公开(公告)号：KR101064258B1

公开(公告)日：2011-09-14

申请号：KR1020080135519

申请日：2008-12-29

Applicant: 한국과학기술연구원

Inventor： 한호규 ,  남기달 ,  신동윤 ,  박찬호 ,  조성우 ,  김은아 ,  남길수 ,  최경일 ,  서선희 ,  신희섭 ,  김동진 ,  배애님 ,  정혜진 ,  추현아 ,  임혜원 ,  조용서 ,  노은주 ,  금교창 ,  최기현 ,  신계정 ,  정찬성 ,  이재균 ,  강용구 ,  김영수 ,  박웅서 ,  김기선 ,  정혜선 ,  송치만 ,  민선준 ,  김은경 ,  이철주 ,  강순방

IPC: C07D277/82 ,  C07D263/58 ,  C07D235/30 ,  A61P25/28

CPC classification number: C07D277/82 ,  C07D235/22 ,  C07D263/58 ,  C07D327/04 ,  C07D333/06

Abstract: 본 발명은 신규한 벤조아릴우레이도 화합물, 및 이의 퇴행성 뇌질환 예방 또는 치료에 있어서의 용도에 관한 것으로, 보다 상세하게는, 화학식 1의 구조를 갖는 벤조아릴우레이도 화합물, 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 예방 또는 치료용 조성물에 관한 것이다. 상기 퇴행성 뇌질환은 알츠하이머, 치매, 파킨슨병, 뇌졸중, 아밀로이드증, 픽 질환 (Pick's disease), 루게릭병, 헌팅턴병, 크로이츠펠트-야콥(Creutzfeld-Jakob)병 등일 수 있다.
[화학식 1]

公开(公告)号：KR1020100086715A

公开(公告)日：2010-08-02

申请号：KR1020090006092

申请日：2009-01-23

Applicant: 한국과학기술연구원

Inventor： 신계정 ,  노은주 ,  이윤석

IPC: C07D239/14 ,  A61K8/40 ,  A61P25/28

CPC classification number: C07D239/26 ,  A61K9/2018 ,  A61K9/2059 ,  A61K9/4858 ,  A61K9/4866 ,  C07C39/21 ,  C07C43/23 ,  C07D239/38

Abstract: PURPOSE: A bis(styryl)pyrimidine and bis(styryl)benzene derivative are provided to reduce beta-amyloid toxicity and to improve memory. CONSTITUTION: A bis(styryl)pyrimidine and bis(styryl)benzene derivative is denoted by chemical formula 1. A method for preparing bis(styryl)pyrimidine and bis(styryl)benzene derivative comprises: a step of condensing a pyridine derivative compound of chemical formula 2 and a benzaldehyde derivative compound of chemical formula 3 under the base presence to obtain a compound of chemical formula 4; and a step of deprotecting the compound of the chemical formula 4. The deprotection is performed in methylchloride solution containing trifluoreacetic acid in hydrochloric acid/ethanol(3:1) solution.

Abstract translation: 目的：提供双（苯乙烯基）嘧啶和双（苯乙烯基）苯衍生物以减少β-淀粉样蛋白毒性并改善记忆。 构成：双（苯乙烯基）嘧啶和双（苯乙烯基）苯衍生物由化学式1表示。制备双（苯乙烯基）嘧啶和双（苯乙烯基）苯衍生物的方法包括：将化学式的吡啶衍生物化合物 式2和化学式3的苯甲醛衍生物化合物在碱存在下得到化学式4的化合物; 和使化学式4的化合物脱保护的步骤。脱盐保护在含有三氟乙酸的盐酸/乙醇（3:1）溶液中的氯甲烷溶液中进行。

