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公开(公告)号：KR1020120003624A
公开(公告)日：2012-01-11
申请号：KR1020100064332
申请日：2010-07-05
Applicant: 한국과학기술연구원
Abstract: PURPOSE: A Siloxane based-low dielectric film using cyclic silsesquioxane is provided to have excellent physical property, thermal stability and crack resistance, and to have high modulus and hardness maintaining excellent low dielectric property. CONSTITUTION: A Siloxane based-low dielectric film using cyclic silsesquioxane comprises a step of manufacturing silsesquioxane sol by sol-gel method by adding the stereoisomer of multi-reactive cyclic silsesquioxane into alkoxy siloxane; a step of manufacturing coating liquid containing the silsesquioxane sol and solvent; and a step of spreading the coating liquid and hardening. The silsesquioxane polymer matrix uses as a precursor for the manufacturing of the dielectric film. The silsesquioxane polymer matrix is the silsesquioxane sol manufactured by the adding of the multi-reactive cyclic silsesquioxane into the alkoxysilane.
Abstract translation: 目的：提供使用环状倍半硅氧烷的硅氧烷低介电膜，具有优异的物理性能，热稳定性和抗裂性，并且具有高模量和硬度，保持优异的低介电性能。 构成：使用环状倍半硅氧烷的硅氧烷低介电膜包括通过溶剂 - 凝胶法制备倍半硅氧烷溶胶的步骤，通过将多反应性环状倍半硅氧烷的立体异构体加入到烷氧基硅氧烷中; 制造含有倍半硅氧烷溶胶和溶剂的涂布液的步骤; 以及涂布液的扩散和硬化的步骤。 倍半硅氧烷聚合物基体用作制造电介质膜的前体。 倍半硅氧烷聚合物基体是通过将多反应性环状倍半硅氧烷加入烷氧基硅烷而制造的倍半硅氧烷溶胶。
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公开(公告)号：KR101052065B1
公开(公告)日：2011-07-27
申请号：KR1020080101249
申请日：2008-10-15
Applicant: 한국과학기술연구원
Inventor： 남길수 , 최경일 , 김혜란 , 서선희 , 백이연 , 김윤지 , 신희섭 , 김동진 , 배애님 , 정혜진 , 추현아 , 임혜원 , 조용서 , 노은주 , 금교창 , 최기현 , 신계정 , 한호규 , 정찬성 , 이재균 , 남기달 , 강용구 , 김영수 , 박웅서 , 김은경 , 김기선 , 정혜선 , 신동윤 , 송치만
IPC: C07D403/12 , C07D403/10
CPC classification number: C07D231/12 , C07D401/04 , C07D405/04 , C07D405/10 , C07D405/12
Abstract: 본 발명은 칼슘이온 채널 조절제로서 유효한 피라졸릴메틸아민-피페라진 유도체 및 이의 약제학적으로 허용 가능한 염, 이들 화합물의 제조방법, 그리고 이 화합물이 갖는 칼슘이온 채널 억제 효과에 의한 질환 치료제로 사용하는 의약적 용도에 관한 것이다.
피라졸릴메틸아민-피페라진 유도체, 칼슘이온 채널 조절제, 뉴런, 탈분극화, 급성통증, 만성통증, 신경병증성 통증, 고혈압치료제Abstract translation: 本发明是有效的吡唑基甲胺作为钙离子通道调节剂 - 哌嗪衍生物和化学，以允许它的药学上可接受的盐，在疾病治疗由钙用于生产这些化合物和药物用于化合物工艺通道具有抑制作用 等等。
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公开(公告)号：KR1020110058557A
公开(公告)日：2011-06-01
申请号：KR1020090115388
申请日：2009-11-26
Applicant: 한국과학기술연구원
IPC: C07C235/32 , A61K31/165 , A01N37/18 , C07C231/02
CPC classification number: Y02A50/473 , Y02A50/481
Abstract: PURPOSE: A triclosan derivative is provided to inhibit the activity of a FabI strain and to enable use as an antimicrobial agent for tuberculous bacillus including introspection strains and various strains. CONSTITUTION: A triclosan derivative is represented by chemical formula 1. In chemical formula 1, n is an integer of 1-6; X is primary or secondary amine, C1-C4 alkylamine, C1-C6 alkylamine including at least one hetero atom selected from oxygen and nitrogen, C5-C10 heterocyclic amine including at least one hetero atom selected from oxygen and nitrogen, phenylamine including at least one hydroxy group, phenylamine in which C1-C4 alkyl ester group or carboxylic acid is substituted, and 6-membered heteroarylamine including at least nitrogen.
