Abstract:
The present invention relates to a novel 5-sulfonylamino-5,6-dihydro-1H-pyrazolo[3,4-c]pyridin-7(4H)-one compound having an inhibitory activity for 5-HT6, which is one of serotonin subtypes, and a pharmaceutical composition comprising the compound as an active ingredient. Since the novel compound of the present invention has 5-HT6 inhibitory activities, the compound can be used for diagnosing, preventing, and treating central nervous system (CNS) diseases such as Alzheimer′s disease (AD), attention deficit disorder (ADHD), epilepsy, depression, obesity, schizophrenia, sleep disorders, and pain disorders.
Abstract:
본 발명에 따른 바이페닐 아마이드 유도체 및 이의 약제적으로 허용 가능한 염은 미토콘드리아에 작용하는 신경보호제로써 우수한 활성을 나타내며, 우울증, 편두통, 불안, 염증성 통증, 신경병성 통증, 체온조절 장애, 생체리듬조절 장애, 수면 장애 및 평활근 관련 질병 등 중추신경계 질환의 치료 및 예방제로 효과를 보인다.
Abstract:
PURPOSE: A biphenyl amide derivative is provided to show superior activity as a neuroprotective agent which functions on mitochondria and to be used as an effective agent for preventing and treating central nervous system disorders. CONSTITUTION: A biphenyl amide derivative is denoted by chemical formula 1. A method for preparing the derivative comprises the steps of bonding a compound of chemical formula 2 and a compound of chemical formula 3. A pharmaceutical composition which functions on 5-HT_7 receptor contains the biphenyl compound of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient.
Abstract:
본 발명은 신규한 1,6-이치환-4,5,6,7-테트라하이드로-1 H -피라졸로[3,4- c ]피리딘-7-온 화합물 및 이의 약제학적 허용 가능한 염화합물과, 상기 화합물의 제조방법, 그리고 상기 화합물이 및 이 화합물을 유효성분으로 하는 항암제용 약제조성물에 관한 것이다.
Abstract:
PURPOSE: A carboazole-based compounds with an anticancer activity and a method for preparing the same are provided to prevent and treat cancer. CONSTITUTION: A carboazole-based compound with an anticancer activity is denoted by chemical formula 1. A pharmaceutical composition for anticancer contains the carboazole-based compounds of chemical formula 1. A method for preparing the carboazole-based compounds comprises: a step of reacting amidation of heterocyclic compounds of chemical formula III with 4-haloazole compounds of chemical formula IV to prepare a 4-halocaboazole-based compound of chemical formula V; and a step of performing Suzuki coupling of the compound of chemical formula V with a boronic acid compound of chemical formula VI.
Abstract:
PURPOSE: A 1H-indazole compound with GSK3 inhibition and pharmaceutically acceptable salt thereof are provided to be used as a therapeutic agent for treating diseases caused by GSK-3 activation. CONSTITUTION: A 1H-indazole compounds is denoted by chemical formula 1. A method for preparing the compound comprises: a step of performing amidation of 3-amino-1H-indazole compounds of chemical formula 2 and a substituted carboxylic acid compound of chemical formula 3 under the presence of pyridine base and 1-ethyl-3-(3'-dimethyl aminopropyl)carbodiimide hydrochloride(EDCI).
Abstract:
하기 화학식 1의 프탈라지논 유도체 또는 이의 약학적으로 허용 가능한 염은, 세로토닌 수용체 길항 작용과 세로토닌 재흡수 억제 작용을 동시에 지니고 있으므로, 이를 함유하는 약학적 조성물은, 우울증, 정신분열증, 불안증, 강박노이로제, 편두통, 식욕부진, 수면장애, 알츠하이머 병, 발작, 약물남용 등의 중추신경계에 관련된 질환 등의 치료제로서 유용하게 사용될 수 있다. [화학식 1]
Abstract:
본 발명은 칼슘이온 채널 조절제로서 유효한 피라졸릴메틸아민-피페라진 유도체 및 이의 약제학적으로 허용 가능한 염, 이들 화합물의 제조방법, 그리고 이 화합물이 갖는 칼슘이온 채널 억제 효과에 의한 질환 치료제로 사용하는 의약적 용도에 관한 것이다. 피라졸릴메틸아민-피페라진 유도체, 칼슘이온 채널 조절제, 뉴런, 탈분극화, 급성통증, 만성통증, 신경병증성 통증, 고혈압치료제
Abstract:
PURPOSE: An oxaspiro compound and a method for preparing the same are provided to be used as an intermediate in a natural product or novel drug synthesis. CONSTITUTION: An oxaspiro compound is denoted by chemical formula 1. In chemical formula 1, R1 and R2 are hydrogen, alkyl group of C1-C6, halogen, nitro, alkyl of C1-C6, or substituted or non-substituted phenyl group as a substituent of C1-C6 alkoxy. The oxaspiro compound of chemical formula 1 is prepared by reacting a carbo compound of chemical formula 3 with methylene cycloalkandiol of chemical formula 2 under the presence of lewis acid. The reaction solvent is dichloro methane. Trimethylsilyl trifluoromethansulfonate(TMSOTf) is used as the lewis acid.