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    트리클로산 유도체 및 이를 함유하는 항생제
    57.
    发明公开
    트리클로산 유도체 및 이를 함유하는 항생제 有权
    TRICLOSAN衍生物和含有它的抗生素

    公开(公告)号：KR1020110058557A

    公开(公告)日：2011-06-01

    申请号：KR1020090115388

    申请日：2009-11-26

    Applicant: 한국과학기술연구원

    Inventor： 금교창 ,  김은경 ,  배애님 ,  서선희 ,  홍승곤 ,  바타라이디팍 ,  슬린코인나 ,  조상래

    IPC: C07C235/32 ,  A61K31/165 ,  A01N37/18 ,  C07C231/02

    CPC classification number: Y02A50/473 ,  Y02A50/481

    Abstract: PURPOSE: A triclosan derivative is provided to inhibit the activity of a FabI strain and to enable use as an antimicrobial agent for tuberculous bacillus including introspection strains and various strains. CONSTITUTION: A triclosan derivative is represented by chemical formula 1. In chemical formula 1, n is an integer of 1-6; X is primary or secondary amine, C1-C4 alkylamine, C1-C6 alkylamine including at least one hetero atom selected from oxygen and nitrogen, C5-C10 heterocyclic amine including at least one hetero atom selected from oxygen and nitrogen, phenylamine including at least one hydroxy group, phenylamine in which C1-C4 alkyl ester group or carboxylic acid is substituted, and 6-membered heteroarylamine including at least nitrogen.

    Abstract translation: 目的：提供三氯生衍生物以抑制FabI菌株的活性，并且可用作结核菌杆菌的抗微生物剂，包括内省菌株和各种菌株。 构成：三氯生衍生物由化学式1表示。在化学式1中，n为1-6的整数; X是伯或仲胺，C 1 -C 4烷基胺，包括至少一个选自氧和氮的杂原子的C 1 -C 6烷基胺，包括至少一个选自氧和氮的杂原子的C 5 -C 10杂环胺，包括至少一个 羟基，其中C 1 -C 4烷基酯基或羧酸被取代的苯胺和至少包含氮的6元杂芳基胺。

    칼슘이온 채널 조절제로서 유효한 피라졸릴메틸아민-피페라진 유도체와 이의 제조방법
    58.
    发明公开
    칼슘이온 채널 조절제로서 유효한 피라졸릴메틸아민-피페라진 유도체와 이의 제조방법 失效
    新型吡咯烷基胺化合物作为钙通道调节剂及其制备方法

    公开(公告)号：KR1020100042111A

    公开(公告)日：2010-04-23

    申请号：KR1020080101249

    申请日：2008-10-15

    Applicant: 한국과학기술연구원

    Inventor： 남길수 ,  최경일 ,  김혜란 ,  서선희 ,  백이연 ,  김윤지 ,  신희섭 ,  김동진 ,  배애님 ,  정혜진 ,  추현아 ,  임혜원 ,  조용서 ,  노은주 ,  금교창 ,  최기현 ,  신계정 ,  한호규 ,  정찬성 ,  이재균 ,  남기달 ,  강용구 ,  김영수 ,  박웅서 ,  김은경 ,  김기선 ,  정혜선 ,  신동윤 ,  송치만

    IPC: C07D403/12 ,  C07D403/10

    CPC classification number: C07D231/12 ,  C07D401/04 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12

    Abstract: PURPOSE: A pyrazolylmethylamine-piperazine derivative which is effective as a calcium ion channel modulator is provided to ensure effective activation as an T-type calcium ion channel antagonist and to use as an agent for preventing and treating brain diseases, heart diseases and pain diseases. CONSTITUTION: A pyrazolylmethylamine-peperazine derivative is denoted by chemical formula 1. A pharmaceutical composition for preventing and treating brain diseases, heart diseases or pain diseases by T-type calcium ion channel antagonism contains the pyrazolylmethylamine-peperazine derivative of chemical formula 1 or its pharmaceutically acceptable salt an active ingredient. The brain disease is epilepsy, depression, Parkison's disease, dementia or somnipathy. The heart disease is hypertension, cardiac arrhythmia, myocardial infarction, or congestive failure. The pain disease is chronic pain, acute pain, or neurogenic pain. The pyrazolylmethylamine-peperazine derivative is prepared by binding pyrazolylmethylamine compound of chemical formula 3 with piperazine acetyl halide compound of chemical formula 2.

