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公开(公告)号：CA2285263C
公开(公告)日：2009-03-10
申请号：CA2285263
申请日：1998-04-10
Applicant: ABBOTT LAB
Inventor： DAANEN JEROME F , LI YIHONG , RYTHER KEITH B , HOLLADAY MARK W , ELLIOTT RICHARD L , LIN NAN-HORNG , WASICAK JAMES T , DART MICHAEL J , HE YUN
IPC: C07D491/048 , A61K31/4355 , A61K31/4365 , A61P25/00 , A61P43/00 , C07D491/04 , C07D495/04 , C07D519/00
Abstract: Novel heterocyclic ether compounds having formula (I) wherein A, m, R, X, Y1 , Y2 and Y3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically- effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.
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公开(公告)号：CA2227695C
公开(公告)日：2008-02-12
申请号：CA2227695
申请日：1996-07-25
Applicant: ABBOTT LAB
Inventor： RYTHER KEITH B , ELLIOTT RICHARD L , DAANEN JEROME F , WASICAK JAMES T , HOLLADAY MARK W , DART MICHAEL J
IPC: C07D491/048 , A61K31/00 , A61K31/435 , A61K31/4353 , A61K31/4355 , A61K31/495 , A61K31/53 , A61P9/00 , A61P25/00 , A61P25/30 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D495/04 , C07D519/00
Abstract: Novel heterocyclic ether compounds having the formula (I) wherein A, m, R, X , Y1, Y2 and Y3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.
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公开(公告)号：AU2007266535A1
公开(公告)日：2007-12-06
申请号：AU2007266535
申请日：2007-05-30
Applicant: ABBOTT LAB
Inventor： NELSON DEREK W , LI TONGMEI , FROST JENNIFER M , RYTHER KEITH B , PEDDI SRIDHAR , TIETJE KARIN ROSEMARIE , PEREZ-MEDRANO ARTURO , KOLASA TEODOZYJ , GALLAGHER MEGAN E , PATEL MEENA V , CARROLL WILLIAM A , FLORJANCIC ALAN S , DART MICHAEL J
IPC: C07D277/46 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , A61P29/00 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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54.发明专利
公开(公告)号：ZA200602274B
公开(公告)日：2007-11-28
申请号：ZA200602274
申请日：2006-03-17
Applicant: ABBOTT LAB
Inventor： ANWER BASHA , DART MICHAEL J , JIANGUO JI , RYTHER KEITH B , MORTELL KATHLEEN H , SCHRIMPF MICHAEL R , BUNNELLE WILLIAM H , GALLAGHER MEGAN E , PACE JENNIFER M , TIETJE KARIN R , NERSESIAN DIANA L , TAO LI
IPC: A61K20090101 , A61K31/435 , A61P20090101 , A61P25/00 , C07D20090101 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
Abstract: Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5-or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazoyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by ±7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
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公开(公告)号：AR041686A1
公开(公告)日：2005-05-26
申请号：ARP030103835
申请日：2003-10-21
Applicant: ABBOTT LAB
Inventor： CHANG SOU-JEN , CHEMBURKAR SANJAY R , CHEN YAN , DART MICHAEL J , FERNANADO DILINIE P , KU YI-YIN , BUNNELLE WILIAM H , BENNANI YOUSSEF L , LOCKWOOD MARK , WANG JIEYI
Abstract: Los compuestos de fórmula (1) son útiles para el tratamiento de epilepsia, trastornos bipolares, trastornos psiquiátricos, migrana, dolor o trastornos del movimiento y para proveer neuroprotección. Reivindicación 1: Un método de tratamiento de migrana, epilepsia o un trastorno bipolar en un mamífero, caracterizado porque comprende la administración a dicho mamífero de una cantidad eficaz para uso terapéutico de un compuesto de la fórmula (1) o un profármaco aceptable para uso farmacéutico del mismo, donde A es cicloalquilo o bicicloalquilo; RA, RB, y RC son, independientemente entre sí, H o alquilo; R1 es -OR2 o -NR3R4; R2 es H, alquilo, arilo, arilalquilo, cicloalquilo, cicloalquilalquilo, heterociclo o heterocicloalquilo; R3 y R4 son, independientemente entre sí, H, alquenilo, alquilo, alquinilo, alcoxicarbonilalquilo, arilo, arilalquilo, carboxialquilo, cicloalquilo, cicloalquilalquilo, heterociclo, heterocicloalquilo, hidroxialquilo, (NR5R6)alquilo, (NR5R6)carbonilalquilo o como se muestra en el resto de fórmula (2), o R3 y R4 tomados junto con el átomo de N al cual están unidos forman un heterociclo, donde dicho heterociclo es azepanilo, azetidinilo, aziridinilo, morfolinilo, piperazinilo, piperidinilo, pirrolidinilo o tiomorfolinilo R5 y R6 son, independientemente entre sí, H, alquenilo, alquilo, alquinilo, alcoxicarbonilalquilo, arilo, arilalquilo, cicloalquilo, cicloalquilalquilo, heterociclo, heterocicloalquilo o hidroxialquilo; R7 es alcoxi, alquilo, hidroxi o -NR5R6; R8 es