公开(公告)号：AU8513998A

公开(公告)日：1999-02-22

申请号：AU8513998

申请日：1998-07-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DELLARIA JOSEPH F ,  FLORJANCIC ALAN S ,  GIESLER JAMIE ,  GONG JIANCHUN ,  GUO YAN ,  HEYMAN H ROBIN ,  HOLMS JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H ,  WADA CAROL K ,  XU LIANHONG

IPC: C07D233/74 ,  A61K31/275 ,  A61K31/351 ,  A61K31/352 ,  A61K31/4035 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4465 ,  A61K31/45 ,  A61K31/454 ,  A61K31/50 ,  A61P1/02 ,  A61P1/04 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C259/06 ,  C07C311/05 ,  C07C311/18 ,  C07C317/28 ,  C07C317/40 ,  C07C323/47 ,  C07C323/62 ,  C07D207/40 ,  C07D207/404 ,  C07D207/416 ,  C07D209/48 ,  C07D211/88 ,  C07D213/68 ,  C07D233/76 ,  C07D233/78 ,  C07D237/14 ,  C07D263/44 ,  C07D275/04 ,  C07D275/06 ,  C07D309/14 ,  C07D311/18 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07C259/00

Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：AU5815598A

公开(公告)日：1998-08-03

申请号：AU5815598

申请日：1998-01-07

Applicant: ABBOTT LAB

Inventor： DAVIDSEN STEVEN K ,  STEINMAN DOUGLAS H ,  SHEPPARD GEORGE S ,  XU LIANHONG ,  HOLMS JAMES H ,  GUO YAN ,  FLORJANCIC ALAN SCOTT ,  SIUMMERS JAMES B ,  MICHAELIDES MICHAEL R

IPC: A61K31/395 ,  A61K31/40 ,  A61K31/404 ,  A61K31/4188 ,  A61K31/427 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/553 ,  A61K38/00 ,  A61K38/55 ,  A61P1/02 ,  A61P7/00 ,  A61P11/06 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D225/06 ,  C07D245/02 ,  C07D245/06 ,  C07D267/00 ,  C07D273/01 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07D487/08 ,  C07K5/078 ,  A61K31/55 ,  A61K38/05 ,  C07D255/02

公开(公告)号：DE3855757D1

公开(公告)日：1997-02-27

申请号：DE3855757

申请日：1988-11-14

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  BROOKS DEE W ,  GUNN BRUCE P ,  HOLMS JAMES H

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/40 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61P29/00 ,  A61P43/00 ,  C07D207/32 ,  C07D207/335 ,  C07D207/34 ,  C07D307/52 ,  C07D307/58 ,  C07D307/68 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D417/04 ,  C07D207/325

Abstract: Substituted furan and pyrrole compounds of formula (I) which are useful in inhibiting lipoxygenase enzymes, particuarly 5-lipoxygenase.

公开(公告)号：IE922293A1

公开(公告)日：1993-01-27

申请号：IE922293

申请日：1992-07-14

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  DAVIDSEN STEVEN K ,  HOLMS JAMES H ,  PIREH DAISY ,  HEYMAN ROBIN H ,  MARTIN MICHAEL B ,  STEINMAN DOUGLAS H ,  SHEPPARD GEORGE S ,  CARRERA GEORGE M

IPC: A61K31/44 ,  A61K31/4406 ,  A61K49/00 ,  A61K49/06 ,  A61P1/04 ,  A61P7/02 ,  A61P7/06 ,  A61P9/02 ,  A61P11/06 ,  A61P17/06 ,  A61P29/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07B47/00 ,  C07D213/69 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07F5/00 ,  C07F13/00

Abstract: PCT No. PCT/US92/05890 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 14, 1992 PCT Pub. No. WO93/01813 PCT Pub. Date Feb. 4, 1993.Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

公开(公告)号：NZ232369A

公开(公告)日：1992-01-29

申请号：NZ23236990

申请日：1990-02-05

Applicant: ABBOTT LAB

Inventor： KERDESKY FRANCIS A J ,  HOLMS JAMES H ,  BROOKS DEE W

IPC: A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61P1/00 ,  A61P11/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D277/34 ,  C07D277/20 ,  C07D277/54 ,  C07D277/64 ,  C07D417/04 ,  C07D277/22 ,  C07D277/24 ,  C07D277/26 ,  C07D277/28 ,  A61K31/47

