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公开(公告)号：KR1020090083254A
公开(公告)日：2009-08-03
申请号：KR1020080009293
申请日：2008-01-29
Applicant: 대한민국 (식품의약품안전처장)
CPC classification number: G01N33/5008 , C12Q1/6844 , C12Q2600/136 , C12Q2600/158 , G01N2500/00
Abstract: A method for predicting the side effect of candidate drug on a cardiac myocyte is provided to develop a drug without side effect by easily verifying side effect of candidate drug. A method for predicting side effect of candidate drug on a heart comprises: a step of preparing an experimental group in which the candidate drug is treated to a cardiac myocyte and control group in which nothing is treated; a step of measuring expression of Gadd45beta gene in cardiac myocyte in experimental and control group; and a step of determining the possibility of damage.
Abstract translation: 提供了一种用于预测候选药物对心肌细胞的副作用的方法，通过容易地验证候选药物的副作用，开发出无副作用的药物。 用于预测候选药物对心脏的副作用的方法包括：制备将候选药物治疗至心肌细胞的实验组和不治疗任何物质的对照组的步骤; 在实验组和对照组中测量心肌细胞中Gadd45beta基因表达的步骤; 并确定损坏的可能性的步骤。
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公开(公告)号：KR100905414B1
公开(公告)日：2009-07-02
申请号：KR1020080060020
申请日：2008-06-25
Applicant: 대한민국 (식품의약품안전처장)
Abstract: A discrimination method of growing district of herbal medicine is provided to analysis the metabolite mixture without DNA analysis or standard material and discriminate the growing district of the herbal medicine. A method for discriminating the growing district of Scutellaria baicalensis Georgi. Comprises: a step of extracting metabolite from a plurality of groups of Scutellaria baicalensis Georgi. Sample; a step of analyzing the metabolite with 1H NMR(Nuclear magnetic resonance) spectroscopy; a step of converting the analyzed result of 1H NMR; a step of analyzing the converted value with multivariate analysis; a step of detecting the difference among the groups and establishing standard model; a step of discriminating the growing district; and a step of analyzing the metabolite from the Scutellaria baicalensis Georgi. and verifying the growing district.
Abstract translation: 提供了生长区草药的辨别方法，对DNA代谢物混合物进行分析，不用DNA分析或标准物质，从而区分中草药生长区。 一种鉴别黄芩生长区的方法。 包括：从多个黄芩黄芩提取代谢物的步骤。 样品; 用1 H NMR（核磁共振）光谱分析代谢物的步骤; 转化1H NMR的分析结果的步骤; 用多变量分析分析转换价值的一个步骤; 检测组间差异，建立标准模型的步骤; 区分增长区的一个步骤; 并分析了黄芩的代谢物。 并验证增长区。
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公开(公告)号：KR100899900B1
公开(公告)日：2009-05-27
申请号：KR1020080128491
申请日：2008-12-17
Applicant: 대한민국 (식품의약품안전처장)
CPC classification number: C12P7/64 , C12Y301/01003
Abstract: 본 발명은 유지의 산화안정성을 개선시키는 방법에 관한 것으로서, 보다 상세하게는 1) 고체 유지와 식물성 유래 액체 유지를 혼합하는 단계; 및 2) 리파아제가 존재하는 연속식 효소 반응기(PBR: Packed Bed Reactor)에서 상기 혼합유를 70℃에서 24∼60분 동안 머무르게 하여 반응시키는 효소적 에스테르교환반응(EI: Enzymatic Interesterification)을 수행하는 단계를 거쳐 유지의 산화안정성을 개선시키는 방법에 관한 것이다.
