公开(公告)号：AT431735T

公开(公告)日：2009-06-15

申请号：AT03777773

申请日：2003-10-22

Applicant: ABBOTT LAB

Inventor： BENNANI YOUSSEF ,  CHANG SOU-JEN ,  CHEMBURKAR SANJAY ,  DART MICHAEL ,  FERNANADO DILINIE ,  GRIEME TIMOTHY

IPC: A61K31/19 ,  A61K31/33 ,  A61K31/397 ,  A61K31/401 ,  A61K31/495 ,  A61K31/537 ,  A61K31/54 ,  A61K31/55 ,  A61P25/08 ,  C07C61/13 ,  C07C61/135 ,  C07C61/29 ,  C07C69/753 ,  C07C233/58 ,  C07C237/22 ,  C07C237/24

Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.

公开(公告)号：DE60325630D1

公开(公告)日：2009-02-12

申请号：DE60325630

申请日：2003-10-22

Applicant: ABBOTT LAB

Inventor： BENNANI YOUSSEF L ,  BUNNELLE WILLIAM H ,  CHANG SOU-JEN ,  CHEMBURKAR SANJAY R ,  CHEN JINHUA ,  DART MICHAEL J ,  FERNANADO DILINIE P ,  KU YI-YIN ,  LOCKWOOD MARK ,  WANG LEI

IPC: A61K31/16 ,  A61K31/19 ,  A61P25/00 ,  A61P29/00 ,  C07C61/00 ,  C07C61/13 ,  C07C61/135 ,  C07C69/753 ,  C07C229/00 ,  C07C233/00 ,  C07C233/58 ,  C07C233/60 ,  C07C233/63

公开(公告)号：AU784291B2

公开(公告)日：2006-03-02

申请号：AU5739300

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C57/04 ,  C07C68/06 ,  C07C69/96 ,  C07C269/06 ,  C07C271/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)

公开(公告)号：CA2524787A1

公开(公告)日：2004-11-25

申请号：CA2524787

申请日：2004-05-03

Applicant: ABBOTT LAB

Inventor： COWART MARLON D ,  GRIEME TIMOTHY A ,  ALTENBACH ROBERT A ,  KU YI-YIN ,  FERNANDO DILINIE P ,  CHANG SOU-JEN

IPC: C07D417/04 ,  A61K31/404 ,  A61K31/423 ,  A61K31/425 ,  A61P25/00 ,  C07D209/14 ,  C07D235/10 ,  C07D235/14 ,  C07D263/56 ,  C07D277/64 ,  C07D279/16 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions. X is O, S, NH, or N(alkyl); Y, and Y~ are each independently selected from the group consistin g of CH, CF, and N; Z is C or N, provided that when X is O or S, Z is N; one o f R1 and R2 is selected from the group consisting of aryl, heteroaryl, and heterocycle; the other of R1 and R2 is selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, cycloalkyl, halo, cyano, and thioalkoxy; R3 i s absent when Z is N and, when present, R3 is selected from the group consisti ng of hydrogen, methyl, alkoxy, halo and cyano; R4 and R5 are each independentl y selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, and cycloalkylalkyl, or R4 and R5 taken together wi th the nitrogen atom to which each is attached form a non-aromatic ring L is - [C(R15)(R16)]n-; m is an integer from 0-3; and n is an integer from 2-3.

公开(公告)号：AU2003283011A1

公开(公告)日：2004-05-13

申请号：AU2003283011

申请日：2003-10-22

Applicant: ABBOTT LAB

Inventor： FERNANADO DILINIE P ,  KU YI-YIN ,  LOCKWOOD MARK ,  WANG LEI ,  BENNANI YOUSSEF L ,  BUNNELLE WILLIAM H ,  CHANG SOU-JEN ,  CHEMBURKAR SANJAY R ,  CHEN JINHUA ,  DART MICHAEL J

IPC: A61P25/00 ,  A61P29/00 ,  C07C61/13 ,  C07C61/135 ,  C07C69/753 ,  C07C233/58 ,  C07C233/60 ,  C07C233/63 ,  A61K31/16 ,  A61K31/19 ,  C07C61/00 ,  C07C229/00 ,  C07C233/00

公开(公告)号：DE69718942D1

公开(公告)日：2003-03-13

申请号：DE69718942

申请日：1997-02-27

Applicant: ABBOTT LAB

Inventor： CHANG SOU-JEN

IPC: C07H17/08

公开(公告)号：AT232210T

公开(公告)日：2003-02-15

申请号：AT97907949

申请日：1997-02-27

Applicant: ABBOTT LAB

Inventor： CHANG SOU-JEN

IPC: C07H17/08

公开(公告)号：HK1047089A1

公开(公告)日：2003-02-07

申请号：HK02107126

申请日：2002-09-26

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07C20060101 ,  C07C68/06 ,  C07D20060101 ,  C07D215/14 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)

公开(公告)号：CA2566898C

公开(公告)日：2013-06-18

申请号：CA2566898

申请日：2005-04-29

Applicant: ABBOTT LAB

Inventor： ALTENBACH ROBERT J ,  BLACK LAWRENCE A ,  CHANG SOU-JEN ,  COWART MARLON D ,  FAGHIH RAMIN ,  GFESSER GREGORY A ,  KU YI-YIN ,  LIU HUAQING ,  LUKIN KIRILL A ,  NERSESIAN DIANA L ,  PU YU-MING ,  CURTIS MICHAEL P

IPC: C07D513/04 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/519 ,  C07D401/00 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04 ,  C07D487/04 ,  C07D491/02 ,  C07D491/04 ,  C07D495/04 ,  C07D498/02 ,  C07D498/04

Abstract: Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R3b, R4, R5, L, X, X', Y, Y', Z, and Z' are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

公开(公告)号：UA97639C2

公开(公告)日：2012-03-12

申请号：UAA200811465

申请日：2007-02-16

Applicant: ABBOTT LAB

Inventor： COWART MARLON D ,  ZHAO CHEN ,  SUN MINGHUA ,  BLACK LAWRENCE A ,  ZHENG GUO ZHU ,  GREGG ROBERT J ,  ZHANG GEOFF G Z ,  SHEIKH AHMAD Y ,  LOU XIAOCHUN ,  HENRY RODGER F ,  BARNES DAVID M ,  KOLACZKOWSKI LAWRENCE ,  HAIGHT ANTHONY R ,  CHANG SOU-JEN ,  WITTENBERGER STEVEN J ,  FICKES MICHAEL G

IPC: C07D487/04 ,  A61K31/407

Abstract: Раскрытыоктагидропирроло[3,4-b]пиррольныепроизводныеформулы I и II, пригодныедлялечениясостоянийилирасстройств, которыепредотвращаютсяилиоблегчаютсяс помощьюлигандоврецепторагистамина-3.Раскрытыоктагидропирроло[3,4-b]пиррольныесоединения, применениетакихсоединений, композиции, содержащиеэтисоединения, испособыполучениятакихсоединений.