    Abstract translation: 目的：提供作为钙离子通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物，以确保作为T型钙离子通道拮抗剂的有效活化，并用作预防和治疗脑疾病，心脏病和疼痛疾病的药剂。 构成：吡唑基甲胺 - 哌嗪衍生物由化学式1表示。用于通过T型钙离子通道拮抗作用预防和治疗脑疾病，心脏病或疼痛疾病的药物组合物含有化学式1的吡唑基甲基 - 哌嗪衍生物或其药学上可接受的盐 可接受的盐为活性成分。 脑疾病是癫痫，抑郁症，帕金森病，痴呆或嗜睡。 心脏病是高血压，心律失常，心肌梗死或充血性衰竭。 疼痛疾病是慢性疼痛，急性疼痛或神经源性疼痛。 通过将化学式3的吡唑基甲基胺化合物与化学式2的哌嗪乙酰卤化合物结合，制备吡唑基甲胺 - 哌嗪衍生物。

    퀴놀린 카복실산 아마이드 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로함유하는 항균 조성물
    59.
    发明公开
    퀴놀린 카복실산 아마이드 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로함유하는 항균 조성물 有权
    喹啉 - 羧酸 - 酰胺衍生物或其药学上可接受的盐，其制备方法和含有它们作为活性成分的抗生素组合物

    公开(公告)号：KR1020090063869A

    公开(公告)日：2009-06-18

    申请号：KR1020070131388

    申请日：2007-12-14

    Applicant: 한국과학기술연구원 ,  재단법인서울대학교산학협력재단

    Inventor： 신계정 ,  문지연 ,  배애님 ,  김은경 ,  서선희

    IPC: C07D215/38 ,  C07D215/48 ,  C07D401/12 ,  A61K31/47

    Abstract: An antibacterial composition containing a quinoline-carboxylic acid amide derivative or its pharmaceutically allowable salt is provided to suppress bacteria proliferation by inhibiting Fab I activation which is related to the last step of fatty acid biosynthesis. An antibacterial composition comprises a quinoline-carboxylic acid-amide derivative of the chemical formula 1 or its pharmaceutically allowable salt. A method for manufacturing the quinoline-carboxylic acid-amide derivative comprises: a step of reacting an aldehyde group of the chemical formula 2 with a phosphate, whose cyano group is substituted, to obtain a compound of the chemical formula 3; a step of performing intramolecular cyclization of the compound of the chemical formula 3 to obtain a quinoline compound of the chemical formula 4; a step of reacting the compound of the chemical formula 4 with a secondary amine to obtain a compound of the chemical formula 1(1a); and a step of reacting the compound of the chemical formula 1(1a) with an isocyanate to obtain the compound of the chemical formula 1.

    Abstract translation: 提供含有喹啉羧酸酰胺衍生物或其药学上可允许的盐的抗菌组合物，通过抑制与脂肪酸生物合成的最后步骤相关的Fab I激活来抑制细菌增殖。 抗菌组合物包含化学式1的喹啉羧酸 - 酰胺衍生物或其药学上可允许的盐。 喹啉羧酸 - 酰胺衍生物的制造方法包括：使化学式2的醛基与氰基取代的磷酸酯反应，得到化学式3的化合物的工序; 化学式3的化合物进行分子内环化的步骤，得到化学式4的喹啉化合物; 使化学式4的化合物与仲胺反应以获得化学式1（1a）的化合物的步骤; 以及使化学式1（1a）的化合物与异氰酸酯反应以获得化学式1的化合物的步骤。

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