고체 유지, 식물성 유래 액체 유지, 리파아제, 에스테르교환반응, 과산화물가, 아니시딘가, 공액 이중산 함량, 산화안정성-
公开(公告)号：KR1020080111737A
公开(公告)日：2008-12-24
申请号：KR1020070060056
申请日：2007-06-19
Applicant: 대한민국 (식품의약품안전처장)
Inventor： 송인찬
CPC classification number: G01R33/58 , A61B5/055 , G01R1/0408 , G01R1/08
Abstract: A phantom for evaluating performance of magnet resonance imager capable of steadily maintaining image of high quality is provided to improve a use within MRI(Magnet Resonance Imager) without a cradle of a complex structure by including a supporting device for phantom own. A phantom(10) for evaluating the performance of a magnet resonance imager capable of steadily maintaining image of high quality comprises a casing, a supporting device(34), a disc(40), a plurality of films(52), a localizer, a porous plate(46), and a wedge member. The casing has an airtight space accommodating water with a form of cylinder. The supporting device fixes the casing inside a coil of a MRI, and fixes a central axis of the cylindrical casing horizontally. The disc is included inside the casing. The film is parallel installed with the disc in a side of the disc. The localizer provides a standard capable of knowing a location of an image. The porous plate is parallel supported in the disc, and has holes(46B) less than a fixation diameter. The wedge member confirms a dislocation internal through an axial direction tomographical image including an incline surface.
Abstract translation: 提供了能够稳定地保持高质量图像的磁共振成像器的性能评估的幻影，以通过包括用于体模自身的支撑装置来提高MRI（磁共振成像仪）中的复杂结构的摇篮的使用。 用于评估能够稳定地保持高质量图像的磁体共振成像器的性能的体模（10）包括壳体，支撑装置（34），盘（40），多个膜（52），定位器， 多孔板（46）和楔形件。 壳体具有容纳水的形式的气缸的气密空间。 支撑装置将壳体固定在MRI的线圈内，并水平地固定圆筒形壳体的中心轴线。 光盘包含在外壳内。 该胶片与光盘平行地安装在光盘的一侧。 定位器提供了能够识别图像位置的标准。 多孔板平行地支撑在盘中，并且具有小于固定直径的孔（46B）。 楔形构件通过包括倾斜面的轴向断层图像确认位错。
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公开(公告)号：KR1020080043494A
公开(公告)日：2008-05-19
申请号：KR1020060112125
申请日：2006-11-14
Applicant: 대한민국 (식품의약품안전처장)
IPC: C12Q1/68
CPC classification number: C12Q1/6827 , C12Q2600/156
Abstract: SNP(single nucleotide polymorphism) markers are provided to discriminate Hanwoo(Korean cattle) from importing cattle accurately, improve the mixed circulation structure of Hanwoo, milk cow, domestic cattle and importing cattle, and maintain and promote production foundation of Hanwoo by protecting gene sources of Hanwoo and identifying classes of Hanwoo. An SNP marker for discriminating Hanwoo from importing cattle is selected from the nucleotide sequences of SEQ ID NO:1 to SEQ ID NO:70. A method for discriminating Hanwoo from importing cattle comprises the steps of: (i) extracting DNA from a cattle to be examined; (ii) amplifying the DNA containing any one base mutation site of SEQ ID NO:1 to SEQ ID NO:70 or a complementary sequence therewith; (iii) synthesizing a primer complementary with the nucleotide sequence of any one base mutation site of SEQ ID NO:1 to SEQ ID NO:70 or with the complementary sequence therewith containing one base site adjacent thereto; (iv) determining the base kind used in the reaction of step (iii) by using a sequencer; and (v) comparing the base kind determined in step (iv) with a control.
