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公开(公告)号：AU5919900A
公开(公告)日：2001-01-22
申请号：AU5919900
申请日：2000-07-06
Applicant: VERTEX PHARMA
Inventor： LAUFFER DAVID , LEDFORD BRIAN
IPC: A61K31/4439 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61K38/18 , A61K38/22 , A61K38/27 , A61K45/00 , A61K45/06 , A61P11/00 , A61P19/00 , A61P21/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P43/00 , C07D241/08 , C07D243/08
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公开(公告)号：HUE037516T2
公开(公告)日：2018-09-28
申请号：HUE14800181
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , COTTRELL KEVIN , DENG HONGBO , DUFFY JOHN , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA , KENNEDY JOSEPH , LAUFFER DAVID , LEDEBOER MARK , LI PAN , MAXWELL JOHN , MORRIS MARK , PIERCE ALBERT , WAAL NATHAN , XU JINWANG
IPC: A61P35/00
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公开(公告)号：LT3057959T
公开(公告)日：2018-06-11
申请号：LT14800181
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , COTTRELL KEVIN , DENG HONGBO , DUFFY JOHN , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA , KENNEDY JOSEPH , LAUFFER DAVID , LEDEBOER MARK , LI PAN , MAXWELL JOHN , MORRIS MARK , PIERCE ALBERT , WAAL NATHAN , XU JINWANG
IPC: C07D403/12 , A61K31/506 , A61P35/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D493/04
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公开(公告)号：BRPI1012037A2
公开(公告)日：2016-05-17
申请号：BRPI1012037
申请日：2010-05-27
Applicant: VERTEX PHARMA
Inventor： LAUFFER DAVID , MCGINTY KIRA , LI PAN
IPC: A61K31/47 , A61P35/00 , C07D513/04
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公开(公告)号：PL2435443T3
公开(公告)日：2014-01-31
申请号：PL10721904
申请日：2010-05-27
Applicant: VERTEX PHARMA
Inventor： LAUFFER DAVID , LI PAN , MCGINTY KIRA
IPC: C07D513/04 , A61K31/47 , A61P35/00
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Patent Agency Ranking
公开(公告)号：SI2435443T1
公开(公告)日：2013-12-31
申请号：SI201030410
申请日：2010-05-27
Applicant: VERTEX PHARMA
Inventor： LAUFFER DAVID , LI PAN , MCGINTY KIRA
IPC: C07D513/00 , A61K31/00 , A61P35/00
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公开(公告)号：NZ596616A
公开(公告)日：2013-05-31
申请号：NZ59661610
申请日：2010-05-27
Applicant: VERTEX PHARMA
Inventor： LAUFFER DAVID , LI PAN , MCGINTY KIRA
IPC: C07D513/04 , A61K31/4196 , A61K31/433 , A61K31/47 , A61P35/00
Abstract: 596616 Disclosed is a compound having the formula (1), wherein R1, R2, R3, R4 and R5 are defined herein, and a pharmaceutical composition comprising said compound additionally comprising a chemotherapeutic or anti-proliferative agent, an anti-inflammatory agent, an agent for treating atherosclerosis, or an agent for treating lung fibrosis. Specific embodiments of the compound include: 3-(difluoro(quinolin-6-yl)methyl)-N-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine, and 3-(difluoro(quinolin-6-yl)methyl)-N-(1,3-dimethyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine.
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公开(公告)号：ES2401192T3
公开(公告)日：2013-04-17
申请号：ES06815526
申请日：2006-09-28
Applicant: VERTEX PHARMA
Inventor： SALITURO FRANCESCO , FARMER LUC , WANG TIANSHENG , WANG JIAN , BETHIEL RANDY , WANNAMAKER MARION , MARTINEZ-BOTELLA GABRIEL , DUFFY JOHN , ARONOV ALEXANDER , LAUFFER DAVID , PIERCE ALBERT
IPC: C07D487/04 , A61K31/495 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00 , C07D519/00
Abstract: Compuesto que tiene la fórmula: en la que cada uno de Z1, Z2 y Z4 es, independientemente, CH o N, en la que al menos uno de Z1 o Z2 es N; R1 es -(radical alifático C1-2)p-R4, estando R1 opcionalmente sustituido con 1-3 apariciones de J; R2 es -(radical alifático C1-2)d-R5, estando R2 opcionalmente sustituido con 1-3 apariciones de J; R4 es H, halógeno, CN, NH2, NO2, CF3, radical alifático C1-3, ciclopropilo, NCH3, OCH3, -C(>=O)NH2,-C(>=O)CH3, -NHC(>=O)CH3 u OH; R5 es H, halógeno, CN, NH2, NO2, CF3, radical alifático C1-3, ciclopropilo, NCH3, OCH3, -C(>=O)NH2,-C(>=O)CH3, -NHC(>=O)CH3 u OH; J es halógeno, OCH3, OH, NO2, NH2, SCH3, NCH3, CN o radical alifático C1-2 no sustituido, o dos grupos J,junto con el carbono al que están unidos, forman un anillo de ciclopropilo o C>=O; p y d son cada uno independientemente 0 ó 1; Q es un anillo de heteroarilo de 5-10 miembros opcionalmente sustituido con 1-5 grupos JQ.
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公开(公告)号：DK2332940T3
公开(公告)日：2013-02-11
申请号：DK10182365
申请日：2005-03-30
Applicant: VERTEX PHARMA
Inventor： WANG JIAN , SALITURO FRANCESCO , FARMER LUC , BETHIEL RANDY , HARRINGTON EDMUND , GREEN JEREMY , COURT JOHN , COME JON , LAUFFER DAVID , ARONOV ALEX , BINCH HAYLEY , BOYALL DEAN , CHARRIER JEAN-DAMIEN , EVERITT SIMON , FRAYSSE DAMIEN , MORTIMORE MICHAEL , PIERARD FRANCOISE , ROBINSON DANIEL , PINDER JOANNE , WANG TIANSHENG , PIERCE ALBERT
IPC: C07D471/04 , C07D519/00
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公开(公告)号：PT2332940E
公开(公告)日：2013-01-30
申请号：PT10182365
申请日：2005-03-30
Applicant: VERTEX PHARMA
Inventor： MORTIMORE MICHAEL , COURT JOHN , WANG JIAN , SALITURO FRANCESCO , WANG TIANSHENG , CHARRIER JEAN-DAMIEN , FARMER LUC , BETHIEL RANDY , HARRINGTON EDMUND , GREEN JEREMY , COME JON , LAUFFER DAVID , BINCH HAYLEY , EVERITT SIMON , FRAYSSE DAMIEN , ROBINSON DANIEL , PINDER JOANNE , PIERCE ALBERT , ARONOV ALEX , PIERARD FRANCOISE
IPC: C07D471/04 , C07D519/00
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