公开(公告)号：US20190115201A1

公开(公告)日：2019-04-18

申请号：US16214566

申请日：2018-12-10

Applicant: MERIDION, LLC

Inventor： Nicholas WILTON

IPC: H01J49/28 ,  H01J49/32 ,  H01J49/22 ,  H01J49/14 ,  H01J49/00 ,  H01J49/04

CPC classification number: H01J49/286 ,  H01J49/0027 ,  H01J49/0422 ,  H01J49/147 ,  H01J49/22 ,  H01J49/328

Abstract: Among other things, we describe methods and apparatus for the ionization of target molecular analytes of interest, e.g., for use in mass spectrometry. In some implementations, a thin molecular stream is emitted in either single or a split mode and encounters both an electron-impact ion source and trochoidal electron monochromator placed sequentially or coincidentally. The first ion source emits high-energy electrons (˜70 eV) to generate characteristic positively-charged mass fragment spectra while the second source emits low-energy electrons in a narrow bandwidth to generate negative molecular ions or other ions via electron capture ionization. The dual ion source may be coupled to analytical instruments such as a gas chromatograph and to any number of mass analyzers such as a polarity switching quadrupole mass analyzer or to multiple mass analyzers.

公开(公告)号：US10153149B2

公开(公告)日：2018-12-11

申请号：US15697333

申请日：2017-09-06

Applicant: LECO Corporation

Inventor： Anatoly N. Verenchikov

IPC: H01J49/28 ,  H01J49/42 ,  H01J49/40 ,  H01J49/00 ,  H01J49/06

Abstract: An apparatus 41 and operation method are provided for an electrostatic trap mass spectrometer with measuring frequency of multiple isochronous ionic oscillations. For improving throughput and space charge capacity, the trap is substantially extended in one Z-direction forming a reproduced two-dimensional field. Multiple geometries are provided for trap Z-extension. The throughput of the analysis is improved by multiplexing electrostatic traps. The frequency analysis is accelerated by the shortening of ion packets and either by Wavelet-fit analysis of the image current signal or by using a time-of-flight detector for sampling a small portion of ions per oscillation. Multiple pulsed converters are suggested for optimal ion injection into electrostatic traps.

公开(公告)号：US20170365456A1

公开(公告)日：2017-12-21

申请号：US15695969

申请日：2017-09-05

Applicant: LECO Corporation

Inventor： Anatoly N. Verenchikov

IPC: H01J49/28 ,  H01J49/06 ,  H01J49/00 ,  H01J49/42 ,  H01J49/40

CPC classification number: H01J49/282 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/062 ,  H01J49/40 ,  H01J49/401 ,  H01J49/406 ,  H01J49/4245

Abstract: An apparatus 41 and operation method are provided for an electrostatic trap mass spectrometer with measuring frequency of multiple isochronous ionic oscillations. For improving throughput and space charge capacity, the trap is substantially extended in one Z-direction forming a reproduced two-dimensional field. Multiple geometries are provided for trap Z-extension. The throughput of the analysis is improved by multiplexing electrostatic traps. The frequency analysis is accelerated by the shortening of ion packets and either by Wavelet-fit analysis of the image current signal or by using a time-of-flight detector for sampling a small portion of ions per oscillation. Multiple pulsed converters are suggested for optimal ion injection into electrostatic traps.

公开(公告)号：US20170062196A1

公开(公告)日：2017-03-02

申请号：US15253344

申请日：2016-08-31

Applicant: CANON KABUSHIKI KAISHA

Inventor： Kota Iwasaki ,  Hiroyuki Hashimoto

IPC: H01J49/00 ,  H01J49/16 ,  H01J49/28 ,  H01J37/244 ,  H01J37/12 ,  H01J37/141 ,  H01J49/10 ,  H01J49/06

CPC classification number: H01J49/0004 ,  H01J37/12 ,  H01J37/141 ,  H01J37/244 ,  H01J49/06 ,  H01J49/142 ,  H01J49/161 ,  H01J2237/226

Abstract: A charged particle image measuring device includes a sample stage, a charged particle lens opposite the sample stage, a two-dimensional detector, a first diaphragm disposed between the sample stage and a position of a crossover that is formed by the charged particle lens and that is closest to a sample, and a second diaphragm disposed between the first diaphragm and the two-dimensional detector.

