公开(公告)号：ZA981301B

公开(公告)日：1998-08-28

申请号：ZA981301

申请日：1998-02-17

Applicant: ABBOTT LAB

Inventor： WASICAK JAMES T ,  GARVEY DAVID S ,  HOLLADAY MARK W ,  LIN NAN-HORNG ,  RYTHER KEITH B

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  C07D ,  A61K

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：CA2698384A1

公开(公告)日：1998-06-18

申请号：CA2698384

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ARNERIC STEPHEN P ,  BAI HAO ,  DART MICHAEL J ,  LIN NAN-HORNG ,  LYNCH JOHN K ,  OR YAT SUN ,  RYTHER KEITH B ,  SULLIVAN JAMES P ,  WASICAK JAMES T ,  EHRLICH PAUL P

IPC: A61P25/04 ,  C07D205/04 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：CA2256022A1

公开(公告)日：1997-12-11

申请号：CA2256022

申请日：1997-06-04

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  RYTHER KEITH ,  LI YIHONG ,  BAI HAO ,  HE YUN ,  LIN NAN-HORNG

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/465 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61P25/00 ,  A61P43/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/47 ,  A61K31/495

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of formula (I) or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula (I) with the variables defined in the specification are also described.

公开(公告)号：CA2515790C

公开(公告)日：2012-11-27

申请号：CA2515790

申请日：2004-02-26

Applicant: ABBOTT LAB

Inventor： HASVOLD LISA A ,  HEXAMER LAURA ,  LI GAOQUAN ,  LIN NAN-HORNG ,  SHAM HING ,  SOWIN TOM ,  SULLIVAN GERARD M ,  WANG LE ,  XIA PING XIA

IPC: C07D243/38 ,  A61K31/551 ,  A61P35/00 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D491/10

Abstract: Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：DE60128543T2

公开(公告)日：2008-01-31

申请号：DE60128543

申请日：2001-02-01

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  DONG LIMING

IPC: C07D213/65 ,  A61K31/44 ,  A61K31/444 ,  A61P25/00 ,  A61P25/04

Abstract: The present invention is directed to a series of substituted pyridine compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions containing these compounds. Preferred compounds are 3'-(5'- and/or 6'-substituted) pyridyl ethers.

公开(公告)号：DE60118955T2

公开(公告)日：2007-01-04

申请号：DE60118955

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE K ,  GWALTNEY L ,  HASVOLD A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI A ,  ROCKWAY W ,  SHAM L ,  SULLIVAN M ,  TONG YUNSONG ,  WANG T ,  WANG LE ,  WANG XILU ,  WANG WEIBO

IPC: C07D233/64 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：PT1339695E

公开(公告)日：2006-08-31

申请号：PT01273519

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY STEPHEN L II ,  HASVOLD LISA A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D233/00 ,  C07D401/00 ,  C07D405/00 ,  C07D409/00

公开(公告)号：ZA200506760B

公开(公告)日：2006-06-28

申请号：ZA200506760

申请日：2005-08-23

Applicant: ABBOTT LAB

Inventor： HASVOLD LISA A ,  LI GAOQUAN ,  SHAM HING ,  SULLIVAN GERARD M ,  XIA PING ,  HEXAMER LAURA ,  LIN NAN-HORNG ,  SOWIN TOM ,  WANG LE

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101

公开(公告)号：DE60118955D1

公开(公告)日：2006-05-24

申请号：DE60118955

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE K ,  GWALTNEY L ,  HASVOLD A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI A ,  ROCKWAY W ,  SHAM L ,  SULLIVAN M ,  TONG YUNSONG ,  WANG T ,  WANG LE ,  WANG XILU ,  WANG WEIBO

IPC: C07D233/64 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：AT323681T

公开(公告)日：2006-05-15

申请号：AT01273519

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY STEPHEN L II ,  HASVOLD LISA A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WANG WEIBO

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.