公开(公告)号：AT25083T

公开(公告)日：1987-02-15

申请号：AT84114255

申请日：1984-11-26

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  SPIEGLER WOLFGANG DR ,  SIEGEL HARDO DR ,  MUELLER CLAUS D DR ,  VON PHILIPSBORN GERDA DR ,  LENKE DIETER PROF DR ,  GRIES JOSEF DR

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

公开(公告)号：DE3171074D1

公开(公告)日：1985-07-25

申请号：DE3171074

申请日：1981-12-23

Applicant: BASF AG

Inventor： THIEME PETER C DR ,  STEINER GERD DR ,  ROHR WOLFGANG DR ,  LENKE DIETER DR ,  GRIES JOSEF DR ,  WEIFENBACH HARALD DR ,  TESCHENDORF HANS-JUERGEN DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST DR

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/496 ,  A61P9/02 ,  A61P11/00 ,  A61P25/20 ,  C07D231/12 ,  C07D233/60 ,  C07D233/61 ,  C07D271/10 ,  C07D295/06 ,  C07D295/067 ,  C07D295/096 ,  C07D521/00

Abstract: Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula where R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4-oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.

公开(公告)号：DE3262516D1

公开(公告)日：1985-04-18

申请号：DE3262516

申请日：1982-03-31

Applicant: BASF AG

Inventor： EHRMANN OSKAR DR ,  RASCHACK MANFRED DR ,  GRIES JOSEF DR ,  KRETZSCHMAR ROLF DR ,  LEHMANN HANS DIETER DR ,  FRIEDRICH LUDWIG DR ,  WUPPERMANN DIRK DR ,  ZIMMERMANN FRANK DR ,  SEITZ WERNER DR ,  TREIBER HANS JOERG DR ,  DENGEL FERDINAND DR ,  FRANK WOLFRAM DR ,  KURBJUWEIT HANS-GEORG DR ,  MUELLER CLAUS D DR

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/75 ,  C07C121/66 ,  C07C149/42

公开(公告)号：GR81309B

公开(公告)日：1984-12-11

申请号：GR810165114

申请日：1981-06-01

Applicant: BASF AG

Inventor： THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST DR ,  LENKE DIETER DR ,  LEHMANN HANS DIETER DR ,  GRIES JOSEF DR

IPC: A61K31/50 ,  C07D237/04

Abstract: Novel 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are substituted in the p-position of the phenyl ring by a carbamate or thiocarbamate group, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders, and as anti-hypertensives.

公开(公告)号：DE3302021A1

公开(公告)日：1984-07-26

申请号：DE3302021

申请日：1983-01-22

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST PROF DR ,  LEHMANN HANS DIETER PROF DR ,  GRIES JOSEF DR ,  FRIEDRICH LUDWIG DR ,  LENKE DIETER PROF DR

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00

Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula (I) where R1, R2, R3, R4, A and B have the meanings given in the description, and their preparation are described. The compounds have thrombocyte aggregation-inhibiting activity.

公开(公告)号：DE3226863A1

公开(公告)日：1983-04-07

申请号：DE3226863

申请日：1982-07-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DIPL CHEM DR ,  MUELLER JOSEF DIPL CHEM DR ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT DIPL ,  HEGE HANS-GUENTHER DIPL CHEM D ,  MUELLER CLAUS D DR ,  GRIES JOSEF DR ,  LENKE DIETER PROF DR ,  PHILIPSBORN GERDA VON DR ,  RASCHACK MANFRED DR

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C97/10 ,  A61K31/135 ,  A61K31/395 ,  C07D295/10

Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

公开(公告)号：CH635086A5

公开(公告)日：1983-03-15

申请号：CH122478

申请日：1978-02-03

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER DR ,  HAGEN HELMUT DR ,  OHNSORGE ULRICH DR ,  FRANKE ALBRECHT DR ,  LENKE DIETER DR ,  GRIES JOSEF DR ,  LEHMANN HANS DIETER DR

IPC: A61K31/428 ,  C07D275/04 ,  A61K31/425

公开(公告)号：DE3869273D1

公开(公告)日：1992-04-23

申请号：DE3869273

申请日：1988-08-06

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  RASCHACK MANFRED DR ,  GRIES JOSEF DR

IPC: A61K31/34 ,  A61K31/343 ,  A61K31/40 ,  A61K31/44 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  C07D307/86 ,  C07D405/06 ,  C07D405/12

Abstract: Benzofuram derivs.of formula (I) are new: R = R' = H or R + R' = a bond; R1 and R2 = H, 1-4C alkyl or phenyl(1-4C)alkyl; Ar = phenyl with 0.3 substits. selected from benzyloxy, F, Cl, Br, OH, 1-6C alkoxy, NH2, mono- or or di(1-4C alkyl)amino, 1-4C acylamino, NO2, CH2OH and 1-4C alkyl or two adjacent substits. are linked to form CH=CH-NH; R4 and R5 = H, 1-4C alkyl or phenyl(1-4C)alkyl, where the phenyl gp. is opt. mono- or disubstd. by F, Cl, Br, 1-4C alkoxy, NH2, mono-or di(1-4C alkyl)amino or NO2, or R4 + R5 = a 3- to 6-membered chain opt. contg. an O or N atom and opt. fused with a benzene ring opt. substd. by F, Ce, Br, 1-4C alkoxy, NH2, mono-or di(1-4C alkyl)amino or NO2; X = COCH=CH, COCH2CH2 or CH(OH)CH2CH2; n = 2 or 3; provided that when R1 = R2 = Me, then R4 = H or alkyl and R5 = opt. substd. phenylakyl or R4+R5 = a 3- to -6 membered chain (opt. contg. O or N) fused with an opt. substd. benzene ring.

公开(公告)号：DE3665861D1

公开(公告)日：1989-11-02

申请号：DE3665861

申请日：1986-11-26

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  BALDINGER VERENA DR ,  GRIES JOSEF DR ,  LENKE DIETER PROF DR ,  RASCHACK MANFRED DR ,  RUEBSAMEN KLAUS DR

IPC: A61K31/135 ,  A61P1/04 ,  A61P9/00 ,  A61P9/12 ,  C07C223/02 ,  C07D317/58 ,  C07D319/18 ,  C07D325/00 ,  C07C95/08

公开(公告)号：DE3460024D1

公开(公告)日：1986-03-06

申请号：DE3460024

申请日：1984-03-10

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  GRIES JOSEF DR ,  MUELLER CLAUS D DR ,  LENKE DIETER PROF DR

IPC: C07D211/52 ,  A61K31/13 ,  A61K31/445 ,  A61K31/451 ,  A61P9/06 ,  C07C67/00 ,  C07C213/00 ,  C07C217/32 ,  C07C313/00 ,  C07C323/25 ,  C07D211/44 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07C93/06

Abstract: Compounds of the general formula I where R1, R2, R3, R4 and n have the meanings given in the description, are useful for treating cardiac disorders.