alquenilo, alcoxialquilo, alcoxicarbonilalquilo, alquiltioalquilo, alquinilo, arilo, arilalquilo, carboxialquilo, cicloalquilo, cicloalquilalquilo, heterociclo, heterocicloalquilo, hidroxialquilo, mercaptoalquilo, (NR5R6) alquilo, (NR5R6) carbonilalquilo o -(CH2)nNHC(=NH)NH2; y n es un número entero entre 1 y 6. Reivindicación 26: Un compuesto, caracterizado porque es de la fórmula (3) o un profármaco aceptable para uso farmacéutico del mismo, donde A es cicloalquilo o bicicloalquilo, donde dicho cicloalquilo y bicicloalquilo están sustituidos optativamente con 1, 2, 3 o 4 grupos alquilo; RA, RB y RC son, independientemente entre sí, H o alquilo; R3 es alquenilo, alquinilo, alcoxicarbonilalquilo, carboxialquilo, cicloalquilo, cicloalquilalquilo, heterociclo, heterocicloalquilo, hidroxialquilo, (NR5R6) alquilo o (NR5R6) carbonilalquilo; R4 es H, alquenilo, alquilo, alquinilo, alcoxicarbonilalquilo, carboxialquilo, cicloalquilo, cicloalquilalquilo, heterociclo, heterocicloalquilo, hidroxialquilo, (NR5R6) alquilo o (NR5R6) carbonilalquilo o como se muestra en el resto de fórmula (2); o R3 y R4 R3 y R4 tomados junto con el átomo de N al cual están unidos forman un heterociclo, donde dicho heterociclo es azepanilo, azetidinilo, aziridinilo, morfolinilo, piperazinilo, piperidinilo, pirrolidinilo o tiomorfolinilo R5 y R6 son, independientemente entre sí, H, alquenilo, alquilo, alquinilo, alcoxicarbonilalquilo, arilo, arilalquilo, cicloalquilo, cicloalquilalquilo, heterociclo, heterocicloalquilo; R7 es alcoxi, alquilo, hidroxi o -NR5R6; R8 es alquenilo, alcoxialquilo, alcoxicarbonilalquilo, alquiltioalquilo, alquinilo, arilo, arilalquilo, carboxialquilo, cicloalquilo, cicloalquilalquilo, heterociclo, heterocicloalquilo, hidroxialquilo, mercaptoalquilo, (NR5R6) alquilo, (NR5R6) carbonilalquilo o -(CH2)nNHC(=NH)NH2; y n es un número entero entre 1 y 6.
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Patent Agency Ranking56.发明专利
公开(公告)号：AU2004274492A1
公开(公告)日：2005-03-31
申请号：AU2004274492
申请日：2004-09-17
Applicant: ABBOTT LAB
Inventor： BUNNELLE WILLIAM H , DART MICHAEL J , TIETJE KARIN R , SCHRIMPF MICHAEL R , RYTHER KEITH B , GALLAGHER MEGAN E , NERSESIAN DIANA L , MORTELL KATHLEEN H , PACE JENNIFER M , BASHA ANWER , JI JIANGUO
IPC: C07D471/04 , A61K31/435 , A61P25/00 , C07D471/08 , C07D487/04 , C07D487/08
Abstract: Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5-or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazoyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by ±7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
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公开(公告)号：ES2209825T3
公开(公告)日：2004-07-01
申请号：ES00906998
申请日：2000-01-25
Applicant: ABBOTT LAB
Inventor： BUNNELLE WILLIAM H , CRISTINA DANIELA BARLOCCO , DAANEN JEROME F , DART MICHAEL J , MEYER MICHAEL D , RYTHER KEITH B
IPC: A61K31/00 , A61K31/407 , A61K31/4355 , A61K31/4365 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/502 , A61P9/10 , A61P15/10 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/048 , C07D495/04 , C07D519/00 , A61K31/395
Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.
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公开(公告)号：SI1147112T1
公开(公告)日：2004-04-30
申请号：SI200030295
申请日：2000-01-25
Applicant: ABBOTT LAB
Inventor： BUNNELLE WILLIAM H , CRISTINA DANIELA BARLOCCO , DAANEN JEROME F , DART MICHAEL J , MEYER MICHAEL D , RYTHER KEITH B , SCHRIMPF MICHAEL R , SIPPY KEVIN B , TOUPENCE RICHARD B
IPC: A61K31/00 , A61P25/00 , C07D401/08 , C07D471/08 , C07D487/08 , C07D519/00 , A61K31/395
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公开(公告)号：AT262519T
公开(公告)日：2004-04-15
申请号：AT98964167
申请日：1998-12-18
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ABREO MELWYN A , GUNN DAVID E , LIN NAN-HORNG , GARVEY DAVID S , RYTHER KEITH , LEBOLD SUZANNE A , ELLIOTT RICHARD L , HE YUN , WASIAK JAMES T , BAI HAO , DART MICHAEL J , EHRLICH PAUL P , LI YIHONG , KINCAID JOHN F , SCHKERYANTZ JEFFREY M , LYNCH JOHN K
IPC: A61K31/427 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61P25/00 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D401/12 , C07D403/12 , C07D417/12 , C07D455/02 , C07D487/04 , A61K31/40 , A61K31/425 , A61K31/44
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公开(公告)号：DK0950057T3
公开(公告)日：2003-03-10
申请号：DK97952392
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P , LIN NAN-HORNG
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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