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公开(公告)号：MX2011010047A
公开(公告)日：2011-10-11
申请号：MX2011010047
申请日：2010-03-25
Applicant: ABBOTT LAB
Inventor： PRATT JOHN K , BETEBENNER DAVID A , WAGNER ROLF , DEGOEY DAVID A , FLENTGE CHARLES A , KRUEGER ALLAN C , STEWART KENT D , LONGENECKER KENTON L , ROCKWAY TODD W , LIU DACHUN , KATI WARREN M , HUTCHINSON DOUGLAS K
IPC: C07D401/04 , A61K31/513 , A61P31/12 , C07D403/04 , C07D407/04 , C07D409/14
Abstract: La presente invención se refiere a: (a) compuestos y sales de los mismos, que entre otras cosas, inhiben HCV; (b) intermediarios útiles para la preparación de dichos compuestos y sales; (c) composiciones que comprenden dichos compuestos y sales; (d) métodos de preparación de dichos intermediaros, compuestos, sales y composiciones; (e) métodos de uso de dichos compuestos, sales y composiciones y (f) equipos que comprenden dichos compuestos, sales y composiciones.
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公开(公告)号：SG171708A1
公开(公告)日：2011-07-28
申请号：SG2011023421
申请日：2010-06-10
Applicant: ABBOTT LAB
Inventor： DEGOEY DAVID A , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , RANDOLPH JOHN T , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHIN V , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , SOLTWEDEL TODD N , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , WAGNER ROLF , MARING CLARENCE J , TUFANO MICHAEL D , BETEBENNER DAVID A , ROCKWAY TODD W , LIU DACHUN , PRATT JOHN K , LAVIN MICHAEL J , SARRIS KATHY , WOLLER KEVIN R , WAGAW SEBLE H , CALIFANO JEAN C , LI WENKE , CASPI DANIEL D , BELLIZZI MARY E
Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：MX2011006332A
公开(公告)日：2011-06-27
申请号：MX2011006332
申请日：2009-12-22
Applicant: ABBOTT LAB
Inventor： DONNER PAMELA L , DEGOEY DAVID A , HUTCHINS CHARLES W , JINKERSON TAMMIE K , KATI WARREN M , MATULENKO MARK A , KEDDY RYAN G
IPC: C07D471/04 , A61K31/519 , A61P31/14
Abstract: Se describen compuestos efectivos para inhibir la réplica de virus Hepatitis C ("HCV"). La presente invención también se refiere a procesos para elaborar dichos compuestos, composiciones que comprenden dichos compuestos, y métodos para utilizar dichos compuestos para tratar infección HCV.
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公开(公告)号：MX2010002902A
公开(公告)日：2010-06-02
申请号：MX2010002902
申请日：2008-09-17
Applicant: ABBOTT LAB
Inventor： BARNES DAVID M , PRATT JOHN K , BETEBENNER DAVID A , DONNER PAMELA L , MARING CLARENCE J , WAGNER ROLF , RANDOLPH JOHN T , DEGOEY DAVID A , FLENTGE CHARLES A , HUTCHINSON DOUGLAS K , KRUEGER ALLAN C , KOTECKI BRIAN J , HAIGHT ANTHONY R , GAO YI , STEWART KENT D , LONGENECKER KENTON L , ROCKWAY TODD W , MOTTER CHRISTOPHER E , LIU DACHUN , ZHANG GEOFF G Z , LOU XIAOCHUN , CHEN SHUANG , KATI WARREN M , LIU YAYA , FRANCZYK THADDEUS S II , HENGEVELD JOHN E
IPC: C07D239/22 , A61K31/513 , A61P31/12 , C07D239/54 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10
Abstract: Esta invención se relaciona con: (a) compuestos y sales de los mismos que, entre otros, inhiben el HCV; (b) intermediarios de utilidad para la preparación de dichos compuestos y sales; (c) composiciones que comprenden dichos compuestos y sales; (d) métodos para preparar dichos intermediarios, compuestos, sales y composiciones; (e) métodos de uso de dichos compuestos, sales y composiciones; y (f) conjuntos de elementos que comprenden dichos compuestos, sales y composiciones.
