公开(公告)号：DE69228932T2

公开(公告)日：1999-11-11

申请号：DE69228932

申请日：1992-07-14

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES ,  DAVIDSEN STEVEN ,  HOLMS JAMES ,  PIREH DAISY ,  HEYMAN H ,  MARTIN MICHAEL ,  STEINMAN DOUGLAS ,  SHEPPARD GEORGE ,  CARRERA GEORGE

IPC: A61K31/44 ,  A61K31/4406 ,  A61K49/00 ,  A61K49/06 ,  A61P1/04 ,  A61P7/02 ,  A61P7/06 ,  A61P9/02 ,  A61P11/06 ,  A61P17/06 ,  A61P29/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07B47/00 ,  C07D213/69 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07F5/00 ,  C07F13/00

Abstract: PCT No. PCT/US92/05890 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 14, 1992 PCT Pub. No. WO93/01813 PCT Pub. Date Feb. 4, 1993.Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

公开(公告)号：CZ9803496A3

公开(公告)日：1999-04-14

申请号：CZ349698

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： ELLIOTT RICHARD L ,  OR YAT SUN ,  CHU DANIEL T ,  GRIESGRABER GEORGE W ,  PLATTNER JACOB J ,  PIREH DAISY

IPC: A61K31/04 ,  A61K31/70 ,  A61K31/7048 ,  A61K31/7052 ,  C07H17/08

CPC classification number: C07H17/08 ,  Y02P20/55

公开(公告)号：AU2745397A

公开(公告)日：1997-11-26

申请号：AU2745397

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： ELLIOTT RICHARD L ,  OR YAT SUN ,  CHU DANIEL T ,  GRIESGRABER GEORGE W ,  PLATTNER JACOB J ,  PIREH DAISY

IPC: A61K31/04 ,  A61K31/70 ,  A61K31/7048 ,  A61K31/7052 ,  C07H17/08

Abstract: Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.

公开(公告)号：CA2253451A1

公开(公告)日：1997-11-13

申请号：CA2253451

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： ELLIOTT RICHARD L ,  PIREH DAISY ,  PLATTNER JACOB J ,  GRIESGRABER GEORGE W ,  CHU DANIEL T ,  OR YAT SUN

IPC: A61K31/04 ,  A61K31/70 ,  A61K31/7048 ,  A61K31/7052 ,  C07H17/08 ,  C07H23/00

Abstract: Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I) (IV) of the invention.

公开(公告)号：CA2112562A1

公开(公告)日：1993-02-04

申请号：CA2112562

申请日：1992-07-14

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  DAVIDSEN STEVEN K ,  HOLMS JAMES H ,  PIREH DAISY ,  HEYMAN H ROBIN ,  MARTIN MICHAEL B ,  STEINMAN DOUGLAS H ,  SHEPPARD GEORGE ,  CARRERA GEORGE M JR

IPC: A61K31/44 ,  A61K31/4406 ,  A61K49/00 ,  A61K49/06 ,  A61P1/04 ,  A61P7/02 ,  A61P7/06 ,  A61P9/02 ,  A61P11/06 ,  A61P17/06 ,  A61P29/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07B47/00 ,  C07D213/69 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07F5/00 ,  C07F13/00 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54

Abstract: 2112562 9301813 PCTABS00019 Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo¢1,2-c!thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo¢1,2-c!oxazoline, or 7-carbonyl(pyridin-3-yl)pyrrolo¢1,2-c!pyrrole group are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

公开(公告)号：DK1560811T3

公开(公告)日：2007-12-10

申请号：DK03774478

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  MICHMERHUIZEN MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：PT1560811E

公开(公告)日：2007-11-14

申请号：PT03774478

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： STEWART KENT D ,  SHAM HING L ,  MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  MICHMERHUIZEN MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SZCZEPANKIEWICZ BRUCE G

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

公开(公告)号：AT368647T

公开(公告)日：2007-08-15

申请号：AT03774478

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN ,  WIEDEMAN PAUL ,  YONG HONG ,  MICHMERHUIZEN MELISSA ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING ,  STEWART KENT ,  SZCZEPANKIEWICZ BRUCE

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：AU2003282800A1

公开(公告)日：2004-04-08

申请号：AU2003282800

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： SZCZEPANKIEWICZ BRUCE G ,  MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  FEENSTRA MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D

IPC: A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D207/00

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：DE69626040T2

公开(公告)日：2004-01-22

申请号：DE69626040

申请日：1996-11-06

Applicant: ABBOTT LAB

Inventor： OR SUN ,  CHU T ,  ELLIOTT L ,  PIREH DAISY

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08

Abstract: A compound selected from groups (I), (II), and (III), wherein A, B, V, W, X and R are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.