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公开(公告)号：BRPI0512970A
公开(公告)日：2008-04-22
申请号：BRPI0512970
申请日：2005-06-29
Applicant: ABBOTT LAB
Inventor： DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , KLEIN LARRY L , KEMPF DALE J , WANG XIU C
IPC: C07F9/09 , A61K31/661 , A61P35/00
Abstract: A compound of the formula I, II or III is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions of inhibiting HIV protease activity and treating HIV infection are also disclosed.
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公开(公告)号：CA2661873A1
公开(公告)日：2008-03-06
申请号：CA2661873
申请日：2007-08-29
Applicant: ABBOTT LAB
Inventor： CHEN HUI-JU , KLEIN LARRY L , HUTCHINSON DOUGLAS K , YEUNG MING C , KEMPF DALE J , HUANG PEGGY P , FLENTGE CHARLES A , RANDOLPH JOHN T
IPC: C07D277/24 , A61K31/426 , A61K31/427 , A61P43/00 , C07D417/12
Abstract: The present invention features compounds of formula (I) or pharmaceutical ly acceptable salts, solvates or prodrugs thereof, and describes methods of using the same to inhibit the metabolizing activities of CYP enzymes. The pr esent invention also describes methods of using these compounds, salts, solv ates or prodrugs to improve the pharmacokinetics of drugs that are metaboliz ed by CYP enzymes.
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公开(公告)号：HK1100037A1
公开(公告)日：2007-08-31
申请号：HK07103390
申请日：2007-03-29
Applicant: ABBOTT LAB DEPT
Inventor： FLENTGE CHARLES A , CHEN HUI-JU , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , HUANG PEGGY P , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , MADIGAN DAROLD L , RANDOLPH JOHN T , SUN MINGHUA , YEUNG MING C , ZHAO CHEN
IPC: A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07C311/17 , C07D20100101 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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公开(公告)号：CA2633752A1
公开(公告)日：2007-07-19
申请号：CA2633752
申请日：2006-12-20
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , LU LIANGJUN , GRAMPOVNIK DAVID J , CARRICK ROBERT J , HE WEPING , KRUEGER ALLAN C , BETEBENNER DAVID A , TUFANO MICHAEL D , PILOT-MATIAS TAMI J , MASSE SHERIE VL , WAGNER ROLF , MCDANIEL KEITH F , IWASAKI NOBUHIKO , DEGOEY DAVID A , LIU DACHUN , ROCKWAY TODD W , MO HONGMEI , COOPER CURT S , DONNER PAMELA L , ANDERSON DAVID D , MOLLA AKHTERUZZAMAN , MOTTER CHRISTOPHER E , ZHANG RONG , GREEN BRIAN E , MADIGAN DAROLD L , PRATT JOHN K , KEMPF DALE J , SHANLEY JASON P
IPC: C07D495/04 , C07D471/04 , C07D513/04
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公开(公告)号：HK1094579A1
公开(公告)日：2007-04-04
申请号：HK07101712
申请日：2007-02-13
Applicant: ABBOTT LAB
Inventor： RANDOLPH JOHN T , CHEN HUI-JU , DEGOEY DAVID A , FLENTGE CHARLES A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , HUANG PEGGY P , HUTCHINSON DOUGLAS K , KEMPF DALE J , KLEIN LARRY L , YEUNG MING C
IPC: A61K20060101 , A61P20060101 , C07C20060101 , C07D20060101
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Patent Agency Ranking
公开(公告)号：DE69034202T2
公开(公告)日：2006-06-22
申请号：DE69034202
申请日：1990-05-17
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , NORBECK DANIEL W , ERICKSON JOHN W , SHAM HING LEUNG , CODACOVI LYNN M , PLATTNER JACOB J
IPC: C07C215/18 , C07D295/18 , A61K31/00 , A61K31/10 , A61K31/12 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/195 , A61K31/335 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/54 , A61K38/00 , A61P31/12 , A61P37/04 , C07C31/125 , C07C33/18 , C07C33/26 , C07C33/46 , C07C39/12 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/59 , C07C45/62 , C07C45/67 , C07C45/74 , C07C49/04 , C07C49/12 , C07C49/17 , C07C49/175 , C07C49/20 , C07C49/215 , C07C49/233 , C07C49/24 , C07C49/255 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/06 , C07C215/20 , C07C215/28 , C07C217/04 , C07C225/06 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/35 , C07C233/36 , C07C233/40 , C07C233/78 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/04 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/08 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/00 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/05 , C07C311/06 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/11 , C07C323/12 , C07C323/25 , C07C323/41 , C07C323/60 , C07C381/00 , C07D207/06 , C07D207/08 , C07D207/12 , C07D207/16 , C07D207/24 , C07D209/42 , C07D211/22 , C07D211/54 , C07D211/62 , C07D211/96 , C07D213/30 , C07D213/40 , C07D213/42 , C07D213/55 , C07D213/56 , C07D213/70 , C07D213/81 , C07D213/82 , C07D215/16 , C07D217/14 , C07D217/16 , C07D217/26 , C07D231/10 , C07D233/60 , C07D233/61 , C07D233/84 , C07D239/38 , C07D263/06 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/36 , C07D277/42 , C07D277/56 , C07D279/12 , C07D295/088 , C07D295/14 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/22 , C07D295/26 , C07D303/04 , C07D303/22 , C07D303/36 , C07D303/40 , C07D303/46 , C07D303/48 , C07D305/14 , C07D307/42 , C07D317/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D521/00 , C07F7/02 , C07F9/30 , C07F9/32 , C07F9/53 , C07K5/02 , C07K5/04 , C07K5/06 , C07K5/062 , C07K5/078
