公开(公告)号：ME03336B

公开(公告)日：2019-10-20

申请号：MEP201955

申请日：2014-03-12

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  DENG HONGBO ,  GU WENXIN ,  GIROUX SIMON ,  JACKSON KATRINA LEE ,  LI PAN ,  XU JINWANG ,  MAXWELL JOHN PATRICK ,  TANG QING ,  RONKIN STEVEN M ,  PIERCE ALBERT CHARLES ,  LAUFFER DAVID J ,  MORRIS MARK A ,  COURT JOHN J ,  COTTRELL KEVIN M ,  WAAL NATHAN D

IPC: A61K31/517 ,  A61P35/00 ,  C07D403/12 ,  C07D405/12 ,  C07D413/04 ,  C07D417/12 ,  C07D491/052

公开(公告)号：HRP20190373T1

公开(公告)日：2019-04-19

申请号：HRP20190373

申请日：2019-02-26

Applicant: VERTEX PHARMA

Inventor： MAXWELL JOHN PATRICK ,  CHARIFSON PAUL S ,  TANG QING ,  RONKIN STEVEN M ,  JACKSON KATRINA LEE ,  PIERCE ALBERT CHARLES ,  LAUFFER DAVID J ,  LI PAN ,  GIROUX SIMON ,  XU JINWANG ,  MORRIS MARK A ,  COURT JOHN J ,  COTTRELL KEVIN M ,  DENG HONGBO ,  WAAL NATHAN D ,  GU WENXIN

IPC: C07D403/12 ,  A61K31/517 ,  A61P35/00 ,  C07D405/12 ,  C07D413/04 ,  C07D417/12 ,  C07D491/052

公开(公告)号：AU2014244555B2

公开(公告)日：2018-06-28

申请号：AU2014244555

申请日：2014-03-12

Applicant: VERTEX PHARMA

Inventor： MAXWELL JOHN PATRICK ,  CHARIFSON PAUL S ,  TANG QING ,  RONKIN STEVEN M ,  JACKSON KATRINA LEE ,  PIERCE ALBERT CHARLES ,  LAUFFER DAVID J ,  LI PAN ,  GIROUX SIMON ,  XU JINWANG ,  COTTRELL KEVIN M ,  MORRIS MARK A ,  WAAL NATHAN D ,  COURT JOHN J ,  GU WENXIN ,  DENG HONGBO

IPC: C07D403/12 ,  A61K31/517 ,  A61P35/00 ,  C07D405/12 ,  C07D413/04 ,  C07D417/12 ,  C07D491/052

Abstract: The present invention relates to compounds (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：CA2764177C

公开(公告)日：2018-06-05

申请号：CA2764177

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: C07D471/04 ,  A61K31/506 ,  A61P31/16

Abstract: Methods of inhibiting the replica-tion of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating in-fluenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically ac-ceptable salt thereof, wherein the values of Struc-tural Formula (IA) are as described herein. A phar-maceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically ac-ceptable carrier, adjuvant or vehicle.

公开(公告)号：ES2604667T3

公开(公告)日：2017-03-08

申请号：ES10726760

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL ,  BANDARAGE UPUL ,  BETHIEL RANDY ,  COURT JOHN ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN ,  KENNEDY JOSEPH ,  LEDEBOER MARK ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  GERMANN URSULA ,  JONES STEVEN ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: A61K31/506 ,  A61P31/16

Abstract: Un compuesto de la fórmula:**Fórmula** o una sal farmacéuticamente aceptable del mismo.

公开(公告)号：HRP20161577T1

公开(公告)日：2017-01-27

申请号：HRP20161577

申请日：2016-11-28

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  GERMANN URSULA A ,  JONES STEVEN ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: A61K31/506 ,  A61P31/16

公开(公告)号：EA025276B1

公开(公告)日：2016-12-30

申请号：EA201270032

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A

IPC: A61K31/506 ,  A61P31/16

Abstract: Изобретениеотноситсяк новомусоединению, аименно - к (2S,3S)-3-((2-(5-фтор-1Н-пирроло[2,3-b]пиридин-3-ил)-5-фторпиримидин-4-ил)амино)бицикло[2,2,2]октан-2-карбоновойкислоте, обладающейсвойствомингибированиярепликациивирусагриппаА вбиологическомобразцеилиу пациента, уменьшенияколичествавирусовгриппав биологическомобразцеилиу пациента. Изобретениетакжеотноситсяк фармацевтическойкомпозиции, содержащейэффективноеколичествотакогосоединенияилиегофармацевтическиприемлемойсолии фармацевтическиприемлемыйноситель, наполнительилиразбавитель, ипредназначенодлясниженияколичествавирусовгриппаА. ТакжераскрываетсяспособсниженияколичествавирусовгриппаА в in vitro биологическомобразце, включающийвведениев указанныйбиологическийобразецэффективногоколичестваданногосоединения.

公开(公告)号：CA2988306A1

公开(公告)日：2016-12-08

申请号：CA2988306

申请日：2016-06-03

Applicant: VERTEX PHARMA

Inventor： DAVIES ROBERT J ,  CAO JINGRONG ,  COCKERILL MEGHAN ELISE ,  COLLIER PHILIP NOEL ,  DENINNO MICHAEL PAUL ,  DOYLE ELISABETH ,  FRANTZ JAMES DANIEL ,  GAO HUAI ,  GOLDMAN BRIAN ANTHONY ,  GREY RONALD LEE ,  GRILLOT ANNE-LAURE ,  GU WENXIN ,  HENDERSON JAMES A ,  KRAUSS RAUL EDUARDO ,  KOLPAK ADRIANNE LYNN ,  LIAO YUSHENG ,  MAGAVI SANJAY SHIVAYOGI ,  MALTAIS FRANCOIS ,  MESSERSMITH DAVID ,  PIERCE ALBERT CHARLES ,  PEROLA EMANUELE ,  RYU ELIZABETH JIN-SUN ,  SYKEN JOSHUA ,  WANG JIAN

IPC: A61K31/4196 ,  A61P25/28 ,  C07D249/14 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14

Abstract: The invention relates to triazole compounds of formula I and I' or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

公开(公告)号：AU2016228190A1

公开(公告)日：2016-10-27

申请号：AU2016228190

申请日：2016-09-14

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DAVIES IOANA ,  DENG HONGBO ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG

IPC: C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61P31/16

Abstract: Abstract The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof and methods of inhibiting the replication of influenza viruses and/or reducing the amount of influenza viruses in a biological sample or patient comprising administering an effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof to the biological sample or patient. The present invention further provides for pharmaceutical compositions comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. x2 "'N \Z1Z" Formula I

公开(公告)号：HK1215530A1

公开(公告)日：2016-09-02

申请号：HK16103417

申请日：2012-10-12

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL P ,  CLARK MICHAEL P MP ,  BANDARAGE UPUL K UK ,  BETHIEL RANDY S RS ,  COURT JOHN J JJ ,  DENG HONGBO ,  DRUTU IOANA I ,  DUFFY JOHN P JP ,  FARMER LUC L ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H DH ,  KENNEDY JOSEPH M JM ,  LEDEBOER MARK W MW ,  LEDFORD BRIAN B ,  MALTAIS FRANCOIS F ,  PEROLA EMANUELE E ,  WANG TIANSHENG ,  WANNAMAKER M WOODS MW ,  GERMANN URSULA A UA ,  JONES STEVEN S ,  JIANG MIN ,  LIN CHAO ,  ZHOU YI ,  BYRN RANDAL R ,  SALITURO FRANCESCO G FG ,  ANN DAK-YEE KWONG

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101