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公开(公告)号：PT793659E
公开(公告)日：2001-07-31
申请号：PT95940008
申请日：1995-11-15
Applicant: ABBOTT LAB
Inventor： LEANNA M ROBERT , MORTON HOWARD E
IPC: B01J31/02 , C07B61/00 , C07D277/24 , C07D277/32
Abstract: A process for the preparation of 5-hydroxymethylthiazole comprises reacting a compound of the formula, with a carboxylic acid salt (optimally in the presence of a quaternary ammonium salt) and hydrolyzing the resulting ester. Subsequent dechlorination gives 5-hydroxymethylthiazole.
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公开(公告)号：PT1272500E
公开(公告)日：2005-09-30
申请号：PT00942860
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： COOPER ARTHUR J , HAIGHT ANTHONY R , KU YI-YIN , MORTON HOWARD E , PLATA DANIEL J , STONER ERIC J , PETERSON MATTHEW J , CINK RUSSELL D , DESHPANDE MAHENDRA N , TIM GRIEME , HILL DAVID R , CHI-PING HSU MARGARET , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , NAPIER JAMES J , RAJE PRASAD S , MICHAEL RASMUSSEN , DAVID RILEY , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
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公开(公告)号：DE60019976D1
公开(公告)日：2005-06-09
申请号：DE60019976
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN , WITTENBERGER
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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公开(公告)号：AT238983T
公开(公告)日：2003-05-15
申请号：AT99101692
申请日：1994-09-26
Applicant: ABBOTT LAB
Inventor： STUK TIMOTHY L , KERDESKY FRANCIS A J , LIJEWSKI-LINCH LINDA M , NORBECK DANIEL W , SCARPETTI DAVID , TIEN JIEN-HEH J , ALLEN MICHAEL S , LANGRIDGE DENTON C , MELCHER LAURA , RENO DANIEL S , SHAM HING LEUNG , ZHAO CHEN , HAIGHT ANTHONY R , LEANNA M ROBERT , MORTON HOWARD E , ROBBINS TIMOTHY A , SOWIN THOMAS J
IPC: C07C213/00 , C07C215/28 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14
Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.
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公开(公告)号：CA2403026A1
公开(公告)日：2001-10-18
申请号：CA2403026
申请日：2001-03-20
Applicant: ABBOTT LAB
Inventor： KERDESKY FRANCIS A J , KING STEVEN A , CHANG SOU-JEN , WAYNE GREGORY S , PEASE JONATHAN P , PREMCHANDRAN RAMIYA , LALLAMAN JOHN E , MORTON HOWARD E , BHAGAVATULA LAKSHMI
IPC: C07H17/08 , A61P31/04 , C07B61/00 , C07D407/14 , C07D409/04 , C07D498/04 , A61K31/7048
Abstract: Disclosed herein is a process for the preparation of erythromycin derivative s, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O-position.
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Patent Agency Ranking
公开(公告)号：GR3035865T3
公开(公告)日：2001-08-31
申请号：GR20010400716
申请日：2001-05-15
Applicant: ABBOTT LAB
Inventor： LEANNA M ROBERT , MORTON HOWARD E
IPC: B01J31/02 , C07B61/00 , C07D277/24 , C07D277/32
Abstract: A process for the preparation of 5-hydroxymethylthiazole comprises reacting a compound of the formula, with a carboxylic acid salt (optimally in the presence of a quaternary ammonium salt) and hydrolyzing the resulting ester. Subsequent dechlorination gives 5-hydroxymethylthiazole.
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公开(公告)号：DK0724563T3
公开(公告)日：2000-03-20
申请号：DK94929340
申请日：1994-09-26
Applicant: ABBOTT LAB
Inventor： STUK TIMOTHY L , KERDESKY FRANCIS A J , LIJEWSKI LINDA M , NORBECK DANIEL W , SCARPETTI DAVID , TIEN JIEN-HEH J , ALLEN MICHAEL S , LANGRIDGE DENTON C , MELCHER LAURA , RENO DANIEL S , SHAM HING LEUNG , ZHAO CHEN , HAIGHT ANTHONY R , LEANNA M ROBERT , MORTON HOWARD E , ROBBINS TIMOTHY A , SOWIN THOMAS J
IPC: C07C213/00 , C07C215/28 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14
Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.
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公开(公告)号：GR900100423A
公开(公告)日：1991-10-10
申请号：GR90100423
申请日：1990-05-31
Applicant: ABBOTT LAB
Inventor： SCHOENLEBER ROBERT W , MARTIN YVONNE C , PERNER RICHARD J , HSIAO CHI-NUNG W , DEBERNARDIS JOHN F , MEYER MICHAEL D , EHRLICH PAUL P , MORTON HOWARD E , KEBABIAN JOHN W , DENINNNO MICHAEL P , STOUT DAVID M , DIDOMENICO STANLEY JR , BASHA FATIMA Z DE
IPC: A61K31/13 , A61K31/135 , A61K31/16 , A61K31/335 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/30 , C07C41/02 , C07C215/48 , C07C215/64 , C07C217/56 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07D207/08 , C07D209/08 , C07D209/62 , C07D221/06 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06 , C07C235/08 , C07C235/18 , C07C217/58 , C07C215/50 , C07C237/22
Abstract: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.
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公开(公告)号：CA2375364C
公开(公告)日：2008-11-25
申请号：CA2375364
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： MCLAUGHLIN MAUREEN A , HAIGHT ANTHONY R , MORTON HOWARD E , PETERSON MATTHEW J , GRIEME TIM , RILEY DAVID , DESHPANDE MAHENDRA N , WITTENBERGER STEVEN J , NAPIER JAMES J , TIEN JIEN-HEH J , RAJE PRASAD S , PLATA DANIEL J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , KING STEVEN A , RASMUSSEN MICHAEL , STONER ERIC J , HSU MARGARET CHI-PING , LEE ELAINE C , LEANNA MARVIN R , HILL DAVID R
IPC: C07H17/08 , A61K31/7048 , A61P31/04 , C07B61/00 , C07H1/00
Abstract: In one aspect, the invention relates to a process for preparing 6-O- substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4"-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates t o processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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公开(公告)号：PT916646E
公开(公告)日：2003-09-30
申请号：PT99101692
申请日：1994-09-26
Applicant: ABBOTT LAB
Inventor： ZHAO CHEN , SHAM HING LEUNG , HAIGHT ANTHONY R , KERDESKY FRANCIS A J , STUK TIMOTHY L , ALLEN MICHAEL S , MELCHER LAURA , LEANNA M ROBERT , ROBBINS TIMOTHY A , MORTON HOWARD E , SOWIN THOMAS J , TIEN JIEN-HEH J , NORBECK DANIEL W , LIJEWSKI-LINCH LINDA M , SCARPETTI DAVID , LANGRIDGE DENTON C , RENO DANIEL S
IPC: C07C213/00 , C07C215/28 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14
Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.
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