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公开(公告)号：NZ719122A
公开(公告)日：2017-12-22
申请号：NZ71912212
申请日：2012-09-28
Applicant: VERTEX PHARMA
Inventor： DURRANT STEVEN JOHN , CHARRIER JEAN-DAMIEN , STUDLEY JOHN , PIERARD FRANCOISE YVONNE THEODORA MARIE , LITTLER BENJAMIN JOSEPH , HUGHES ROBERT MICHAEL , SIESEL DAVID ANDREW , URBINA ARMANDO , SHI YI , ANGELL PAUL
IPC: C07D413/04 , A61K31/497 , A61P35/00
Abstract: The present disclosure relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present disclosure also relates to compounds useful as inhibitors of ATR protein kinase. The disclosure relates to pharmaceutically acceptable compositions comprising the compounds; methods of treating of various diseases, disorders, and conditions using the compounds; processes for preparing the compounds; intermediates for the preparation of the compounds; and solid forms of the compounds. The compounds have formula (I) or (II) wherein the variables are as defined herein.
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公开(公告)号：AU2017206213A1
公开(公告)日：2017-08-03
申请号：AU2017206213
申请日：2017-07-20
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , STUDLEY JOHN , PIERARD FRANCOISE YVONNE THEODORA MARIE , DURRANT STEVEN JOHN , LITTLER BENJAMIN JOSEPH , HUGHES ROBERT MICHAEL , SIESEL DAVID ANDREW , ANGELL PAUL , URBINA ARMANDO , SHI YI
IPC: C07D413/04 , A61K31/497 , A61P35/00
Abstract: Abstract [002821 The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. [002831 The compounds of this invention have formula I or II: NH 0 -N HN R NH 2 04 H -R4 R N- Rla RC R4 R lb wherein the variables are as defined herein.
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83.发明专利
公开(公告)号：JOP20190125A1
公开(公告)日：2017-06-16
申请号：JOP20190125
申请日：2019-05-28
Applicant: VERTEX PHARMA
Inventor： ZHOU JINGLAN , VAN GOOR FREDRICK F , HADIDA RUAH SARA SABINA , SIESEL DAVID ANDREW , CLEVELAND THOMAS , GULEVICH ANTON , PIERRE FABRICE JEAN DENIS , STAVROPOULOS KATHY , GROOTENHUIS PETER DIEDERIK JAN , KANG PING , YOUNG TOMOTHY JOHN , ANDERSON COREY , ALCACIO TIMOTHY , KESHAVARZ-SHOKRI ALI , MCCARTNEY JASON , ANGELL PAUL TIMOTHY , GROSS RAYMOND STANLEY , MILLER MARK THOMAS , HUGHES ROBERT M , ABELA ALEXANDER RUSSELL , JOSHI PRAMOD VIRUPAX , SHI YI , CLEMENS JEREMY J , UY JOHNNY , BAEK MINSON , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , TERMIN ANDREAS P , SHRESTHA MUNA , FERRIS LORI ANN , HSIA CLARA KUANG-JU , PARASELLI PRASUNA
Abstract: يتمالكشفعنمركباتلهاالصيغة ( I )، أملاحمقبولةصيدليًامنها،مشتقاتمعالجةبالديوتيريوممنأيٍمماسبق،ونواتجأيضلأيٍمماسبق. كمايتمالكشفعنتركيباتصيدليةتشتملعليها،وطرقلعلاجالتليفالكيسيباستخدامها،وطرقلتصنيعها. كمايتمالكشفعنصورفيالحالةالصلبةللمركب 1 وأملاحوذواباتمنه.
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公开(公告)号：AU2019405477B2
公开(公告)日：2025-04-03
申请号：AU2019405477
申请日：2019-12-17
Applicant: VERTEX PHARMA
Inventor： BRODNEY MICHAEL , GAGNON KEVIN , HU KAN-NIAN , MEDEK ALES , ROSE PETER , SHI YI , SHRESTHA MUNA , WITKOS FAITH , CAO JINGRONG , COME JON H , DAKIN LESLIE A , DENIS FRANCOIS , DORSCH WARREN A , FORTIER ANNE , HAMEL MARTINE , KRUEGER ELAINE B , LEDFORD BRIAN , NANTHAKUMAR SUGANTHINI S , NICOLAS OLIVIER , SAYEGH CAMIL , SENTER TIMOTHY J , WANG TIANSHENG
IPC: A61P13/12 , A61K31/4025 , C07D403/12
Abstract: The disclosure provides at least one entity chosen from compounds of formula (I), solid state forms of the same, compositions comprising the same, and methods of using the same, including use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).
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公开(公告)号：MX388103B
公开(公告)日：2025-03-19
申请号：MX2019006637
申请日：2019-06-06
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , KESHAVARZ-SHOKRI ALI , TERMIN ANDREAS P , GULEVICH ANTON , HSIA CLARA KUANG-JU , ANDERSON COREY , SIESEL DAVID ANDREW , PIERRE FABRICE JEAN DENIS , VAN GOOR FREDRICK F , KHATUYA HARIPADA , MCCARTNEY JASON , CLEMENS JEREMY J , ZHOU JINGLAN , UY JOHNNY , STAVROPOULOS KATHY , FERRIS LORI ANN , MILLER MARK THOMAS , BAEK MINSON , SHRESTHA MUNA , KRENITSKY PAUL JHON , ANGELL PAUL TIMOTHY , GROOTENHUIS PETER DIEDIERIK JAN , KANG PING , JOSHI PRAMOD VIRUPAX , PARASELLI PRASUNA , GROSS RAYMOND STANLEY , HUGHES ROBERT M , HADIDA RUAH SARA SABINA , CLEVELAND THOMAS , ALCACIO TIMOTHY , YOUNG TOMOTHY JOHN , SHI YI
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Se describen compuestos de Fórmula (I): (ver fórmulas) sales farmacéuticamente aceptables de este, derivados deuterados de cualquiera de los anteriores y metabolitos de cualquiera de los anteriores. También se describen composiciones farmacéuticas que los comprenden, métodos para el tratamiento de la fibrosis quística mediante el uso de estos y métodos para confeccionarlos. Se describen además las formas en estado sólido del Compuesto 1 y sales y solvatos de este.
