公开(公告)号：US08095193B2

公开(公告)日：2012-01-10

申请号：US11393341

申请日：2006-03-30

Applicant: Trent Ridder ,  Ben ver Steeg ,  James McNally

Inventor： Trent Ridder ,  Ben ver Steeg ,  James McNally

IPC: A61B5/1455 ,  G08B13/14

CPC classification number: A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0088 ,  A61B5/117 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/7264 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0291 ,  G01N21/274 ,  G01N21/35 ,  G01N21/359 ,  G01N21/474 ,  G01N2201/129

Abstract: The present invention relates generally to non-invasive methods and apparatuses for determining analyte properties of a subject and identity characteristics of a subject. Embodiments of the present invention provide analyte property determination and identity determination or verification from the same spectroscopic information, making unauthorized use or misleading results less likely that in systems that include separate analyte and identity determinations. The invention can be used to prevent operation of automobiles or other equipment unless the operator has an acceptable alcohol concentration, and to limit operation of automobiles or other equipment to authorized individuals who are not intoxicated or drug-impaired.

Abstract translation: 本发明一般涉及用于确定受试者的分析物特性和受试者身份特征的非侵入性方法和装置。 本发明的实施方案提供了来自相同光谱信息的分析物质性质确定和鉴别确认或验证，使得在包括单独的分析物和身份确定的系统中不太可能使用未经授权的使用或误导结果。 本发明可以用于防止汽车或其他设备的操作，除非操作人员具有可接受的酒精浓度，并且将汽车或其他设备的操作限制于不会中毒或药物受损的授权个人。

公开(公告)号：US08089625B2

公开(公告)日：2012-01-03

申请号：US12516341

申请日：2007-11-26

Applicant: Laura Marcu ,  Javier A. Jo ,  Daniel Elson

Inventor： Laura Marcu ,  Javier A. Jo ,  Daniel Elson

IPC: G01J3/30

CPC classification number: G01N21/6408 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0294 ,  G01J3/2889 ,  G01J3/4406 ,  G01N21/6402 ,  G01N21/6486 ,  G01N2021/6421 ,  G01N2021/6484

Abstract: One embodiment of the present invention provides a system that characterizes a biological sample by analyzing light emissions from the biological sample in response to an excitation. The system first radiates the biological sample with a laser impulse to cause the biological sample to produce a responsive light emission. Next, the system uses a wavelength splitting device to split the responsive light emission into a set of spectral bands of different central wavelengths. The system applies temporal delays to the set of spectral bands so that each spectral band arrives at an optical detector at a different time, thereby allowing the optical detector to temporally resolve the responsive light emission for each spectral band separately. Next, the system captures the delayed spectral bands within a single detection window of the optical detector. The system then processes the captured spectral bands.

Abstract translation: 本发明的一个实施方案提供了一种通过响应于激发分析来自生物样品的光发射来表征生物样品的系统。 系统首先用激光脉冲辐射生物样品，使生物样品产生响应性发光。 接下来，系统使用波长分离装置将响应光发射分成不同中心波长的一组光谱带。 该系统将时间延迟应用于频谱带集合，使得每个频谱带在不同时间到达光学检测器，从而允许光学检测器分别时间地分辨每个频谱带的响应光发射。 接下来，系统捕获在光学检测器的单个检测窗口内的延迟的光谱带。 然后系统处理捕获的光谱带。

公开(公告)号：US08085397B2

公开(公告)日：2011-12-27

申请号：US12500802

申请日：2009-07-10

Applicant: Frank Martin Haran ,  Ross MacHattie ,  Ronald E Beselt

Inventor： Frank Martin Haran ,  Ross MacHattie ,  Ronald E Beselt

IPC: G01J3/28 ,  G01J3/10

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/36 ,  G01N21/3559 ,  G01N21/86 ,  G01N2021/8663 ,  G01N2201/084

Abstract: Fiber optic sensors employ a high brightness light source such as a fiber optic supercontinuum source, multiplexed superluminescent light emitting diodes, or a broadband tunable laser diode. Light is delivered to the measurement location via fiber optics and sensor optics directs infrared radiation onto material the being monitored that is located in a hostile environment. A disperse element is positioned in the detection beam path in order to separate the wavelengths and to perform spectral analysis. A spectral analysis of the radiation that emerges from the sheet yields information on a plurality of parameters for the material. For papermaking applications, the moisture level, temperature and cellulose content in the paper can be obtained.

