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公开(公告)号：AU2021246527A1
公开(公告)日：2022-10-27
申请号：AU2021246527
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： GIROUX SIMON , CLARK MICHAEL PHILIP , BRODNEY MICHAEL AARON , JONES PETER , DENINNO MICHAEL PAUL , GU WENXIN , TANG QING , STONE STEVEN DAVID , SENTER TIMOTHY J , GALE-DAY ZACHARY , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE , COTTRELL KEVIN MICHAEL
IPC: C07D215/20 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00 , C07D215/22 , C07D215/24 , C07D215/38 , C07D217/24 , C07D217/26 , C07D401/04 , C07D401/12 , C07D405/14 , C07D413/12 , C07D413/14
Abstract: 7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-l-antitrypsin modulators for treating alpha-l-antitrypsin deficiency (AATD).
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公开(公告)号：AU2019261308B2
公开(公告)日：2022-09-08
申请号：AU2019261308
申请日：2019-04-23
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： YU HENRY , CLARK MICHAEL , BEMIS GUY , BOYD MICHAEL , CHANDUPATLA KISHAN , COLLIER PHILIP , DENG HONGBO , DONG HUIJUN , DORSCH WARREN , HOOVER RUSSELL R , JOHNSON JR MAC ARTHUR , KUKAMI SHASHANK , PENNEY MARINA , RONKIN STEVEN , TAKEMOTO DARIN , TANG QING , WAAL NATHAN D , WANG TIANSHENG , LAUFFER DAVID J , LI PAN
IPC: C07D413/14 , A61K31/553 , A61P35/00 , C07D403/04 , C07D409/14 , C07D413/04
Abstract: The present invention provides compounds of Formula (I'), or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g. cancer).
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公开(公告)号：RS63281B1
公开(公告)日：2022-06-30
申请号：RSP20220537
申请日：2019-04-23
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： YU HENRY , CLARK MICHAEL , BEMIS GUY , BOYD MICHAEL , CHANDUPATLA KISHAN , COLLIER PHILIP , DENG HONGBO , DONG HUIJUN , DORSCH WARREN , HOOVER RUSSELL R , JOHNSON MAC ARTHUR JR , KULKARNI SHASHANK , PENNEY MARINA , RONKIN STEVEN , TAKEMOTO DARIN , TANG QING , WAAL NATHAN D , WANG TIANSHENG , LAUFFER DAVID J , LI PAN
IPC: C07D413/14 , A61K31/553 , A61P35/00 , C07D403/04 , C07D409/14 , C07D413/04
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公开(公告)号：LT3784666T
公开(公告)日：2022-06-10
申请号：LTUS2019028607
申请日：2019-04-23
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： YU HENRY , CLARK MICHAEL , BEMIS GUY , BOYD MICHAEL , CHANDUPATLA KISHAN , COLLIER PHILIP , DENG HONGBO , DONG HUIJUN , DORSCH WARREN , HOOVER RUSSELL , JOHNSON MAC , KULKARNI SHASHANK , PENNEY MARINA , RONKIN STEVEN , TAKEMOTO DARIN , TANG QING , WAAL NATHAN , WANG TIANSHENG , LAUFFER DAVID J , LI PAN
IPC: C07D413/14 , A61K31/553 , A61P35/00 , C07D403/04 , C07D409/14 , C07D413/04
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公开(公告)号：AU2020286424A1
公开(公告)日：2022-01-06
申请号：AU2020286424
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , BRODNEY MICHAEL AARON , CLARK MICHAEL PHILIP , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GAGNON KEVIN JAMES , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , GREY JR RONALD LEE , GUIDO SAMANTHA , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , LAI MEI-HSIU , LIU SIYING , LOOKER ADAM , MAXWELL BRAD , MAXWELL JOHN PATRICK , MEDEK ALES , NUHANT PHILIPPE MARCEL , OVERHOFF KIRK ALAN , RODAY SETU , ROEPER STEFANIE , RONKIN STEVEN M , SAWANT RUPA , SHI YI , SHRESTHA MUNA , SPOSATO MARISA , STAVROPOULOS KATHY , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN , XU JINWANG , ZAKY MARIAM , COTTRELL KEVIN MICHAEL
IPC: C07D231/56 , A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
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Patent Agency Ranking
公开(公告)号：CO2021005884A2
公开(公告)日：2021-05-20
申请号：CO2021005884
申请日：2021-05-05
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , BRODNEY MICHAEL AARON , ECCLES MARY ELIZABETH , GAGNON KEVIN JAMES , HOOD SARAH CAROL , HUSSEY JOSHUA KENNEDY , LOOKER ADAM , MAXWELL JOHN PATRICK , MEDEK ALES , NAVAMAL METTACHIT , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , TANG QING , WALDO MICHAEL , BANDARAGE UPUL KEERTHI , BOUCHER DIANE M , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , DEWEY FANNING LEV TYLER , FIMOGNARI JR ROBERT FRANCIS , GARCIA BARRANTES PEDRO M , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , NUHANT PHILIPPE MARCEL , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , XU JINWANG , MAXWELL BRAD D , COTTRELL KEVIN MICHAEL
IPC: A61P1/16 , A61K31/4162 , A61K31/4178 , A61K31/4196 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61P11/00 , C07D471/14 , C07D487/04 , C07D487/14 , C07D519/00
Abstract: Nuevos compuestos, composiciones y métodos para usar y preparar los mismos, los cuales pueden ser útiles para tratar la deficiencia de alfa-1 antitripsina (AATD).