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Patent Agency Ranking
公开(公告)号：MX382171B
公开(公告)日：2025-03-13
申请号：MX2016006199
申请日：2016-05-12
Applicant: VERTEX PHARMA
Inventor： MEDEK ALES , MACIKENAS DAINIUS , VAN ALSTEN JOHN GREGG , NTI-ADDAE KWAME W , LEDEBOER MARK WILLEM , WALDO MICHAEL , ASMAL MOHAMMED , MUDUNURI PRAVEEN , BYRN RANDAL , ROBERTSON SARAH MARIE , O'NEIL SIMON ADAM , JONES STEVEN , JURKAUSKAS VALDAS , TSAI WANJUNG , SHI YI
IPC: C07D403/04 , A61K31/506 , A61P31/16 , C07D471/04
Abstract: Se describen formas polimórficas del Compuesto (1) o una sal farmacéuticamente aceptable del mismo, en donde el Compuesto (1) se representa por la siguiente fórmula estructural: (ver Fórmula) que son Forma A de la sal HCl del Compuesto (1) · 1/2H2O, Forma F de la sal HCl del Compuesto (1) · 3H2O, Forma D de la sal HCl del Compuesto (1), Forma A del Compuesto (1), y Forma A de la sal tosilada del Compuesto (1). Tales formas polimórficas se emplean para tratar influenza, inhibir la replicación del virus de influenza, o reducir la cantidad de virus de influenza en una muestra biológica o en un sujeto.
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公开(公告)号：AU2020328028B2
公开(公告)日：2025-03-06
申请号：AU2020328028
申请日：2020-08-13
Applicant: VERTEX PHARMA
Inventor： SHI YI , GAGNON KEVIN J , LI JICONG , LU JENNIFER , MEDEK ALES , SHRESTHA MUNA , WALDO MICHAEL , ZHANG BEILI , ZWICKER CARL L , ANDERSON COREY DON , CLEMENS JEREMY J , CLEVELAND THOMAS , COON TIMOTHY RICHARD , FRIEMAN BRYAN , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE , SWIFT SARA E , ZHOU JINGLAN
IPC: C07D513/22 , A61K31/435 , A61P11/00
Abstract: Crystalline forms of Compound I: Formula (I) pharmaceutically acceptable salts thereof, and solvates and hydrates thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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公开(公告)号：JOP20210131A1
公开(公告)日：2023-01-30
申请号：JOP20210131
申请日：2019-12-17
Applicant: VERTEX PHARMA
Inventor： SHI YI , MEDEK ALES , BRODNEY MICHAEL , DAKIN LESLIE A , DORSCH WARREN A , DENIS FRANCOIS , ROSE PETER , SENTER TIMOTHY J , SHRESTHA MUNA , SAYEGH CAMIL , GAGNON KEVIN , FORTIER ANNE , CAO JINGRONG , KRUEGER ELAINE B , COME JON H , LEDFORD BRIAN , NANTHAKUMAR SUGANTHINI S , NICOLAS OLIVIER , HAMEL MARTINE , HU KAN-NIAN , WANG TIANSHENG , WITKOS FAITH
Abstract: غيرمتوفر
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公开(公告)号：CA2850566C
公开(公告)日：2022-05-03
申请号：CA2850566
申请日：2012-09-28
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , STUDLEY JOHN , PIERARD FRANCOISE YVONNE THEODORA MARIE , DURRANT STEVEN JOHN , LITTLER BENJAMIN JOSEPH , HUGHES ROBERT MICHAEL , SIESEL DAVID ANDREW , ANGELL PAUL , URBINA ARMANDO , SHI YI
IPC: C07C269/06
Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules of formula I or II: which may be useful in the treatment of cancer. Compounds of the invention may be prepared via a compound of formula 4-11: which may be prepared by reacting a compound of formula 4-i: under suitable chlorooxime formation conditions to form the compound of formula 4-ii.
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公开(公告)号：AU2020328028A1
公开(公告)日：2022-03-17
申请号：AU2020328028
申请日：2020-08-13
Applicant: VERTEX PHARMA
Inventor： SHI YI , GAGNON KEVIN J , LI JICONG , LU JENNIFER , MEDEK ALES , SHRESTHA MUNA , WALDO MICHAEL , ZHANG BEILI , ZWICKER CARL L , ANDERSON COREY DON , CLEMENS JEREMY J , CLEVELAND THOMAS , COON TIMOTHY RICHARD , FRIEMAN BRYAN , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE , SWIFT SARA E , ZHOU JINGLAN
IPC: C07D513/22 , A61K31/435 , A61P11/00
Abstract: Crystalline forms of Compound I: Formula (I) pharmaceutically acceptable salts thereof, and solvates and hydrates thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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