Abstract translation: 光纤传感器采用高亮度光源，例如光纤超连续光源，多路超发光发光二极管或宽带可调激光二极管。 光通过光纤传输到测量位置，并且传感器光学器件将红外辐射引导到位于恶劣环境中被监测的材料上。 分散元件位于检测光束路径中，以分离波长并进行光谱分析。 从片材出射的辐射的光谱分析产生关于材料的多个参数的信息。 对于造纸应用，可以获得纸张中的水分含量，温度和纤维素含量。

公开(公告)号：US20110292376A1

公开(公告)日：2011-12-01

申请号：US12983175

申请日：2010-12-31

Applicant: Igor V. Kukushkin ,  Leonid V. Kulik ,  Aleksandr B. Van'kov ,  Oleg A. Volkov

Inventor： Igor V. Kukushkin ,  Leonid V. Kulik ,  Aleksandr B. Van'kov ,  Oleg A. Volkov

IPC: G01N21/00 ,  G01J3/30 ,  G01J1/58 ,  G01J3/44

CPC classification number: G01J3/02 ,  G01J1/58 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/44 ,  G01N21/6445 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/6417 ,  G01N2021/6484

Abstract: An apparatus and method for detecting Raman and photoluminescence spectra of a substance and identifying said substance by Raman and/or photoluminescence spectral characteristics of said substance are disclosed. An apparatus comprises a replaceable laser source aggregate with a laser source, a collimating system, a socket for receiving said replaceable laser source aggregate, while ensuring the operation of said apparatus with no further adjustment of a positioning of said collimating system or said laser source, a filtering system, a light dispersing system optimized for a spectral resolution and a spectral range sufficient to simultaneously obtain Raman and photoluminescence spectra of said substance, a detector, and at least one controller for processing electrical signals. The disclosed and claimed method provides for obtaining Raman and photoluminescence spectra of a substance simultaneously, for separating said spectra into components based on Raman and photoluminescence contents, for analyzing said Raman and photoluminescence contents, and for identifying said substance by utilizing a set of spectral processing methods.

Abstract translation: 公开了一种用于检测物质的拉曼和光致发光光谱并通过所述物质的拉曼和/或光致发光光谱特征鉴定所述物质的装置和方法。 一种装置包括具有激光源的可替换激光源聚集体，准直系统，用于接收所述可替换激光源聚集体的插座，同时确保所述装置的操作，而不进一步调整所述准直系统或所述激光源的定位， 过滤系统，针对光谱分辨率优化的光分散系统和足以同时获得所述物质的拉曼和光致发光光谱的光谱范围，检测器和用于处理电信号的至少一个控制器。 所公开的和要求保护的方法提供了同时获得物质的拉曼和光致发光光谱，用于将所述光谱分离成基于拉曼和光致发光含量的成分，用于分析所述拉曼和光致发光含量，并通过利用一组光谱处理来鉴定所述物质 方法。

公开(公告)号：US20110282166A1

公开(公告)日：2011-11-17

申请号：US12969295

申请日：2010-12-15

Applicant: Zhongping Chen ,  Gangjun Liu ,  Mihael Balu ,  Bruce Tromberg ,  Eric Olaf Potma

Inventor： Zhongping Chen ,  Gangjun Liu ,  Mihael Balu ,  Bruce Tromberg ,  Eric Olaf Potma

IPC: A61B5/1455 ,  A61B6/00 ,  G01J3/44

CPC classification number: G01J3/44 ,  A61B1/00165 ,  A61B1/043 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/441 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0297 ,  G01N21/65 ,  G01N2021/653 ,  G01N2201/08 ,  G01N2201/0866

