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公开(公告)号：DE60315336D1
公开(公告)日：2007-09-13
申请号：DE60315336
申请日：2003-09-15
Applicant: ABBOTT LAB
Inventor： MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG , MICHMERHUIZEN MELISSA J , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SHAM HING L , STEWART KENT D , SZCZEPANKIEWICZ BRUCE G
IPC: C07D207/00 , A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.
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公开(公告)号：SA01220501A
公开(公告)日：2005-12-03
申请号：SA01220501
申请日：2001-10-31
Applicant: ABBOTT LAB
Inventor： LIU GANG , SZCZEPANKIEWICZ BRUCE , PEI ZHONGHUA , XIN ZHILI , OOST THORSTEN K , JANOWICK DAVID A
Abstract: يتعلقالاختراعالراهنبمركباتبالصيغة (١):أوأملاحهاالمقبولةعلاجياوالتيتمثلمثبطاتبروتينتيروسينفسفاتاز PTPIB،وبتحضيرالمركباتوالتراكيبالتيتحتويعلىالمركباتوعلاجالأمراضباستخدامهذهالمركبات.
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公开(公告)号：HRP20010776A2
公开(公告)日：2002-12-31
申请号：HRP20010776
申请日：2001-10-23
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , GELDERN THOMAS W VON , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD STEVEN A , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：HU0200222A2
公开(公告)日：2002-06-29
申请号：HU0200222
申请日：1999-12-29
Applicant: ABBOTT LAB
Inventor： BOYD STEVEN A , FREEMAN JENNIFER C , VON GELDERN TOM , GUNAWARDANA INDRANI W , JAE HWAN-SOO , LINK JAMES , LIU GANG , LYNCH JOHN K , PEI ZHONGHUA , STAEGER MICHAEL A , WINN MARTIN , XIN ZHILI , ZHU GUI-DONG
IPC: C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：HK1040985A1
公开(公告)日：2002-06-28
申请号：HK02102655
申请日：2002-04-09
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , GELDERN VON THOMAS W , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD STEVEN A , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00 , C07C , C07D , A61K , A61P
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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Patent Agency Ranking
公开(公告)号：CA2369238A1
公开(公告)日：2000-10-12
申请号：CA2369238
申请日：2000-04-03
Applicant: ABBOTT LAB
Inventor： XIN ZHILI , WINN MARTIN , LYNCH JOHN K , JAE HWAN-SOO , LIU GANG , WANG SHELDON , VON GELDERN THOMAS W , PEI ZHONGHUA , ZHU GUI-DONG , BOYD STEVEN A , LINK JAMES , FREEMAN JENNIFER C , STAEGER MICHAEL A , GUNAWARDANA INDRANI W
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: The present invention relates to cinnamide compounds of formula (I), in whic h at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：NZ565461A
公开(公告)日：2011-08-26
申请号：NZ56546106
申请日：2006-08-25
Applicant: ABBOTT LAB
Inventor： PEI ZHONGHUA , VON GELDERN THOMAS , MADAR DAVID J , LI XIAOFENG , BASHA FATIMA , YONG HONG , LONGENECKER KENTON L , BACKES BRADLEY J , JUDD ANDREW S , MULHERN MATHEW M , STEWART KENT D
IPC: C07D317/64 , A61K31/137 , C07C211/40 , C07C211/54 , C07C211/62 , C07D213/38 , C07D213/68 , C07D487/04
Abstract: Disclosed is a cyclohexyl amine of formula (Ia) or a pharmaceutically acceptable salt thereof, wherein m is 4; Ar 1 is aryl, R1 is hydrogen, and R2 and R3 are defined in the specification for treating diabetes, type II diabetes, hyperglycemia, metabolic syndrome, hyperinsulinemia, or obesitycardiovascular disease, atherosclerosis, cerebrovascular diseases, diseases and disorders of the central nervous system, schizophrenia, anxiety, bipolar disease, depression, insomnia, cognitive disorders, gastrointestinal diseases and disorders, cancer, inflammation and inflammatory diseases, respiratory diseases and disorders, musculo-skeletal disorders, osteoporosis, menopausal symptoms, periodontal diseases and gingivitis.
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公开(公告)号：CA2670736A1
公开(公告)日：2008-06-05
申请号：CA2670736
申请日：2007-11-26
Applicant: ABBOTT LAB
Inventor： IYENGAR RAJESH R , LIU BO X , KYM PHILIP R , ZHAO GANG , GAO JU , YEH VINCE , SOUERS ANDREW J , PEI ZHONGHUA , HANSEN TODD MATTHEW , XIN ZHILI
IPC: A61K31/17 , A61P1/16 , A61P3/00 , C07C229/40
Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Pharmaceutical compositions of formula (I) and related methods for treating or preventing metabolic diseas es or conditions.
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公开(公告)号：DE60315336T2
公开(公告)日：2008-05-08
申请号：DE60315336
申请日：2003-09-15
Applicant: ABBOTT LAB
Inventor： MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG , MICHMERHUIZEN MELISSA J , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SHAM HING L , STEWART KENT D , SZCZEPANKIEWICZ BRUCE G
IPC: C07D207/00 , A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.
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公开(公告)号：EA009052B1
公开(公告)日：2007-10-26
申请号：EA200401528
申请日：2000-04-03
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN TON , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD STEVEN A , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K
IPC: C07D211/62 , C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/32 , C07D211/46 , C07D211/60 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: Настоящееизобретениеотноситсяк новымпроизводнымдиарилсульфидовформулы (I), вкоторыхпокрайнеймереодиниз R-Rпредставляет "цис-циннамид" (а) или "транс-циннамид" (b), адругиерадикалыопределеныв формулеизобретенияи которыемогутбытьиспользованыдлялечениявоспалительныхи иммунныхзаболеваний; кспособамполучениязаявленныхсоединенийи промежуточнымсоединениям, используемымв указанныхспособах.
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