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公开(公告)号：AT417836T
公开(公告)日：2009-01-15
申请号：AT02079949
申请日：1993-12-16
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , NORBECK DANIEL W , SHAM HING LEUNG , ZHAO CHEN , SOWIN THOMAS J , RENO DANIEL S , HAIGHT ANTHONY R , COOPER ARTHUR J
IPC: C07D275/02 , C07D277/24 , A61K31/395 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K38/00 , A61K45/06 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D20060101 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/10 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/06 , C07D261/08 , C07D263/24 , C07D263/30 , C07D263/32 , C07D263/48 , C07D265/30 , C07D277/22 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D521/00 , C07F5/02 , C07F5/04 , C07K5/06 , C07K5/065
Abstract: A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.
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公开(公告)号：HK1104558A1
公开(公告)日：2008-01-18
申请号：HK07109677
申请日：2007-09-05
Applicant: ABBOTT LAB
Inventor： DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , KLEIN LARRY L , KEMPF DALE J , WANG XIU C
IPC: A61K20060101 , A61P20060101 , C07F20060101
Abstract: A compound of the formula I, II or III is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions of inhibiting HIV protease activity and treating HIV infection are also disclosed.
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公开(公告)号：CA2393271C
公开(公告)日：2007-12-11
申请号：CA2393271
申请日：1991-11-15
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , NORBECK DANIEL W , WITTENBERGER STEVEN J , CODACOVI LYNN M , SHAM HING L , PLATTNER JACOB J , ZHAO CHEN
IPC: A61K31/42 , C07D277/28 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/435 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K38/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C53/134 , C07C211/00 , C07C215/18 , C07C215/20 , C07C215/28 , C07C215/30 , C07C215/80 , C07C219/18 , C07C233/40 , C07C237/10 , C07C237/22 , C07C269/04 , C07C271/02 , C07C271/16 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/24 , C07D20060101 , C07D213/00 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/36 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D213/79 , C07D215/20 , C07D233/54 , C07D233/84 , C07D235/14 , C07D235/16 , C07D237/10 , C07D239/26 , C07D241/12 , C07D261/08 , C07D261/12 , C07D263/20 , C07D263/32 , C07D277/20 , C07D277/24 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/02 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/34 , C07D307/42 , C07D307/66 , C07D333/16 , C07D333/36 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D521/00 , C07K1/113 , C07K5/06 , C07K5/065 , C07K5/08 , C07K14/81
Abstract: A retroviral protease inhibiting compound is diclosed. The compound is of the formula (see formula I) wherein R1 is hydrogen and R2 and R3 are independently selected from C6-aryl-C1-to-C6-alkyl, C9-to-C10-aryl-C1-to-C6-alkyl, C3-to-C7- cycloalkyl-C1-to-C6-alkyl and (heterocyclic)-C1-to-C6-alkyl; and A and B are independently selected from R6-C(O)-(NH)-(CH(R5))- C(O)- and R6-C(O)- wherein at each occurrence R6 is independently selected from R7-N(C1-to-C6-loweralkyl)-, R7-O- and R7-S- wherein R7 is heterocyclic or (heterocyclic)-C1-to-C6-alkyl and at each occurrence R5 is independently selected from C1-to-C6-loweralkyl; or a pharmaceutically acceptable salt, thereof. Also disclosed are a composition use and kit for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhibitors.
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公开(公告)号：HK1100659A1
公开(公告)日：2007-09-28
申请号：HK07102279
申请日：2007-02-28
Applicant: ABBOTT LAB
Inventor： DEGOEY DAVID A , FLENTGE CHARLES A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , KEMPF DALE J , KLEIN LARRY L , YEUNG MING C , RANDOLPH JOHN T , WANG XIU C , YU SU
IPC: A61K20060101 , A61P20060101 , C07D20060101 , C07D213/30 , C07D213/40 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
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公开(公告)号：CA2633760A1
公开(公告)日：2007-07-05
申请号：CA2633760
申请日：2006-12-20
Applicant: ABBOTT LAB
Inventor： TUFANO MICHAEL D , KRUEGER ALLAN C , SHANLEY JASON P , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , LU LIANGJUN , ANDERSON DAVID D , HE WEPING , MOLLA AKHTERUZZAMAN , ZHANG RONG , COOPER CURT S , IWASAKI NOBUHIKO , PILOT-MATIAS TAMI , MASSE SHERIE VL , BETEBENNER DAVID A , CARRICK ROBERT J , ROCKWAY TODD W , WAGNER ROLF , MO HONGMEI , KEMPF DALE J
IPC: C07D471/04
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (HCV) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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Patent Agency Ranking
公开(公告)号：AU2005270124A1
公开(公告)日：2006-02-09
申请号：AU2005270124
申请日：2005-06-29
Applicant: ABBOTT LAB
Inventor： FLOSI WILLIAM J , KLEIN LARRY L , WANG XIU C , GRAMPOVNIK DAVID J , DEGOEY DAVID A , KEMPF DALE J
IPC: C07F9/00 , A61K31/661 , A61P35/00 , C07F9/09
Abstract: A compound of the formula I, II or III is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions of inhibiting HIV protease activity and treating HIV infection are also disclosed.
