公开(公告)号：CR20130156A

公开(公告)日：2013-05-23

申请号：CR20130156

申请日：2013-04-03

Applicant: ABBOTT LAB

Inventor： LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  DIXON RICHARD W ,  ROGUSKA MICHAEL ,  HINTON PAUL R ,  KUMAR SHANKAR

IPC: C07K16/00

Abstract: Proteínas de unión a IL-12 p40, en particular anticuerpos que se unen a la interleuquina-12 humana (hIL-12) y/o IL-23 humana (hIL-23). Específicamente, la invención se relaciona con anticuerpos que son quiméricos, con injertos de CDR y anticuerpos humanizados. Los anticuerpos preferidos tienen gran afinidad por hIL-12 y/o hIL-23 y neutralizan la actividad de hIL-12 y/o hIL-23 in vitro y in vivo. Un anticuerpo de la invención puede ser un anticuerpo de longitud completa o una porción de unión al antígeno del mismo.

公开(公告)号：SG174782A1

公开(公告)日：2011-10-28

申请号：SG2011064268

申请日：2007-09-07

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  DIXON RICHARD W ,  BELK JONATHAN P ,  YING HUA ,  ARGIRIADI MARIA A ,  CUFF CAROLYN A ,  HINTON PAUL R ,  KUMAR SHANKAR ,  MELIM TERRY L ,  CHEN YAN

Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, SDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hTL-13 activity is detrimental.

公开(公告)号：SG163559A1

公开(公告)日：2010-08-30

申请号：SG2010047561

申请日：2006-06-29

Applicant: ABBOTT LAB

Inventor： LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  DIXON RICHARD W ,  ROGUSKA MICHAEL ,  HINTON PAUL R ,  KUMAR SHANKAR

Abstract: The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL- 23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL- 23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.

公开(公告)号：MX2009010362A

公开(公告)日：2009-10-16

申请号：MX2009010362

申请日：2008-03-27

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  CALDERWOOD DAVID J ,  DIXON RICHARD W ,  FRANK KRISTINE E ,  BREINLINGER ERIC C

IPC: A01N43/58 ,  A61K31/50 ,  C07D471/00

Abstract: La presente invención está dirigida a compuestos de imidazopirazina novedosos útiles como inhibidores de cinasa y podrían ser útiles en el tratamiento de ciertas condiciones y enfermedades, especialmente condiciones y enfermedades inflamatorias y trastornos y condiciones proliferativas, por ejemplo, cánceres.

公开(公告)号：CR9599A

公开(公告)日：2009-06-05

申请号：CR9599

申请日：2007-12-18

Applicant: ABBOTT LAB

Inventor： LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  DIXON RICHARD W ,  ROGUSKA MICHAEL ,  HINTON PAUL R ,  KUMAR SHANKAR

IPC: C07K14/715

Abstract: Proteinas de union a IL-12p40, en particular anticuerpos que se unen a la interleuquina-12 humana (hIL-12) y/o IL-23 humana (hIL-23). Especificamente, ia invencion se relaciona con anticuerpos que son quimericos, con injertos de CDR y anticuerpos humanizados.

公开(公告)号：CA2662701A1

公开(公告)日：2008-10-23

申请号：CA2662701

申请日：2007-09-07

Applicant: ABBOTT LAB

Inventor： KUMAR SHANKAR ,  HINTON PAUL R ,  WU CHENGBIN ,  CUFF CAROLYN A ,  MELIM TERRY L ,  DIXON RICHARD W ,  BELK JONATHAN P ,  CHEN YAN ,  ARGIRIADI MARIA A ,  YING HUA

IPC: C07K16/24 ,  C07K16/46 ,  C12N15/13 ,  C12P21/08

Abstract: The present invention encompasses IL- 13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and human ized antibodies. Preferred antibodies have high affinity for hIL-13 and neut ralize hIL-13 activity in vitro and in vivo. An antibody of the invention ca n be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provide d. The antibodies, or antibody portions, of the invention are useful for det ecting hIL-13 and for inhibiting hlL-13 activity, e.g., in a human subject s uffering from a disorder in which hTL-13 activity is detrimental.

公开(公告)号：MXPA06010904A

公开(公告)日：2007-06-11

申请号：MXPA06010904

申请日：2005-03-24

Applicant: ABBOTT LAB

Inventor： MICHAELIDES MICHAEL R ,  HOLMS JAMES H ,  STEINMAN DOUGLAS H ,  MUCKEY MELANIE A ,  WADA CAROL K ,  ARNOLD LEE D ,  DINGES JURGEN ,  DIXON RICHARD W ,  DJURIC STEVAN W ,  ERICSSON ANNA M ,  FISCHER KIMBA ,  GASIECKI ALAN F ,  GRACIAS VIJAYA J ,  RAFFERTY PAUL ,  XIA ZHIREN ,  AKRITOPOULOU-ZANZE IRINI ,  ZHANG HENRY Q ,  TAKESHITA MAKOTO

IPC: C07D409/04 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  A61P35/00 ,  A61P37/00 ,  C07D231/54 ,  C07D409/14 ,  C07D413/14 ,  C07D491/04 ,  C07D495/04

Abstract: Se utilizan los compuestos de la presente invencion para inhibir proteinas de tirosin-cinasas. Tambien se describen los metodos para hacer los compuestos, composiciones que los contienen y metodos de tratamiento utilizando los compuestos.

公开(公告)号：CA2618482A1

公开(公告)日：2007-03-01

申请号：CA2618482

申请日：2006-08-18

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  SALFELD JOCHEN G ,  GHAYUR TARIQ ,  DIXON RICHARD W

IPC: A61K49/00 ,  A61K31/192 ,  A61K31/343 ,  A61K31/365 ,  A61K31/4152 ,  A61K31/445 ,  A61K31/496 ,  A61K31/551 ,  A61K31/60 ,  A61K39/395

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

公开(公告)号：AU2006265932A1

公开(公告)日：2007-01-11

申请号：AU2006265932

申请日：2006-06-29

Applicant: ABBOTT LAB

Inventor： FUNG EMMA ,  HINTON PAUL R ,  LACY SUSAN E ,  ROGUSKA MICHAEL ,  KUMAR SHANKAR ,  DIXON RICHARD W ,  BELK JONATHAN P

IPC: C07K14/715

Abstract: The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.

公开(公告)号：ZA200206266B

公开(公告)日：2003-11-06

申请号：ZA200206266

申请日：2002-08-06

Applicant: ABBOTT LAB

Inventor： GHAYUR TARIQ ,  DIXON RICHARD W ,  ROGUSKA MIKE ,  WHITE MICHAEL ,  LABKOVSKY BORIS ,  SALFELD JOCHEN ,  DUNCAN ALEXANDER ROBERT ,  BROCKLEHURST SIMON MARK ,  MANKOVICH JOHN ,  SHORROCK CELIA PATRICIA ,  THOMPSON JULIA ELIZABETH ,  LENNARD SIMON NICHOLAS

IPC: A61K39/395 ,  C12N15/02 ,  A61K45/00 ,  A61P1/04 ,  A61P3/10 ,  A61P5/14 ,  A61P7/00 ,  A61P7/02 ,  A61P7/06 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/14 ,  A61P19/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P39/00 ,  A61P39/02 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08 ,  C07K

Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular, antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-I8 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.