Abstract:
The present invention relates to a benzimidazole derivative which has pharmaceutical activity as a neuroprotective agent by modulating mitochondrial functions and a pharmaceutical composition comprising the same as an active ingredient. The benzimidazole derivative or a pharmaceutically acceptable salt thereof, according to the present invention, has an excellent activity as a neuroprotective agent affecting mitochondria, thereby can be used as a medicine for diseases such as Alzheimer′s disease, Parkinson′s disease, Huntington′s disease, ischemic brain disease, diabetes, and schizophrenia.
Abstract:
PURPOSE: A carboazole-based compounds with an anticancer activity and a method for preparing the same are provided to prevent and treat cancer. CONSTITUTION: A carboazole-based compound with an anticancer activity is denoted by chemical formula 1. A pharmaceutical composition for anticancer contains the carboazole-based compounds of chemical formula 1. A method for preparing the carboazole-based compounds comprises: a step of reacting amidation of heterocyclic compounds of chemical formula III with 4-haloazole compounds of chemical formula IV to prepare a 4-halocaboazole-based compound of chemical formula V; and a step of performing Suzuki coupling of the compound of chemical formula V with a boronic acid compound of chemical formula VI.
Abstract:
PURPOSE: A 1H-indazole compound with GSK3 inhibition and pharmaceutically acceptable salt thereof are provided to be used as a therapeutic agent for treating diseases caused by GSK-3 activation. CONSTITUTION: A 1H-indazole compounds is denoted by chemical formula 1. A method for preparing the compound comprises: a step of performing amidation of 3-amino-1H-indazole compounds of chemical formula 2 and a substituted carboxylic acid compound of chemical formula 3 under the presence of pyridine base and 1-ethyl-3-(3'-dimethyl aminopropyl)carbodiimide hydrochloride(EDCI).
Abstract:
하기 화학식 1의 프탈라지논 유도체 또는 이의 약학적으로 허용 가능한 염은, 세로토닌 수용체 길항 작용과 세로토닌 재흡수 억제 작용을 동시에 지니고 있으므로, 이를 함유하는 약학적 조성물은, 우울증, 정신분열증, 불안증, 강박노이로제, 편두통, 식욕부진, 수면장애, 알츠하이머 병, 발작, 약물남용 등의 중추신경계에 관련된 질환 등의 치료제로서 유용하게 사용될 수 있다. [화학식 1]
Abstract:
본 발명은 칼슘이온 채널 조절제로서 유효한 피라졸릴메틸아민-피페라진 유도체 및 이의 약제학적으로 허용 가능한 염, 이들 화합물의 제조방법, 그리고 이 화합물이 갖는 칼슘이온 채널 억제 효과에 의한 질환 치료제로 사용하는 의약적 용도에 관한 것이다. 피라졸릴메틸아민-피페라진 유도체, 칼슘이온 채널 조절제, 뉴런, 탈분극화, 급성통증, 만성통증, 신경병증성 통증, 고혈압치료제