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公开(公告)号：CA2170020C
公开(公告)日：2005-08-02
申请号：CA2170020
申请日：1993-12-16
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , NORBECK DANIEL W , SHAM HING LEUNG , ZHAO CHEN , SOWIN THOMAS J , RENO DANIEL S , HAIGHT ANTHONY R , COOPER ARTHUR J
IPC: C07D275/02 , A61K31/395 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K38/00 , A61K45/06 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D20060101 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/10 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/06 , C07D261/08 , C07D263/24 , C07D263/30 , C07D263/32 , C07D263/48 , C07D265/30 , C07D277/22 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D521/00 , C07F5/02 , C07F5/04 , C07K5/06 , C07K5/065
Abstract: A retroviral protease inhibiting compound of formula (A) is disclosed - (see formula I)
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公开(公告)号：CA2549228A1
公开(公告)日：2005-07-07
申请号：CA2549228
申请日：2004-11-10
Applicant: ABBOTT LAB
Inventor： CHEN HUI-JU , RANDOLPH JOHN T , YEUNG MING C , DEGOEY DAVID A , KLEIN LARRY L , GRAMPOVNIK DAVID J , FLENTGE CHARLES A , FLOSI WILLIAM J , KEMPF DALE J , HUTCHINSON DOUGLAS K , HUANG PEGGY P
IPC: C07D401/14 , A61K31/4166 , A61K31/4178 , A61P31/18 , C07C243/24 , C07C271/22 , C07D401/06 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14
Abstract: A compound of the formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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公开(公告)号：NZ510328A
公开(公告)日：2005-01-28
申请号：NZ51032896
申请日：1996-12-06
Applicant: ABBOTT LAB
Inventor： SHAM HING LEUNG , NORBECK DANIEL W , KEMPF DALE J , COOPER ARTHUR J , OLIVER PATRICIA A , LIU JIH-HEH J , STONER ERIC J , PLATA DANIEL J , BETEBENNER DAVID A , HERRIN THOMAS R , CONDON STEPHEN L , DICKMAN DANIEL A , KOLACZKOWSKI LAWRENCE , STENGEL PETER J , TIEN JIEH-HUA , PATEL KETAN M , HANNICK STEVEN M , KUMAR GONDI N , CHEN XIAOQI
IPC: A61K31/00 , C07D253/00 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/55 , A61K38/05 , A61K45/00 , A61P31/18 , A61P43/00 , C07C231/12 , C07C235/20 , C07C273/18 , C07C275/16 , C07D20060101 , C07D207/22 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/40 , C07D207/404 , C07D207/408 , C07D207/416 , C07D211/72 , C07D211/84 , C07D223/06 , C07D233/28 , C07D233/30 , C07D233/32 , C07D233/36 , C07D233/40 , C07D233/42 , C07D233/66 , C07D239/06 , C07D239/10 , C07D239/20 , C07D239/22 , C07D241/06 , C07D241/08 , C07D241/18 , C07D243/04 , C07D253/06 , C07D263/16 , C07D263/20 , C07D263/22 , C07D263/34 , C07D265/04 , C07D267/04 , C07D277/12 , C07D277/32 , C07D277/34 , C07D279/06 , C07D281/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
Abstract: The compound (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxyl-5-[2S-(1-tetrahydro-pyrimid-2-only)-3-methylbutanoyl]amino-1,6-diphenylhexane, amorphous forms, and amorphous solid forms are claimed. Also claimed is the use of the compound in the manufacture of medicaments and medicaments containing the compound for the treatment of HIV infection and for inhibiting HIV protease. (62) Divided out of 338003
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公开(公告)号：CZ294246B6
公开(公告)日：2004-11-10
申请号：CZ176298
申请日：1996-12-06
Applicant: ABBOTT LAB
Inventor： SHAM HING LEUNG , NORBECK DANIEL W , CHEN XIAOQI , BETEBENNER DAVID A , KEMPF DALE J , HERRIN THOMAS R , KUMAR GONDI N , CONDON STEPHEN L , COOPER ARTHUR J , DICKMAN DANIEL A , HANNICK STEVEN M , KOLACZKOWSKI LAWRENCE , OLIVER PATRICIA A , PLATA DANIEL J , STENGEL PETER J , STONER ERIC J , TIEN JIEH-HEH J , LIU JIH-HUA , PATEL KETAN M
IPC: C07D253/00 , A61K31/00 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/427 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/513 , A61K31/53 , A61K31/55 , A61K38/05 , A61K45/00 , A61P31/18 , A61P43/00 , C07C231/12 , C07C235/20 , C07C273/18 , C07C275/16 , C07D20060101 , C07D207/22 , C07D207/26 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/40 , C07D207/404 , C07D207/408 , C07D207/416 , C07D211/72 , C07D211/84 , C07D223/06 , C07D233/28 , C07D233/30 , C07D233/32 , C07D233/36 , C07D233/40 , C07D233/42 , C07D233/66 , C07D239/06 , C07D239/10 , C07D239/20 , C07D239/22 , C07D241/06 , C07D241/08 , C07D241/18 , C07D243/04 , C07D253/06 , C07D263/16 , C07D263/20 , C07D263/22 , C07D263/34 , C07D265/04 , C07D267/04 , C07D277/12 , C07D277/32 , C07D277/34 , C07D279/06 , C07D281/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D233/22 , A61P31/00 , A61P31/22
Abstract: In the present invention, there is described a compound of the general formula I functioning a HIV protease inhibitor. Methods and compositions for inhibiting a HIV infection are disclosed, too.
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