Abstract translation: 目的：提供三氯生衍生物以抑制FabI菌株的活性，并且可用作结核菌杆菌的抗微生物剂，包括内省菌株和各种菌株。 构成：三氯生衍生物由化学式1表示。在化学式1中，n为1-6的整数; X是伯或仲胺，C 1 -C 4烷基胺，包括至少一个选自氧和氮的杂原子的C 1 -C 6烷基胺，包括至少一个选自氧和氮的杂原子的C 5 -C 10杂环胺，包括至少一个 羟基，其中C 1 -C 4烷基酯基或羧酸被取代的苯胺和至少包含氮的6元杂芳基胺。
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Patent Agency Ranking
公开(公告)号：KR100963315B1
公开(公告)日：2010-06-14
申请号：KR1020080012356
申请日：2008-02-11
Applicant: 한국과학기술연구원
CPC classification number: C12N9/001 , C07K2299/00 , C12Y103/01009 , G01N2333/90206 , G01N2500/20
Abstract: 본 발명은
Thermotoga
maritima 균주로부터 유래하는 FabK (enoyl-acyl carrier protein reductase) 단백질에 관한 것으로, 상기 단백질의 활성 부위와 3차원 결정 구조를 규명하여, 이를 이용하여 신규한 FabK 단백질 저해물질을 스크리닝하여, 기존의 항생제에 내성을 보이는 균주에 대해서 우수한 항균 활성을 보이는 신규 활성 조절 물질을 개발하는 기술에 관한 것이다.-
公开(公告)号：KR1020100042111A
公开(公告)日：2010-04-23
申请号：KR1020080101249
申请日：2008-10-15
Applicant: 한국과학기술연구원
Inventor： 남길수 , 최경일 , 김혜란 , 서선희 , 백이연 , 김윤지 , 신희섭 , 김동진 , 배애님 , 정혜진 , 추현아 , 임혜원 , 조용서 , 노은주 , 금교창 , 최기현 , 신계정 , 한호규 , 정찬성 , 이재균 , 남기달 , 강용구 , 김영수 , 박웅서 , 김은경 , 김기선 , 정혜선 , 신동윤 , 송치만
IPC: C07D403/12 , C07D403/10
CPC classification number: C07D231/12 , C07D401/04 , C07D405/04 , C07D405/10 , C07D405/12
Abstract: PURPOSE: A pyrazolylmethylamine-piperazine derivative which is effective as a calcium ion channel modulator is provided to ensure effective activation as an T-type calcium ion channel antagonist and to use as an agent for preventing and treating brain diseases, heart diseases and pain diseases. CONSTITUTION: A pyrazolylmethylamine-peperazine derivative is denoted by chemical formula 1. A pharmaceutical composition for preventing and treating brain diseases, heart diseases or pain diseases by T-type calcium ion channel antagonism contains the pyrazolylmethylamine-peperazine derivative of chemical formula 1 or its pharmaceutically acceptable salt an active ingredient. The brain disease is epilepsy, depression, Parkison's disease, dementia or somnipathy. The heart disease is hypertension, cardiac arrhythmia, myocardial infarction, or congestive failure. The pain disease is chronic pain, acute pain, or neurogenic pain. The pyrazolylmethylamine-peperazine derivative is prepared by binding pyrazolylmethylamine compound of chemical formula 3 with piperazine acetyl halide compound of chemical formula 2.
Abstract translation: 目的：提供作为钙离子通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物，以确保作为T型钙离子通道拮抗剂的有效活化，并用作预防和治疗脑疾病，心脏病和疼痛疾病的药剂。 构成：吡唑基甲胺 - 哌嗪衍生物由化学式1表示。用于通过T型钙离子通道拮抗作用预防和治疗脑疾病，心脏病或疼痛疾病的药物组合物含有化学式1的吡唑基甲基 - 哌嗪衍生物或其药学上可接受的盐 可接受的盐为活性成分。 脑疾病是癫痫，抑郁症，帕金森病，痴呆或嗜睡。 心脏病是高血压，心律失常，心肌梗死或充血性衰竭。 疼痛疾病是慢性疼痛，急性疼痛或神经源性疼痛。 通过将化学式3的吡唑基甲基胺化合物与化学式2的哌嗪乙酰卤化合物结合，制备吡唑基甲胺 - 哌嗪衍生物。
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公开(公告)号：KR1020090072904A
公开(公告)日：2009-07-02
申请号：KR1020080012356
申请日：2008-02-11
Applicant: 한국과학기술연구원
CPC classification number: C12N9/001 , C07K2299/00 , C12Y103/01009 , G01N2333/90206 , G01N2500/20
Abstract: A method for developing a FabK inhibitor is provided to screen a FabK inhibiting agent using active fragment of FabK and three dimensional structure. A method for crystallizing a FabK protein comprises a step of containing FabK protein solution with container solution comprising buffer solution, metal salt and precipitator. The concentration of FabK protein solution is 3-30mg/ml. The pH concentration and concentration is 4-9.5 and 0.005-1.5M. The metal salt is alkaline metal salt and alkaline metal salt. A precipitator is selected from alcohol of C1-4, and the concentration in the container solution is 1-40%(v/v). FabK-FMN(falvin mononucleotide) complex crystalline has three dimensional structure. A method for developing an inhibitor of FabK inhibitor is to use the three dimensional crystalline structure information.
