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公开(公告)号：DE69427361T2
公开(公告)日：2002-04-18
申请号：DE69427361
申请日：1994-08-30
Applicant: ABBOTT LAB
Inventor： LIN NAN-HORNG , HE YUN , ELLIOTT L , CHORGHADE S , WITTENBERGER J , BUNNELLE H , NARAYANAN A , SINGAM PULLA R , ESCH K , BEER O , WITZIG C , HERZIG C , RAO V RAMA
IPC: C07D413/04 , C07D207/09
Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.
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公开(公告)号：AT210656T
公开(公告)日：2001-12-15
申请号：AT93923826
申请日：1993-10-08
Applicant: ABBOTT LAB
Inventor： ABREO MELWYN A , GUNN DAVID E , LIN NAN-HORNG , ELLIOTT RICHARD L , GARVEY DAVID S , LEBOLD SUZANNE A , WASICAK JAMES T
IPC: A61K31/427 , A61K31/439 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/497 , A61K31/501 , A61P25/00 , A61P25/28 , C07D401/12 , C07D403/12 , C07D411/12 , C07D417/12 , C07D471/08 , C07D487/04 , A61K31/425 , A61K31/445 , A61K31/495
Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.
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83.发明专利
公开(公告)号：GR3036387T3
公开(公告)日：2001-11-30
申请号：GR20010401243
申请日：2001-08-14
Applicant: ABBOTT LAB
Inventor： LIN NAN-HORNG , HE YUN , ELLIOTT RICHARD L , CHORGHADE MUKUND S , WITTENBERGER STEVEN J , BUNNELLE WILLIAM H , NARAYANAN BIKSHANDAR A , SINGAM PULLA R , ESCH THOMAS K J , BEER DIETER O , WITZIG CHRISTIAN C , HERZIG THOMAS C , RAO ALLA V RAMA
IPC: C07D413/04 , C07D207/09
Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.
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公开(公告)号：CA2407093A1
公开(公告)日：2001-11-01
申请号：CA2407093
申请日：2001-04-25
Applicant: ABBOTT LAB
Inventor： GWALTNEY STEPHEN L II , SULLIVAN GERALD M , WANG GARY T , FAKHOURY STEPHEN A , HUTCHINS CHARLES W , LI QUN , SHAM HING L , HASVOLD LISA A , WANG XILU , LIN NAN-HORNG , CURTIN MICHAEL L , WANG WEI-BO , O'CONNOR STEPHEN J , JENNINGS NELSON LISSA TAKA
IPC: C07D233/22 , A61K31/381 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/4245 , A61K31/426 , A61K31/4406 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61P17/06 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D213/30 , C07D213/36 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85 , C07D231/12 , C07D233/26 , C07D233/54 , C07D249/04 , C07D249/08 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/16 , C07D333/24 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D409/10 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/10 , C07D417/12 , A61K31/33 , C07D213/74 , C07D409/12
Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhib it farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
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公开(公告)号：ES2153360T3
公开(公告)日：2001-03-01
申请号：ES92912971
申请日：1992-05-28
Applicant: ABBOTT LAB
Inventor： GARVEY DAVID S , CARRERA GEORGE M JR , ARNERIC STEPHEN P , SHUE YOUE-KONG , LIN NAN-HORNG , HE YUN
IPC: A61K31/40 , A61K31/415 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/44 , A61P25/00 , A61P25/22 , A61P25/28 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: Novel isoxazole isothiazole and pyrazole compounds of the formula: wherein A, R1, and R2 are specifically defined, or pharmaceutical salts thereof, are selective and potent cholinergic ligands at neuronal nicotinic receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function, as well as in the treatment of alcohol intoxication and petit real absence epilepsy.
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Patent Agency Ranking
公开(公告)号：BG103556A
公开(公告)日：2000-06-30
申请号：BG10355699
申请日：1999-07-06
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT S , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRICH PAUL P
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
Abstract: The invention relates to a method for pain control in mammals, including humans where selected compounds are applied with the formula or their pharmaceutically acceptable salts, the meaning of the substituents being listed in the description. The invention also relates to selected (R) and (S) compounds with formula I which can be used as analgetics, as means for the prevention of dying of neuron cells and as antiphlogistic preparations. 38 claims, 7 figures
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公开(公告)号：CA2109585C
公开(公告)日：2000-02-15
申请号：CA2109585
申请日：1992-05-28
Applicant: ABBOTT LAB
Inventor： GARVEY DAVID S , CARRERA GEORGE M JR , ARNERIC STEPHEN P , SHUE YOUE-KONG , LIN NAN-HORNG , HE YUN
IPC: A61K31/40 , A61K31/415 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/44 , A61P25/00 , A61P25/22 , A61P25/28 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/41
Abstract: Selective and potent nicotinic agonists of formula (1), or pharmaceuticallyacceptable salts thereof, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.
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公开(公告)号：PL333920A1
公开(公告)日：2000-01-31
申请号：PL33392097
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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公开(公告)号：CZ204899A3
公开(公告)日：2000-01-12
申请号：CZ204899
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHAN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B
IPC: A61K31/44 , A61P25/04 , C07D205/04 , C07D401/12
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公开(公告)号：TR9901904T2
公开(公告)日：1999-10-21
申请号：TR9901904
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
CPC classification number: C07D401/12 , A61K31/4427 , A61K31/485 , C07D205/04 , Y02P20/55 , A61K2300/00
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