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公开(公告)号：CA2403026A1
公开(公告)日：2001-10-18
申请号：CA2403026
申请日：2001-03-20
Applicant: ABBOTT LAB
Inventor： KERDESKY FRANCIS A J , KING STEVEN A , CHANG SOU-JEN , WAYNE GREGORY S , PEASE JONATHAN P , PREMCHANDRAN RAMIYA , LALLAMAN JOHN E , MORTON HOWARD E , BHAGAVATULA LAKSHMI
IPC: C07H17/08 , A61P31/04 , C07B61/00 , C07D407/14 , C07D409/04 , C07D498/04 , A61K31/7048
Abstract: Disclosed herein is a process for the preparation of erythromycin derivative s, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O-position.
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公开(公告)号：SK1452000A3
公开(公告)日：2001-05-10
申请号：SK1452000
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: C07D491/048 , A61K31/40 , A61K31/41 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/495 , A61K31/506 , A61K31/535 , A61K31/55 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/08 , A61P13/12 , A61P21/00 , A61P21/04 , A61P25/06 , A61P35/00 , A61P43/00 , C07D207/16 , C07D207/26 , C07D207/27 , C07D403/04 , C07D405/00 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D491/056
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53.发明专利
公开(公告)号：NZ330818A
公开(公告)日：2000-05-26
申请号：NZ33081897
申请日：1997-02-12
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN SOO , TASKER ANDREW S , VON GELDERN THOMAS W , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/4035 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/506 , A61K31/675 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P25/06 , A61P43/00 , C07D207/16 , C07D211/60 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07D471/04 , C07D491/04 , C07F9/572
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin. Endothelin has been shown to constrict arteries and veins, increase mean arterial blood pressure, decrease cardiac output, increase cardiac contractility in vitro, stimulate mitogenesis in vascular smooth muscle including guinea pig trachea, human urinary bladder strips and rat uterus in vitro, induce formation of gastric ulcers, stimulate release of atrial natriuretic factor in vitro and in vivo, increase plasma levels of vasopressin, aldosterone and catecholamines, inhibit release of renin in vitro and stimulate release of gonadotropins in vitro. The compound of formula (I) wherein, Z is -C(R18)(R19)-or -C(O)- wherein R18 and R19 are independently selected from hydrogen and lower alkyl; n is 0 or 1; R is (CH2)m-W wherein m is an integer from 0-6 and W is (a) -C(O)2-G wherein G is H or a carboxy protecting group, (b) -PO3H2, (c) -P(O)(OH)E wherein E is hydrogen, lower alkyl or arylalkyl, (d) -CN, (e) -C(O)NHR17 wherein R17 is lower alkyl, (f) alkylaminocarbonyl, (g) dialkylaminocarbonyl, (h) tetrazolyl, (i) hydroxy, (j) alkoxy, (k) sulfonamido, (l) -C(O)NHS(O)2R16 wherein R16 is loweralkyl, haloalkyl, aryl or dialkylamino, (m) -S(O)2NHC(O)R16, (n)-(u) are represented in the figures provided; R1-R25 are selected from common hydrocarbon groups.