Abstract translation: 提供用于开发FabK抑制剂的方法，以使用FabK的活性片段和三维结构筛选FabK抑制剂。 用于结晶FabK蛋白的方法包括含有包含缓冲溶液，金属盐和除尘器的容器溶液的FabK蛋白溶液的步骤。 FabK蛋白溶液的浓度为3-30mg / ml。 pH浓度为4-9.5和0.005-1.5M。 金属盐是碱金属盐和碱金属盐。 沉淀器选自C1-4的醇，容器溶液中的浓度为1-40％（v / v）。 FabK-FMN（falvin单核苷酸）复合结晶具有三维结构。 开发FabK抑制剂抑制剂的方法是使用三维晶体结构信息。
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67.发明公开퀴놀린 카복실산 아마이드 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로함유하는 항균 조성물 有权喹啉 - 羧酸 - 酰胺衍生物或其药学上可接受的盐，其制备方法和含有它们作为活性成分的抗生素组合物
公开(公告)号：KR1020090063869A
公开(公告)日：2009-06-18
申请号：KR1020070131388
申请日：2007-12-14
Applicant: 한국과학기술연구원 , 재단법인서울대학교산학협력재단
IPC: C07D215/38 , C07D215/48 , C07D401/12 , A61K31/47
Abstract: An antibacterial composition containing a quinoline-carboxylic acid amide derivative or its pharmaceutically allowable salt is provided to suppress bacteria proliferation by inhibiting Fab I activation which is related to the last step of fatty acid biosynthesis. An antibacterial composition comprises a quinoline-carboxylic acid-amide derivative of the chemical formula 1 or its pharmaceutically allowable salt. A method for manufacturing the quinoline-carboxylic acid-amide derivative comprises: a step of reacting an aldehyde group of the chemical formula 2 with a phosphate, whose cyano group is substituted, to obtain a compound of the chemical formula 3; a step of performing intramolecular cyclization of the compound of the chemical formula 3 to obtain a quinoline compound of the chemical formula 4; a step of reacting the compound of the chemical formula 4 with a secondary amine to obtain a compound of the chemical formula 1(1a); and a step of reacting the compound of the chemical formula 1(1a) with an isocyanate to obtain the compound of the chemical formula 1.
Abstract translation: 提供含有喹啉羧酸酰胺衍生物或其药学上可允许的盐的抗菌组合物，通过抑制与脂肪酸生物合成的最后步骤相关的Fab I激活来抑制细菌增殖。 抗菌组合物包含化学式1的喹啉羧酸 - 酰胺衍生物或其药学上可允许的盐。 喹啉羧酸 - 酰胺衍生物的制造方法包括：使化学式2的醛基与氰基取代的磷酸酯反应，得到化学式3的化合物的工序; 化学式3的化合物进行分子内环化的步骤，得到化学式4的喹啉化合物; 使化学式4的化合物与仲胺反应以获得化学式1（1a）的化合物的步骤; 以及使化学式1（1a）的化合物与异氰酸酯反应以获得化学式1的化合物的步骤。
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公开(公告)号：KR1020060091533A
公开(公告)日：2006-08-21
申请号：KR1020050012459
申请日：2005-02-15
Applicant: 한국과학기술연구원
Abstract: 미생물 배양 분석을 위한 분광장치에 있어서, 양압과 음압을 발생하기 위한 압력발생부, 상기 압력발생부의 압력에 의해 시료를 유입과 유출하기 위한 제1 수용부, 상기 제1 수용부를 제1축으로 이동시키기 위한 제1축 이동부, 상기 제1축 이동부를 제1축에 수직한 제2축과 제3축으로 이동시키기 위한 스테이지, 및 발광소자와 수광소자 사이에 위치한 제2 수용부를 포함하는 분광장치가 제공된다.
분광장치, 미생물, 자동, 압력, 스테이지
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