公开(公告)号：CA2633757A1

公开(公告)日：2007-07-05

申请号：CA2633757

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： KRUEGER ALLAN C ,  DEGOEY DAVID A ,  MARING CLARENCE J ,  ROCKWAY TODD W ,  WAGNER ROLF ,  ANDERSON DAVID D ,  IWASAKI NOBUHIKO ,  DONNER PAMELA L ,  ZHANG RONG ,  HE WEPING ,  MOTTER CHRISTOPHER E ,  GRAMPOVNIK DAVID J ,  MOLLA AKHTERUZZAMAN ,  LU LIANGJUN ,  BETEBENNER DAVID A ,  GREEN BRIAN E ,  CARRICK ROBERT J ,  COOPER CURT S ,  KEMPF DALE J ,  PILOT-MATIAS TAMI J ,  LIU DACHUN ,  MO HONGMEI ,  SHANLEY JASON P ,  MASSE SHERIE VL ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  PRATT JOHN K ,  TUFANO MICHAEL D

IPC: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：AU2006330924A1

公开(公告)日：2007-07-05

申请号：AU2006330924

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： KEMPF DALE J ,  WAGNER ROLF ,  KRUEGER ALLAN C ,  GREEN BRIAN E ,  PILOT-MATIAS TAMI J ,  ANDERSON DAVID D ,  GRAMPOVNIK DAVID J ,  PRATT JOHN K ,  MCDANIEL KEITH F ,  MARING CLARENCE J ,  MOTTER CHRISTOPHER E ,  MADIGAN DAROLD L ,  LU LIANGJUN ,  TUFANO MICHAEL D ,  ZHANG RONG ,  MASSE SHERIE VL ,  HE WEPING ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  SHANLEY JASON P ,  COOPER CURT S ,  CARRICK ROBERT J ,  ROCKWAY TODD W ,  LIU DACHUN ,  DONNER PAMELA L ,  IWASAKI NOBUHIKO ,  DEGOEY DAVID A ,  BETEBENNER DAVID A

IPC: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：ZA200504413B

公开(公告)日：2006-12-27

申请号：ZA200504413

申请日：2005-05-30

Applicant: ABBOTT LAB

Inventor： PRATT JOHN K ,  DONNER PAMELA L ,  KEMPF DALE J ,  MARING CLARENCE J ,  RONG ZHANG ,  BETEBENNER DAVID A ,  GREEN BRIAN E ,  MCDANIEL KEITH F ,  STOLL VINCENT S

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101 ,  C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00

公开(公告)号：DE69429173T2

公开(公告)日：2002-07-04

申请号：DE69429173

申请日：1994-07-15

Applicant: ABBOTT LAB

Inventor： KLEIN LARRY L ,  MARING CLARENCE J

IPC: A61K31/335 ,  A61K31/337 ,  A61P35/00 ,  C07D305/14

Abstract: A compound or prodrug thereof having the formula ain of taxol and Z is selected from the group consisting of -CHO, -CH2OH, -CH2OR', -CH2NR'R'', -CH=NR', -CH=NOR', -CH=NNR=R'', -CH(OH)SO3Na, -CH2OPO3=, -CH2OSO3=, -CN and a radical of the formula where X and Y are independently selected from -O-, -S-, and -N(R')-, as well as a method for preparing the compounds of the invention, a method of their use for the inhibition of tumors and pharmaceutical compositions containing the same.

公开(公告)号：DE69429173D1

公开(公告)日：2002-01-03

申请号：DE69429173

申请日：1994-07-15

Applicant: ABBOTT LAB

Inventor： KLEIN LARRY L ,  MARING CLARENCE J

IPC: A61K31/335 ,  A61K31/337 ,  A61P35/00 ,  C07D305/14

Abstract: A compound or prodrug thereof having the formula ain of taxol and Z is selected from the group consisting of -CHO, -CH2OH, -CH2OR', -CH2NR'R'', -CH=NR', -CH=NOR', -CH=NNR=R'', -CH(OH)SO3Na, -CH2OPO3=, -CH2OSO3=, -CN and a radical of the formula where X and Y are independently selected from -O-, -S-, and -N(R')-, as well as a method for preparing the compounds of the invention, a method of their use for the inhibition of tumors and pharmaceutical compositions containing the same.

公开(公告)号：HU0101224A2

公开(公告)日：2001-08-28

申请号：HU0101224

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  GU YU-GUI ,  KATI WARREN M ,  KEMPF DALE J ,  KENNEDY APRIL ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MARING CLARENCE J ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572

公开(公告)号：AU2039301A

公开(公告)日：2001-04-30

申请号：AU2039301

申请日：2000-10-02

Applicant: ABBOTT LAB

Inventor： STEWART KENT D ,  KEMPF DALE J ,  KLEIN LARRY L ,  MARING CLARENCE J ,  STOLL VINCENT S

IPC: A61K31/35 ,  A61P31/16 ,  C07D309/28

公开(公告)号：AU1076001A

公开(公告)日：2001-04-30

申请号：AU1076001

申请日：2000-10-10

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GIRANDA VINCENT L ,  KEMPF DALE J ,  STOLL VINCENT S ,  SUN MINGHUA ,  ZHAO CHEN ,  GU YU GUI ,  HANESSIAN STEPHEN ,  WANG GARY T ,  KRUEGER ALLAN C ,  CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KENNEDY APRIL L ,  KLEIN LARRY L ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  TU NOAH P ,  WAGENAAR FRANK L ,  WANG SHELDON ,  WIEDEMAN PAUL E ,  XU YIBO ,  YEUNG MING C ,  BAYRAKDARIAN MALKEN ,  LUO XUEHONG

IPC: C07D401/12 ,  A61K31/357 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4025 ,  A61K31/405 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/42 ,  A61K31/422 ,  A61K31/425 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/66 ,  A61K31/662 ,  A61P31/00 ,  A61P31/12 ,  A61P31/16 ,  A61P43/00 ,  C07D20060101 ,  C07D207/00 ,  C07D207/12 ,  C07D207/16 ,  C07D207/26 ,  C07D207/32 ,  C07D207/327 ,  C07D207/38 ,  C07D207/46 ,  C07D303/16 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D407/06 ,  C07D407/12 ,  C07D409/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/40 ,  C07F9/572

公开(公告)号：NO20005301A

公开(公告)日：2000-12-08

申请号：NO20005301

申请日：2000-10-20

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU-GUI ,  CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40

CPC classification number: C07D207/327 ,  C07D207/16 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/06 ,  C07D409/06 ,  C07D413/04 ,  C07D417/04 ,  C07D417/06 ,  C07F9/5722

公开(公告)号：NO20005301D0

公开(公告)日：2000-10-20

申请号：NO20005301

申请日：2000-10-20

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU-GUI ,  CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  C07D