公开(公告)号：MX9709721A

公开(公告)日：1998-07-31

申请号：MX9709721

申请日：1997-12-05

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  LIN NAN-HORNG ,  RYTHER KEITH B ,  HE YUN

IPC: A61K31/00 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61P25/00 ,  A61P25/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Compuestos de éter eterocíclico de 3-pirodiloximetilo nivedosos que tienen la Formula (I), en donde * es un centro quiral, y n, X, R1, R2, A y B se definen específicamente, los cuales son utiles para controlar la transmicion sináptica química; composiciones farmacéuticas terapéuticamente efectivas de los mismos; y el uso de estas composiciones para controlar de una manera selectiva la transmision sináptica en mamiferos.

公开(公告)号：AU5804596A

公开(公告)日：1996-12-30

申请号：AU5804596

申请日：1996-05-28

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  LIN NAN-HORNG ,  RYTHER KEITH B ,  HE YUN

IPC: A61K31/00 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61P25/00 ,  A61P25/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R , R , A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：CA2223062A1

公开(公告)日：1996-12-19

申请号：CA2223062

申请日：1996-05-28

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  HE YUN ,  RYTHER KEITH B ,  HOLLADAY MARK W

IPC: A61K31/00 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61P25/00 ,  A61P25/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R1, R2, A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：PT100525A

公开(公告)日：1993-09-30

申请号：PT10052592

申请日：1992-05-28

Applicant: ABBOTT LAB

Inventor： GARVEY DAVID S ,  SHUE YOUE-KONG ,  ARNERIC STEPHEN P ,  LIN NAN-HORNG ,  CARRERA GEORGE M JR ,  HE YUN

IPC: A61K31/415 ,  A61K31/42 ,  A61K31/422 ,  A61K31/425 ,  A61K31/40 ,  A61K31/427 ,  A61K31/44 ,  A61P25/00 ,  A61P25/22 ,  A61P25/28 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D413/00 ,  C07D417/00

Abstract: Novel isoxazole isothiazole and pyrazole compounds of the formula: wherein A, R1, and R2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.

公开(公告)号：CA2273917C

公开(公告)日：2010-05-25

申请号：CA2273917

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ARNERIC STEPHEN P ,  BAI HAO ,  DART MICHAEL J ,  LIN NAN-HORNG ,  LYNCH JOHN K ,  OR YAT SUN ,  RYTHER KEITH B ,  SULLIVAN JAMES P ,  WASICAK JAMES T ,  EHRLICH PAUL P

IPC: A61P25/04 ,  C07D401/12 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D205/04 ,  C07D401/14 ,  C07D405/14

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：CA2285263C

公开(公告)日：2009-03-10

申请号：CA2285263

申请日：1998-04-10

Applicant: ABBOTT LAB

Inventor： DAANEN JEROME F ,  LI YIHONG ,  RYTHER KEITH B ,  HOLLADAY MARK W ,  ELLIOTT RICHARD L ,  LIN NAN-HORNG ,  WASICAK JAMES T ,  DART MICHAEL J ,  HE YUN

IPC: C07D491/048 ,  A61K31/4355 ,  A61K31/4365 ,  A61P25/00 ,  A61P43/00 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: Novel heterocyclic ether compounds having formula (I) wherein A, m, R, X, Y1 , Y2 and Y3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically- effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：MX2008015004A

公开(公告)日：2008-12-05

申请号：MX2008015004

申请日：2007-05-24

Applicant: ABBOTT LAB

Inventor： HEXAMER LAURA ,  WANG LE ,  TONG YUNSONG ,  DJURIC STEVAN W ,  XIA ZHIREN ,  ZHANG HENRY Q ,  PENNING THOMAS D ,  GIRANDA VINCENT L ,  DIEBOLD ROBERT B ,  LIN NAN-HORNG ,  MIYASHIRO JULIE M ,  PRZYTULINSKA MAGDALENA ,  SOWIN THOMAS ,  SULLIVAN GERARD ,  TAO ZHI-FU ,  VASUDEVAN ANIL ,  WOODS KEITH W

IPC: C07C225/20 ,  A61K31/132 ,  A61K31/505 ,  A61P35/00 ,  C07D249/14 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20

Abstract: Se describen compuestos que inhiben Plk1, composiciones que contienen los compuestos y métodos para tratar enfermedades utilizando los compuestos.

公开(公告)号：MY136181A

公开(公告)日：2008-08-29

申请号：MYPI20014939

申请日：2001-10-24

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WANG WEIBO ,  GWALTNEY STEPHEN L II ,  HASVOLD LISA A ,  LI QUN ,  LI TONGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: SUBSTITUTED IMIDAZOLES AND THIAZOLES HAVING THE FORMULA I ARE USEFUL FOR INHIBITING FARNESYLTRANSFERASE.ALSO DISCLOSED ARE FARNESYLTRANSFERASE-INHIBITING COMPOSITIONS AND METHODS OF INHIBITING FARNESYLTRANSFERASE IN A PATIENT .

公开(公告)号：CA2647592A1

公开(公告)日：2007-12-06

申请号：CA2647592

申请日：2007-05-24

Applicant: ABBOTT LAB

Inventor： PRZYTULINSKA MAGDALENA ,  VASUDEVAN ANIL ,  TONG YUNSONG ,  DIEBOLD ROBERT B ,  SOWIN THOMAS ,  LIN NAN-HORNG ,  XIA ZHIREN ,  PENNING THOMAS D ,  WOODS KEITH W ,  WANG LE ,  DJURIC STEVAN W ,  MIYASHIRO JULIE M ,  ZHANG HENRY Q ,  TAO ZHI-FU ,  SULLIVAN GERARD ,  HEXAMER LAURA ,  GIRANDA VINCENT L

IPC: C07C225/20 ,  A61K31/132 ,  A61K31/505 ,  A61P35/00 ,  C07D249/14 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20

Abstract: Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.

公开(公告)号：DE60128543D1

公开(公告)日：2007-07-05

申请号：DE60128543

申请日：2001-02-01

Applicant: ABBOTT LAB

Inventor： LIN NAN-HORNG ,  DONG LIMING

IPC: C07D213/65 ,  A61K31/44 ,  A61K31/444 ,  A61P25/00 ,  A61P25/04

Abstract: The present invention is directed to a series of substituted pyridine compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions containing these compounds. Preferred compounds are 3'-(5'- and/or 6'-substituted) pyridyl ethers.