公开(公告)号：WO0129020A9

公开(公告)日：2002-10-03

申请号：PCT/US0027090

申请日：2000-10-02

Applicant: ABBOTT LAB

Inventor： STEWART KENT D ,  KEMPF DALE J ,  KLEIN LARRY L ,  MARING CLARENCE J ,  STOLL VINCENT S

IPC: A61K31/35 ,  A61P31/16 ,  C07D309/28

CPC classification number: C07D309/28

Abstract: The present invention provides compounds which are neuraminidase inhibitors characterized by a unique three-dimensional conformation and orientation relative to the Sites of Occupation 1-4 of the enzyme. Also provided are pharmaceutical compositions containing said compounds, as well as methods of using said compounds and compositions.

Abstract translation: 本发明提供了作为神经氨酸酶抑制剂的化合物，其特征在于相对于酶的占位位置1-4的独特的三维构象和取向。 还提供含有所述化合物的药物组合物，以及使用所述化合物和组合物的方法。

公开(公告)号：WO0128979A3

公开(公告)日：2001-12-27

申请号：PCT/US0027938

申请日：2000-10-10

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GIRANDA VINCENT L ,  KEMPF DALE J ,  STOLL VINCENT S ,  SUN MINGHUA ,  ZHAO CHEN ,  GU YU GUI ,  WANG GARY T ,  KRUEGER ALLAN C ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KENNEDY APRIL L ,  LIN ZHEN ,  MADIGAN DONALD L ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  WANG SHELDON ,  YEUNG MING C

IPC: A61K31/195 ,  C07C233/48 ,  C07C237/24 ,  C07C271/22 ,  C07C271/24 ,  C07C279/16 ,  C07D233/54 ,  C07D263/32 ,  C07D307/24 ,  C07D317/30 ,  C07D405/04 ,  A61K31/325 ,  A61K31/34 ,  A61K31/415 ,  A61K31/42 ,  A61P31/00

CPC classification number: C07D233/64 ,  C07B2200/07 ,  C07B2200/09 ,  C07C233/48 ,  C07C237/24 ,  C07C271/22 ,  C07C271/24 ,  C07C279/16 ,  C07C2601/08 ,  C07C2601/10 ,  C07D263/32 ,  C07D307/24 ,  C07D317/30 ,  C07D405/04

Abstract: Disclosed are compounds of formula (I), (II) or (III) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

Abstract translation: 公开了可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶的式（I），（II）或（III）的化合物。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。

公开(公告)号：CA2666590C

公开(公告)日：2015-10-06

申请号：CA2666590

申请日：2007-10-19

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： TURNER SEAN COLM ,  BAKKER MARGARETHA HENRICA MARIA ,  STEWART KENT D

IPC: C07D401/12 ,  A61K31/4709 ,  A61K31/497 ,  A61P25/00 ,  C07D413/14 ,  C07D471/04

Abstract: The present invention relates to a heterocyclic compound of the general formula (I) and their use and preparation, methods of making the compounds, compositions containing at least one of said compounds, and methods of treatment using at least one compound. In particular, compounds of the general formula (I) are useful for inhibiting glycogen synthase kinase 3 (GSK-3),

公开(公告)号：AU2014280939A1

公开(公告)日：2015-01-22

申请号：AU2014280939

申请日：2014-12-24

Applicant: ABBOTT LAB

Inventor： KRUEGER ALLAN C ,  GAO YI ,  KOTECKI BRIAN J ,  FLENTGE CHARLES A ,  MOTTER CHRISTOPHER E ,  MARING CLARENCE J ,  LIU DACHUN ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  BARNES DAVID M ,  HUTCHINSON DOUGLAS K ,  ZHANG GEOFF G Z ,  HENGEVELD JOHN E ,  PRATT JOHN K ,  RANDOLPH JOHN T ,  SARRIS KATHY ,  STEWART KENT D ,  LONGENECKER KENTON L ,  TUFANO MICHAEL D ,  DONNER PAMELA L ,  HUANG PEGGY P ,  HENRY RODGER F ,  WAGNER ROLF ,  CHEN SHUANG ,  FRANCZYK II THADDEUS S ,  ROCKWAY TODD W ,  KATI WARREN M ,  LOU XIAOCHUN ,  LIU YAYA ,  HAUGHT ANTHONY R

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

Abstract: URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2,4-dioxo-3,4 dihydropyrimidin-1(2H)-yl)-2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N (4(3-t-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxy-styryl phenyl)methanesulfonamide.

