公开(公告)号：CA2534542A1

公开(公告)日：2005-02-24

申请号：CA2534542

申请日：2004-08-04

Applicant: ABBOTT LAB

Inventor： WHITE TAMMIE K ,  ZHENG GUO ZHU ,  TURNER SEAN C ,  SCHMIDT ROBERT G JR ,  DRIZIN IRENE ,  PERNER RICHARD J ,  KOENIG JOHN R ,  GOMTSYAN ARTHUR R ,  DIDOMENICO STANLEY JR ,  BAYBURT EROL K ,  LEE CHIH-HUNG

IPC: C07D217/24 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/5377 ,  C07D209/08 ,  C07D217/02 ,  C07D217/22 ,  C07D217/26 ,  C07D231/56 ,  C07D237/28 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D451/02 ,  C07D521/00

Abstract: Compounds of Formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.

公开(公告)号：NZ511041A

公开(公告)日：2003-03-28

申请号：NZ51104199

申请日：1999-10-28

Applicant: ABBOTT LAB

Inventor： DRIZIN IRENE ,  KORT MICHAEL E ,  CARROLL WILLIAM A ,  GRIOS KONSTANTINOS A ,  ALTENBACH ROBERT J

IPC: C07D335/02 ,  A61K20060101 ,  A61K31/436 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/55 ,  A61P20060101 ,  A61P1/00 ,  A61P9/12 ,  A61P11/06 ,  A61P13/00 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/28 ,  C07C45/00 ,  C07C45/29 ,  C07C45/41 ,  C07C45/63 ,  C07C205/44 ,  C07D20060101 ,  C07D211/86 ,  C07D219/00 ,  C07D309/30 ,  C07D471/04 ,  C07D471/14 ,  C07D491/00 ,  C07D491/04 ,  C07D491/052 ,  C07D491/14 ,  C07D491/147 ,  C07D491/153 ,  C07D495/04 ,  C07D495/14 ,  C07D513/00 ,  C07D4 ,  A61K ,  A61K47 ,  A61P ,  A61B ,  A61P13/10 ,  A61P21/00

Abstract: A compound of formula I, where: n is 0-1; m is 1-2; A is NR2, O or S; A' is NR3, O, S or CR4R5; D is CH2 or C(O); D' is CH2, C(O), S(O), or S(O)2 ; R1 is aryl or heterocycle; R2 and R3 are independently hydrogen, alkoxyalkyl, alkyl, arylalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, heterocycloalkyl, hydroxy, hydroxyalkyl, -NZ1Z2, or (NZ1Z2)alkyl, wherein Z1 and Z2 are independently hydrogen, alkyl, alkylcarbonyl, aryl, arylalkyl, and formyl; R4 and R5 are independently hydrogen or alkyl; R6 and R7 are independently hydrogen or alkyl; with the proviso that when D is CH2 then D' is other than CH2; and with the proviso that when D' is S(O) or S(O)2 then A' is CR4 R5. Also described is a pharmaceutical composition comprising the compound of formula I. The compound of formula I is useful for treating asthma, epilepsy, hypertension, Raynaud's syndrome, migraine, pain, eating disorders, functional bowel disorders, neurodegeneration, stroke, urinary incontinence, male erectile dysfunction, premature ejaculation, female anorgasmia, clitoral erectile insufficiency, vaginal engorgement, dyspareunia and vaginismus. Also described is the intermediate compound of formula IX, where: A is O, S or NR2; wherein R2 is hydrogen, alkoxyalkyl, alkyl, arylalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, heterocycloalkyl, hydroxy, hydroxyalkyl, -NZ1Z2 or (NZ1Z2)alkyl where Z1 and Z2 are hydrogen, alkyl, alkylcarbonyl, aryl, arylalkyl or formyl; with the proviso that R2 is other than benzyl.

