公开(公告)号：PE20090705A1

公开(公告)日：2009-07-17

申请号：PE2008001621

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： WAGNER ROLF ,  TUFANO MICHAEL D ,  STEWART KENT D ,  ROCKWAY TODD W ,  RANDOLPH JOHN T ,  PRATT JOHN K ,  MOTTER CHRISTOPHER E ,  MARING CLARENCE J ,  LONGENECKER KENTON L ,  LIU YAYA ,  LIU DACHUN ,  KRUEGER ALLAN C ,  KATI WARREN M ,  HUTCHINSON DOUGLAS K ,  HUANG PEGGY P ,  FLENTGE CHARLES A ,  DONNER PAMELA L ,  DEGOEY DAVID A ,  BETEBENNER DAVID A ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK THADDEUS S II ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  SARRIS KATHY ,  ZHANG GEOFF G Z

IPC: A61K31/513 ,  C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D409/10 ,  C07D417/10

Abstract: REFERIDA A UN COMPUESTO DE FORMULA (I), DONDE---- ES ENLACE SIMPLE CARBONO-CARBONO O UN ENLACE DOBLE CARBONO-CARBONO; R1 ES H, -CH3, GRUPO PROTECTOR DE N; R2 ES H, HALO, -OH, -CH3, CICLOPROPILO, ENTRE OTROS; R3 ES H, OXO, HALO, METILO; R4 ES HALO, ALQUILO, NO2, AZIDO, ENTRE OTROS; R5 ES H, -OH, ALQUILO, ALQUILOXI, ENTRE OTROS; R6 ES CARBOCICLILO DE 2 ANILLOS FUSIONADOS O HETEROCICLILO DE 2 ANILLOS FUSIONADOS, ENTRE OTROS; L ES UN ENLACE. DICHO COMPUESTO TIENE UN PATRON DE DIFRACCION DE RAYOS X DE POLVOS EXPRESADOS EN GRADOS 2 TETA DE 8,3+-0,2; 9,7+-0,2; 10,5+-0,2, ENTRE OTROS. UN COMPUESTO PREFRIDO ES N-(6-(3-TER-BUTIL-5-(2,4-DIOXO-3,4-DIHIDROPIRIMIDIN-1(2H)IL)2-METOXIFENIL)NAFTALEN-2-IL)METANSULFONAMIDA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE LA FORMA CRISTALINA Y A UN PROCEDIMIENTO DE PREPARACION DE DICHA COMPOSICION LA CUAL ES UTIL PARA EL TRATAMIENTO DE LA HEPATITIS C

公开(公告)号：HK1122292A1

公开(公告)日：2009-05-15

申请号：HK09101289

申请日：2009-02-11

Applicant: ABBOTT LAB DEPT

Inventor： ROCKWAY TODD W ,  BETEBENNER DAVID A ,  KRUEGER ALLAN C ,  IWASAKI NOBUHIKO ,  COOPER CURT S ,  ANDERSON DAVID D ,  KEMPF DALE J ,  MADIGAN DAROLD L ,  MOTTER CHRISTOPHER E ,  SHANLEY JASON P ,  TUFANO MICHAEL D ,  WAGNER ROLF ,  ZHANG RONG ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  PILOT-MATIAS TAMI ,  MASSE SHERIE VL ,  CARRICK ROBERT J ,  HE WEPING ,  LU LIANGJUN

IPC: C07D20060101

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (HCV) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：HK1121765A1

公开(公告)日：2009-04-30

申请号：HK09101934

申请日：2009-03-02

Applicant: ABBOTT LAB

Inventor： BETEBENNER DAVID A ,  DEGOEY DAVID A ,  MARING CLARENCE J ,  KRUEGER ALLAN C ,  IWASAKI NOBUHIKO ,  ROCKWAY TODD W ,  COOPER CURT S ,  ANDERSON DAVID D ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  LIU DACHUN ,  MCDANIEL KEITH F ,  MADIGAN DAROLD L ,  MOTTER CHRISTOPHER E ,  PRATT JOHN K ,  SHANLEY JASON P ,  TUFANO MICHAEL D ,  WAGNER ROLF ,  ZHANG RONG ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  PILOT-MATIAS TAMI J ,  MASSE SHERIE VL ,  CARRICK ROBERT J ,  HE WEPING ,  LU LIANGJUN ,  GRAMPOVNIK DAVID J

