公开(公告)号：DK1789419T3

公开(公告)日：2009-08-10

申请号：DK04810009

申请日：2004-10-21

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  DEININGER DAVID D ,  LIAO YUSHENG ,  RONKIN STEVEN M ,  STAMOS DEAN ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  DRUMM JOSEPH ,  GRILLOT ANNE-LAURE ,  LE TIRAN ARNAUD

IPC: C07D491/04 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/506 ,  A61P31/00 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

公开(公告)号：CA2824516C

公开(公告)日：2019-02-26

申请号：CA2824516

申请日：2012-01-13

Applicant: VERTEX PHARMA

Inventor： LE TIRAN ARNAUD ,  GRILLOT ANNE-LAURE ,  CHARIFSON PAUL ,  BENNANI YOUSSEF LAAFIRET ,  O'DOWD HARDWIN ,  PEROLA EMANUELE

IPC: C07D405/14 ,  A61K31/506 ,  A61P31/04 ,  C07F9/6558

Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti¬ bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.

公开(公告)号：ES2545516T3

公开(公告)日：2015-09-11

申请号：ES12702920

申请日：2012-01-13

Applicant: VERTEX PHARMA

Inventor： LE TIRAN ARNAUD ,  GRILLOT ANNE-LAURE ,  CHARIFSON PAUL S ,  BENNANI YOUSSEF LAAFIRET ,  O'DOWD HARDWIN ,  PEROLA EMANUELE

IPC: C07D405/14 ,  A61K31/506 ,  A61P31/04 ,  C07F9/6558

Abstract: Un compuesto de fórmula **Fórmula** donde R es hidrógeno o flúor; X es hidrógeno, -PO(OH)2, -PO(OH)O-M+, -PO(O-)2*2M+ o -PO(O-)2*D2+; M+ es un catión monovalente farmacéuticamente aceptable; y D2+ es un catión divalente farmacéuticamente aceptable; o una de sus sales farmacéuticamente aceptables.

公开(公告)号：CL2013002025A1

公开(公告)日：2013-12-27

申请号：CL2013002025

申请日：2013-07-12

Applicant: VERTEX PHARMA

Inventor： LE TIRAN ARNAUD ,  GRILLOT ANNE-LAURE ,  CHARIFSON PAUL ,  BENNANI YOUSSEF LAAFIRET ,  O DOWD HARDWIN ,  PEROLA EMANUELE

IPC: C07D405/14 ,  A61K31/506 ,  A61P31/04

公开(公告)号：AU2012205415A1

公开(公告)日：2013-08-01

申请号：AU2012205415

申请日：2012-01-13

Applicant: VERTEX PHARMA

Inventor： LE TIRAN ARNAUD ,  GRILLOT ANNE-LAURE ,  CHARIFSON PAUL S ,  BENNANI YOUSSEF LAAFIRET ,  O'DOWD HARDWIN ,  PEROLA EMANUELE

IPC: C07D405/14 ,  A61K31/506 ,  A61P31/04 ,  C07F9/6558

Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti¬ bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.

公开(公告)号：AR084863A1

公开(公告)日：2013-07-10

申请号：ARP120100137

申请日：2012-01-16

Applicant: VERTEX PHARMA

Inventor： PEROLA EMANUELE ,  LE TIRAN ARNAUD ,  GRILLOT ANNE ,  LAURE-CHARIFSON PAUL ,  BENNANI YOUSSEF L ,  ODOWD HARDWIN

IPC: C07D405/14 ,  A61K31/506 ,  A61P31/04 ,  C07F9/6558

Abstract: Reivindicación 1: Un compuesto de la fórmula caracterizado porque tiene la fórmula (1) donde R es hidrógeno o flúor; X es hidrógeno, -PO(OH)2, -PO(OH)O-M+, -PO(O-)2·2M+, o -PO(O-)2·D2+; M+ es un catión monovalente farmacéuticamente aceptable; y D2+ es un catión divalente farmacéuticamente aceptable; o una sal farmacéuticamente aceptable del mismo.

公开(公告)号：NZ588700A

公开(公告)日：2012-07-27

申请号：NZ58870009

申请日：2009-04-14

Applicant: VERTEX PHARMA

Inventor： WANG TIANSHENG ,  ARONOV ALEXANDER ,  CORNEBISE MARK ,  MALTAIS FRANCOIS ,  LEDOBOER MARK ,  LE TIRAN ARNAUD ,  MARONE VALERIE ,  MESSERSMITH DAVID ,  COTTRELL KEVIN ,  COME JON H

IPC: C07D417/04 ,  A61K31/428 ,  A61K31/4365 ,  A61P37/00 ,  C07D513/04

Abstract: Provided are inhibitors of phosphatidylinositol 3-kinases with formula (I) as depicted, with defined substituents. The compounds are useful for lessening the severity of a disease or condition selected from an autoimmune disease or an inflammatory disease of the brain or spinal cord.

公开(公告)号：CA2752596A1

公开(公告)日：2010-08-26

申请号：CA2752596

申请日：2010-02-16

Applicant: VERTEX PHARMA

Inventor： ARONOV ALEX ,  BANDARAGE UPUL KEERTHI ,  COTTRELL KEVIN ,  DAVIES ROBERT ,  KRUEGER ELAINE ,  LEDEBOER MARK ,  LEDFORD BRIAN ,  LE TIRAN ARNAUD ,  LIAO YUSHENG ,  MESSERSMITH DAVID ,  WANG TIANSHENG ,  XU JINWANG

IPC: C07D513/04 ,  A61K31/4365 ,  A61P25/00

Abstract: The present invention relates to compounds (I) useful as inhibitors of PBK, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：DK1592686T3

公开(公告)日：2009-10-19

申请号：DK04775744

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  DEININGER DAVID D ,  LIAO YUSHENG ,  RONKIN STEVEN M ,  STAMOS DEAN ,  PEROLA EMAUELE ,  WANG TIANSHENG ,  DRUMM JOSEPH ,  GRILLOT ANNE-LAURE ,  LE TIRAN ARNAUD

IPC: C07D403/14 ,  A61K31/4184 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

Abstract: The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

公开(公告)号：DE602004021644D1

公开(公告)日：2009-07-30

申请号：DE602004021644

申请日：2004-10-21

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  DEININGER DAVID D ,  GRILLOT ANNE-LAURE ,  LIAO YUSHENG ,  RONKIN STEVEN M ,  STAMOS DEAN ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  LE TIRAN ARNAUD ,  DRUMM JOSEPH

IPC: C07D491/04 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/506 ,  A61P31/00 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.