Abstract translation: 带电粒子图像测量装置包括样品台，与样品台相对的带电粒子透镜，二维检测器，设置在样品台与由带电粒子透镜形成的交叉位置之间的第一隔膜， 最靠近样品，第二隔膜设置在第一隔膜和二维检测器之间。

公开(公告)号：US09564306B2

公开(公告)日：2017-02-07

申请号：US14760639

申请日：2014-01-07

Applicant: Luxembourg Institute of Science And Technology (LIST)

Inventor： Hung Quang Hoang ,  David Dowsett ,  Tom Wirtz

IPC: H01J49/26 ,  H01J49/28 ,  H01J49/02 ,  H01J49/20 ,  H01J49/30

CPC classification number: H01J49/28 ,  H01J49/025 ,  H01J49/20 ,  H01J49/30

Abstract: The present invention relates to a compact and portable mass spectrometer device comprising a source of ions, a non-scanning magnetic sector for separating ions originating at the source of ions according to their mass-to-charge ratios, and a detection means. The magnetic sector comprises an ion entrance plane and at least two ion exit planes, which allow to optimize the resolving power of the mass spectrometer for specific mass-to charge ratio sub-ranges.

Abstract translation: 本发明涉及一种包括离子源的紧凑且便携的质谱仪装置，以及用于根据其质荷比分离源自离子源的离子的​​非扫描磁性扇区和检测装置。 磁性部分包括离子入射面和至少两个离子出射平面，其允许优化用于特定质量 - 电荷比子范围的质谱仪的分辨能力。

公开(公告)号：US09548195B2

公开(公告)日：2017-01-17

申请号：US15093152

申请日：2016-04-07

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Christian Albrecht Hock ,  Dmitry Grinfeld ,  Richard Heming

IPC: H01J49/00 ,  H01J49/42 ,  H01J49/04 ,  H01J49/06 ,  H01J49/28 ,  H01J49/40

CPC classification number: H01J49/427 ,  H01J49/0031 ,  H01J49/0481 ,  H01J49/063 ,  H01J49/282 ,  H01J49/40 ,  H01J49/4225 ,  H01J49/424 ,  H01J49/4245

Abstract: A method of ejecting ions to be analyzed from a quadrupole ion trap in which a trapping field is created by one or more RF voltages applied to one or more electrodes of the trap, the method comprising the steps of cooling the ions to be analyzed within the quadrupole ion trap until the ions are thermalized, reducing the amplitude of one or more RF voltages applied to the quadrupole ion trap and applying the reduced amplitude RF voltages for one half cycle after the one or more RF voltages have reached a zero crossing point, turning off the RF voltages applied to the quadrupole ion trap, and ejecting the ions to be analyzed from the quadrupole ion trap.

Abstract translation: 从四极离子阱中排出要分析的离子的方法，其中通过施加到阱的一个或多个电极的一个或多个RF电压产生捕获场，该方法包括以下步骤：将待分析的离子冷却在 四极离子阱，直到离子被热化，减少施加到四极离子阱的一个或多个RF电压的幅度，并且在一个或多个RF电压已经达到过零点之后将减小幅度的RF电压施加一个半周期，转动 关闭施加到四极离子阱的RF电压，并从四极离子阱中喷射待分析的离子。

公开(公告)号：US09437412B2

公开(公告)日：2016-09-06

申请号：US14801642

申请日：2015-07-16

Applicant: Thermo Finnigan LLC

Inventor： Alexander Alekseevich Makarov

IPC: H01J49/00 ,  H01J49/28 ,  H01J49/42 ,  H01J49/22

CPC classification number: H01J49/282 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/22 ,  H01J49/424 ,  H01J49/425

Abstract: This invention relates generally to multi-reflection electrostatic systems, and more particularly to improvements in and relating to the Orbitrap electrostatic ion trap. A method of operating an electrostatic ion trapping device having an array of electrodes operable to mimic a single electrode is proposed, the method comprising determining three or more different voltages that, when applied to respective electrodes of the plurality of electrodes, generate an electrostatic trapping field that approximates the field that would be generated by applying a voltage to the single electrode, and applying the three or more so determined voltages to the respective electrodes. Further improvements lie in measuring a plurality of features from peaks with different intensities from one or more collected mass spectra to derive characteristics, and using the measured characteristics to improve the voltages to be applied to the plurality of electrodes.

