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    SAMPLE TRANSFERRING APPARATUS FOR MASS CYTOMETRY
    13.
    发明申请
    SAMPLE TRANSFERRING APPARATUS FOR MASS CYTOMETRY 审中-公开

    公开(公告)号：US20170098532A1

    公开(公告)日：2017-04-06

    申请号：US15231592

    申请日：2016-08-08

    Applicant: Fluidigm Canada Inc.

    Inventor： RAYMOND JONG

    IPC: H01J49/04 ,  G01N15/10 ,  H01J49/10

    CPC classification number: H01J49/0445 ,  G01N15/06 ,  G01N15/10 ,  G01N35/10 ,  G01N2015/0065 ,  G01N2015/1006 ,  H01J49/045 ,  H01J49/105

    Abstract: In a mass cytometer or mass spectrometer, a sample of elemental tagged particles is transferred from a dispersion to a gas flow through a carrier aerosol spray for atomization and ionization by inductively coupled plasma (ICP) source. The configuration of the sample transfer apparatus allow for total consumption of the sample by passing the sample spray through a deceleration stage to decelerate the spray of particles from its high velocity expansion. Following the deceleration stage, the decelerated sample of particles can be accelerated and focused through an acceleration stage for transferring into the ICP. This effectively improves the particle transfer between the sample spray and the ICP.

    Nebulizer and analyzer
    14.
    发明授权
    Nebulizer and analyzer 有权
    雾化器和分析仪

    公开(公告)号：US09520278B2

    公开(公告)日：2016-12-13

    申请号：US14597727

    申请日：2015-01-15

    Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  S.T. JAPAN INC.

    Inventor： Kazumi Inagaki ,  Shin-ichiro Fujii ,  Shin-ichi Miyashita ,  Koichi Chiba ,  Takao Nakagawa ,  Masaaki Abe ,  Nobuyoshi Kitagawa ,  Yosuke Nakagawa

    IPC: H01J49/04 ,  H01J49/10

    CPC classification number: H01J49/045 ,  H01J49/105

    Abstract: An object is to mix multiple liquids sufficiently and then nebulize the mixed liquids while maintaining the nebulizing efficiency. A nebulizer includes a first inner tube disposed inside an outer tube and having therein a first sample passage through which a first liquid sample flows, a second inner tube disposed inside the outer tube in parallel with the first inner tube and having therein a second sample passage through which a second liquid sample flows, a membranous member disposed with a gap between the membranous member and sample outlets formed at respective ends of the inner tubes. The gap forms mixing space in which a gas passing through a gas passage converts the first and second liquid samples flowing out of the sample outlets into droplets and mixes the droplets and the membranous member has multiple holes through which the mixed liquid samples pass along with the gas.

    Abstract translation: 目的是充分混合多种液体，然后使混合液体雾化，同时保持喷雾效率。 喷雾器包括设置在外管内的第一内管，其中具有第一液体样品流过的第一样品通道，与第一内管平行设置在第二内管内的第二内管，其中具有第二样品通道 第二液体样品通过其流动，膜构件设置在膜构件和形成在内管的各个端部处的样品出口之间的间隙。 间隙形成混合空间，其中通过气体通道的气体将从样品出口流出的第一和第二液体样品转化成液滴并混合液滴，并且膜构件具有多个孔，混合液体样品通过该孔与 加油站。

    Enhanced Spray Formation for Liquid Samples
    17.
    发明申请
    Enhanced Spray Formation for Liquid Samples 有权
    液体样品增强喷雾形成

    公开(公告)号：US20160181082A1

    公开(公告)日：2016-06-23

    申请号：US14910032

    申请日：2014-08-05

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Thomas Covey ,  Peter Kovarik

    IPC: H01J49/16 ,  H01J49/04

    CPC classification number: H01J49/165 ,  H01J49/045

    Abstract: Methods and systems for generating ions from a liquid sample for mass spectrometry are provided herein. In various aspects, the methods and systems can enhance the break-up of a jet of the liquid sample upon injection into an ionization chamber. In some aspects, methods and systems perturb the liquid sample prior to discharge to increase the internal energy of the sample so as to enhance the formation of liquid droplets when the liquid sample is injected into the ionization chamber.

    Abstract translation: 本文提供了用于从用于质谱的液体样品产生离子的方法和系统。 在各个方面，所述方法和系统可以在注入电离室时增强液体样品的射流的分解。 在一些方面，方法和系统在放电之前扰乱液体样品以增加样品的内部能量，以便当液体样品注入电离室时增强液滴的形成。

    Apparatus and method for generating chemical signatures using differential desorption
    18.
    发明授权
    Apparatus and method for generating chemical signatures using differential desorption 有权
    使用差分解吸法生成化学特征的装置和方法

    公开(公告)号：US09337007B2

    公开(公告)日：2016-05-10

    申请号：US14738899

    申请日：2015-06-14

    Applicant: IONSENSE INC.