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公开(公告)号：NO20000542L
公开(公告)日：2000-04-04
申请号：NO20000542
申请日：2000-02-02
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY ALAN , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: C07D491/048 , A61K31/40 , A61K31/41 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/495 , A61K31/506 , A61K31/535 , A61K31/55 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/08 , A61P13/12 , A61P21/00 , A61P21/04 , A61P25/06 , A61P35/00 , A61P43/00 , C07D207/16 , C07D207/26 , C07D207/27 , C07D403/04 , C07D405/00 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D491/056 , A61K
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公开(公告)号：NO20000542A
公开(公告)日：2000-04-04
申请号：NO20000542
申请日：2000-02-02
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY ALAN , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: C07D491/048 , A61K31/40 , A61K31/41 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/495 , A61K31/506 , A61K31/535 , A61K31/55 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/08 , A61P13/12 , A61P21/00 , A61P21/04 , A61P25/06 , A61P35/00 , A61P43/00 , C07D207/16 , C07D207/26 , C07D207/27 , C07D403/04 , C07D405/00 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D491/056 , A61K
CPC classification number: C07D207/27 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14
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Patent Agency Ranking56.发明专利
公开(公告)号：AU2262097A
公开(公告)日：1997-09-02
申请号：AU2262097
申请日：1997-02-12
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J JR , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/4035 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/506 , A61K31/675 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P25/06 , A61P43/00 , C07D207/16 , C07D211/60 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07D471/04 , C07D491/04 , C07F9/572 , C07F9/59
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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公开(公告)号：CY1113070T1
公开(公告)日：2016-04-13
申请号：CY121100626
申请日：2012-07-13
Applicant: ABBOTT LAB
Inventor： ALLEN MICHAEL S , PREMCHANDRAN RAMIYA H , CHANG SOU-JEN , CONDON STEPHEN , DEMATTEI JOHN J , KING STEVEN A , KOLACZKOWSKI LAWRENCE , MANNA SUKUMAR , NICHOLS PAUL J , PATEL HEMANT H , PATEL SUBHASH R , PLATA DANIEL J , STONER ERIC J , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
IPC: C07D215/14 , C07C33/03 , C07C43/303 , C07C47/22 , C07C57/04 , C07C68/06 , C07C69/96 , C07C269/06 , C07C271/12 , C07D215/18 , C07D401/12 , C07H17/08
Abstract: Ηεφεύρεσηαφοράσεμιαμέθοδογιαπαρασκευήκινολινο-υποκατεστημένωνενώσεωνανθρακικούκαικαρβαμικού, οιοποίεςείναισημαντικάενδιάμεσαστηνσύνθεσητωναντιβιοτικών 6-O-υποκατεστημένουμακρολιδίου. Ημέθοδοςχρησιμοποιείτιςκαταλυόμενεςαπόμέταλλοαντιδράσειςσύζευξηςγιαναπαρέχειανθρακικόή καρβαμικότουτύπου (Ι) ή (II) ήυπόστρωμαπουμπορείναανάγεταιγιαναληφθούναυτά.
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公开(公告)号：CA2368768C
公开(公告)日：2011-10-11
申请号：CA2368768
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： ALLEN MICHAEL S , PREMCHANDRAN RAMIYA H , CHANG SOU-JEN , CONDON STEPHEN , DEMATTEI JOHN J , KING STEVEN A , KOLACZKOWSKI LAWRENCE , MANNA SUKUMAR , NICHOLS PAUL J , PATEL HEMANT H , PATEL SUBHASH R , PLATA DANIEL J , STONER ERIC J , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
IPC: C07D215/14 , C07C68/06 , C07D215/18 , C07D401/12 , C07H17/08
Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.
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59.发明专利
公开(公告)号：CA2245587C
公开(公告)日：2008-12-30
申请号：CA2245587
申请日：1997-02-12
Applicant: ABBOTT LAB
Inventor： BOYD STEVEN A , WINN MARTIN , HUTCHINS CHARLES W , HENRY KENNETH J , LIU GANG , SZCZEPANKIEWICZ BRUCE G , WITTENBERGER STEVEN J , TASKER ANDREW S , KING STEVEN A , VON GELDERN THOMAS W , KESTER JEFFREY A , JAE HWAN-SOO , SORENSEN BRYAN K
IPC: C07D405/04 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/4035 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/506 , A61K31/675 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P25/06 , A61P43/00 , C07D207/16 , C07D211/60 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07D471/04 , C07D491/04 , C07F9/572
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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公开(公告)号：DE60019976T2
公开(公告)日：2006-02-16
申请号：DE60019976
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN , WITTENBERGER
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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