公开(公告)号：US20160005584A1

公开(公告)日：2016-01-07

申请号：US14795453

申请日：2015-07-09

Applicant: LECO Corporation

Inventor： Anatoly N. Verenchikov

IPC: H01J49/28 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/282 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/062 ,  H01J49/40 ,  H01J49/401 ,  H01J49/406 ,  H01J49/4245

Abstract: An electrostatic mass spectrometer and a method of mass spectrometric analysis utilizing novel traps are disclosed. The mass spectrometer includes an ion source, an ion pulse injector, an ion detector, a set of analyzer electrodes connected to a set of power supplies, and a vacuum chamber enclosing the set of analyzer electrodes. The analyzer electrodes have multiple sets of elongated slits forming an array of elongated volumes. Each elongated volume is formed by a single set of slits aligned between the electrodes, and each volume forms a two-dimensional electrostatic field in an X-Y plane and is extended in a locally orthogonal Z-direction. Each two-dimensional field is arranged to trap moving ions in the X-Y plane and to enable isochronous ion motion along a mean ion trajectory within the X-Y plane.

Abstract translation: 公开了静电质谱仪和利用新型捕集阱的质谱分析方法。 质谱仪包括离子源，离子脉冲注入器，离子检测器，连接到一组电源的一组分析器电极，以及包围该组分析器电极的真空室。 分析器电极具有形成细长体积阵列的多组细长狭缝。 每个细长体积由在电极之间排列的单组狭缝形成，并且每个体积在X-Y平面中形成二维静电场，并在局部正交的Z方向上延伸。 每个二维场布置成捕获X-Y平面中的移动离子，并使得能够沿着X-Y平面内的平均离子轨迹进行同步离子运动。

公开(公告)号：US09190254B1

公开(公告)日：2015-11-17

申请号：US14570529

申请日：2014-12-15

Applicant: UNIVERSITY OF NORTHERN IOWA RESEARCH FOUNDATION

Inventor： Curtiss Dwight Hanson

IPC: B01D59/46 ,  B01D59/44 ,  H01J49/28 ,  H01J49/00 ,  H01J49/06 ,  H01J49/10 ,  H01J9/14

CPC classification number: H01J49/065 ,  H01J9/14 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/10 ,  H01J49/282 ,  H01J49/42 ,  H01J49/4225 ,  H01J49/4235 ,  H01J49/425

Abstract: In one aspect of the invention, an ion trap mass analyzer includes a variable- or multi-potential type ion guide (MPIG) assembly which has been pre-configured to produce a parabolic-type potential field. Each MPIG electrode has a resistive coating of designed characteristics. In one example the coating varies in thickness along the length of an underlying uniform substrate. The MPIG assembly can be a single MPIG electrode or an array of a plurality of MPIG electrodes. An array can facilitate delocalization for improved performance. This chemical modification of a uniform underlying substrate promotes cheaper and flexible instruments. The modified MPIG electrodes also allow miniaturization (e.g. micro and perhaps even nano-scale), which allows miniaturization of the instrument in which the single or plural modified MPIG electrode(s) are placed. This promotes portability and field use instead of limitation to laboratory settings.

Abstract translation: 在本发明的一个方面，离子阱质量分析器包括已经预配置成产生抛物线型电场的可变或多电位型离子导向器（MPIG）组件。 每个MPIG电极具有设计特性的电阻涂层。 在一个实例中，涂层沿着下面的均匀基底的长度的厚度变化。 MPIG组件可以是单个MPIG电极或多个MPIG电极的阵列。 阵列可以促进离域化以提高性能。 统一的底层衬底的这种化学改性促进了便宜和灵活的仪器。 改进的MPIG电极还允许小型化（例如微量甚至是纳米尺度），这允许其中放置单个或多个修改的MPIG电极的仪器的小型化。 这促进了可移植性和现场使用，而不是限于实验室设置。

公开(公告)号：US09190253B2

公开(公告)日：2015-11-17

申请号：US14531661

申请日：2014-11-03

Applicant: Hamid Badiei ,  Samad Bazargan

Inventor： Hamid Badiei ,  Samad Bazargan

IPC: H01J49/26 ,  H01J49/28 ,  H01J49/10 ,  H01J49/00 ,  H01J49/06 ,  H01J49/24

CPC classification number: H01J49/061 ,  H01J49/00 ,  H01J49/0031 ,  H01J49/0045 ,  H01J49/005 ,  H01J49/0072 ,  H01J49/0077 ,  H01J49/10 ,  H01J49/105 ,  H01J49/24

Abstract: Certain embodiments described herein are directed to systems including a cell downstream of a mass analyzer. In some instances, the cell is configured as a reaction cell, a collision cell or a reaction/collision cell. The system can be used to suppress unwanted ions and/or remove interfering ions from a stream comprising a plurality of ions.

Abstract translation: 本文描述的某些实施例涉及包括质量分析器下游的单元的系统。 在一些情况下，细胞被配置为反应池，碰撞池或反应/碰撞池。 该系统可用于抑制不需要的离子和/或从包含多个离子的流中除去干扰离子。