    Inventor： Brian D Musselman

    IPC: H01J49/00 ,  H01J49/16

    CPC classification number: H01J49/165 ,  G01N1/4022 ,  G01N2001/028 ,  G01N2030/009 ,  G01N2030/062 ,  H01J49/0031 ,  H01J49/045 ,  H01J49/16

    Abstract: The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.

    Abstract translation: 本发明涉及一种生成分析物混合物的化学特征的方法和装置。 本发明涉及使用SPME表面吸收和吸附分析物混合物中的一种或两种。 在本发明的一个实施方案中，然后将表面暴露于用适当的空间分辨率选择的不同温度的离子化物质以解吸分析物混合物的化学特征。

    IMPROVEMENTS IN AND RELATING TO THE PRODUCTION AND CONTROL OF IONS
    19.
    发明申请
    IMPROVEMENTS IN AND RELATING TO THE PRODUCTION AND CONTROL OF IONS 有权
    对离子的生产和控制的改进和相关

    公开(公告)号：US20160049285A1

    公开(公告)日：2016-02-18

    申请号：US14781618

    申请日：2014-04-04

    Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA

    Inventor： DIMITRIS PAPANASTASIOU ,  EMMANUEL RAPTAKIS ,  DIAMANTIS KOUNADIS ,  ALEXANDER LEKKAS ,  IOANNIS ORFANOPOULOS

    IPC: H01J49/16 ,  H01J49/04

    CPC classification number: H01J49/167 ,  H01J49/0404 ,  H01J49/045 ,  H01J49/0495 ,  H01J49/162

    Abstract: Techniques are provided for generating charged droplets of liquid entrained within a gas flow within a vacuum chamber and for controlling the gas flow. The gas flow with the entrained charged droplets of liquid is jetted into the vacuum chamber along a predetermined jetting axis. The gas jet is received within a gas conduit housed within the vacuum chamber and having a conduit bore coaxial with the predetermined jetting axis. The received gas jet is caused to be restrained to form a laminar gas flow entrained with charged droplets inside of the gas conduit for guiding the entrained charged droplets therealong.

    Abstract translation: 提供了技术来产生夹带在真空室内的气流中的带电液滴并用于控制气流。 具有夹带的液体的带电液滴的气流沿着预定的喷射轴线被喷射到真空室中。 气体射流被容纳在容纳在真空室内的气体管道中，并且具有与预定喷射轴线同轴的导管孔。 引起接收的气体射流被限制以形成夹带在气体导管内部的带电荷的液滴的层流气流，用于在其上引导夹带的带电液滴。

    METHOD AND APPARATUS FOR CONTROLLING THE SUPPLY OF IONS
    20.
    发明申请
    METHOD AND APPARATUS FOR CONTROLLING THE SUPPLY OF IONS 审中-公开
    用于控制离子供应的方法和装置

    公开(公告)号：US20150144781A1

    公开(公告)日：2015-05-28

    申请号：US14409735

    申请日：2013-06-17

    Applicant: Micromass UK Limited

    Inventor： Kevin R. Howes ,  Simon Meffan-Main ,  Richard B. Moulds

    IPC: H01J49/10 ,  H01J49/00 ,  H01J49/04

    CPC classification number: H01J49/10 ,  H01J49/0031 ,  H01J49/0431 ,  H01J49/0445 ,  H01J49/045 ,  H01J49/16

    Abstract: A method for controlling the supply of ions from a liquid chromatograph through an ion source into a mass spectrometer. The ion source is foreseen to be either an electrospray ionization sources or an impaction spraying ion sources. The ion source can be operated in two modes: a mode in which ions are supplied into the mass spectrometer and a mode in which ions are prevented to be supplied into the mass spectrometer. In this latter mode, the supply of ions into the mass spectrometer is prevented by reducing the potential applied to the ionization source, reducing the nebulizer gas flow and/or increasing the cone gas flow.

    Abstract translation: 用于控制从液相色谱仪通过离子源将离子供给到质谱仪中的方法。 离子源可预见为电喷雾离子源或冲击喷射离子源。 离子源可以以两种模式操作：将离子供给到质谱仪中的模式以及防止将离子供给到质谱仪中的模式。 在后一种模式中，通过降低施加到电离源的电位，减少雾化器气体流量和/或增加锥形气体流量来防止向质谱仪中提供离子。

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