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公开(公告)号：WO2011156337A3
公开(公告)日：2012-04-26
申请号：PCT/US2011039397
申请日：2011-06-07
Applicant: ABBOTT LAB , ENANTA PHARM INC , CHEN HUI-JU , MCDANIEL KEITH F , GREEN BRIAN E , SHANLEY JASON P , KRUGER ALBERT W , GANDARILLA JORGE , WELCH DENNIE S , CINK RUSSELL D , GAI YONGHUA , WANG GUOQIANG , OR YAT SUN
Inventor： CHEN HUI-JU , MCDANIEL KEITH F , GREEN BRIAN E , SHANLEY JASON P , KRUGER ALBERT W , GANDARILLA JORGE , WELCH DENNIE S , CINK RUSSELL D , GAI YONGHUA , WANG GUOQIANG , OR YAT SUN
IPC: C07D487/04 , A61K31/407 , A61K31/498 , A61P31/14
CPC classification number: C07K5/081 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
Abstract translation: 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号：WO2010030359A3
公开(公告)日：2010-05-27
申请号：PCT/US2009005082
申请日：2009-09-10
Applicant: ENANTA PHARJMACEUTICALS INC , ABBOTT LAB , KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM , SHEIKH AHMAD , MEI JIANZHANG
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM , SHEIKH AHMAD , MEI JIANZHANG
CPC classification number: C07K1/113 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of use thereof. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
Abstract translation: 本发明涉及新的大环化合物及其使用方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号：EP2340029A4
公开(公告)日：2012-06-13
申请号：EP09813360
申请日：2009-09-10
Applicant: ENANTA PHARM INC , ABBOTT LAB
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM , SHEIKH AHMAD , MEI JIANZHANG
IPC: A61K38/00 , A61K38/12 , C07D487/04
CPC classification number: C07K1/113 , C07D487/04
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公开(公告)号：AU2013205039A1
公开(公告)日：2013-05-16
申请号：AU2013205039
申请日：2013-04-13
Applicant: ABBOTT LAB , ENANTA PHARM INC
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , YONGHUA GAI , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM , SHEIKH AHMAD , MEI JIANZHANG
Abstract: MACROCYCLIC HEPATITIS C SERINE PROTEASE Abstract The present invention relates to novel macrocyclic compounds and methods of use thereof. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutical acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutical carrier or excipient.
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公开(公告)号：CA2549228A1
公开(公告)日：2005-07-07
申请号：CA2549228
申请日：2004-11-10
Applicant: ABBOTT LAB
Inventor： CHEN HUI-JU , RANDOLPH JOHN T , YEUNG MING C , DEGOEY DAVID A , KLEIN LARRY L , GRAMPOVNIK DAVID J , FLENTGE CHARLES A , FLOSI WILLIAM J , KEMPF DALE J , HUTCHINSON DOUGLAS K , HUANG PEGGY P
IPC: C07D401/14 , A61K31/4166 , A61K31/4178 , A61P31/18 , C07C243/24 , C07C271/22 , C07D401/06 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14
Abstract: A compound of the formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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Patent Agency Ranking
公开(公告)号：PL343678A1
公开(公告)日：2001-08-27
申请号：PL34367899
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
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公开(公告)号：BG104962A
公开(公告)日：2001-07-31
申请号：BG10496200
申请日：2000-11-17
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-JU , CHEN YCANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
Abstract: Disclosed are compounds of formula which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminodase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes. 56 claims
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公开(公告)号：AU6408499A
公开(公告)日：2000-04-26
申请号：AU6408499
申请日：1999-10-01
Applicant: ABBOTT LAB
Inventor： WANG WEI-BO , LI QUN , HASVOLD LISA A , CHEN HUI-JU , LI LEPING , LARTEY PAUL A , CLAIBORNE AKIYO , STEINER BETH A , BENNANI YOUSSEF , DICKMAN DANIEL , DING HONG
IPC: C07C67/343 , C07D295/155 , C07K7/56 , C07K7/00
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公开(公告)号：CA2329422A1
公开(公告)日：1999-10-28
申请号：CA2329422
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MADIGAN DAROLD L , LIN ZHEN , KRUEGER ALLAN C , MARING CLARENCE J , DEGOEY DAVID A , XU YIBO , YEUNG MING C , FLOSI WILLIAM J , ZHAO CHEN , KENNEDY APRIL , MUCHMORE STEVEN W , STEWART KENT D , KEMPF DALE J , SHAM HING L , GRAMPOVNIK DAVID J , STOLL VINCENT S , KATI WARREN M , WANG GARY T , GU YU-GUI , SUN MINGHUA , WANG SHELDON , MCDANIEL KEITH F , GIRANDA VINCENT L , KLEIN LARRY L , CHEN YUANWEI , CHEN HUI-JU
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
Abstract: Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
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公开(公告)号：ZA201101558B
公开(公告)日：2018-11-28
申请号：ZA201101558
申请日：2011-02-28
Applicant: ABBOTT LAB , ENANTA PHARM INC
Inventor： ENGSTROM KEN , GRIEME TIM , WAGAW SABLE H , CHEN HUI-JU , KU YIYIN , MEI JIANZHANG , GAI YONGHUA , LIU DONG , OR YAT SUN , SHANLEY JASON P , GRAMPOVNIK DAVID J , SUN YING , SHEIKH AHMAD , MCDANIEL KEITH F , KEMPF DALE J
Abstract: The present invention relates to novel macrocyclic compounds and methods of use thereof. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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