公开(公告)号：PE20140407A1

公开(公告)日：2014-04-25

申请号：PE2013001090

申请日：2009-06-09

Applicant: ABBOTT LAB

Inventor： WISHART NEIL ,  ARGIRIADI MARIA A ,  CALDERWOOD DAVID J ,  ERICSSON ANNA M ,  FIAMENGO BRYAN A ,  FRANK KRISTINE E ,  FRIEDMAN MICHAEL ,  GEORGE DAWN M ,  GOEDKEN ERIC R ,  JOSEPHSOHN NATHAN S ,  LI BIQIN C ,  MORYTKO MICHAEL J ,  STEWART KENT D ,  VOSS JEFFREY W ,  WALLACE GRIER A ,  WANG LU ,  WOLLER KEVIN R

IPC: C07D487/14 ,  A61K31/4985 ,  A61P35/00 ,  C07D498/14 ,  C07D513/14

Abstract: REFERIDA A UN COMPUESTO TRICICLICO DE FORMULA (I), DONDE T ES CR6, N, O, NR6, S; U ES N, CR4; X ES CR3, NR3; Y ES N O C; R1, R2 Y R5 SON H, HALOGENO, NO2, CN, ENTRE OTROS; R3 ES H, CICLOALQUILO C5-C12, ARILO C6-C10, ENTRE OTROS; R4 Y R6 SON H, HALOGENO, CICLOALQUILO C5-C12, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-((3R,4R)-3-(6H-IMIDAZO[1,5-a]PIRROLO[2,3-e]PIRAZIN-1-IL)-4-METILPIPERIDIN-1-IL)-3-OXOPROPANONITRILO, 7-(5-METOXI-1-METIL-1H-INDOL-3-IL)-1-METIL-6H-IMIDAZO[1,5-a]PIRROLO[2,3-e]PIRAZINA, 1-CICLOHEXIL-6H-IMIDAZO[1,5-a]PIRROLO[2,3-e]PIRAZINA, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES INMUNOLOGICAS Y ONCOLOGICAS

公开(公告)号：CA2699989C

公开(公告)日：2014-03-25

申请号：CA2699989

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： DONNER PAMELA L ,  RANDOLPH JOHN T ,  KRUEGER ALLAN C ,  BETEBENNER DAVID A ,  HUTCHINSON DOUGLAS K ,  LIU DACHUN ,  LIU YAYA ,  LONGENECKER KENTON L ,  MARING CLARENCE J ,  PRATT JOHN K ,  ROCKWAY TODD W ,  STEWART KENT D ,  WAGNER ROLF ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK THADDEUS S II ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  ZHANG GEOFF G Z

IPC: C07D239/22 ,  A61K31/506 ,  A61K31/513 ,  A61P31/14 ,  C07D239/54 ,  C07D239/553 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions. The compounds are usefull in the treatment of hepatitis C and are of the following general structure: Formula (I)

公开(公告)号：AU2013202002A1

公开(公告)日：2013-04-18

申请号：AU2013202002

申请日：2013-03-26

Applicant: ABBOTT LAB

Inventor： KRUEGER ALLAN C ,  GAO YI ,  KOTECKI BRIAN J ,  FLENTGE CHARLES A ,  MOTTER CHRISTOPHER E ,  MARING CLARENCE J ,  LIU DACHUN ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  BARNES DAVID M ,  HUTCHINSON DOUGLAS K ,  ZHANG GEOFF G Z ,  HENGEVELD JOHN E ,  PRATT JOHN K ,  RANDOLPH JOHN T ,  SARRIS KATHY ,  STEWART KENT D ,  LONGENECKER KENTON L ,  TUFANO MICHAEL D ,  DONNER PAMELA L ,  HUANG PEGGY P ,  HENRY RODGER F ,  WAGNER ROLF ,  CHEN SHUANG ,  FRANCZYK II THADDEUS S ,  ROCKWAY TODD W ,  KATI WARREN M ,  LOU XIAOCHUN ,  LIU YAYA ,  HAIGHT ANTHONY R

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

Abstract: URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4 dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E) N-(4(3-t-butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1(2H)-yl)2-methoxy-styryl phenyl)methanesulfonamide.

