公开(公告)号：NO20022156D0

公开(公告)日：2002-05-06

申请号：NO20022156

申请日：2002-05-06

Applicant: ABBOTT LAB

Inventor： ELMORE STEVEN W ,  COOPER CURT S ,  SCHULTZ COLLEEN C ,  HUTCHINSON DOUGLAS K ,  DONNER PAMELA L ,  GREEN BRIAN E ,  ANDERSON DAVID D ,  XIE QINGHUA ,  DINGES JURGEN ,  LYNCH LINDA M

IPC: A61K31/4375 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/542 ,  A61P31/04 ,  A61P43/00 ,  C07B61/00 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  C07D

公开(公告)号：SK11972000A3

公开(公告)日：2001-08-06

申请号：SK11972000

申请日：1999-02-12

Applicant: ABBOTT LAB ,  LIGAND PHARM INC

Inventor： COUGHLAN MICHAEL J ,  ELMORE STEVEN W ,  KORT MICHAEL E ,  KYM PHILIP R ,  MOORE JIMMIE L ,  PRATT JOHN K ,  WANG ALAN X ,  EDWARDS JAMES P ,  JONES TODD K

IPC: C07D491/052 ,  A61K31/4738 ,  A61K31/519 ,  A61P29/00 ,  C07D491/04 ,  A61K31/44 ,  A61K31/505

公开(公告)号：DK0808318T3

公开(公告)日：2000-10-16

申请号：DK96903340

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： SIPPY KEVIN B ,  MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  ELMORE STEVEN W ,  TIETJE KARIN R ,  WENDT MICHAEL D ,  YAMAMOTO DIANE M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  A61K31/395 ,  C07D487/16

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：ZA9901156B

公开(公告)日：1999-08-12

申请号：ZA9901156

申请日：1999-02-12

Applicant: ABBOTT LAB ,  LIGAND PHARM INC

Inventor： COGHLAN MICHAEL J ,  ELMORE STEVEN W ,  KORT MICHAEL E ,  KYM PHILIP R ,  MOORE JIMMIE L ,  PRATT JOHN K ,  WANG ALAN X ,  EDWARDS JAMES P ,  JONES TODD K

IPC: A61K20060101 ,  C07D20060101 ,  C07D ,  A61K

公开(公告)号：CA2211212A1

公开(公告)日：1996-08-01

申请号：CA2211212

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  LEE EDMUND L ,  CARROLL WILLIAM A ,  LEBOLD SUZANNE A ,  WENDT MICHAEL D ,  KERWIN JAMES F JR ,  YAMAMOTO DIANE M ,  DRIZIN IRENE ,  ALTENBACH ROBERT J ,  SIPPY KEVIN B ,  ELMORE STEVEN W ,  TIETJE KARIN R ,  BASHA FATIMA Z

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  A61K31/505

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an .alpha.-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.

公开(公告)号：HK1177202A1

公开(公告)日：2013-08-16

申请号：HK13104084

申请日：2013-04-03

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DAI YUJIA ,  DING HONG ,  DOHERTY GEORGE A ,  ELMORE STEVEN W ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON ,  MANTEI ROBERT A ,  MCCLELLAN WILLIAM J ,  PARK CHANG H ,  PARK CHEOL-MIN ,  PETROS ANDREW M ,  SONG XIAOHONG ,  SOUERS ANDREW J ,  SULLIVAN GERARD M ,  TAO ZHI-FU ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WENDT MICHAEL D ,  HANSEN TODD M

IPC: C07D20060101

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：ECSP12012020A

公开(公告)日：2012-08-31

申请号：ECSP12012020

申请日：2012-07-03

Applicant: ABBOTT LAB

Inventor： HASVOLD LISA A ,  SULLIVAN GERARD M ,  WANG GARY ,  WANG XILU ,  MANTEI ROBERT A ,  ELMORE STEVEN W ,  SOUERS ANDREW J ,  BRUNCKO MILAN ,  SONG XIAOHONG ,  WANG LE ,  KUNZER AARON R ,  PARK CHEOL-MIN ,  WENDT MICHAEL D ,  DAI YUJIA ,  DING HONG ,  HEXAMER LAURA ,  MCCLELLAN WILLIAM J ,  PARK CHANG H ,  PETROS ANDREW M ,  HANSEN TODD M ,  DOHERTY GEORGE A ,  TAO ZHI FU

IPC: C07D209/08 ,  C07D211/58 ,  C07D213/74 ,  C07D235/06 ,  C07D277/24 ,  C07D309/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.

公开(公告)号：CR20120347A

公开(公告)日：2012-08-14

申请号：CR20120347

申请日：2012-06-25

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DAI YUJIA ,  DING HONG ,  DOHERTY GEORGE A ,  ELMORE STEVEN W ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON ,  MANTEI ROBERT A ,  MCCLELLAN WILLIAM J ,  PARK CHANG H ,  PARK CHEOL-MIN ,  PETROS ANDREW M ,  SONG XIAOHNG ,  SOUERS ANDREW J ,  SULLIVAN GERARD ,  TAO ZHI-GU ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WENDT MICHAEL D ,  HANSEN TODD M

IPC: C07D209/08 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.

公开(公告)号：SG181491A1

公开(公告)日：2012-07-30

申请号：SG2012040820

申请日：2010-06-01

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  DOHERTY GEORGE A ,  ELMORE STEVEN W ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON ,  MANTEI ROBERT A ,  MCCLELLAN WILLIAM J ,  PARK CHANG H ,  PARK CHEOL-MIN ,  PETROS ANDREW M ,  SONG XIAOHONG ,  SOUERS ANDREW J ,  SULLIVAN GERARD M ,  TAO ZHI-FU ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WENDT MICHAEL D ,  HANSEN TODD M

Abstract: Disclosed are compounds (I) which inhibit the activity of anti-apoptotic Bc1-2 or Bc1 xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti apoptotic Bc1-2 protein.

公开(公告)号：ZA201103807B

公开(公告)日：2012-02-29

申请号：ZA201103807

申请日：2011-05-24

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  ELMORE STEVEN W ,  HEXAMER LAURA ,  MANTEI ROBERT A ,  PARK CHANG HEE ,  PETROS ANDREW J ,  SOUERS ANDREW J ,  TAO ZHI-FU ,  WANG LE ,  WENDT MICHAEL D ,  DAI YUJIA ,  DOHERTY GEORGE A ,  HASVOLD LISA A ,  KUNZER AARON R ,  MCCLELLAN WILLIAM J ,  PARK CHEOL-MIN ,  SONG XIAOHONG ,  SULLIVAN GERARD M ,  WANG GARY T ,  WANG XILU

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.