公开(公告)号：CA2633653A1

公开(公告)日：2007-07-05

申请号：CA2633653

申请日：2006-12-21

Applicant: VERTEX PHARMA

Inventor： STAMOS DEAN ,  ZHOU JINGLAN ,  ARUMUGAM VIJAYALAKSMI ,  GUTIERREZ COREY ,  LEHSTEN DANIELLE ,  KNOLL TARA ,  ZIMMERMANN NICOLE ,  WHITNEY TARA ,  MARTINBOROUGH ESTHER ,  TERMIN ANDREAS ,  NEUBERT TIMOTHY ,  KAWATKAR AARTI ,  WILSON DEAN ,  SHETH URVI ,  FANNING LEV T D

IPC: C07D239/42 ,  A61K31/506 ,  A61P25/04 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  C07D491/10

Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：BRPI0919930A2

公开(公告)日：2016-02-16

申请号：BRPI0919930

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： HURLEY DENNIS ,  GOOR FREDERICK VAN ,  BINCH HAYLEY ,  FANNING LEV T D ,  BOTFIELD MARTYN ,  NUMA MEHDI MICHEL DJAMEL ,  GROOTENHUIS PETER D J ,  SHETH URVI ,  YANG XIAOQING

IPC: C07D451/02 ,  A61K31/439 ,  A61P11/00

公开(公告)号：AU2008298545B2

公开(公告)日：2013-12-12

申请号：AU2008298545

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： HAZLEWOOD ANNA ,  HADIDA RUAH SARA S ,  BINCH HAYLEY ,  FANNING LEV T D ,  GROOTENHUIS PETER D J ,  ZHOU JINGLAN

IPC: C07D471/04 ,  A61K31/4375 ,  A61P3/00

Abstract: The present invention relates to modulators of ATP-B inding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：AU2008335031B2

公开(公告)日：2013-11-28

申请号：AU2008335031

申请日：2008-12-12

Applicant: VERTEX PHARMA

Inventor： GROOTENHUIS PETER D J ,  PIERCE ALBERT ,  BINCH HAYLEY ,  FANNING LEV T D

IPC: C07D487/04 ,  A61K31/517 ,  A61K31/519 ,  A61P1/18 ,  A61P3/06 ,  A61P25/16 ,  A61P25/28

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof of formula (I), including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using such CFTR modulators.

公开(公告)号：ZA201103411B

公开(公告)日：2012-09-26

申请号：ZA201103411

申请日：2011-05-10

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  KAY DAVID ,  O'DONNELL MICHAEL ,  KNEGTEL RONALD ,  MACCORMICK SOMHAIRLE ,  PINDER JOANNE ,  VIRANI ANISA ,  YOUNG STEPHEN ,  BINCH HAYLEY ,  CLEVELAND THOMAS ,  FANNING LEV T D ,  HURLEY DENNIS J ,  JOSHI PRAMOD ,  SHETH URVI ,  SILINA ALINA ,  REAPER PHILIP MICHAEL

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

公开(公告)号：NZ568393A

公开(公告)日：2011-08-26

申请号：NZ56839306

申请日：2006-11-13

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN ,  FANNING LEV T D ,  KRENITSKY PAUL ,  TERMIN ANDREAS ,  JOSHI PRAMOD ,  SHETH URVI

IPC: C07D403/04 ,  A61K31/505 ,  A61P29/00

Abstract: Disclosed are substituted quinazoline compound of formula (IA) or formula (IB), wherein the variables are as defined in the specification, which have the activity as inhibitors of voltage-gate sodium channels, and are suitable for use in the treatment of disease, condition, or disorder that is implicated in the activation or hyperactivity of voltage-gated sodium channels, wherein the disease, condition, or disorder is selected from acute, chronic, neuropathic, or inflammatory pain, arthritis, migraine, cluster headaches, trigeminal neuralgia, herpetic neuralgia, general neuralgias, epilepsy or epilepsy conditions, neurodegenerative disorders, psychiatric disorders such as anxiety and depression, myotonia, arrhythmia, movement disorders, neuroendocrine disorders, ataxia, multiple sclerosis, irritable bowel syndrome, incontinence, visceral pain, osteoarthritis pain, postherpetic neuralgia, diabetic neuropathy, radicular pain, sciatica, back pain, head or neck pain, severe or intractable pain, nociceptive pain, breakthrough pain, postsurgical pain, or cancer pain.