公开(公告)号：SG183733A1

公开(公告)日：2012-09-27

申请号：SG2012060521

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： WAGNER ROLF ,  TUFANO MICHAEL D ,  STEWART KENT D ,  ROCKWAY TODD W ,  RANDOLPH JOHN T ,  PRATT JOHN K ,  MOTTER CHRISTOPHER E ,  MARING CLARENCE J ,  LONGENECKER KENTON L ,  LIU YAYA ,  LIU DACHUN ,  KRUEGER ALLAN C ,  KATI WARREN M ,  HUTCHINSON DOUGLAS K ,  HUANG PEGGY P ,  FLENTGE CHARLES A ,  DONNER PAMELA L ,  DEGOEY DAVID A ,  BETEBENNER DAVID A ,  BARNES DAVID M

Abstract: URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C AbstractPresent application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-buty1-5- (2,4dioxo3,4dihydropyrimidin1(2H)y1)(2methoxyphenyl)naphthalen2yemethanesulfonamide &(E)-N-(4(3-t-buty1-5-(2,4-dioxo-3)4-dihydropyrimidin-1(2H)-3,02-methoxy-styryl phenyOmethanesulfonamide.No Suitable figure

公开(公告)号：CR20120294A

公开(公告)日：2012-09-03

申请号：CR20120294

申请日：2012-05-30

Applicant: ABBOTT LAB

Inventor： WISHART NEIL ,  ARGIRIADI MARIA A ,  BRENINLINGER ERIC C ,  CALDERWOOD DAVID J ,  ERICSSON ANNA M ,  FIAMENGO BRYAN A ,  FRANK KRISTINE E ,  FRIEDMAN MICHAEL ,  GEORGE DAWN M ,  GOEDKEN ERIC R ,  JOSEPHSOHN NATHAN S ,  LI BIQIN C ,  MORYTKO MICHAEL J ,  MULLEN KELLY D ,  SOMAL GAGANDEEP ,  STEWART KENT D ,  VOSS JEFFREY W ,  WALLACE GRIER A ,  WANG LU ,  WOLLER KEVIN R

IPC: A01N43/42 ,  A61K31/44

Abstract: Un compuesto con la Fórmula (Ia), (Ib), (Ic), (Id), (Ie), (Si), (Ig), (Ih), (Ii), (Ij), (Ik), o (Il), según se las define aquí, sales farmacéuticamente aceptables, prodrogas, metabolitos, estereoisómeros e isómeros de los mismos biológicamente activos, donde las variables se han definido aquí. Los compuestos de la invención son útiles para tratar condiciones inmunológicas y oncológicas.

公开(公告)号：PT2203431E

公开(公告)日：2011-10-12

申请号：PT08832330

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： HAIGHT ANTHONY R ,  KATI WARREN M ,  KRUEGER ALLAN C ,  STEWART KENT D ,  PRATT JOHN K ,  HENGEVELD JOHN E ,  BETEBENNER DAVID A ,  DONNER PAMELA L ,  MARING CLARENCE J ,  RANDOLPH JOHN T ,  HUTCHINSON DOUGLAS K ,  LIU DACHUN ,  LIU YAYA ,  LONGENECKER KENTON L ,  ROCKWAY TODD W ,  WAGNER ROLF ,  BARNES DAVID M ,  CHEN SHUANG ,  GAO YI ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  ZHANG GEOFF G Z ,  FLENTGE CHARLES A ,  DEGOEY DAVID A ,  MOTTER CHRISTOPHER E ,  FRANCZYK THADDEUS S II

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10