公开(公告)号：KR1020090084149A

公开(公告)日：2009-08-05

申请号：KR1020080010155

申请日：2008-01-31

Applicant: 한국과학기술연구원

Inventor： 이창준 ,  노은주 ,  최진규 ,  한경석 ,  박정은 ,  강상수

IPC: A61K31/522 ,  A61K31/52 ,  A61P35/00

CPC classification number: A61K31/522

Abstract: A composition which contains caffeine, its analog, or its pharmaceutically allowable salt is provided to suppress infiltration, metastasis, and proliferation and prevent and/or treat brain cancer. A composition for preventing and treating brain cancer comprises caffeine, caffeine anaolog, or its pharmaceutically allowable salt as an active ingredient. The caffeine, caffeine analog or its pharmaceutically allowable salt has the content of 0.3-30 mM. The daily dose of the composition is 1-5 mg/kg and the composition is administered at one time or several times. The brain cancer is glioma, exothelioma, pituitary adenoma, schwannoma, craniopharyngioma or the congenital brain tumor. The composition selectively block the subtype 3 of activation of inositol-1,4,5-triphosphate receptoer(IP3R).

Abstract translation: 提供含有咖啡因，其类似物或其药学上可允许的盐的组合物以抑制浸润，转移和增殖，并预防和/或治疗脑癌。 用于预防和治疗脑癌的组合物包括咖啡因，咖啡因厌氧菌或其药学上可允许的盐作为活性成分。 咖啡因，咖啡因类似物或其药学上允许的盐的含量为0.3-30mM。 组合物的日剂量为1-5mg / kg，组合物一次或多次施用。 脑癌是神经胶质瘤，外皮瘤，垂体腺瘤，神经鞘瘤，颅咽管瘤或先天性脑瘤。 组合物选择性阻断肌醇-1,4,5-三磷酸盐受体（IP3R）的活化亚型3。

公开(公告)号：KR100892591B1

公开(公告)日：2009-04-08

申请号：KR1020070117886

申请日：2007-11-19

Applicant: 한국과학기술연구원

Inventor： 이창준 ,  노은주 ,  오수진 ,  박정환 ,  이재균

IPC: C07C229/58 ,  C07C229/52

CPC classification number: C07C229/58

Abstract: A chloride channel blocking agent containing anthranilic acid derivative is provided to show excellent validity and selectivity which result from excellent blocking activities of the anthranilic acid derivative. An anthranilic acid derivative is a compound having a structure represented by the formula I. In the formula I, R1 and R2 are independently selected from the group consisting of pentyl group, hexyl group, heptyl group, octyl group, decyl group, dodecyl group, tetradecyl group, hexadecyl group, cyclohexyl group, phenyl group, benzyl group, racemic-alphamethyl-benzyl group, chiral-alpha methyl-benzyl group, trifluoromethyl group, ethoxy group, butyloxy group, pentyloxy group, hexyloxy group, trifluoromethyloxy group and nitro group or two identical or different halogen atoms.

Abstract translation: 提供含有邻氨基苯甲酸衍生物的氯化物通道阻断剂，以显示由于邻氨基苯甲酸衍生物的优异的阻断活性而产生的优异的有效性和选择性。 邻氨基苯甲酸衍生物是具有由式I表示的结构的化合物。在式I中，R 1和R 2独立地选自戊基，己基，庚基，辛基，癸基，十二烷基， 十四烷基，十六烷基，环己基，苯基，苄基，外消旋 - 甲基 - 苄基，手性-α甲基 - 苄基，三氟甲基，乙氧基，丁氧基，戊氧基，己氧基，三氟甲氧基和硝基 或两个相同或不同的卤素原子。

公开(公告)号：KR1020040090283A

公开(公告)日：2004-10-22

申请号：KR1020030024334

申请日：2003-04-17

Applicant: 한국과학기술연구원

Inventor： 송충의 ,  정다운 ,  노은주 ,  김관묵

IPC: C07C29/74

CPC classification number: Y02P20/584

Abstract: PURPOSE: A method for preparing vicinal chiral diol compounds through asymmetric dehydroxylation by using an osmium catalyst immobilized to imidazolium salts and chiral ligands, is provided to improve the production yield with high optical purity and recycling properties, without deteriorating the catalyst activity and enantiomeric excess. The method is environmentally friendly, due to the immobilization of the highly toxic and volatile osmium compound. CONSTITUTION: The method for preparing neighboring chiral diol compounds by using an osmium catalyst immobilized to imidazolium salts comprises: (1) adding chiral ligands represented by formulas 1 and 2, an imidazolium salt represented by formula 3 and an osmium catalyst to a solvent with stirring, and then further adding an auxiliary oxidizer and olefin compounds thereto with stirring; (2) removing all of the volatile compounds under reduced pressure; (3) extracting the residues free of volatile compounds from the step (2) with an organic solvent; and (4) separating vicinal chiral diol compounds out of the organic phase of the step (3).