Abstract: A retroviral protease inhibiting compound of the formula A - X - B or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein X is a linking group; A is (1) substituted amino, (2) substituted carbonyl, (3) functionalized imino, (4) functionalized alkyl, (5) functionalized acyl, (6) functionalized heterocyclic or (7) functionalized (heterocyclic)alkyl; and B is (1) substituted carbonyl independently defined as herein, (2) substituted amino independently defined as herein, (3) functionalized imino independently defined as herein, (4) functionalized alkyl independently defined as herein, (5) functionalized acyl independently defined as herein, (6) functionalized heterocyclic independently defined as herein or (7) functionalized (heterocyclic)alkyl independently defined as herein. o
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公开(公告)号：AT302180T
公开(公告)日：2005-09-15
申请号：AT97119700
申请日：1990-05-17
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , NORBECK DANIEL W , ERICKSON JOHN W , SHAM HING LEUNG , CODACOVI LYNN M , PLATTNER JACOB J
IPC: C07D295/18 , A61K31/00 , A61K31/10 , A61K31/12 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/195 , A61K31/335 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/54 , A61K38/00 , A61P31/12 , A61P37/04 , C07C31/125 , C07C33/18 , C07C33/26 , C07C33/46 , C07C39/12 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/59 , C07C45/62 , C07C45/67 , C07C45/74 , C07C49/04 , C07C49/12 , C07C49/17 , C07C49/175 , C07C49/20 , C07C49/215 , C07C49/233 , C07C49/24 , C07C49/255 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/06 , C07C215/18 , C07C215/20 , C07C215/28 , C07C217/04 , C07C225/06 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/35 , C07C233/36 , C07C233/40 , C07C233/78 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/04 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/08 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/00 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/05 , C07C311/06 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/11 , C07C323/12 , C07C323/25 , C07C323/41 , C07C323/60 , C07C381/00 , C07D207/06 , C07D207/08 , C07D207/12 , C07D207/16 , C07D207/24 , C07D209/42 , C07D211/22 , C07D211/54 , C07D211/62 , C07D211/96 , C07D213/30 , C07D213/40 , C07D213/42 , C07D213/55 , C07D213/56 , C07D213/70 , C07D213/81 , C07D213/82 , C07D215/16 , C07D217/14 , C07D217/16 , C07D217/26 , C07D231/10 , C07D233/60 , C07D233/61 , C07D233/84 , C07D239/38 , C07D263/06 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/36 , C07D277/42 , C07D277/56 , C07D279/12 , C07D295/088 , C07D295/14 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/22 , C07D295/26 , C07D303/04 , C07D303/22 , C07D303/36 , C07D303/48 , C07D305/14 , C07D307/42 , C07D317/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D521/00 , C07F7/02 , C07F9/30 , C07F9/32 , C07F9/53 , C07K5/02 , C07K5/04 , C07K5/06 , C07K5/062 , C07K5/078 , C07D303/40 , C07D303/46
Abstract: A retroviral protease inhibiting compound of the formula A - X - B or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein X is a linking group; A is (1) substituted amino, (2) substituted carbonyl, (3) functionalized imino, (4) functionalized alkyl, (5) functionalized acyl, (6) functionalized heterocyclic or (7) functionalized (heterocyclic)alkyl; and B is (1) substituted carbonyl independently defined as herein, (2) substituted amino independently defined as herein, (3) functionalized imino independently defined as herein, (4) functionalized alkyl independently defined as herein, (5) functionalized acyl independently defined as herein, (6) functionalized heterocyclic independently defined as herein or (7) functionalized (heterocyclic)alkyl independently defined as herein. o
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公开(公告)号：CA2792483A1
公开(公告)日：2005-07-07
申请号：CA2792483
申请日：2004-11-10
Applicant: ABBOTT LAB
Inventor： FLENTGE CHARLES A , CHEN HUI-JU , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , HUANG PEGGY P , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , MADIGAN DAROLD L , RANDOLPH JOHN T , SUN MINGHUA , YEUNG MING C , ZHAO CHEN
IPC: C07D277/20 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/27 , A61K31/277 , A61K31/341 , A61K31/4168 , A61K31/426 , A61K31/44 , A61K31/65 , A61K45/06 , A61P31/18 , C07C311/00 , C07C311/17 , C07D213/00 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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公开(公告)号：CA2549098A1
公开(公告)日：2005-06-30
申请号：CA2549098
申请日：2004-12-09
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , WANG XIU C , RANDOLPH JOHN T , YEUNG MING C , DEGOEY DAVID A , FLENTGE CHARLES A , FLOSI WILLIAM J , YU SU , GRAMPOVNIK DAVID J , KLEIN LARRY L
IPC: C07D401/06 , A61K31/427 , A61K31/4436 , A61K31/4439 , A61P31/18 , C07D213/30 , C07D213/40 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
Abstract: A compound of the formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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公开(公告)号：AU2004201149A1
公开(公告)日：2004-04-22
申请号：AU2004201149
申请日：2004-03-18
Applicant: ABBOTT LAB
Inventor： KUMAR GONDI N , HERRIN THOMAS R , KEMPF DALE J , BETEBENNER DAVID A , CHEN XIAOQI , NORBECK DANIEL W , SHAM HING LEUNG , PATEL KETAN M , LIU JIH-HUA , TIEN JIEH-HEH J , STONER ERIC J , STENGEL PETER J , PLATA DANIEL J , OLIVER PATRICIA A , KOLACZKOWSKI LAWRENCE , HANNICK STEVEN M , DICKMAN DANIEL A , COOPER ARTHUR J , CONDON STEPHEN L
IPC: A61K31/415 , C07D207/26 , C07D207/40 , C07D233/32 , C07D239/10 , C07D239/22 , C07D241/08 , C07D263/22
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