公开(公告)号：CA2423103C

公开(公告)日：2010-08-24

申请号：CA2423103

申请日：2001-09-20

Applicant: ABBOTT LAB

Inventor： MCCLELLAN WILLIAM ,  OOST THORSTEN ,  BRUNCKO MILAN ,  WANG XILU ,  AUGERI DAVID J ,  BAUMEISTER STEVEN A ,  DICKMAN DANIEL A ,  DING HONG ,  DINGES JURGEN ,  FESIK STEPHEN W ,  HAJDUK PHILIP J ,  KUNZER AARON R ,  NETTESHEIM DAVID G ,  PETROS ANDREW M ,  ROSENBERG SAUL H ,  SHEN WANG ,  THOMAS SHEELA A ,  WENDT MICHAEL D

IPC: C07C311/51 ,  A61K31/18 ,  A61K31/428 ,  A61K31/63 ,  A61K31/635 ,  A61P9/10 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/02 ,  C07C311/46 ,  C07C317/28 ,  C07C323/12 ,  C07C323/17 ,  C07C323/25 ,  C07C323/30 ,  C07C323/37 ,  C07C323/43 ,  C07C323/44 ,  C07C323/48 ,  C07C323/58 ,  C07C323/60 ,  C07D203/10 ,  C07D205/04 ,  C07D205/12 ,  C07D207/09 ,  C07D207/24 ,  C07D207/40 ,  C07D207/404 ,  C07D209/08 ,  C07D209/52 ,  C07D209/54 ,  C07D209/96 ,  C07D211/14 ,  C07D211/44 ,  C07D211/70 ,  C07D211/74 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D213/69 ,  C07D213/70 ,  C07D213/71 ,  C07D215/14 ,  C07D215/22 ,  C07D215/227 ,  C07D215/38 ,  C07D215/48 ,  C07D217/04 ,  C07D221/20 ,  C07D231/12 ,  C07D233/60 ,  C07D235/08 ,  C07D235/26 ,  C07D241/08 ,  C07D241/16 ,  C07D249/04 ,  C07D263/32 ,  C07D263/56 ,  C07D263/58 ,  C07D277/62 ,  C07D277/64 ,  C07D295/13 ,  C07D295/14 ,  C07D295/155 ,  C07D295/16 ,  C07D295/185 ,  C07D295/20 ,  C07D295/205 ,  C07D295/215 ,  C07D295/26 ,  C07D307/14 ,  C07D317/54 ,  C07D317/58 ,  C07D333/28 ,  C07D333/68 ,  C07D333/70 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/06 ,  C07D417/12 ,  C07D451/02 ,  C07D491/107

Abstract: N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.

公开(公告)号：CA2747170A1

公开(公告)日：2010-07-15

申请号：CA2747170

申请日：2009-12-17

Applicant: ABBOTT LAB ,  GENENTECH INC ,  INST MEDICAL W & E HALL

Inventor： BAELL JONATHON BAYLDON ,  BUI CHINH THIEN ,  COLMAN PETER ,  CZABOTAR PETER ,  DUDLEY DANETTE A ,  FAIRBROTHER WAYNE J ,  FLYGARE JOHN A ,  LASSENE GUILLAUME LAURENT ,  NDUBAKU CHUDI ,  NIKOLAKOPOULOS GEORGE ,  SLEEBS BRAD EDMUND ,  SMITH BRIAN JOHN ,  WATSON KEITH GEOFFREY ,  ELMORE STEVEN W ,  HASVOLD LISA A ,  PETROS ANDREW M ,  SOUERS ANDREW J ,  TAO ZHI-FU ,  WANG LE ,  WANG XILU ,  DESHAYES KURT

IPC: A01N43/00

Abstract: In one aspect, the present invention provides for a compound of Formula I; in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.

公开(公告)号：CA2744708A1

公开(公告)日：2010-06-10

申请号：CA2744708

申请日：2009-12-04

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DAI YUJIA ,  DING HONG ,  DOHERTY GEORGE A ,  ELMORE STEVEN W ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON R ,  MANTEI ROBERT A ,  MCCLELLAN WILLIAM J ,  PARK CHANG H ,  PARK CHEOL-MIN ,  PETROS ANDREW M ,  SONG XIAOHONG ,  SOUERS ANDREW J ,  SULLIVAN GERARD M ,  TAO ZHI-FU ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WENDT MICHAEL D

IPC: C07D405/12 ,  A61K31/395 ,  A61K31/496 ,  A61P35/00 ,  C07D295/04 ,  C07D309/00 ,  C07D401/00 ,  C07D403/12

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：NZ547160A

公开(公告)日：2009-11-27

申请号：NZ54716004

申请日：2004-11-12

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  ELMORE STEVEN ,  KUNZER AARON R ,  LYNCH CHRISTOPHER L ,  MCCLELLAN WILLIAM ,  PARK CHEOL-MIN ,  PETROS ANDREW ,  SONG XIAOHONG ,  WANG XILU ,  TU NOAH ,  WENDT MICHAEL D