Abstract translation: 目的：提供通过使用固定在咪唑鎓盐和手性配体上的锇催化剂通过不对称脱羟基化制备邻位手性二醇化合物的方法，以提高具有高光学纯度和再循环性能的产率，而不会降低催化剂活性和对映体过量。 该方法是环境友好的，由于高毒性和挥发性锇化合物的固定。 构成：通过使用固定在咪唑鎓盐上的锇催化剂制备相邻的手性二醇化合物的方法包括：（1）将由式1和2表示的手性配体，式3表示的咪唑盐和锇催化剂加入到溶剂中，同时搅拌 ，然后在搅拌下进一步加入辅助氧化剂和烯烃化合物; （2）减压除去所有的挥发性化合物; （3）用有机溶剂从步骤（2）中提取不含挥发性化合物的残留物; 和（4）从步骤（3）的有机相中分离出相邻的手性二醇化合物。

公开(公告)号：KR1020020009277A

公开(公告)日：2002-02-01

申请号：KR1020000042858

申请日：2000-07-25

Applicant: 한국과학기술연구원 ,  한화화인케미칼 주식회사

Inventor： 송충의 ,  노은주 ,  유병묵 ,  김수창 ,  채기병 ,  김근식

IPC: C07C251/24

Abstract: PURPOSE: Provided are a chiral salen derivative used as a chiral ligand in an asymmetric epoxidation of olefin for producing chiral epoxy compounds and a chiral salen-metal derivative used as a chiral catalyst in the asymmetric epoxidation of olefin. CONSTITUTION: The chiral salen derivative is represented by the formula 1 and the chiral salen-metal derivative is represented by the formula 3, wherein R is C1-C24 straight or branched alkyl, halogen, alcohol, mercapto, or carboxyl-substituted C1-C24 straight or branched alkyl, cycloalkyl, aryl, or heteroaryl, H(1) and H(2) are trans each other, M is a transition metal ion such as Cr, Mn, V, Fe, Mo, W, Ru, Co, Ti, or Os, and A is an anion such as Cl-, CH3COO-, PF6-, or SbF6-.

Abstract translation: 目的：提供用作生产手性环氧化合物的烯烃不对称环氧化的手性配体的手性色胺衍生物和在烯烃的不对称环氧化中用作手性催化剂的手性盐金属衍生物。 构成：手性盐酸衍生物由式1表示，手性盐金属衍生物由式3表示，其中R为C1-C24直链或支链烷基，卤素，醇，巯基或羧基取代的C1-C24 直链或支链烷基，环烷基，芳基或杂芳基，H（1）和H（2）彼此相互反转，M是过渡金属离子如Cr，Mn，V，Fe，Mo，W，Ru，Co， Ti或Os，A是阴离子如Cl-，CH 3 COO-，PF 6 - 或SbF 6 - 。

公开(公告)号：KR101683061B1

公开(公告)日：2016-12-07

申请号：KR1020130014048

申请日：2013-02-07

Applicant: 한국과학기술연구원

Inventor： 노은주 ,  심태보 ,  안대로 ,  최승호

IPC: C07D487/04 ,  A61K31/519 ,  C07D519/04 ,  A61K31/52

CPC classification number: C07D487/04 ,  A61K31/519 ,  C07D519/00

Abstract: 본발명은신규 7피롤로[2,3-]피리미딘-4-싸이올유도체또는약학적으로허용가능한이의염의제조방법및 이를유효성분으로하는약학적조성물에관한것것으로, 본발명에따른신규 7피롤로[2,3-]피리미딘-4-싸이올유도체를함유하는조성물은야누스키나제(JAK)의과활성에의해유발되는질환의예방또는치료에유용하게사용될수 있다.

