公开(公告)号：DE69231557D1

公开(公告)日：2000-12-14

申请号：DE69231557

申请日：1992-05-28

Applicant: ABBOTT LAB

Inventor： GARVEY DAVID S ,  CARRERA JR ,  ARNERIC STEPHEN P ,  SHUE YOUE-KONG ,  LIN NAN-HORNG ,  HE YUN

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/42 ,  A61K31/422 ,  A61K31/425 ,  A61K31/427 ,  A61K31/44 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: Novel isoxazole isothiazole and pyrazole compounds of the formula: wherein A, R1, and R2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.

公开(公告)号：PT100525B

公开(公告)日：1999-10-29

申请号：PT10052592

申请日：1992-05-28

Applicant: ABBOTT LAB

Inventor： GARVEY DAVID S ,  SHUE YOUE-KONG ,  ARNERIC STEPHEN P ,  LIN NAN-HORNG ,  CARRERA GEORGE M JR ,  HE YUN

IPC: A61K31/415 ,  A61K31/42 ,  A61K31/422 ,  A61K31/425 ,  A61K31/40 ,  A61K31/427 ,  A61K31/44 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: Novel isoxazole isothiazole and pyrazole compounds of the formula: wherein A, R1, and R2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.

公开(公告)号：AU709784B2

公开(公告)日：1999-09-09

申请号：AU5804596

申请日：1996-05-28

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  LIN NAN-HORNG ,  RYTHER KEITH B ,  HE YUN

IPC: A61K31/00 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61P25/00 ,  A61P25/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R , R , A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：CA2285263A1

公开(公告)日：1998-10-22

申请号：CA2285263

申请日：1998-04-10

Applicant: ABBOTT LAB

Inventor： RYTHER KEITH B ,  HOLLADAY MARK W ,  WASICAK JAMES T ,  LI YIHONG ,  LIN NAN-HORNG ,  DAANEN JEROME F ,  ELLIOTT RICHARD L ,  DART MICHAEL J ,  HE YUN

IPC: A61K31/4355 ,  A61K31/4365 ,  A61P25/00 ,  A61P43/00 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00 ,  A61K31/435

Abstract: Novel heterocyclic ether compounds having formula (I) wherein A, m, R, X, Y1, Y2 and Y3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：CA2256022A1

公开(公告)日：1997-12-11

申请号：CA2256022

申请日：1997-06-04

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  RYTHER KEITH ,  LI YIHONG ,  BAI HAO ,  HE YUN ,  LIN NAN-HORNG

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/465 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61P25/00 ,  A61P43/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/47 ,  A61K31/495

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of formula (I) or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula (I) with the variables defined in the specification are also described.

公开(公告)号：DE69730229T2

公开(公告)日：2005-07-28

申请号：DE69730229

申请日：1997-06-04

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  HOLLADAY W ,  RYTHER KEITH ,  LI YIHONG ,  BAI HAO

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/465 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61P25/00 ,  A61P43/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission.

公开(公告)号：DK1047690T3

公开(公告)日：2004-07-05

申请号：DK98964167

申请日：1998-12-18

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  GARVEY DAVID S ,  RYTHER KEITH ,  LEBOLD SUZANNE A ,  ELLIOTT RICHARD L ,  HE YUN ,  WASIAK JAMES T ,  BAI HAO ,  DART MICHAEL J ,  EHRLICH PAUL P ,  LI YIHONG ,  KINCAID JOHN F ,  SCHKERYANTZ JEFFREY M ,  LYNCH JOHN K

IPC: A61K31/427 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D455/02 ,  C07D487/04 ,  A61K31/40 ,  A61K31/425 ,  A61K31/44 ,  A61K31/47 ,  A61K31/50 ,  A61K31/505

公开(公告)号：PT717741E

公开(公告)日：2001-10-31

申请号：PT94931741

申请日：1994-08-30

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  ELLIOTT RICHARD L ,  HE YUN ,  CHORGHADE MUKUND S ,  WITTENBERGER STEVEN J ,  BUNNELLE WILLIAM H ,  NARAYANAN BIKSHANDAR A ,  SINGAM PULLA R ,  ESCH THOMAS K J ,  BEER DIETER O ,  WITZIG CHRISTIAN C ,  HERZIG THOMAS C ,  RAO ALLA V RAMA

IPC: C07D413/04 ,  C07D207/09

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

公开(公告)号：ES2158905T3

公开(公告)日：2001-09-16

申请号：ES94931741

申请日：1994-08-30

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  ELLIOTT RICHARD L ,  CHORGHADE MUKUND S ,  WITTENBERGER STEVEN J ,  BUNNELLE WILLIAM H

IPC: C07D413/04 ,  C07D207/09

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.

公开(公告)号：DE69427361D1

公开(公告)日：2001-07-05

申请号：DE69427361

申请日：1994-08-30

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  ELLIOTT L ,  CHORGHADE S ,  WITTENBERGER J ,  BUNNELLE H ,  NARAYANAN A ,  SINGAM PULLA R ,  ESCH K ,  BEER O ,  WITZIG C ,  HERZIG C ,  RAO V RAMA

IPC: C07D413/04 ,  C07D207/09

Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.