Abstract translation: 提供SNP（单核苷酸多态性）标记，以准确鉴别汉诺牛（韩国牛）进口牛，改善Hanwoo，奶牛，家畜牛和进口牛的混合循环结构，保护和促进Hanwoo的生产基础，保护基因来源 的Hanwoo，并确定Hanwoo的课程。 从SEQ ID NO：1至SEQ ID NO：70的核苷酸序列中选择用于鉴别Hanwoo与进口牛的SNP标记。 一种鉴别Hanwoo与进口牛的方法包括以下步骤：（i）从待检牛的DNA中提取DNA; （ii）扩增含有SEQ ID NO：1至SEQ ID NO：70的任一个碱基突变位点的DNA或其互补序列; （iii）合成与SEQ ID NO：1至SEQ ID NO：70的任一个碱基突变位点的核苷酸序列互补的引物或与其相邻的一个碱基位点的互补序列互补的引物; （iv）使用定序器确定步骤（iii）的反应中使用的碱基类型; 和（v）将步骤（iv）中确定的碱基类型与对照相比较。
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Patent Agency Ranking
公开(公告)号：KR100818795B1
公开(公告)日：2008-04-03
申请号：KR1020070124198
申请日：2007-12-03
Applicant: 대한민국 (식품의약품안전처장)
CPC classification number: G06Q10/087
Abstract: A system for managing reagents with RFID(Radio Frequency IDentification) is provided to perform general reagent management such as information, usage, stock, and expiration management, and manage storage location and safety of each reagent in the lab by using the RFID. A storage ID tag(100) is attached to a reagent storage(1) of a lab, and stores an ID code for identifying the reagent storage and a list of the reagents stored in the reagent storage. A reagent ID tag(200) is attached to a lid of a reagent bottle(5) stored in the reagent storage, and stores the ID code of the reagent storage for storing the reagent and information related to the reagent. A portable terminal(300) receives/outputs the ID code of the reagent storage, the reagent list, and the reagent information stored in the reagent storage ID tag and the reagent ID tag by including an RFID reader. A reagent management server(400) receives/stores information recognized by the portable terminal through the network, manages usage/storage of each reagent, issues a warning for an incorrect storage location by checking the storage location of each reagent bottle, issues the warning for emergency, and provides emergency management information.
Abstract translation: 提供用于管理RFID试剂的系统（射频识别），以进行一般试剂管理，如信息，使用，库存和到期管理，并通过使用RFID管理实验室中每种试剂的存储位置和安全性。 存储ID标签（100）附接到实验室的试剂库（1），并且存储用于识别试剂储存器的ID代码和存储在试剂储存器中的试剂列表。 将试剂ID标签（200）附着到存储在试剂库中的试剂瓶（5）的盖上，存储试剂储存用的试剂储存库的ID码和与试剂有关的信息。 便携式终端（300）通过包括RFID阅读器来接收/输出存储在试剂储存ID标签和试剂ID标签中的试剂存储的ID码，试剂列表和试剂信息。 试剂管理服务器（400）通过网络接收/存储由便携式终端识别的信息，管理每种试剂的使用/存储，通过检查每个试剂瓶的存储位置对不正确的存储位置发出警告，发出警告 紧急情况，并提供应急管理信息。
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公开(公告)号：KR1020080008929A
公开(公告)日：2008-01-24
申请号：KR1020060114284
申请日：2006-11-20
Applicant: 대한민국 (식품의약품안전처장)
IPC: A61K31/352 , A61P25/28 , A23L1/29 , A23L1/30
Abstract: A health functional food comprising Oroxylin A is provided to improve spatial-perceptual ability of an animal group of which memory is decreased by scopolamine and carotid ligation, thereby being usefully used for treating and preventing cognitive impairment. A health functional food for preventing and improving Alzheimer's disease or cerebro vascular dementia comprises Oroxylin A and a sitologically acceptable food supplemental additive, wherein the Oroxylin A is isolated from an extract of Scutellaria baicalensis GEORGI. The food is in the form of powder, granule, tablet, capsule or drink.