公开(公告)号：ZA200103248B

公开(公告)日：2002-07-22

申请号：ZA200103248

申请日：2001-04-20

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  ALTENBACH ROBERT J ,  KORT MICHAEL E ,  AGRIOS KONSTANTINOS A ,  DRIZIN IRENE

IPC: A61K20060101 ,  A61K31/44 ,  A61K31/55 ,  A61P20060101 ,  C07D20060101 ,  C07D219/00 ,  C07D471/04 ,  C07D471/14 ,  C07D491/00 ,  C07D491/04 ,  C07D491/14 ,  C07D495/14 ,  C07D513/00 ,  C07D ,  A61K ,  A61P

公开(公告)号：BG105524A

公开(公告)日：2001-12-31

申请号：BG10552401

申请日：2001-05-19

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  AGRIOS KONSTANTINOS A ,  ALTENBACH ROBERT J ,  DRIZIN IRENE ,  KORT MICHAEL E

IPC: C07D335/02 ,  A61K20060101 ,  A61K31/436 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/55 ,  A61P20060101 ,  A61P1/00 ,  A61P9/12 ,  A61P11/06 ,  A61P13/00 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/28 ,  C07C45/00 ,  C07C45/29 ,  C07C45/41 ,  C07C45/63 ,  C07C205/44 ,  C07D20060101 ,  C07D211/86 ,  C07D219/00 ,  C07D309/30 ,  C07D471/04 ,  C07D471/14 ,  C07D491/00 ,  C07D491/04 ,  C07D491/052 ,  C07D491/14 ,  C07D491/147 ,  C07D491/153 ,  C07D495/04 ,  C07D495/14 ,  C07D513/00 ,  A61K31/47 ,  A61P13/10 ,  A61P21/00 ,  A61P29/00

Abstract: The present invention provides novel compounds of formula which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells. And inhibiting bladder contractions. 98 claims

公开(公告)号：AU735764B2

公开(公告)日：2001-07-12

申请号：AU5516998

申请日：1997-12-04

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F ,  WENDT MICHAEL D ,  HAIGHT ANTHONY R ,  ZHANG WEIJIANG

IPC: A61K31/517 ,  A61K31/519 ,  A61P13/08 ,  A61P13/10 ,  A61P15/04 ,  A61P43/00 ,  C07D207/26 ,  C07D311/58 ,  C07D491/04 ,  C07D491/052 ,  C07D495/04 ,  C07D519/00 ,  A61K31/415

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.

公开(公告)号：CZ20004428A3

公开(公告)日：2001-05-16

申请号：CZ20004428

申请日：2000-03-06

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  CHEN YIYUAN ,  DRIZIN IRENE ,  KERWIN JAMES F ,  MOORE JIMMIE L

IPC: A61K31/473 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P25/06 ,  C07D211/82 ,  C07D211/90 ,  C07D215/20

公开(公告)号：GR3034485T3

公开(公告)日：2000-12-29

申请号：GR20000402174

申请日：2000-09-26

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  ELMORE STEVEN W ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  WENDT MICHAEL D ,  YAMAMOTO DIANE M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：CZ20002137A3

公开(公告)日：2000-10-11

申请号：CZ20002137

申请日：1998-12-16

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  HOLLADAY MARK W ,  SULLIVAN JAMES P ,  DRIZIN IRENE ,  ZHANG HENRY Q

IPC: A61K31/38 ,  A61K31/44 ,  A61K31/47 ,  C07D211/84 ,  C07D215/36 ,  C07D221/00 ,  C07D333/00 ,  C07D337/00 ,  C07D495/04 ,  C07D495/14

公开(公告)号：AU3616800A

公开(公告)日：2000-09-21

申请号：AU3616800

申请日：2000-03-06

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  CHEN YIYUAN ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  MOORE JIMMIE L

IPC: A61K31/435 ,  A61P9/12 ,  A61P11/06 ,  A61P13/00 ,  A61P15/10 ,  A61P25/08 ,  A61P25/28 ,  C07C45/29 ,  C07D221/04 ,  C07D221/06 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D211/82 ,  C07D215/20 ,  C07D211/90 ,  A61K31/473

Abstract: Compounds of formula Iare useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：NO20003104D0

公开(公告)日：2000-06-16

申请号：NO20003104

申请日：2000-06-16

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  HOLLADAY MARK W ,  SULLIVAN JAMES P ,  DRIZIN IRENE ,  ZHANG HENRY Q

IPC: A61K31/4365 ,  A61K31/47 ,  A61K31/4743 ,  A61P1/00 ,  A61P1/14 ,  A61P9/08 ,  A61P9/12 ,  A61P11/06 ,  A61P13/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  C07C45/29 ,  C07D215/36 ,  C07D221/04 ,  C07D495/04 ,  C07D495/14 ,  C07D

Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.