公开(公告)号：MX2011012521A

公开(公告)日：2012-01-30

申请号：MX2011012521

申请日：2010-05-27

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  LI PAN ,  MCGINTY KIRA

IPC: C07D513/04 ,  A61K31/47 ,  A61P35/00

Abstract: La presente invención describe compuestos de fórmula (I), que son útiles en la inhibición de proteína cinasa c-Met. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden compuestos de fórmula (I) y métodos para usar las composiciones el tratamiento de trastornos proliferativos.

公开(公告)号：SI1730146T1

公开(公告)日：2011-09-30

申请号：SI200531340

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO ,  FARMER LUC ,  BETHIEL RANDY ,  HARRINGTON EDMUND ,  GREEN JEREMY ,  COURT JOHN ,  COME JON ,  LAUFFER DAVID ,  ARONOV ALEX ,  BINCH HAYLEY ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN ,  EVERITT SIMON ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  PIERARD FRANCOISE ,  ROBINSON DANIEL ,  PINDER JOANNE ,  WANG TIANSHENG ,  PIERCE ALBERT

IPC: C07D471/00 ,  C07D471/04 ,  C07D519/00

公开(公告)号：NZ568666A

公开(公告)日：2011-09-30

申请号：NZ56866606

申请日：2006-11-30

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  ARONOV ALEXANDER ,  LI PAN ,  DEININGER DAVID ,  MCGINTY KIRA ,  STAMOS DEAN ,  COME JON ,  STEWART MICHELLE

IPC: C07D519/00 ,  A61K31/433 ,  A61P35/00 ,  C07D487/04 ,  C07D513/04

Abstract: Disclosed herein are [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives of formula (Ia), wherein the substituents are defined in the specification, methods for their preparation and compositions comprising said compounds. The compound are useful inhibitors of c-Met and therefore are also useful in the treatment/lessening the severity of proliferative disorders in a patient such as gastric adenocarcinoma, gliobastoma, renal cancer, small cell lung carcinoma, colon cancer, colorectal cancer, prostate cancer, brain cancer, liver cancer, pancreatic cancer, breast cancer, or a myleoproliferative disorder.

公开(公告)号：DK1730146T3

公开(公告)日：2011-08-15

申请号：DK05756052

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： GREEN JEREMY ,  COURT JOHN ,  PINDER JOANNE ,  WANG TIANSHENG ,  SALITURO FRANCESCO ,  FARMER LUC ,  BETHIEL RANDY ,  HARRINGTON EDMUND ,  COME JON ,  LAUFFER DAVID ,  ARONOV ALEX ,  BINCH HAYLEY ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN ,  EVERITT SIMON ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  PIERARD FRANCOISE ,  ROBINSON DANIEL ,  PIERCE ALBERT

IPC: C07D471/04 ,  C07D519/00

公开(公告)号：NZ567133A

公开(公告)日：2011-07-29

申请号：NZ56713306

申请日：2006-09-28

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANSCESCO ,  FARMER LUC ,  WANG TIANSHENG ,  WANG JIAN ,  BETHIEL RANDY ,  WANNAMAKER MARION ,  MARTINEZ-BOTELLA GABRIEL ,  ARONOV ALEXANDER ,  LAUFFER DAVID ,  PIERCE ALBERT ,  DUFFY JOHN

IPC: C07D519/00 ,  A61K31/495 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D487/04

Abstract: Disclosed is a pyrimidine having the formula (I) or a pharmaceutically acceptable salt thereof, wherein each of Z1, Z2, and Z4 is, independently, CH or N, wherein at least one of Z1 or Z2 is N, R1, R2, JQ, JQ1 and JQ2 is defined in the specification. Also disclosed is the use of said compound for the treatment of allergic or type I hypersensitivity reactions, asthma, diabetes, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, amyotrophic lateralsclerosis, multiple sclerosis, schizophrenia, cardiomyocyte hypertrophy, reperfusion/ischemia, stroke, baldness, transplant rejection, graft versus host disease, rheumatoid arthritis, a solid malignancy, a hematologic malignancy, a leukemia, a lymphoma and a myeloproliferative disorder.

公开(公告)号：MX2011004188A

公开(公告)日：2011-06-09

申请号：MX2011004188

申请日：2009-10-20

Applicant: VERTEX PHARMA

Inventor： TANG QING ,  LAUFFER DAVID ,  GRILLOT ANNE-LAURE ,  LI PAN ,  MCGINTY KIRA ,  WAAL NATHAN ,  RONKIN STEVEN

IPC: C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D451/06 ,  F02C1/00

Abstract: La presente invención se refiere a compuestos de fórmula I útiles para la inhibición de la proteína cinasa c-Met. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden los compuestos de la invención y método para utilizar las composiciones en el tratamiento de los trastornos proliferativos. Ver formula (I).

公开(公告)号：HK1142882A1

公开(公告)日：2010-12-17

申请号：HK10108367

申请日：2010-10-11

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO ,  FARMER LUC ,  BETHIEL RANDY ,  HARRINGTON EDMUND ,  GREEN JEREMY ,  COURT JOHN ,  COME JON ,  LAUFFER DAVID ,  ARONOV ALEX ,  BINCH HAYLEY ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN J ,  EVERITT SIMON ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  PIERARD FRANCOISE ,  ROBINSON DANIEL ,  WANG JIAN ,  PINDER JOANNE ,  WANG TIANSHENG ,  PIERCE ALBERT

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101 ,  C07D471/04 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I), which are inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：CA2762479A1

公开(公告)日：2010-12-02

申请号：CA2762479

申请日：2010-05-27

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  LI PAN

IPC: C07D513/04 ,  A61K31/47 ,  A61P35/00

Abstract: The present invention relates to compounds of formula (I), which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.

公开(公告)号：NZ549880A

公开(公告)日：2010-04-30

申请号：NZ54988005

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO ,  FARMER LUC ,  BETHIEL RANDY ,  HARRINGTON EDMUND ,  GREEN JEREMY ,  COURT JOHN ,  COME JON ,  LAUFFER DAVID ,  ARONOV ALEX ,  BINCH HAYLEY ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN ,  EVERITT SIMON ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  PIERARD FRANCOISE ,  ROBINSON DANIEL ,  WANG JIAN ,  PINDER JOANNE ,  WANG TIANSHENG ,  PIERCE ALBERT

IPC: C07D471/04 ,  C07D519/00

Abstract: Disclosed is a compound of formula (IB) or pharmaceutically acceptable salts thereof wherein the substituents are disclosed within the specification. Also disclosed is the use of a compound of formula (IB) in the manufacture of a medicament for inhibiting JAK-3, ROCK or Aurora kinase activity.

公开(公告)号：CA2740583A1

公开(公告)日：2010-04-29

申请号：CA2740583

申请日：2009-10-20

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID ,  LI PAN ,  MCGINTY KIRA ,  RONKIN STEVEN ,  TANG QING ,  GRILLOT ANNE-LAURE ,  WAAL NATHAN

IPC: C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D451/06

Abstract: The present invention relates to compounds of formula (I) useful in the inhibition of c- Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative disorders.