公开(公告)号：CA2504385A1

公开(公告)日：2004-05-21

申请号：CA2504385

申请日：2003-10-31

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  STOLL VINCENT S ,  ZHANG RONG ,  GREEN BRIAN E ,  DONNER PAMELA L ,  PRATT JOHN K ,  BETEBENNER DAVID A ,  MCDANIEL KEITH F ,  KEMPF DALE J

IPC: A61P31/00 ,  C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  C07D471/00 ,  C07D513/00 ,  C07D513/14 ,  A61K31/554

Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.

公开(公告)号：BR0010622A

公开(公告)日：2003-07-15

申请号：BR0010622

申请日：2000-10-02

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GIRANDA VINCENT L ,  KEMPF DALE J ,  STOLL VINCENT S ,  SUN MINGHUA ,  ZHAO CHEN ,  GU YU GUI ,  HANESSIAN STEPHEN ,  WANG GARY T ,  WANG JIANCHIO ,  KRUEGER ALLAN C

IPC: A61P31/12 ,  C07D309/28 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  A61K31/351

公开(公告)号：ES2168304T3

公开(公告)日：2002-06-16

申请号：ES94921511

申请日：1994-07-15

Applicant: ABBOTT LAB

Inventor： KLEIN LARRY L ,  MARING CLARENCE J

IPC: A61K31/335 ,  A61K31/337 ,  A61P35/00 ,  C07D305/14

Abstract: A compound or prodrug thereof having the formula ain of taxol and Z is selected from the group consisting of -CHO, -CH2OH, -CH2OR', -CH2NR'R'', -CH=NR', -CH=NOR', -CH=NNR=R'', -CH(OH)SO3Na, -CH2OPO3=, -CH2OSO3=, -CN and a radical of the formula where X and Y are independently selected from -O-, -S-, and -N(R')-, as well as a method for preparing the compounds of the invention, a method of their use for the inhibition of tumors and pharmaceutical compositions containing the same.

公开(公告)号：AT209034T

公开(公告)日：2001-12-15

申请号：AT94921511

申请日：1994-07-15

Applicant: ABBOTT LAB

Inventor： KLEIN LARRY L ,  MARING CLARENCE J

IPC: A61K31/335 ,  A61K31/337 ,  A61P35/00 ,  C07D305/14

Abstract: A compound or prodrug thereof having the formula ain of taxol and Z is selected from the group consisting of -CHO, -CH2OH, -CH2OR', -CH2NR'R'', -CH=NR', -CH=NOR', -CH=NNR=R'', -CH(OH)SO3Na, -CH2OPO3=, -CH2OSO3=, -CN and a radical of the formula where X and Y are independently selected from -O-, -S-, and -N(R')-, as well as a method for preparing the compounds of the invention, a method of their use for the inhibition of tumors and pharmaceutical compositions containing the same.

公开(公告)号：PL343678A1

公开(公告)日：2001-08-27

申请号：PL34367899

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU-GUI ,  CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40 ,  C07D407/04

公开(公告)号：BG104962A

公开(公告)日：2001-07-31

申请号：BG10496200

申请日：2000-11-17

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU-GUI ,  CHEN HUI-JU ,  CHEN YCANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40 ,  C07D407/04

Abstract: Disclosed are compounds of formula which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminodase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes. 56 claims

公开(公告)号：AU7990000A

公开(公告)日：2001-04-30

申请号：AU7990000

申请日：2000-10-02

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GIRANDA VINCENT L ,  KEMPF DALE J ,  STOLL VINCENT S ,  SUN MINGHUA ,  ZHAO CHEN ,  GU YU GUI ,  HANESSIAN STEPHEN ,  WANG GARY T ,  WANG JIANCHIO ,  KRUEGER ALLAN C

IPC: A61P31/12 ,  C07D309/28 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  A61K31/351

公开(公告)号：AU7831200A

公开(公告)日：2001-04-30

申请号：AU7831200

申请日：2000-09-22

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  KEMPF DALE J ,  KENNEDY APRIL ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  MCDANIEL KEITH F ,  STOLL VINCENT S ,  SUN MINGHUA ,  ZHAO CHEN

IPC: A61P31/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61K31/4353 ,  A61K31/5383 ,  C07D209/00 ,  C07D221/00 ,  C07D265/00

公开(公告)号：CA2329422A1

公开(公告)日：1999-10-28

申请号：CA2329422

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： MADIGAN DAROLD L ,  LIN ZHEN ,  KRUEGER ALLAN C ,  MARING CLARENCE J ,  DEGOEY DAVID A ,  XU YIBO ,  YEUNG MING C ,  FLOSI WILLIAM J ,  ZHAO CHEN ,  KENNEDY APRIL ,  MUCHMORE STEVEN W ,  STEWART KENT D ,  KEMPF DALE J ,  SHAM HING L ,  GRAMPOVNIK DAVID J ,  STOLL VINCENT S ,  KATI WARREN M ,  WANG GARY T ,  GU YU-GUI ,  SUN MINGHUA ,  WANG SHELDON ,  MCDANIEL KEITH F ,  GIRANDA VINCENT L ,  KLEIN LARRY L ,  CHEN YUANWEI ,  CHEN HUI-JU

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40 ,  C07D407/04

Abstract: Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

公开(公告)号：AT151772T

公开(公告)日：1997-05-15

申请号：AT89109890

申请日：1989-06-01

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  MARING CLARENCE J ,  LARTEY PAUL A ,  KLEIN LARRY L

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.