公开(公告)号：NZ569694A

公开(公告)日：2011-06-30

申请号：NZ56969406

申请日：2006-12-21

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN ,  FANNING LEV T D ,  SHETH URVI ,  MARTINBOROUGH ESTHER ,  TERMIN ANDREAS ,  NEUBERT TIMOTHY ,  ZIMMERMANN NICOLE ,  KNOLL TARA ,  WHITNEY TARA ,  KAWATKAR AARTI ,  LEHSTEN DANIELLE ,  STAMOS DEAN ,  ZHOU JINGLAN ,  ARUMUGAM VIJAYALAKSMI ,  GUTIERREZ COREY

IPC: C07D239/42 ,  A61K31/506 ,  A61P25/04 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12 ,  C07D471/10 ,  C07D491/10

Abstract: Disclosed are heterocyclic derivatives represented by general formula (I), or pharmaceutically acceptable salts thereof, wherein x and y are each independently 1 or 2 and x + y is 3, and the substituents are defined within the specification. Also disclosed is the use of the compounds of formula (I) for treating pain.

公开(公告)号：AU2009313198A1

公开(公告)日：2011-06-30

申请号：AU2009313198

申请日：2009-11-10

Applicant: VERTEX PHARMA

Inventor： JEAN-DAMIEN CHARRIER ,  STEVEN DURRANT ,  DAVID KAY ,  MICHAEL O'DONNELL ,  RONALD KNEGTEL ,  SOMHAIRLE MACCORMICK ,  JOANNE PINDER ,  ANISA VIRANI ,  STEPHEN YOUNG ,  HAYLEY BINCH ,  THOMAS CLEVELAND ,  FANNING LEV T D ,  DENNIS HURLEY ,  PRAMOD JOSHI ,  URVI SHETH ,  ALINA SILINA ,  MICHAEL REAPER PHILIP

IPC: C07D401/04 ,  A61K31/4965 ,  A61P35/00 ,  C07D403/04 ,  C07D413/04

Abstract: The present disclosure relates to pyrazine compounds of formula (I) wherein L, n, R, and R are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.

公开(公告)号：CA2772792A1

公开(公告)日：2011-03-24

申请号：CA2772792

申请日：2010-09-17

Applicant: VERTEX PHARMA

Inventor： AMBHAIKAR NARENDRA BHALCHANDRA ,  BEAR BRIAN RICHARD ,  FANNING LEV T D ,  HUGHES ROBERT ,  LITTLER BENJAMIN

IPC: C07D487/08

Abstract: The present invention relates to a process for preparing azabicyclic compounds that are useful intermediates for synthesizing pharmaceutical compounds or salts thereof.

公开(公告)号：CA2742042A1

公开(公告)日：2010-04-29

申请号：CA2742042

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  FANNING LEV T D ,  BOTFIELD MARTYN ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK ,  NUMA MEHDI MICHEL DJAMEL

IPC: C07D487/08 ,  A61K31/4709 ,  A61P11/00 ,  A61P43/00

Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR (Formula I) or pharmaceutically acceptable salts thereof, wherein: ring A is selected from: (a), (b), (c), (d), wherein: R1 is -CH3 -CF3 or -CN; R2 is hydrogen, -CH3, -CF3, -OH, or -CH2OH; R3 is hydrogen, -CH3, -OCH3, or -CN; provided that both R2 and R3 are not simultaneously hydrogen; and one of X and Y is nitrogen and the other is carbon.