公开(公告)号：US20150048246A1

公开(公告)日：2015-02-19

申请号：US14349724

申请日：2012-10-01

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  David J. Landridge

IPC: H01J49/42 ,  H01J49/36

CPC classification number: H01J49/424 ,  H01J49/065 ,  H01J49/066 ,  H01J49/36

Abstract: An annular ion guide is disclosed comprising inner and outer electrodes. Ions are confined within an annular ion guiding region by RF or pseudo-potential barriers in both an outward and inward radial direction.

Abstract translation: 公开了一种环形离子导向器，其包括内电极和外电极。 离子通过RF或伪电位势垒在向外和向内的径向方向上被限制在环形离子引导区域内。

公开(公告)号：US20140326874A1

公开(公告)日：2014-11-06

申请号：US14279957

申请日：2014-05-16

Applicant: Carl Zeiss Microscopy GmbH

Inventor： Albrecht Glasmachers ,  Alexander Laue ,  Michel Aliman ,  Hubert Mantz ,  Ulrike Zeile ,  Holger Doemer

IPC: H01J37/26 ,  H01J49/10 ,  H01J37/28 ,  H01J3/26

CPC classification number: H01J37/265 ,  H01J3/26 ,  H01J37/244 ,  H01J37/256 ,  H01J37/28 ,  H01J49/063 ,  H01J49/065 ,  H01J49/10 ,  H01J2237/05 ,  H01J2237/2449 ,  H01J2237/2527

Abstract: An apparatus for transmission of energy of an ion to at least one gas particle and/or for transportation of an ion and a particle beam device having an apparatus such as this are disclosed. In particular, a container is provided, in which a gas is arranged which has gas particles, wherein the container has a transport axis. Furthermore, at least one first multipole unit and at least one second multipole unit are provided, which are arranged along the transport axis. The first multipole unit and the second multipole unit are formed by printed circuit boards. Furthermore, an electronic circuit is provided, which provides each multipole unit with a potential, such that a potential gradient is generated, in particular along the transport axis.

Abstract translation: 公开了一种用于将离子的能量传输到至少一个气体颗粒和/或用于输送离子的装置和具有这样的装置的粒子束装置。 特别地，提供一种容器，其中布置有气体颗粒的气体，其中容器具有输送轴线。 此外，提供沿着输送轴线布置的至少一个第一多极单元和至少一个第二多极单元。 第一多极单元和第二多极单元由印刷电路板形成。 此外，提供了一种电子电路，其为每个多极单元提供电势，使得产生电位梯度，特别是沿输送轴。

公开(公告)号：US20140322817A1

公开(公告)日：2014-10-30

申请号：US14330373

申请日：2014-07-14

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Jason Lee Wildgoose ,  Jeffery Mark Brown

IPC: H01J49/04 ,  H01J49/40

CPC classification number: H01J49/0481 ,  H01J49/0072 ,  H01J49/065 ,  H01J49/40 ,  Y10T436/24

Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.

Abstract translation: 公开了一种质谱仪，其包括电子转移解离单元。 当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子。 电池包括形成球形捕获体积的多个环形电极。 在大多数捕集体积下，离子经历可忽略的RF加热，使得分析物和试剂离子的动能能够降低到高于热温度。 从而提供具有增强的灵敏度的电子转移解离电池。 在细胞内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，使得可以获得质量分析仪的分辨率的显着提高。

公开(公告)号：US20140166895A1

公开(公告)日：2014-06-19

申请号：US14187613

申请日：2014-02-24

Applicant: Micromass UK Limited

Inventor： Daniel James Kenny

IPC: H01J49/06 ,  H01J49/02

CPC classification number: H01J49/062 ,  H01J49/02 ,  H01J49/065 ,  H01J49/422

Abstract: An ion guide is disclosed comprising a plurality of axial groupings of electrodes, wherein each axial grouping of electrodes comprises a ring or annular electrode which has been radially segmented into a plurality of electrode segments.

Abstract translation: 公开了一种离子导向器，其包括多个轴向分组的电极，其中电极的每个轴向分组包括已经被径向分割成多个电极段的环形或环形电极。

公开(公告)号：US20140158880A1

公开(公告)日：2014-06-12

申请号：US14097848

申请日：2013-12-05

Applicant: Korea Basic Science Institute

Inventor： Mo Yang ,  Seung Yong Kim ,  Hyun Sik Kim

IPC: H01J49/06

CPC classification number: H01J49/065 ,  H01J49/421 ,  H01J49/424 ,  Y10T29/49826

Abstract: An ion trap mass spectrometer is provided, including: an electron emitter; an ion trap storing ions generated by ionization resulting from an impact with electrons emitted from the electron emitter; a secondary ion filter for blocking out secondary ions generated due to ions selectively released by the ion trap; and a detector detecting ions selectively released from the ion trap, wherein the electron emitter, the ion trap, the secondary ion filter, and the ion detector are arranged on the same axis, so that a pure mass spectrum can be measured by excluding the secondary ions which are causes of background noise signals in the procedure of detection of the ions by the ion trap mass spectrometer.