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公开(公告)号：SG11202009500QA
公开(公告)日：2020-11-27
申请号：SG11202009500Q
申请日：2019-04-23
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： YU HENRY , CLARK MICHAEL , BEMIS GUY , BOYD MICHAEL , CHANDUPATLA KISHAN , COLLIER PHILIP , DENG HONGBO , DONG HUIJUN , DORSCH WARREN , HOOVER RUSSELL , JOHNSON MAC , KUKAMI SHASHANK , PENNEY MARINA , RONKIN STEVEN , TAKEMOTO DARIN , TANG QING , WAAL NATHAN , WANG TIANSHENG , LAUFFER DAVID J , LI PAN
IPC: C07D413/14 , A61K31/553 , A61P35/00 , C07D403/04 , C07D409/14 , C07D413/04
Abstract: The present invention provides compounds of Formula (I'), or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g. cancer).
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公开(公告)号：UY38403A
公开(公告)日：2020-04-30
申请号：UY38403
申请日：2019-10-07
Applicant: VERTEX PHARMA
Inventor： JONES PETER , NUHANT PHILIPPE MARCEL , BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE M , DEWEY FANNING LEV TYLER , ECCLES MARY ELIZABETH , FIMOGNARI JR ROBERT FRANCIS , GAGNON KEVIN JAMES , BOYD MICHAEL JOHN , GARCÍA BARRANTES PEDRO M , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , HUSSEY JOSHUA KENNEDY , JOHNSON JR , KESAVAN SARATHY , LOOKER ADAM , MAXWELL BRAD D , MAXWELL JOHN PATRICK , MEDEK ALES , NAVAMAL METTACHIT , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , WALDO MICHAEL , XU JINWANG , DAMAGNEZ VERONIQUE , BRODNEY MICHAEL AARON
IPC: A61P1/16 , A61K31/4162 , A61K31/437 , A61K31/497 , A61P11/00 , C07D471/14 , C07D487/04 , C07D487/14 , C07F5/04
Abstract: Nuevos compuestos, composiciones y métodos de uso y preparación de los mismos, que pueden ser útiles para el tratamiento de la deficiencia de alfa-1 antitripsina (AATD).
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公开(公告)号：HUE047130T2
公开(公告)日：2020-04-28
申请号：HUE17184079
申请日：2005-05-13
Applicant: VERTEX PHARMA
Inventor： MARTINEZ-BOTELLA GABRIEL , HALE MICHAEL , MALTAIS FRANÇOIS , TANG QING , STRAUB JUDITH
IPC: A61K31/4439 , A61P9/00 , A61P25/00 , A61P37/00 , C07D401/04 , C07F9/58 , C07F9/6558
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公开(公告)号：ME03336B
公开(公告)日：2019-10-20
申请号：MEP201955
申请日：2014-03-12
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , DENG HONGBO , GU WENXIN , GIROUX SIMON , JACKSON KATRINA LEE , LI PAN , XU JINWANG , MAXWELL JOHN PATRICK , TANG QING , RONKIN STEVEN M , PIERCE ALBERT CHARLES , LAUFFER DAVID J , MORRIS MARK A , COURT JOHN J , COTTRELL KEVIN M , WAAL NATHAN D
IPC: A61K31/517 , A61P35/00 , C07D403/12 , C07D405/12 , C07D413/04 , C07D417/12 , C07D491/052
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