edward, Mäntylä

    IPC: C07K14/00 ,  C07K14/47 ,  C07K19/00 ,  G01N1/28 ,  H01J37/20

    CPC classification number: C07K14/001 ,  C07K14/24 ,  C07K14/47 ,  C07K19/00 ,  C07K2319/00 ,  H01J37/20 ,  H01J37/295 ,  H01J2237/201

    Abstract: Protein layers (1) repeating regularly in two dimensions comprise protein protomers (2) which each comprise at least two monomers (5), (6) genetically fused together. The monomers (5), (6) are monomers of respective oligomer assemblies (3), (4) into which the monomers are assembled to assembly of the protein layer. The first oligomer assembly (3) belongs to a dihedral point group of order O, where O equals (3), (4) or (6) and has a set of O rotational symmetry axes of order (2). The second oligomer assembly (4) has a rotational symmetry axis of order (2). Due to the symmetry of the oligomer assemblies (3), (4), the rotational symmetry axes of each second oligomer assembly (4) is aligned with one of said set of O rotational symmetry axes of a first oligomer assembly (3) with (2) protomers being arranged symmetrically therearound. Thus, an 2-fold fusion between the oligomer assemblies (3), (4) is produced and the arrangements of the rotational symmetry axes of the oligomer assemblies (3), (4) cause the protein layer to repeat regularly. The protein layer has many uses, for example to support molecular entities for biosensing, x-ray crystallography or electron microscopy.

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