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公开(公告)号：CA2313776A1
公开(公告)日：1999-06-24
申请号：CA2313776
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： DAVIDSON DONALD J , SHEPPARD GEORGE S , WOODS KEITH W , HENKIN JACK , MCCROSKEY RICHARD W
IPC: A61K31/53 , A61P27/02 , A61P35/00 , A61P43/00 , C07D251/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/10 , C07D407/04 , C07D407/10 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/10 , C07D417/04 , C07D453/02
Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
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公开(公告)号：CA2647592C
公开(公告)日：2014-01-28
申请号：CA2647592
申请日：2007-05-24
Applicant: ABBOTT LAB
Inventor： DIEBOLD ROBERT B , DJURIC STEVAN W , GIRANDA VINCENT L , HEXAMER LAURA , LIN NAN-HORNG , MIYASHIRO JULIE M , PENNING THOMAS D , PRZYTULINSKA MAGDALENA , SOWIN THOMAS , SULLIVAN GERARD , TAO ZHI-FU , TONG YUNSONG , VASUDEVAN ANIL , WANG LE , WOODS KEITH W , XIA ZHIREN , ZHANG HENRY Q
IPC: C07C225/20 , A61K31/132 , A61K31/505 , A61P35/00 , C07D249/14 , C07D277/64 , C07D285/06 , C07D333/20
Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, (see formula I) wherein X1, C1, and D1 are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting Plk1, Plk1 causes mitotic arrest, and inhibitors of Plk1 are cytotoxic agents that are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.
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公开(公告)号：UY33925A
公开(公告)日：2012-09-28
申请号：UY33925
申请日：2012-02-27
Applicant: ABBOTT LAB
Inventor： YUNSONG TONG , PENNING THOMAS D , FLORJANCIC ALAN P , JULIE MIYASHIRO , WOODS KEITH W
IPC: A61K31/519 , A61P35/00 , C07D487/04 , C07D487/14
Abstract: Compuestos de fórmula I,o sus sales farmacéuticamente aceptables, donde X, Y, Z, R3 y R4 tienen los valores que se definen en la memoria descriptiva. Composiciones que contienen dichos compuestos, que son útiles para inhibir las quinasas, tales como wee-1. Métodos para tratar enfermedades como el cáncer.
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公开(公告)号：MX2012000711A
公开(公告)日：2012-03-16
申请号：MX2012000711
申请日：2010-07-14
Applicant: ABBOTT LAB
Inventor： FLORJANCIC ALAN S , ZHU GUIDONG , PENNING THOMAS D , GANDHI VIRAJ B , TONG YUN-SONG , WOODS KEITH W , LAI CHUN-QIU , GONG JANE
IPC: C07D487/04 , A61P35/00
Abstract: La presente invención se refiere a compuestos de fórmula (I) o sales farmacéuticas aceptables (ver fórmula (I)) en donde R1a, R1b, X, e Y se definen en la descripción. La presente invención se refiere también a composiciones que contiene los compuestos los cuales son útiles para inhibir las cinasas tal como Cdc7 y métodos para tratar enfermedades tal como el cáncer.
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公开(公告)号：PT1037886E
公开(公告)日：2003-09-30
申请号：PT98963082
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： HENKIN JACK , DAVIDSON DONALD J , SHEPPARD GEORGE S , WOODS KEITH W , MCCROSKEY RICHARD W
IPC: A61K31/53 , A61P27/02 , A61P35/00 , A61P43/00 , C07D251/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/10 , C07D407/04 , C07D407/10 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/10 , C07D417/04 , C07D453/02
Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
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Patent Agency Ranking
公开(公告)号：AU2002353147A8
公开(公告)日：2003-06-30
申请号：AU2002353147
申请日：2002-12-12
Applicant: ABBOTT LAB
Inventor： HUTCHINS CHARLES , SONG XIAOHONG , LI QUN , LI TONGMEI , ROSENBERG SAUL H , STOLL VINCENT S , PACKARD GARRICK , GIRANDA VINCENT L , GONG JIANCHUN , DIEBOLD ROBERT , WOODS KEITH W , FISCHER JOHN P , THOMAS SHEELA A , ZHU GUI-DONG , ABRAMS JASON N , DINGES JURGEN , GANDHI VIRAJ
IPC: C07D239/48 , A61K31/416 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/502 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61P35/00 , A61P43/00 , C07D213/63 , C07D213/65 , C07D213/75 , C07D213/82 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/34 , C07D475/02 , C07D495/04 , C07D498/04
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公开(公告)号：AU2002353147A1
公开(公告)日：2003-06-30
申请号：AU2002353147
申请日：2002-12-12
Applicant: ABBOTT LAB
Inventor： LI QUN , WOODS KEITH W , ZHU GUI-DONG , FISCHER JOHN P , GONG JIANCHUN , LI TONGMEI , GANDHI VIRAJ , THOMAS SHEELA A , PACKARD GARRICK , SONG XIAOHONG , ABRAMS JASON N , DIEBOLD ROBERT , DINGES JURGEN , HUTCHINS CHARLES , STOLL VINCENT S , ROSENBERG SAUL H , GIRANDA VINCENT L
IPC: C07D239/48 , A61K31/416 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/502 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61P35/00 , A61P43/00 , C07D213/63 , C07D213/65 , C07D213/75 , C07D213/82 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/34 , C07D475/02 , C07D495/04 , C07D498/04
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公开(公告)号：HU0202076A2
公开(公告)日：2002-11-28
申请号：HU0202076
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： DAVIDSON DONALD J , HENKIN JACK , MCCROSKEY RICHARD W , SHEPPARD GEORGE S , WOODS KEITH W
IPC: A61K31/53 , A61P27/02 , A61P35/00 , A61P43/00 , C07D251/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/10 , C07D407/04 , C07D407/10 , C07D409/04 , C07D409/06 , C07D409/10 , C07D413/10 , C07D417/04 , C07D453/02
Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
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公开(公告)号：HK1045299A1
公开(公告)日：2002-11-22
申请号：HK02105330
申请日：2002-07-18
Applicant: ABBOTT LAB
Inventor： QUN LI , SHAM HING , STEINER BETH A , GWALTNEY STEPHEN L II , BARR KENNETH J , IMADE HOVIS M , ROSENBERG SAUL , WOODS KEITH W
IPC: A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12 , C07C
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公开(公告)号：AU5170900A
公开(公告)日：2000-12-18
申请号：AU5170900
申请日：2000-05-26
Applicant: ABBOTT LAB
Inventor： QUN LI , SHAM HING , STEINER BETH A , GWALTNEY STEPHEN L II , BARR KENNETH J , IMADE HOVIS M , ROSENBERG SAUL , WOODS KEITH W
IPC: A61K31/10 , A61K31/136 , A61K31/167 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/44 , A61K31/47 , A61K31/63 , A61P35/00 , A61P43/00 , C07C235/56 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , C07C311/46 , C07C317/18 , C07C317/22 , C07C317/28 , C07C317/36 , C07C317/46 , C07C323/20 , C07C323/29 , C07D209/08 , C07D209/30 , C07D209/32 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/38 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D319/18 , C07D403/12
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