公开(公告)号：ES2604667T3

公开(公告)日：2017-03-08

申请号：ES10726760

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL ,  BANDARAGE UPUL ,  BETHIEL RANDY ,  COURT JOHN ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN ,  KENNEDY JOSEPH ,  LEDEBOER MARK ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  GERMANN URSULA ,  JONES STEVEN ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: A61K31/506 ,  A61P31/16

Abstract: Un compuesto de la fórmula:**Fórmula** o una sal farmacéuticamente aceptable del mismo.

公开(公告)号：HRP20161577T1

公开(公告)日：2017-01-27

申请号：HRP20161577

申请日：2016-11-28

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  GERMANN URSULA A ,  JONES STEVEN ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: A61K31/506 ,  A61P31/16

公开(公告)号：EA025276B1

公开(公告)日：2016-12-30

申请号：EA201270032

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A

IPC: A61K31/506 ,  A61P31/16

Abstract: Изобретениеотноситсяк новомусоединению, аименно - к (2S,3S)-3-((2-(5-фтор-1Н-пирроло[2,3-b]пиридин-3-ил)-5-фторпиримидин-4-ил)амино)бицикло[2,2,2]октан-2-карбоновойкислоте, обладающейсвойствомингибированиярепликациивирусагриппаА вбиологическомобразцеилиу пациента, уменьшенияколичествавирусовгриппав биологическомобразцеилиу пациента. Изобретениетакжеотноситсяк фармацевтическойкомпозиции, содержащейэффективноеколичествотакогосоединенияилиегофармацевтическиприемлемойсолии фармацевтическиприемлемыйноситель, наполнительилиразбавитель, ипредназначенодлясниженияколичествавирусовгриппаА. ТакжераскрываетсяспособсниженияколичествавирусовгриппаА в in vitro биологическомобразце, включающийвведениев указанныйбиологическийобразецэффективногоколичестваданногосоединения.

公开(公告)号：CA2988306A1

公开(公告)日：2016-12-08

申请号：CA2988306

申请日：2016-06-03

Applicant: VERTEX PHARMA

Inventor： DAVIES ROBERT J ,  CAO JINGRONG ,  COCKERILL MEGHAN ELISE ,  COLLIER PHILIP NOEL ,  DENINNO MICHAEL PAUL ,  DOYLE ELISABETH ,  FRANTZ JAMES DANIEL ,  GAO HUAI ,  GOLDMAN BRIAN ANTHONY ,  GREY RONALD LEE ,  GRILLOT ANNE-LAURE ,  GU WENXIN ,  HENDERSON JAMES A ,  KRAUSS RAUL EDUARDO ,  KOLPAK ADRIANNE LYNN ,  LIAO YUSHENG ,  MAGAVI SANJAY SHIVAYOGI ,  MALTAIS FRANCOIS ,  MESSERSMITH DAVID ,  PIERCE ALBERT CHARLES ,  PEROLA EMANUELE ,  RYU ELIZABETH JIN-SUN ,  SYKEN JOSHUA ,  WANG JIAN

IPC: A61K31/4196 ,  A61P25/28 ,  C07D249/14 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14

Abstract: The invention relates to triazole compounds of formula I and I' or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

公开(公告)号：AU2016228190A1

公开(公告)日：2016-10-27

申请号：AU2016228190

申请日：2016-09-14

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DAVIES IOANA ,  DENG HONGBO ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG

IPC: C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61P31/16

Abstract: Abstract The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof and methods of inhibiting the replication of influenza viruses and/or reducing the amount of influenza viruses in a biological sample or patient comprising administering an effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof to the biological sample or patient. The present invention further provides for pharmaceutical compositions comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. x2 "'N \Z1Z" Formula I

公开(公告)号：AU2016204286A1

公开(公告)日：2016-08-11

申请号：AU2016204286

申请日：2016-06-23

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: A61K31/506 ,  A61P31/16

Abstract: Abstract Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：SG10201503833SA

公开(公告)日：2015-06-29

申请号：SG10201503833S

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DAVIES IOANA ,  DENG HONGBO ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A compound is represented by Structural Formula ( I ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：CA2921198A1

公开(公告)日：2015-02-26

申请号：CA2921198

申请日：2014-08-21

Applicant: VERTEX PHARMA

Inventor： BRUMMEL CHRISTOPHER LEE ,  MALTAIS FRANCOIS ,  DEININGER DAVID D ,  LEDFORD BRIAN ,  DORSCH WARREN

IPC: C07D239/95 ,  C07B59/00 ,  C07D471/04

Abstract: The present invention relates to a deuterated pyrrolo[2,3-b]pyridinyl compound that is useful for inhibiting Janus kinases. The invention also relates to processes and intermediates useful for preparing such a compound.

公开(公告)号：SG10201405827PA

公开(公告)日：2014-11-27

申请号：SG10201405827P

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A ,  FRANCESCO G SALITURO ,  ANN DAK-YEE KWONG

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：CL2014000245A1

公开(公告)日：2014-08-18

申请号：CL2014000245

申请日：2014-01-31

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DENG HONGBO ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  DAVIS IOANA

IPC: C07D471/04 ,  A61K31/506 ,  A61P31/16