公开(公告)号：DE69432611D1

公开(公告)日：2003-06-05

申请号：DE69432611

申请日：1994-09-26

Applicant: ABBOTT LAB

Inventor： STUK THIMOTHY L ,  KERDESKY FRANCIS A J ,  LIJEWSKI LINDA M ,  NORBECK DANIEL W ,  SCARPETTI DAVID ,  TIEN JIEN-HEH J ,  ALLEN MICHAEL S ,  LANGRIDGE DENTON C ,  MELCHER LAURA ,  RENO DANIEL S ,  SHAM HING LEUNG ,  ZHAO CHEN ,  HAIGHT ANTHONY R ,  LEANNA M ROBERT ,  MORTON HOWARD E ,  ROBBINS TIMOTHY A ,  SOWIN THOMAS J

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：DK0793659T3

公开(公告)日：2001-06-11

申请号：DK95940008

申请日：1995-11-15

Applicant: ABBOTT LAB

Inventor： LEANNA M ROBERT ,  MORTON HOWARD E

IPC: B01J31/02 ,  C07B61/00 ,  C07D277/24 ,  C07D277/32

Abstract: A process for the preparation of 5-hydroxymethylthiazole comprises reacting a compound of the formula, with a carboxylic acid salt (optimally in the presence of a quaternary ammonium salt) and hydrolyzing the resulting ester. Subsequent dechlorination gives 5-hydroxymethylthiazole.

公开(公告)号：GR3031939T3

公开(公告)日：2000-03-31

申请号：GR990403031

申请日：1999-11-25

Applicant: ABBOTT LAB

Inventor： STUK TIMOTHY L ,  KERDESKY FRANCIS A J ,  LIJEWSKI LINDA M ,  NORBECK DANIEL W ,  SCARPETTI DAVID ,  TIEN JIEN-HEH J ,  ALLEN MICHAEL S ,  LANGRIDGE DENTON C ,  MELCHER LAURA ,  RENO DANIEL S ,  SHAM HING LEUNG ,  ZHAO CHEN ,  HAIGHT ANTHONY R ,  LEANNA M ROBERT ,  MORTON HOWARD E ,  ROBBINS TIMOTHY A ,  SOWIN THOMAS J

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：AT183993T

公开(公告)日：1999-09-15

申请号：AT94929340

申请日：1994-09-26

Applicant: ABBOTT LAB

Inventor： STUK TIMOTHY L ,  KERDESKY FRANCIS A J ,  LIJEWSKI LINDA M ,  NORBECK DANIEL W ,  SCARPETTI DAVID ,  TIEN JIEN-HEH J ,  ALLEN MICHAEL S ,  LANGRIDGE DENTON C ,  MELCHER LAURA ,  RENO DANIEL S ,  SHAM HING LEUNG ,  ZHAO CHEN ,  HAIGHT ANTHONY R ,  LEANNA M ROBERT ,  MORTON HOWARD E ,  ROBBINS TIMOTHY A ,  SOWIN THOMAS J

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：HK1011677A1

公开(公告)日：1999-07-16

申请号：HK98112593

申请日：1998-11-30

Applicant: ABBOTT LAB

Inventor： STUK TIMOTHY L ,  KERDESKY FRANCIS A J ,  LIJEWSKI LINDA M ,  NORBECK DANIEL W ,  SCARPETTI DAVID ,  TIEN JIEN-HEH J ,  ALLEN MICHAEL S ,  LANGRIDGE DENTON C ,  MELCHER LAURA ,  RENO DANIEL S ,  SHAM HING LEUNG ,  ZHAO CHEN ,  HAIGHT ANTHONY R ,  LEANNA ROBERT M ,  MORTON HOWARD E ,  ROBBINS TIMOTHY A ,  SOWIN THOMAS J

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14 ,  C07C

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：AT134373T

公开(公告)日：1996-03-15

申请号：AT90909264

申请日：1990-05-22

Applicant: ABBOTT LAB

Inventor： SCHOENLEBER ROBERT W ,  KEBABIAN JOHN W ,  MARTIN YVONNE C ,  DENINNO MICHAEL P ,  PERNER RICHARD J ,  STOUT DAVID M ,  HSIAO CHI-NUNG W ,  DIDOMENICO STANLEY JR ,  DEBERNARDIS JOHN F ,  BASHA FATIMA Z ,  MEYER MICHEAL D ,  DE BISWANATH ,  EHRLICH PAUL P ,  CAMPBELL JAMES R ,  MORTON HOWARD E ,  LIJEWSKI LINDA M