Abstract translation: 本发明涉及一种制备新颖的7H-吡咯并[2,3-d]嘧啶-4-硫醇衍生物或其药学上可接受的盐的方法，以及含有它们作为活性成分的药物组合物。 含有根据本发明的新型7H-吡咯并[2,3-d]嘧啶-4-硫醇衍生物的组合物可用于预防或治疗由Janus激酶（JAK）的过度活动引起的疾病。

公开(公告)号：KR101651994B1

公开(公告)日：2016-08-30

申请号：KR1020140011776

申请日：2014-01-29

Applicant: 한국과학기술연구원

Inventor： 한호규 ,  남기달 ,  노은주 ,  송치만 ,  윤준 ,  한민수

IPC: C07D205/04 ,  A61K31/397 ,  A61P25/00

Abstract: 아릴옥시아제티딘화합물, 및이를포함하는약학조성물이제공된다. 상기아릴옥시아제티딘화합물은신경전달물질인세레토닌, 노에피네프린및 도파민등의재흡수를동시에억제할수 있어, 우울증, 기타정신질환, 조루증, 또는신경병증성통증의예방및/또는유용하게사용될수 있다.

公开(公告)号：KR1020160063026A

公开(公告)日：2016-06-03

申请号：KR1020140166484

申请日：2014-11-26

Applicant: 한국과학기술연구원

Inventor： 심태보 ,  윤호종 ,  윤지혜 ,  허우영 ,  노은주 ,  곽연의

IPC: C07D403/14 ,  A61K31/497 ,  A61P35/00

CPC classification number: C07D403/04 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04 ,  C07D403/14 ,  A61K31/497 ,  Y10S428/917

Abstract: 본발명은단백질키나아제저해활성을갖는헤테로아릴아민화합물, 이의약학적으로허용가능한염, 그리고이 화합물을유효성분으로함유하는비정상세포성장으로유발되는질환의예방및 치료용약학적조성물에관한것이다. 본발명의신규화합물은방광암, 자궁내막암등의주요유발인자인 FGFR 및그의점 돌연변이및 FGFR 이외에신호전달에관여하는다양한단백질키나아제에대하여우수한억제효과를나타내므로, 이들단백질키나아제에의해유발되는비정상세포성장질환의예방및 치료제로서유용하다.

Abstract translation: 本发明涉及具有激酶抑制活性的杂芳基胺化合物及其药学上可接受的盐，以及包含该化合物作为预防和治疗由异常细胞生长引起的疾病的活性成分的药物组合物。 根据本发明的新化合物显示出抑制FGFR作为膀胱癌或子宫内膜癌的主要原因，其点突变和参与除FGFR之外的信号传递的各种蛋白激酶的优异作用，因此可用作预防药物 并治疗由这种蛋白激酶引起的异常细胞生长的疾病。

公开(公告)号：KR1020160038175A

公开(公告)日：2016-04-07

申请号：KR1020140130390

申请日：2014-09-29

Applicant: 한국과학기술연구원

Inventor： 노은주 ,  전보라미 ,  이창준 ,  홍진표 ,  정주연 ,  강상수

IPC: C07D417/06 ,  C07D279/22 ,  A61K31/541 ,  A61K31/5415

CPC classification number: C07D417/06 ,  A61K31/541 ,  A61K31/5415 ,  C07D279/22

Abstract: 본발명은페노싸이아진유도체또는이의약학적으로허용가능한염, 이화합물의제조방법및 이를유효성분으로하는약학적조성물에관한것으로, 본발명에따른페노싸이아진유도체는칼모듈린(CaM)을저해하는효과를가지고있으므로폐암세포내칼슘의양을고농도로유지시켜세포의사멸을돕는다. 따라서본 발명에따른페노싸이아진유도체는폐암과같은악성종양등의예방또는치료에유용하게사용될수 있다.

Abstract translation: 本发明涉及吩噻嗪衍生物或其药学上可接受的盐，其制备方法和包含其作为活性成分的药物组合物。 根据本发明的吩噻嗪衍生物具有抑制钙调蛋白（CaM）的作用，从而通过维持肺癌细胞中高含量的钙含量来帮助肺癌细胞凋亡。 因此，根据本发明的吩噻嗪衍生物可用于预防或治疗诸如肺癌等恶性肿瘤。