Abstract: A fiber-delivered probe suitable for CARS imaging of thick tissues is practical. The disclosed design is based on two advances. First, a major problem in CARS probe design is the presence of a very strong anti-Stokes component in silica delivery fibers generated through a FWM process. Without proper spectral filtering, this component affects the CARS image from the tissue sample. The illustrated embodiments of the invention efficiently suppress this spurious anti-Stokes component through the use of a separate fiber for excitation delivery and for signal detection, which allows the incorporation of dichroic optics for anti-Stokes rejection. Second, the detection of backscattered CARS radiation from the sample is optimized by using a large core multi mode fiber in the detection channel. This scheme produces high quality CARS images free of detector aperture effects. Miniaturization of this fiber-delivered probe results in a practical handheld probe for clinical CARS imaging.

Abstract translation: 适用于厚组织CARS成像的纤维输送探针是实用的。 所公开的设计基于两个进展。 首先，CARS探针设计中的一个主要问题是在通过FWM工艺生成的二氧化硅输送纤维中存在非常强的反斯托克斯组分。 没有适当的光谱过滤，该组件会影响来自组织样本的CARS图像。 本发明的所示实施例通过使用用于激发传递和信号检测的单独光纤来有效地抑制这种寄生的反斯托克斯分量，这允许并入用于反斯托克斯抑制的二向色光学器件。 其次，通过在检测通道中使用大型核心多模光纤，优化了样品背散射CARS辐射的检测。 该方案可生成高品质的CARS图像，无需检测器孔径效果。 该光纤传送探针的小型化导致临床CARS成像的实用手持式探头。

公开(公告)号：US08055108B2

公开(公告)日：2011-11-08

申请号：US12366323

申请日：2009-02-05

Applicant: Mohammed N. Islam

Inventor： Mohammed N. Islam

IPC: G02B6/00

CPC classification number: G01J3/108 ,  G01B9/02091 ,  G01J3/0218 ,  G01J3/0245 ,  G01J3/42 ,  G01J2003/102 ,  G01J2003/423 ,  G02B6/29349 ,  G02F1/365 ,  G02F2001/3528 ,  G02F2202/32 ,  H01S3/06725 ,  H01S3/06754 ,  H01S3/094007 ,  H01S3/094069 ,  H01S3/094076 ,  H01S3/1024 ,  H01S3/302 ,  H01S5/0064 ,  H01S5/0085 ,  H01S5/0092 ,  H01S5/1092 ,  H01S5/146 ,  H01S5/4012 ,  H01S2301/085

Abstract: A broadband light source includes one or more laser diodes that are capable of generating a pump signal having a wavelength shorter than 2.5 microns, a pulse width of at least 100 picoseconds and a pump optical spectral width. The light source also includes one or more optical amplifiers that are coupled to the pump signal and are capable of amplifying the pump signal to a peak power of at least 500 W. The light source further includes a first fiber that is coupled to the one or more optical amplifiers. The first fiber including an anomalous group-velocity dispersion regime and a modulational instability mechanism that operates to modulate the pump signal. In one particular embodiment, the pump signal wavelength resides in the anomalous group-velocity dispersion regime of the first fiber and where different intensities in the pump signal can cause relative motion between different parts of the modulated pump signal produced through modulational instability in the first fiber. The light source also including a nonlinear element that is coupled to the first fiber that is capable of broadening the pump optical spectral width to at least 100 nm through a nonlinear effect in the nonlinear element.

