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公开(公告)号：NO315604B1
公开(公告)日：2003-09-29
申请号：NO996579
申请日：1999-12-30
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16 , A61K31/415
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：PT1001930E
公开(公告)日：2003-04-30
申请号：PT98936014
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： STEINMAN DOUGLAS H , GUO YAN , WADA CAROL K , DAVIDSEN STEVEN K , CURTIN MICHAEL L , MICHAELIDES MICHAEL R , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , HEYMAN H ROBIN , HOLMS JAMES H , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：DE69809924D1
公开(公告)日：2003-01-16
申请号：DE69809924
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：AT228122T
公开(公告)日：2002-12-15
申请号：AT00905758
申请日：2000-01-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , HEYMAN HOWARD R , HOLMES JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H
IPC: A61K31/341 , A61K31/357 , A61K31/40 , A61K31/421 , A61P1/02 , A61P1/04 , A61P17/02 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D207/09 , C07D207/14 , C07D207/48 , C07D263/04 , C07D307/14 , C07D317/28 , A61K31/335
Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：AU4340202A
公开(公告)日：2002-06-18
申请号：AU4340202
申请日：2001-10-26
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , FREY ROBIN R , GUO YAN , HEYMAN HOWARD R , HOLMS JAMES H , JI ZHIQIN , MICHAELIDES MICHAEL R , VASUDEVAN ANIL , WADA CAROL K
IPC: C07C45/29 , C07C45/30 , C07C45/45 , C07C45/51 , C07C45/67 , C07C47/277 , C07C49/255 , C07C59/90 , C07C69/716 , C07C235/14 , C07C235/16 , C07C235/20 , C07C235/74 , C07C235/80 , C07C243/38 , C07C255/54 , C07C255/60 , C07C311/19 , C07C317/32 , C07C317/44 , C07C323/41 , C07C323/60 , C07D209/08 , C07D209/42 , C07D213/30 , C07D213/40 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/06 , C07D257/04 , C07D263/14 , C07D263/32 , C07D263/58 , C07D271/10 , C07D277/46 , C07D277/56 , C07D277/74 , C07D277/82 , C07D285/08 , C07D295/112 , C07D307/68 , C07D307/85 , C07D317/58 , C07D317/66 , C07D317/68 , C07D413/04 , C07D413/12 , C07D417/04 , C07D491/10
Abstract: Substituted trifluoromethyl ketones, ketooxazoles, ketoamides, ketoesters, and diketones having the formula or therapeutically acceptable salts thereof, are histone deacetylase (HDAC) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
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Patent Agency Ranking
公开(公告)号：BR0007278A
公开(公告)日：2001-11-27
申请号：BR0007278
申请日：2000-01-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , HEYMAN HOWARD R , HOLMES JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H
IPC: A61K31/341 , A61K31/357 , A61K31/40 , A61K31/421 , A61P1/02 , A61P1/04 , A61P17/02 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D207/09 , C07D207/14 , C07D207/48 , C07D263/04 , C07D307/14 , C07D317/28 , A61K31/335
Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：AU5921801A
公开(公告)日：2001-11-07
申请号：AU5921801
申请日：2001-04-25
Applicant: ABBOTT LAB
Inventor： WANG WEI-BO , CURTIN MICHAEL L , FAKHOURY STEPHEN A , GWALTNEY STEPHEN L II , HASVOLD LISA A , HUTCHINS CHARLES W , LI QUI , LIN NAN-HORNG , NELSON LISSA TAKA JENNINGS , O'CONNOR STEPHEN J , SHAM HING L , SULLIVAN GERALD M , WANG GARY T , WANG XILU
IPC: C07D233/22 , A61K31/381 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/4245 , A61K31/426 , A61K31/4406 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61P17/06 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D213/30 , C07D213/36 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85 , C07D231/12 , C07D233/26 , C07D233/54 , C07D249/04 , C07D249/08 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/16 , C07D333/24 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D409/10 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/10 , C07D417/12 , C07D233/00
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公开(公告)号：TR199903287T2
公开(公告)日：2000-09-21
申请号：TR9903287
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16 , A61K31/415
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：BG103995A
公开(公告)日：2000-07-31
申请号：BG10399599
申请日：1999-12-13
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16 , A61K31/415
Abstract: The compounds with the formula are inhibitors of matrix metallproteinases. The invention also relates to pharmaceutical compositions and methods for the inhibition of matrix metallproteinases in mammals. 18 claims
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公开(公告)号：NO996579L
公开(公告)日：2000-01-24
申请号：NO996579
申请日：1999-12-30
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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