IPC: A61K31/13 ,  A61K31/135 ,  A61K31/16 ,  A61K31/335 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K38/00 ,  A61P9/00 ,  A61P25/00 ,  A61P25/18 ,  A61P25/30 ,  C07C41/02 ,  C07C215/48 ,  C07C215/64 ,  C07C217/56 ,  C07C217/74 ,  C07C219/28 ,  C07C233/18 ,  C07C237/08 ,  C07C271/16 ,  C07C271/44 ,  C07C309/65 ,  C07C323/60 ,  C07D207/08 ,  C07D209/08 ,  C07D209/62 ,  C07D221/06 ,  C07D221/10 ,  C07D221/20 ,  C07D311/76 ,  C07D311/78 ,  C07D311/96 ,  C07D313/08 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D407/04 ,  C07D407/12 ,  C07D493/10 ,  C07K5/06 ,  C07D409/04 ,  C07D311/74 ,  C07D487/00 ,  C07D209/56 ,  C07D211/00 ,  C07C69/76 ,  A01N43/32

Abstract: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.

公开(公告)号：CA2403026C

公开(公告)日：2007-09-25

申请号：CA2403026

申请日：2001-03-20

Applicant: ABBOTT LAB

Inventor： MORTON HOWARD E ,  PEASE JONATHAN P ,  KERDESKY FRANCIS A J ,  KING STEVEN A ,  BHAGAVATULA LAKSHMI ,  LALLAMAN JOHN E ,  PREMCHANDRAN RAMIYA ,  CHANG SOU-JEN ,  WAYNE GREGORY S

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/04 ,  C07B61/00 ,  C07D407/14 ,  C07D409/04 ,  C07D498/04

Abstract: Disclosed herein is a process for the preparation of erythromycin derivative s, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O- position.

公开(公告)号：AT294809T

公开(公告)日：2005-05-15

申请号：AT00942860

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： STONER ERIC J ,  PETERSON MATTHEW J ,  KU YI-YIN ,  CINK RUSSELL D ,  COOPER ARTHUR J ,  DESHPANDE MAHENDRA N ,  GRIEME TIM ,  HAIGHT ANTHONY R ,  HILL DAVID R ,  HSU MARGARET CHI-PING ,  KING STEVEN A ,  LEANNA MARVIN R ,  LEE ELAINE C ,  MCLAUGHLIN MAUREEN A ,  MORTON HOWARD E ,  NAPIER JAMES J ,  PLATA DANIEL J ,  RAJE PRASAD S ,  RASMUSSEN MICHAEL ,  RILEY DAVID ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: A61P31/04 ,  C07B61/00 ,  C07H1/00 ,  C07H17/08 ,  A61K31/70

Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

公开(公告)号：DK0916646T3

公开(公告)日：2003-08-25

申请号：DK99101692

申请日：1994-09-26

Applicant: ABBOTT LAB

Inventor： KERDESKY FRANCIS A J ,  NORBECK DANIEL W ,  ALLEN MICHAEL S ,  LANGRIDGE DENTON C ,  MELCHER LAURA ,  RENO DANIEL S ,  SHAM HING LEUNG ,  LEANNA M ROBERT ,  MORTON HOWARD E ,  ROBBINS TIMOTHY A ,  STUK TIMOTHY L ,  LIJEWSKI-LINCH LINDA M ,  SCARPETTI DAVID ,  TIEN JIEN-HEH J ,  ZHAO CHEN ,  HAIGHT ANTHONY R ,  SOWIN THOMAS J

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：ES2156955T3

公开(公告)日：2001-08-01

申请号：ES95940008

申请日：1995-11-15

Applicant: ABBOTT LAB

Inventor： LEANNA M ROBERT ,  MORTON HOWARD E

IPC: B01J31/02 ,  C07B61/00 ,  C07D277/24 ,  C07D277/32

Abstract: A process for the preparation of 5-hydroxymethylthiazole comprises reacting a compound of the formula, with a carboxylic acid salt (optimally in the presence of a quaternary ammonium salt) and hydrolyzing the resulting ester. Subsequent dechlorination gives 5-hydroxymethylthiazole.