IPC: A61K31/635 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61P35/00 ,  C07C311/51 ,  C07C323/25 ,  C07D205/04 ,  C07D207/16 ,  C07D211/44 ,  C07D211/46 ,  C07D211/60 ,  C07D211/74 ,  C07D213/70 ,  C07D213/75 ,  C07D233/06 ,  C07D233/84 ,  C07D239/06 ,  C07D263/58 ,  C07D277/36 ,  C07D277/74 ,  C07D295/13 ,  C07D295/14 ,  C07D295/155 ,  C07D295/192 ,  C07D307/64 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D409/12 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D487/04 ,  C07D487/08

Abstract: Disclosed are N-acylsulfonamide compounds of formula (I), wherein the substituents are as defined in the specification, which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases such as bladder cancer, brain cancer, breast cancer, bone marrow cancer, cervical cancer, chronic lymphocytic leukemia, colorectal cancer, esophageal cancer, hepatocellular cancer, lymphoblastic leukemia, follicular lymphoma, lymphoid malignancies of T-cell or B-cell origin, melanoma, myelogenous leukemia, myeloma, oral cancer, ovarian cancer, non-small cell lung cancer, prostate cancer, small cell lung cancer or spleen cancer.

公开(公告)号：DOP2009000246A

公开(公告)日：2009-11-15

申请号：DO2009000246

申请日：2009-10-14

Applicant: ABBOTT LAB

Inventor： ELMORE STEVEN W ,  SOUERS ANDREW J ,  BRUNCKO MILAN ,  SONG XIAOHONG ,  WANG XILU ,  HASVOLD LISA A ,  WANG LE ,  KUNZER AARON R ,  PARK CHEOL-MIN ,  WENDT MICHAEL D ,  TAO ZHI-FU ,  MADAR DAVID

IPC: C07D209/34

Abstract: Compuestos que inhiben la actividad de la proteína antiapoptóticas Mcl-1, composiciones que contienen los compuestos, y métodos para tratar enfermedades relacionadas con la sobreexpresion o falta de regulación de la proteína Mcl-1

公开(公告)号：MY136181A

公开(公告)日：2008-08-29

申请号：MYPI20014939

申请日：2001-10-24

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WANG WEIBO ,  GWALTNEY STEPHEN L II ,  HASVOLD LISA A ,  LI QUN ,  LI TONGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: SUBSTITUTED IMIDAZOLES AND THIAZOLES HAVING THE FORMULA I ARE USEFUL FOR INHIBITING FARNESYLTRANSFERASE.ALSO DISCLOSED ARE FARNESYLTRANSFERASE-INHIBITING COMPOSITIONS AND METHODS OF INHIBITING FARNESYLTRANSFERASE IN A PATIENT .

公开(公告)号：DE60316128D1

公开(公告)日：2007-10-18

申请号：DE60316128

申请日：2003-03-14

Applicant: ABBOTT LAB

Inventor： ELMORE STEVEN W ,  PARK CHEOL-MIN ,  WANG XILU

IPC: C07D295/20 ,  A61K31/4418 ,  A61K31/4422 ,  A61K31/495 ,  A61K31/5377 ,  A61P25/18 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07D211/16 ,  C07D211/18 ,  C07D211/26 ,  C07D211/58 ,  C07D211/82 ,  C07D211/90 ,  C07D295/215

公开(公告)号：CA2606147A1

公开(公告)日：2007-04-12

申请号：CA2606147

申请日：2006-05-12

Applicant: ABBOTT LAB

Inventor： WANG XILU ,  ELMORE STEVEN W ,  SONG XIAOHONG ,  KUNZER AARON R ,  LYNCH CHRISTOPHER L ,  PARK CHEOL MIN ,  MCCELLAN WILLIAM J ,  BRUNCKO MILAN ,  DING HONG

IPC: C07D295/14 ,  A61K31/496 ,  A61P35/00 ,  C07D487/08 ,  C07D491/08

Abstract: Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.

公开(公告)号：DK1339695T3

公开(公告)日：2006-07-31

申请号：DK01273519

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY STEPHEN L II ,  LI TOMGMEI ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  TONG YUNSONG ,  WANG GARY T ,  WANG XILU ,  WANG WEIBO ,  HASVOLD LISA A ,  LI QUN ,  LIN NAN-HORNG ,  SHAM HING L ,  SULLIVAN GERARD M ,  WANG LE

IPC: C07D233/64 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：CA2546101A1

公开(公告)日：2005-06-02

申请号：CA2546101

申请日：2004-11-12

Applicant: ABBOTT LAB

Inventor： WANG XILU ,  SONG XIAOHONG ,  MCCLELLAN WILLIAM ,  PARK CHEOL-MIN ,  LYNCH CHRISTOPHER L ,  PETROS ANDREW ,  TU NOAH ,  WENDT MICHAEL D ,  BRUNCKO MILAN ,  DING HONG ,  KUNZER AARON R ,  ELMORE STEVEN

IPC: C07D295/14 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/635 ,  A61P35/00 ,  C07C311/51 ,  C07C323/25 ,  C07D205/04 ,  C07D207/16 ,  C07D211/44 ,  C07D211/46 ,  C07D211/60 ,  C07D211/74 ,  C07D213/70 ,  C07D213/75 ,  C07D233/06 ,  C07D233/84 ,  C07D239/06 ,  C07D263/58 ,  C07D277/36 ,  C07D277/74 ,  C07D295/13 ,  C07D295/155 ,  C07D295/192 ,  C07D307/64 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D409/12 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D487/04 ,  C07D487/08

Abstract: Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti - apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein famil y member.