Abstract translation: 提供了一种离子阱质谱仪，包括：电子发射体; 离子阱，其存储由从电子发射体发射的电子的撞击而产生的离子产生的离子; 用于阻断由离子阱选择性释放的离子产生的二次离子的二次离子过滤器; 以及检测器，其检测离子阱选择性释放的离子，其中电子发射体，离子阱，二次离子过滤器和离子检测器被布置在相同的轴上，使得可以通过排除次级 离子是离子阱质谱仪检测离子的过程中背景噪声信号的原因。

公开(公告)号：US08735805B2

公开(公告)日：2014-05-27

申请号：US14064616

申请日：2013-10-28

Applicant: Micromass UK Limited

Inventor： Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

IPC: H01J49/40 ,  H01J49/42 ,  H01J49/00 ,  H01J49/06

CPC classification number: G01N27/622 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/02 ,  H01J49/062 ,  H01J49/065 ,  H01J49/066 ,  H01J49/40 ,  H01J49/401 ,  H01J49/42

Abstract: A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide.

Abstract translation: 公开了一种质谱仪，其包括离子迁移谱仪或分离器，以及布置在离子迁移谱仪或分离器下游的离子导向器。 在离子导向器中产生多个轴向势阱，使得从离子迁移谱仪或分离器接收的离子变得限制在单独的轴向势阱中。 潜在的孔保持从离子迁移谱仪或分离器接收的离子的保真度和/或组成。 势阱沿离子导向器的长度平移。

公开(公告)号：US20140131566A1

公开(公告)日：2014-05-15

申请号：US14156838

申请日：2014-01-16

Applicant: Micromass UK Limited

Inventor： Daniel James Kenny ,  Robert Harold Bateman ,  Martin Raymond Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle

IPC: H01J49/06 ,  H01J49/34

CPC classification number: H01J49/005 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/065 ,  H01J49/34 ,  H01J49/4235

Abstract: A collision or fragmentation cell is disclosed comprising a plurality of electrodes wherein a first RF voltage is applied to an upstream group of electrodes and a second different RF voltage is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell is optimised by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell is optimised by the second different RF voltage applied to the downstream group of electrodes.

Abstract translation: 公开了包括多个电极的碰撞或分裂单元，其中将第一RF电压施加到上游电极组，并且将第二不同的RF电压施加到下游电极组。 通过施加到上游电极组的第一RF电压来优化进入碰撞或破碎电池的母体离子的径向约束，并且通过第二不同RF电压优化在碰撞或断裂电池内产生的子或碎片离子的径向约束 应用于下游电极组。

公开(公告)号：US20140084156A1

公开(公告)日：2014-03-27

申请号：US13626698

申请日：2012-09-25

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Trygve RISTROPH ,  Gershon PERELMAN

IPC: H01J49/36

CPC classification number: H01J49/065 ,  H01J49/062 ,  H01J49/066 ,  H01J49/067

Abstract: Ion guides for use in mass spectrometry (MS) systems are described. The ion guides are configured to provide a reflective electrodynamic field and a direct current (DC or static) electric field to provide ion beams that are more spatially confined with a comparatively large mass range. Some ion guides are provided between the ion source and the first stage vacuum chamber of the MS system.

Abstract translation: 描述了用于质谱（MS）系统的离子导向器。 离子导向器被配置为提供反射电动力场和直流（DC或静态）电场，以提供在空间上被限制在较大质量范围内的离子束。 在离子源和MS系统的第一级真空室之间提供一些离子导向器。

公开(公告)号：US08658970B2

公开(公告)日：2014-02-25

申请号：US13375076

申请日：2010-05-28

Applicant: Daniel James Kenny

Inventor： Daniel James Kenny

IPC: H01J49/42

CPC classification number: H01J49/062 ,  H01J49/02 ,  H01J49/065 ,  H01J49/422

Abstract: An ion guide is disclosed comprising a plurality of axial groupings of electrodes, wherein each axial grouping of electrodes comprises a ring or annular electrode which has been radially segmented into a plurality of electrode segments.

Abstract translation: 公开了一种离子导向器，其包括多个轴向分组的电极，其中电极的每个轴向分组包括已经被径向分割成多个电极段的环形或环形电极。

公开(公告)号：US08563921B2

公开(公告)日：2013-10-22

申请号：US13645910

申请日：2012-10-05

Applicant: Micromass UK Limited

Inventor： Jeffery Mark Brown ,  Martin Raymond Green

IPC: H01J49/28

CPC classification number: H01J49/28 ,  H01J49/0072 ,  H01J49/065

Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.

Abstract translation: 公开了一种质谱仪，其包括电子转移离解装置，其包括离子导向器。 控制系统确定离子导向器内的前体离子的碎裂和电荷减少的程度，并且改变离子通过离子导向器传输的速度，以便优化碎裂和电荷还原过程。