Abstract translation: 宽带光源包括能够产生波长短于2.5微米的泵浦信号，至少100皮秒的脉冲宽度和泵浦光谱宽度的一个或多个激光二极管。 光源还包括耦合到泵浦信号并且能够将泵浦信号放大到至少500W的峰值功率的一个或多个光放大器。光源还包括第一光纤，其耦合到一个或 更多的光放大器。 第一光纤包括异常组 - 速度色散方案和用于调制泵浦信号的调制不稳定机制。 在一个特定实施例中，泵浦信号波长驻留在第一光纤的异常群 - 速度色散方案中，并且其中泵浦信号中的不同强度可引起通过第一光纤中的调制不稳定性产生的调制泵浦信号的不同部分之间的相对运动 。 光源还包括耦合到第一光纤的非线性元件，其能够通过非线性元件中的非线性效应将泵浦光谱宽度扩展至至少100nm。

公开(公告)号：US08054462B2

公开(公告)日：2011-11-08

申请号：US12638231

申请日：2009-12-15

Applicant: Thomas H. Chyba ,  Thomas Stewart McKechnie

Inventor： Thomas H. Chyba ,  Thomas Stewart McKechnie

IPC: G01J3/44

CPC classification number: G01J3/02 ,  G01J1/04 ,  G01J1/0477 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0294 ,  G01J3/36 ,  G01J3/44

Abstract: Systems and methods for increasing the quantum efficiency of a photocathode used in an intensified an intensified array detector with a photocathode, such as a charge-coupled device (ICCD) are presented. A quantum efficiency enhancement device is disposed in front of an ICCD and is configured to enable or facilitate an increase in the angle of incidence of incoming rays incident on the photocathode. The ICCD itself may be tilted to achieve an increased angle of incidence, and such tilting is preferably only in a direction in which pixel columns of the ICCD extend such that a plane of incidence of incoming light to the ICCD is perpendicular to a direction of wavelength dispersion. The quantum efficiency enhancement device may include re-imaging optics, an optical tilt compensator and optical coupler.

Abstract translation: 提出了用于增强光电阴极强化阵列检测器（如电荷耦合器件（ICCD））中使用的光电阴极的量子效率的系统和方法。 量子效率增强装置设置在ICCD的前面，并且被配置为能够或有助于增加入射到光电阴极上的入射角的入射角。 ICCD本身可以倾斜以实现增加的入射角，并且这种倾斜优选仅在ICCD的像素列延伸的方向上，使得到ICCD的入射光的入射平面垂直于波长的方向 分散。 量子效率增强器件可以包括重新成像光学器件，光学倾斜补偿器和光耦合器。

公开(公告)号：US20110261351A1

公开(公告)日：2011-10-27

申请号：US13020944

申请日：2011-02-04

Applicant: Patrick Treado ,  Charles W. Gardner, JR. ,  Matthew Nelson ,  Ryan Priore

Inventor： Patrick Treado ,  Charles W. Gardner, JR. ,  Matthew Nelson ,  Ryan Priore

IPC: G01N21/27 ,  G01N21/75

CPC classification number: G01J3/32 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/0289 ,  G01J3/36 ,  G01J3/4338 ,  G01J3/44 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N33/0057

Abstract: A system and method for detection of explosive agents using hyperspectral imaging. A system comprising an illumination source, a spectral encoding device, and at least one imaging detector configured for at least one of SWIR and MWIR hyperspectral imaging of a target comprising an unknown material. A method comprising illuminating a target comprising an unknown material, assessing interacted photons using a spectral encoding device, and detecting interacted photons using at least one of SWIR hyperspectral imaging and MWIR hyperspectral imaging. Algorithms and chemometric techniques may be applied to assess the MWIR hyperspectral image to identify the unknown material as comprising an explosive agent or a non-explosive agent. A video imaging device may also be configured to provide a video image of an area of interest, which may be assessed to identify a target for interrogation using SWIR and MWIR hyperspectral imaging.