IPC: C07D20060101

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：CA2699989A1

公开(公告)日：2009-03-26

申请号：CA2699989

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： DONNER PAMELA L ,  RANDOLPH JOHN T ,  KRUEGER ALLAN C ,  BETEBENNER DAVID A ,  HUTCHINSON DOUGLAS K ,  LIU DACHUN ,  LIU YAYA ,  LONGENECKER KENTON L ,  MARING CLARENCE J ,  PRATT JOHN K ,  ROCKWAY TODD W ,  STEWART KENT D ,  WAGNER ROLF ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK THADDEUS S II ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  ZHANG GEOFF G Z

IPC: C07D239/22 ,  A61K31/506 ,  A61K31/513 ,  A61P31/14 ,  C07D239/54 ,  C07D239/553 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions. The compounds are usefull in the treatment of hepatitis C and are of the following general structure: Formula (I)

公开(公告)号：CA2699981A1

公开(公告)日：2009-03-26

申请号：CA2699981

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： WAGNER ROLF ,  TUFANO MICHAEL D ,  STEWART KENT D ,  ROCKWAY TODD W ,  RANDOLPH JOHN T ,  PRATT JOHN K ,  MOTTER CHRISTOPHER E ,  MARING CLARENCE J ,  LONGENECKER KENTON L ,  LIU YAYA ,  LIU DACHUN ,  KRUEGER ALLAN C ,  KATI WARREN M ,  HUTCHINSON DOUGLAS K ,  HUANG PEGGY P ,  FLENTGE CHARLES A ,  DONNER PAMELA L ,  DEGOEY DAVID A ,  BETEBENNER DAVID A ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK THADDEUS S II ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  SARRIS KATHY ,  ZHANG GEOFF G Z

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

Abstract: Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.

公开(公告)号：CA2672737A1

公开(公告)日：2008-11-06

申请号：CA2672737

申请日：2007-12-19

Applicant: ABBOTT LAB

Inventor： ANDERSON DAVID D ,  WAGNER ROLF ,  CARRICK ROBERT J ,  ZHANG RONG ,  HE WENPING ,  ROCKWAY TODD W ,  MARING CLARENCE J ,  PILOT-MATIAS TAMI J ,  MASSE SHERIE V L ,  COOPER CURT S ,  BETEBENNER DAVID A ,  MO HONGMEI ,  MOLLA AKHTERUZZAMAN ,  LU LIANGJUN

IPC: A01N43/42 ,  A61K31/44

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to composi tions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and interme diates for the syntheses of such compounds, and methods of using such compou nds for the treatment of HCV or other viral infections.

公开(公告)号：CA2633752A1

公开(公告)日：2007-07-19

申请号：CA2633752

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  LU LIANGJUN ,  GRAMPOVNIK DAVID J ,  CARRICK ROBERT J ,  HE WEPING ,  KRUEGER ALLAN C ,  BETEBENNER DAVID A ,  TUFANO MICHAEL D ,  PILOT-MATIAS TAMI J ,  MASSE SHERIE VL ,  WAGNER ROLF ,  MCDANIEL KEITH F ,  IWASAKI NOBUHIKO ,  DEGOEY DAVID A ,  LIU DACHUN ,  ROCKWAY TODD W ,  MO HONGMEI ,  COOPER CURT S ,  DONNER PAMELA L ,  ANDERSON DAVID D ,  MOLLA AKHTERUZZAMAN ,  MOTTER CHRISTOPHER E ,  ZHANG RONG ,  GREEN BRIAN E ,  MADIGAN DAROLD L ,  PRATT JOHN K ,  KEMPF DALE J ,  SHANLEY JASON P

IPC: C07D495/04 ,  C07D471/04 ,  C07D513/04

公开(公告)号：PT1339695E

公开(公告)日：2006-08-31

申请号：PT01273519

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY STEPHEN L II ,  HASVOLD LISA A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D233/00 ,  C07D401/00 ,  C07D405/00 ,  C07D409/00

公开(公告)号：AT323681T

公开(公告)日：2006-05-15

申请号：AT01273519

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY STEPHEN L II ,  HASVOLD LISA A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WANG WEIBO

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：AT319689T

公开(公告)日：2006-03-15

申请号：AT01934906

申请日：2001-04-25

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DALTON CHRISTOPHER R ,  GIRANDA VINCENT L ,  GONG JIANCHUN ,  MCCLELLAN WILLIAM J ,  NIENABER VICKI L ,  ROCKWAY TODD W ,  SAUER DARYL R ,  WEITZBERG MOSHE

IPC: A61K31/472 ,  A61K31/4725 ,  A61P9/00 ,  A61P15/16 ,  A61P15/18 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D217/02 ,  C07D217/04 ,  C07D217/06 ,  C07D217/26 ,  C07D401/06 ,  C07D405/04 ,  C07D405/10