Abstract: A composition for the inhibition of lipoxygenase enzymes comprising a pharmaceutically acceptable carrier and a compound of the formula: I wherein R1 and R2 are independently selected from the group consisting of alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, arylalkenyl, reduced heteroaryl, and reduced heteroarylalkyl and substituted derivatives thereof having one or more substituents independently selected from the group consisting of halogen, alkyl, halosubstituted alkyl, aryl, arylalkyl, reduced heteroaryl, arylalkoxy, cyano, nitro, COR4, SO2R4, NR5R6, OR6, COCX1X2NR6R7, CON(OH)R6, NR6COR4, CR5(NH2)CO2R5, NHCX1X2CO2R5, N(OH)CONR5R6, N(OH)COR4, NHCONR5R6, C(NOH)NHOH and CONHNR5R6; R3 is selected from the group consisting of hydrogen, a pharmaceutically acceptable salt, COR4, COCX1X2NR6R7, CR8R9OR10, CH2CR8(OR10)CH2OR11 and SiR12R13R14; R4 is selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced heteroaryl, reduced heteroarylalkyl, OR5, NHCX1X2CO2R5 and NR6R7; R5 is selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, aryl, arylalkyl, reduced heteroaryl, and reduced heteroarylalkyl; R6 and R7 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, aryl, arylalkyl, reduced heteroaryl, reduced heteroarylalkyl and (CH2)nOR5 where n is 2-4 and R5 is as defined above; R8, R9, R10 and R11 are independently selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl and (CH2)nOR5 or at least two of R8, R9, R10 and R11 together form a ring system containing 5-10 atoms wherein said ring system is carbocyclic, heterocyclic or reduced heterocyclic and R5 and n are as defined above; R12, R13 and R14 are independently selected from the group consisting of alkyl and aryl; and X1 and X2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, aryl, and arylalkyl; and the acid addition salts thereof.

公开(公告)号：CA2631664C

公开(公告)日：2012-05-08

申请号：CA2631664

申请日：2006-12-08

Applicant: ABBOTT LAB

Inventor： MICHAELIDES MICHAEL R ,  MCCLELLAN WILLIAM J ,  FREY ROBIN R ,  CURTIN MICHAEL L ,  STEINMAN DOUGLAS H ,  DAI YUJIA ,  HOLMS JAMES H

IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  C07D495/04

Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating cancer using the compounds are disclosed.

公开(公告)号：MXPA06010904A

公开(公告)日：2007-06-11

申请号：MXPA06010904

申请日：2005-03-24

Applicant: ABBOTT LAB

Inventor： MICHAELIDES MICHAEL R ,  HOLMS JAMES H ,  STEINMAN DOUGLAS H ,  MUCKEY MELANIE A ,  WADA CAROL K ,  ARNOLD LEE D ,  DINGES JURGEN ,  DIXON RICHARD W ,  DJURIC STEVAN W ,  ERICSSON ANNA M ,  FISCHER KIMBA ,  GASIECKI ALAN F ,  GRACIAS VIJAYA J ,  RAFFERTY PAUL ,  XIA ZHIREN ,  AKRITOPOULOU-ZANZE IRINI ,  ZHANG HENRY Q ,  TAKESHITA MAKOTO

IPC: C07D409/04 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  A61P35/00 ,  A61P37/00 ,  C07D231/54 ,  C07D409/14 ,  C07D413/14 ,  C07D491/04 ,  C07D495/04

Abstract: Se utilizan los compuestos de la presente invencion para inhibir proteinas de tirosin-cinasas. Tambien se describen los metodos para hacer los compuestos, composiciones que los contienen y metodos de tratamiento utilizando los compuestos.

公开(公告)号：CA2527814A1

公开(公告)日：2004-12-16

申请号：CA2527814

申请日：2004-06-02

Applicant: ABBOTT LAB

Inventor： HOLMS JAMES H ,  HEYMAN HOWARD R ,  MICHAELIDES MICHAEL ,  FREY ROBIN R ,  DAVIDSEN STEVEN K ,  STEINMAN DOUGLAS H ,  CURTIN MICHAEL L

IPC: C07D209/46 ,  A61K31/4035 ,  A61P35/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds having the formula, (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compound s and compositions containing the compounds.

公开(公告)号：AT236873T

公开(公告)日：2003-04-15

申请号：AT96940406

申请日：1996-11-13

Applicant: ABBOTT LAB

Inventor： FESIK STEPHEN W ,  SUMMERS JAMES B JR ,  DAVIDSEN STEVEN K ,  SHEPPARD GEORGE S ,  STEINMAN DOUGLAS H ,  CARRERA GEORGE M JR ,  FLORJANCIC ALAN ,  HOLMS JAMES H

IPC: A61P19/02 ,  A61K31/185 ,  A61K31/275 ,  A61P29/00 ,  A61P35/04 ,  A61P43/00 ,  C07C259/06 ,  C07C323/60 ,  A61K31/16

Abstract: Compounds of formula or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.

公开(公告)号：AU758870B2

公开(公告)日：2003-04-03

申请号：AU8513998

申请日：1998-07-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DELLARIA JOSEPH F ,  FLORJANCIC ALAN S ,  GIESLER JAMIE ,  GONG JIANCHUN ,  GUO YAN ,  HEYMAN H ROBIN ,  HOLMS JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H ,  WADA CAROL K ,  XU LIANHONG

IPC: C07D233/74 ,  A61K31/275 ,  A61K31/351 ,  A61K31/352 ,  A61K31/4035 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4465 ,  A61K31/45 ,  A61K31/454 ,  A61K31/50 ,  A61P1/02 ,  A61P1/04 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C259/06 ,  C07C311/05 ,  C07C311/18 ,  C07C317/28 ,  C07C317/40 ,  C07C323/47 ,  C07C323/62 ,  C07D207/40 ,  C07D207/404 ,  C07D207/416 ,  C07D209/48 ,  C07D211/88 ,  C07D213/68 ,  C07D233/76 ,  C07D233/78 ,  C07D237/14 ,  C07D263/44 ,  C07D275/04 ,  C07D275/06 ,  C07D309/14 ,  C07D311/18 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07C259/00

Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.