Abstract translation: 使用高光谱成像检测爆炸物的系统和方法。 一种包括照明源，光谱编码装置和至少一个成像检测器的系统，该至少一个成像检测器被配置用于包括未知材料的靶的SWIR和MWIR高光谱成像中的至少一个。 一种方法，包括照射包括未知材料的靶，使用光谱编码装置评估相互作用的光子，以及使用SWIR高光谱成像和MWIR高光谱成像中的至少一种来检测相互作用的光子。 可以应用算法和化学计量技术来评估MWIR高光谱图像，以将未知材料识别为包括爆炸剂或非爆炸剂。 视频成像设备还可以被配置为提供感兴趣区域的视频图像，其可以被评估以使用SWIR和MWIR高光谱成像识别用于询问的目标。

公开(公告)号：US20110261350A1

公开(公告)日：2011-10-27

申请号：US12661469

申请日：2010-03-17

Applicant: Wayne D. Jung ,  Russell W. Jung ,  Alan R. Loudermilk

Inventor： Wayne D. Jung ,  Russell W. Jung ,  Alan R. Loudermilk

IPC: G01N21/17

CPC classification number: G01J3/02 ,  G01J3/0205 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/0278 ,  G01J3/04 ,  G01J3/508 ,  G01J3/51 ,  G01J3/513 ,  G01J2003/2866 ,  G01N21/03

Abstract: Optical characteristic measuring systems and methods such as for determining the color or other optical characteristics of an object are disclosed. Perimeter receiver fiber optics are spaced apart from a source fiber optic and receive light from the surface of the object being measured. Light from the perimeter fiber optics pass to a variety of filters. The system utilizes the perimeter receiver fiber optics to determine information regarding the height and angle of the probe with respect to the object being measured. Under processor control, the optical characteristics measurement may be made at a predetermined height and angle. Various color spectral photometer arrangements are disclosed. Translucency, fluorescence, gloss and/or surface texture data also may be obtained. Audio feedback may be provided to guide operator use of the system. The probe may have a removable or shielded tip for contamination prevention. A method of producing prostheses based on measured data also is disclosed. Measured data also may be stored and/or organized as part of a data base.

Abstract translation: 公开了用于确定物体的颜色或其他光学特性的光学特性测量系统和方法。 周边接收器光纤与源光纤间隔开，并接收来自待测物体表面的光。 来自周边光纤的光通过各种滤光片。 该系统利用周边接收机光纤来确定关于探头相对于被测量物体的高度和角度的信息。 在处理器控制下，可以以预定的高度和角度进行光学特性测量。 公开了各种颜色光谱光度计布置。 也可以获得半透明度，荧光，光泽度和/或表面纹理数据。 可以提供音频反馈以指导操作者使用该系统。 探头可能具有可移除或屏蔽的尖端，以防止污染。 还公开了一种基于测量数据生产假体的方法。 测量数据也可以作为数据库的一部分存储和/或组织。

公开(公告)号：US08031336B2

公开(公告)日：2011-10-04

申请号：US12377309

申请日：2008-06-05

Applicant: Katsumi Shibayama ,  Tomofumi Suzuki ,  Masashi Ito

Inventor： Katsumi Shibayama ,  Tomofumi Suzuki ,  Masashi Ito

IPC: G01J3/02 ,  G01J3/18

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0259 ,  G01J3/0291

Abstract: The spectrometer 1 is provided with a package 2 in which a light guiding portion 7 is provided, a spectroscopic module 3 accommodated inside the package 2, and a support member 29 arranged on an inner wall plane of the package 2 to support the spectroscopic module 3. The spectroscopic module 3 is provided with a body portion 11 for transmitting light made incident from the light guiding portion 7 and a spectroscopic portion 13 for dispersing light passed through the body portion 11 on a predetermined plane of the body portion 11, and the spectroscopic portion 13 is supported by the support member 29 on the predetermined plane in a state of being spaced away from the inner wall plane.

Abstract translation: 光谱仪1设置有其中设置有导光部7的封装2，容纳在封装2内部的分光模块3和布置在封装2的内壁面上以支撑光谱模块3的支撑构件29 分光模块3设置有用于透射从导光部7入射的光的主体部11和用于将通过主体部11的光分散在主体部11的预定平面上的分光部13， 部分13在与内壁平面间隔开的状态下由支撑构件29支撑在预定平面上。