Abstract translation: 提供了包含奥昔木蛋白A的健康功能食品，以提高通过东莨菪碱和颈动脉结扎使记忆减少的动物组的空间感知能力，从而有效地用于治疗和预防认知障碍。 一种用于预防和改善阿尔茨海默病或脑血管性痴呆的健康功能食品包括奥昔木蛋白A和可食用的食品补充添加剂，其中，从黄芩黄芩提取物中分离出OroxylA A. 食物为粉末，颗粒，片剂，胶囊或饮料。
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公开(公告)号：KR1020080002374A
公开(公告)日：2008-01-04
申请号：KR1020060061176
申请日：2006-06-30
Applicant: 대한민국 (식품의약품안전처장)
IPC: A61K31/352 , A61P25/30
Abstract: An agent comprising baicalein is provided to inhibit occurrence of symptoms including place dependence, crawling behavior and head-twitch, caused by drug abuse and addiction without side effects, so that the drug abuse and addiction is treated. An agent comprising baicalein obtained from the extract of Scutellariae radix, which is prepared by extracting with hot water, treats drug abuse and addiction formed by administration of narcotic anodynes or narcotics, especially inhibits crawling behavior and place dependence formed by administering apomorphine and cocaine, respectively, wherein the daily dosage of bicalein is 8-16 mg/kg.
Abstract translation: 提供包含黄芩素的药剂，以抑制药物滥用和成瘾引起的地方依赖性，爬行行为和头痛等症状的发生，而没有副作用，从而治疗药物滥用和成瘾。 通过由热水提取制备的黄芩提取物的黄芩苷的药剂治疗药物滥用和通过施用麻醉药物或麻醉剂形成的成瘾药物，特别是抑制爬行行为和放置通过施用阿朴吗啡和可卡因形成的依赖性 其中白蛋白的日剂量为8-16mg / kg。
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公开(公告)号：KR100779419B1
公开(公告)日：2007-11-30
申请号：KR1020050068094
申请日：2005-07-26
Applicant: 대한민국 (식품의약품안전처장)
IPC: A61K36/66 , A61K36/539 , A61P29/00
Abstract: 몰핀 또는 날부핀인 진통제와 황금추출물, 베타인 또는 이들의 혼합물인 중독성 경감물질의 혼합물을 유효성분으로 하고, 약제학적으로 허용되는 담체를 포함하는 중독성이 경감된 진통제에 관한 것이다. 본 발명의 중독성이 경감된 진통제는 마약성 진통제의 투여에 의하여 형성되는 약물 의존성을 경감시킬 수 있으므로, 안전하고 효과적인 통증 해소에 널리 활용될 수 있을 것이다.
몰핀, 날부핀, 마약성 진통제, 황금추출물, 베타인-
公开(公告)号：KR1020060032014A
公开(公告)日：2006-04-14
申请号：KR1020040081018
申请日：2004-10-11
Applicant: 대한민국 (식품의약품안전처장)
IPC: A01K67/027
Abstract: 본 발명은 hPS2 돌연변이 유전자 및 TAK 유전자를 발현하는 이중형질전환 치매 마우스에 관한 것으로서, 보다 구체적으로는 pTet 유전자의 프로모터(promoter)를 TAK 유전자에 연결시킨 재조합 유전자 및 pTet 유전자의 프로모터(promoter)를 hPS2m 유전자에 연결시킨 재조합 유전자를 마우스의 수정란에 각각 미세주입(microinjection)하고, 이 수정란들을 대리모 마우스의 난관(oviduct)에 이식함으로써 생산된 형질전환 마우스를 생산하고, 상기 형질전환 마우스를 교배함으로써 생산된 이중형질전환 치매 마우스에 관한 것이다.
본 발명에 의한 형질전환 치매 마우스는 PS2 유전자의 발현조절이 가능하며, 인간 치매환자의 치매 증상과 유사한 행동학적 이상과 아밀로이드 β-42 축적 및 Tau 단백질의 활성화, 카테닌의 활성화 등의 특성을 나타내는 것으로, 치매 질환의 치료제 또는 치매 질환의 조기 진단법 개발에 매우 유용하게 이용될 수 있다.
치매 * 알츠하이머 질환 * 테트라사이클린 유도 치매 마우스 * PS2 * 아밀로이드 β-42 * Tau 단백질 * 카테닌
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