公开(公告)号：AU2007220889A1

公开(公告)日：2007-09-07

申请号：AU2007220889

申请日：2007-02-16

Applicant: ABBOTT LAB

Inventor： FICKES MICHAEL G ,  SUN MINGHUA ,  ZHAO CHEN ,  SHEIKH AHMAD Y ,  HENRY RODGER F ,  BARNES DAVID M ,  GREGG ROBERT J ,  HAIGHT ANTHONY R ,  KOLACZKOWSKI LAWRENCE ,  WITTENBERGER STEVEN J ,  ZHANG GEOFF G Z ,  COWART MARLON D ,  LOU XIAOCHUN ,  ZHENG GUO ZHU ,  BLACK LAWRENCE A ,  CHANG SOU-JEN

IPC: C07D487/04 ,  A61K31/407

Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

公开(公告)号：CA2505427A1

公开(公告)日：2004-05-27

申请号：CA2505427

申请日：2003-11-05

Applicant: ABBOTT LAB

Inventor： LIU HUAQING ,  LUKIN KIRILL A ,  NERSESIAN DIANA L ,  PU YU-MING ,  SHARMA PADAM N ,  BLACK LAWRENCE A ,  BENNANI YOUSSEF L ,  CHANG SOU-JEN ,  CURTIS MICHAEL P ,  ALTENBACH ROBERT J ,  COWART MARLON D ,  GFESSER GREGORY A ,  FAGHIH RAMIN ,  KU YI-YIN

IPC: A61P3/00 ,  A61P25/00 ,  C07C255/58 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/20 ,  C07D213/30 ,  C07D213/38 ,  C07D213/61 ,  C07D213/64 ,  C07D213/85 ,  C07D215/12 ,  C07D215/14 ,  C07D215/20 ,  C07D217/14 ,  C07D237/12 ,  C07D237/14 ,  C07D237/28 ,  C07D239/26 ,  C07D239/28 ,  C07D239/42 ,  C07D239/52 ,  C07D241/12 ,  C07D241/42 ,  C07D263/32 ,  C07D277/28 ,  C07D295/073 ,  C07D295/092 ,  C07D295/096 ,  C07D295/112 ,  C07D295/135 ,  C07D295/155 ,  C07D401/04 ,  C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  A61K31/40 ,  C07D261/08 ,  C07D295/088 ,  C07D295/116

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for prepari ng compounds within the scope of formula (I).

公开(公告)号：CA2502906A1

公开(公告)日：2004-05-06

申请号：CA2502906

申请日：2003-10-22

Applicant: ABBOTT LAB

Inventor： BUNNELLE WILLIAM H ,  CHANG SOU-JEN ,  DART MICHAEL J ,  FERNANADO DILINIE P ,  CHEMBURKAR SANJAY R ,  BENNANI YOUSSEF L ,  LOCKWOOD MARK ,  WANG LEI ,  KU YI-YIN ,  CHEN JINHUA

IPC: A61P25/00 ,  A61P29/00 ,  C07C61/13 ,  C07C61/135 ,  C07C69/753 ,  C07C233/58 ,  C07C233/60 ,  C07C233/63 ,  A61K31/16 ,  A61K31/19 ,  C07C61/00 ,  C07C229/00 ,  C07C233/00

Abstract: The present invention relates to the use of compounds of Formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.

公开(公告)号：ES2191821T3

公开(公告)日：2003-09-16

申请号：ES97907949

申请日：1997-02-27

Applicant: ABBOTT LAB

Inventor： CHANG SOU-JEN

IPC: C07H17/08

公开(公告)号：CA2403026A1

公开(公告)日：2001-10-18

申请号：CA2403026

申请日：2001-03-20

Applicant: ABBOTT LAB

Inventor： KERDESKY FRANCIS A J ,  KING STEVEN A ,  CHANG SOU-JEN ,  WAYNE GREGORY S ,  PEASE JONATHAN P ,  PREMCHANDRAN RAMIYA ,  LALLAMAN JOHN E ,  MORTON HOWARD E ,  BHAGAVATULA LAKSHMI

IPC: C07H17/08 ,  A61P31/04 ,  C07B61/00 ,  C07D407/14 ,  C07D409/04 ,  C07D498/04 ,  A61K31/7048

Abstract: Disclosed herein is a process for the preparation of erythromycin derivative s, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O-position.

公开(公告)号：CA2250941A1

公开(公告)日：1997-10-16

申请号：CA2250941

申请日：1997-02-27

Applicant: ABBOTT LAB

Inventor： CHANG SOU-JEN

IPC: C07H17/08

Abstract: A process of preparing 9-oxime erythromycin A using acetic acid and isopropanol is provided.

公开(公告)号：CA2719425C

公开(公告)日：2014-08-12

申请号：CA2719425

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C57/04 ,  C07C68/06 ,  C07C69/54 ,  C07C69/96 ,  C07C271/08 ,  C07D215/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or substrate that can be reduced to obtain the same.

公开(公告)号：CA2566896C

公开(公告)日：2012-10-30

申请号：CA2566896

申请日：2005-04-29

Applicant: ABBOTT LAB

Inventor： ALTENBACH ROBERT J ,  BLACK LAWRENCE A ,  CHANG SOU-JEN ,  COWART MARLON D ,  FAGHIH RAMIN ,  GFESSER GREGORY A ,  KU YI-YIN ,  LIU HUAQING ,  LUKIN KIRILL A ,  NERSESIAN DIANA L ,  PU YU-MING ,  CURTIS MICHAEL P

IPC: C07D417/14 ,  A61K31/4709 ,  A61P25/00 ,  A61P25/28 ,  C07D215/12 ,  C07D401/04 ,  C07D401/08 ,  C07D401/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04

Abstract: Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2and L3, to a heteroaromatic core, and X, X', Y, Y', Z, Z', R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

公开(公告)号：DK1192139T3

公开(公告)日：2012-07-23

申请号：DK00942823

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  NICHOLS PAUL J ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  KING STEVEN A ,  WITTENBERGER STEVEN J

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C57/04 ,  C07C68/06 ,  C07C69/96 ,  C07C269/06 ,  C07C271/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

公开(公告)号：BRPI0708258A2

公开(公告)日：2011-05-24

申请号：BRPI0708258

申请日：2007-02-16

Applicant: ABBOTT LAB

Inventor： COWART MARLON D ,  ZHAO CHEN ,  SUN MINGHUA ,  BLACK LAWRENCE A ,  ZHENG GUO ZHU ,  GREGG ROBERT J ,  ZHANG GEOFF G ,  SHEIKH AHMAD Y ,  LOU XIAOCHUN ,  HENRY RODGER F ,  BARNES DAVID M ,  KOLACZKOWSKI LAWRENCE ,  HAIGHT ANTHONY R ,  CHANG SOU-JEN ,  WITTENBERGER STEVEN J ,  FICKES MICHAEL G

IPC: C07D487/04 ,  A61K31/407

Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.