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公开(公告)号：PE07052009A1
公开(公告)日：2009-07-17
申请号：PE0016212008
申请日：2008-09-17
Applicant: ABBOTT LAB
Inventor： WAGNER ROLF , TUFANO MICHAEL D , STEWART KENT D , ROCKWAY TODD W , RANDOLPH JOHN T , PRATT JOHN K , MOTTER CHRISTOPHER E , MARING CLARENCE J , LONGENECKER KENTON L , LIU YAYA , LIU DACHUN , KRUEGER ALLAN C , KATI WARREN M , HUTCHINSON DOUGLAS K , HUANG PEGGY P , FLENTGE CHARLES A , DONNER PAMELA L , DEGOEY DAVID A , BETEBENNER DAVID A , BARNES DAVID M , CHEN SHUANG , FRANCZYK THADDEUS S II , GAO YI , HAIGHT ANTHONY R , HENGEVELD JOHN E , HENRY RODGER F , KOTECKI BRIAN J , LOU XIAOCHUN , SARRIS KATHY , ZHANG GEOFF G Z
IPC: A61K31/513 , C07D239/22 , C07D239/54 , C07D401/10 , C07D409/10 , C07D417/10
CPC classification number: A61K31/513 , A61K31/5377 , C07D239/22 , C07D239/54 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D417/14
Abstract: REFERIDA A UN COMPUESTO DE FORMULA (I), DONDE---- ES ENLACE SIMPLE CARBONO-CARBONO O UN ENLACE DOBLE CARBONO-CARBONO; R1 ES H, -CH3, GRUPO PROTECTOR DE N; R2 ES H, HALO, -OH, -CH3, CICLOPROPILO, ENTRE OTROS; R3 ES H, OXO, HALO, METILO; R4 ES HALO, ALQUILO, NO2, AZIDO, ENTRE OTROS; R5 ES H, -OH, ALQUILO, ALQUILOXI, ENTRE OTROS; R6 ES CARBOCICLILO DE 2 ANILLOS FUSIONADOS O HETEROCICLILO DE 2 ANILLOS FUSIONADOS, ENTRE OTROS; L ES UN ENLACE. DICHO COMPUESTO TIENE UN PATRON DE DIFRACCION DE RAYOS X DE POLVOS EXPRESADOS EN GRADOS 2 TETA DE 8,3+-0,2; 9,7+-0,2; 10,5+-0,2, ENTRE OTROS. UN COMPUESTO PREFRIDO ES N-(6-(3-TER-BUTIL-5-(2,4-DIOXO-3,4-DIHIDROPIRIMIDIN-1(2H)IL)2-METOXIFENIL)NAFTALEN-2-IL)METANSULFONAMIDA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE LA FORMA CRISTALINA Y A UN PROCEDIMIENTO DE PREPARACION DE DICHA COMPOSICION LA CUAL ES UTIL PARA EL TRATAMIENTO DE LA HEPATITIS C
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Patent Agency Ranking
公开(公告)号：PL343678A1
公开(公告)日：2001-08-27
申请号：PL34367899
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
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公开(公告)号：BG104962A
公开(公告)日：2001-07-31
申请号：BG10496200
申请日：2000-11-17
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-JU , CHEN YCANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
Abstract: Disclosed are compounds of formula which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminodase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes. 56 claims
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公开(公告)号：CA2329422A1
公开(公告)日：1999-10-28
申请号：CA2329422
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MADIGAN DAROLD L , LIN ZHEN , KRUEGER ALLAN C , MARING CLARENCE J , DEGOEY DAVID A , XU YIBO , YEUNG MING C , FLOSI WILLIAM J , ZHAO CHEN , KENNEDY APRIL , MUCHMORE STEVEN W , STEWART KENT D , KEMPF DALE J , SHAM HING L , GRAMPOVNIK DAVID J , STOLL VINCENT S , KATI WARREN M , WANG GARY T , GU YU-GUI , SUN MINGHUA , WANG SHELDON , MCDANIEL KEITH F , GIRANDA VINCENT L , KLEIN LARRY L , CHEN YUANWEI , CHEN HUI-JU
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
Abstract: Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
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公开(公告)号：BRPI0816994A2
公开(公告)日：2015-03-24
申请号：BRPI0816994
申请日：2008-09-17
Applicant: ABBOTT LAB
Inventor： ROLF WAGNER , TUFANO MICHAEL D , STEWART KENT D , ROCKWAY TODD W , RANDOLPH JOHN T , PRATT JOHN K , MOTTER CHRISTOPHER E , MARING CLARENCE J , LONGENECKER KENTON L , LIU YAYA , LIU DACHUN , KRUEGER ALLAN C , KATI WARREN M , HUTCHINSON DOUGLAS K , HUANG PEGGY P , FLENTGE CHARLES A , DONNER PAMELA L , DEGOEY DAVID A , BETEBENNER DAVID A , BARNES DAVID M , CHEN SHUANG , FRANCZYK THADDEUS S , GAO YI , HAIGHT ANTHONY R , HENGEVELD JOHN E , HENRY RODGER F , KOTECKI BRIAN J , LOU XIAOCHUN , SARRIS KATHY , ZHANG GEOFF G Z
IPC: C07D239/22 , A61K31/513 , A61P31/12 , C07D239/54 , C07D401/10 , C07D403/10 , C07D409/10 , C07D413/10 , C07D417/10
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公开(公告)号：CA2737601C
公开(公告)日：2014-10-21
申请号：CA2737601
申请日：2010-06-10
Applicant: ABBOTT LAB
Inventor： DEGOEY DAVID A , KATI WARREN M , HUTCHINS CHARLES W , DONNER PAMELA L , KRUEGER ALLAN C , RANDOLPH JOHN T , MOTTER CHRISTOPHER E , NELSON LISSA T , PATEL SACHIN V , MATULENKO MARK A , KEDDY RYAN G , JINKERSON TAMMIE K , HUTCHINSON DOUGLAS K , FLENTGE CHARLES A , WAGNER ROLF , MARING CLARENCE J , TUFANO MICHAEL D , BETEBENNER DAVID A , ROCKWAY TODD W , LIU DACHUN , PRATT JOHN K , SARRIS KATHY , WOLLER KEVIN R , WAGAW SEBLE H , CALIFANO JEAN C , LI WENKE , CASPI DANIEL D , BELLIZZI MARY E , GAO YI
IPC: C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/4439 , A61P31/14 , C07D401/14 , C07D417/14 , C07K5/062 , C07K5/065
Abstract: Compounds for Formula I effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection. (see formula I)
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